There exists in the medical field a desperate need to optimize the use of pharmaceutical resources in order to reduce side effects and unnecessary costs. The ability of the user population to metabolize correctly the active ingredients of each pharmaceutical product depends on the genetic profile of each person. Pharmacogenetics is responsible for over 80% of the efficacy and safety of drugs; however, unawareness of the pharmacogenetic profile of the population and the lack of pharmacogenetic information in the prospectuses of drugs cause over 50% of medical prescriptions to prove unsuitable. The objective of this project is to provide the scientific community with a tool which (i) enables detailed knowledge of the pharmacogenetics of over 1,400 drugs commonly prescribed worldwide, approved by the FDA in the USA, by the EMA in Europe and by Koseisho in Japan; (ii) facilitates personalized drug use for physicians; and (iii) defines the relationship existing between the genetics of diseases and the level of pharmacogenetic intervention.
EuroPharmaGenics is a historic milestone in pharmacogenetics, consisting of the digitalization, in interactive website format, of the first World Guide for Drug Use and Pharmacogenomics (WGPGX).
The World Guide for Drug Use and Pharmacogenomics (R. Cacabelos, Ed. EuroEspes Publishing, 2012) is the result of over five years’ work by a multidisciplinary team whose members, in addition to contributing their own professional experience, undertook the mission of searching the principal databases worldwide and reviewing thousands of papers on genetics, genomics, pharmacology, metabolism, therapeutics and pharmacogenetics, with the objective of systematizing the available knowledge of pharmacogenomics in an interactive database and in a volume which would be of use to physicians, geneticists, pharmacologists, pharmacists, molecular biologists, researchers, health professionals, regulatory agencies, health administrators and all other types of user with a desire to learn and to understand the keystones of practical, efficacious pharmacogenomic procedures.
This is an interactive clinical application intended for users in the fields of medicine and research, of great usefulness for the personalization of pharmacological therapy through awareness of the influence of genetic variability on drug activity, thus preventing adverse effects and ineffective response, all too common in medical practice. It enables us to practise a personalized medicine, greatly increasing therapeutic success.