Aagaard-Tillery K, Spong CY, Thom E. Pharmacogenomics of maternal tobacco use: metabolic gene polymorphisms and risk of adverse pregnancy outcomes. Obstet Gynecol 2010; 115:568-77.

Aamodt AH, Stovner LJ, Thorstensen K, Lydersen S, White LR, Aasly JO. Prevalence of haemochromatosis gene mutations in Parkinson's disease. J Neurol Neurosurg Psychiatry 2007; 78:315-7.

Aarnoudse AJ, Dieleman JP, Visser LE et al. Common ATP-binding cassette B1 variants are associated with increased digoxin serum concentration. Pharmacogenet Genomics 2008; 18:299-305.

Aarnoutse RE, Kleinnijenhuis J, Koopmans PP et al. Effect of low-dose ritonavir (100 mg twice daily) on the activity of cytochrome P450 2D6 in healthy volunteers. Clin Pharmacol Ther 2005; 78:664-74.

Abad S, Moachon L, Blanche P, Bavoux F, Sicard D, Salmon-Céron D. Possible interaction between gliclazide, fluconazole and sulfamethoxazole resulting in severe hypoglycaemia. Br J Clin Pharmacol 2001; 52:456-7.

Abadie-Viollon C, Martin H, Blanchard N et al. Follow-up to the pre-validation of a harmonised protocol for assessment of CYP induction responses in freshly isolated and cryopreserved human hepatocytes with respect to culture format, treatment, positive reference inducers and incubation conditions. Toxicol In Vitro 2010; 24:346-56.

Abass K, Reponen P, Mattila S, Pelkonen O. Metabolism of carbosulfan II. Human interindividual variability in its in vitro hepatic biotransformation and the identification of the cytochrome P450 isoforms involved. Chem Biol Interact 2010; 185:163-73.

Abass K, Reponen P, Mattila S, Pelkonen O. Metabolism of α-thujone in human hepatic preparations in vitro. Xenobiotica 2011; 41:101-11.

Abass K, Reponen P, Turpeinen M, Jalonen J, Pelkonen O. Characterization of diuron N-demethylation by mammalian hepatic microsomes and cDNA-expressed human cytochrome P450 enzymes. Drug Metab Dispos 2007; 35:1634-41.

Abass K, Turpeinen M, Pelkonen O. An evaluation of the cytochrome P450 inhibition potential of selected pesticides in human hepatic microsomes. J Environ Sci Health B 2009; 44:553-63.

Abate C, Niso M, Contino M et al. 1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Δ(8)-Δ(7) sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity. ChemMedChem 2011; 6:73-80.

Abaut AY, Chevanne F, Le Corre P. Influence of efflux transporters on liver, bile and brain disposition of amitriptyline in mice. Int J Pharm 2009; 378:80-5.

Abbas N, Lücking CB, Ricard S et al. A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease. Hum Mol Genet 1999; 8:567-74.

Abbas R, Chow CP, Browder NJ et al. In vitro metabolism and interaction of cilostazol with human hepatic cytochrome P450 isoforms. Hum Exp Toxicol 2000; 19:178-84.

Abbasi M, Lavasanifar A, Berthiaume LG, Weinfeld M, Uludağ H. Cationic polymer-mediated small interfering RNA delivery for P-glycoprotein down-regulation in tumor cells. Cancer 2010; 116:5544-54.

Abbasi M, Lavasanifar A, Uludaˇ H. Recent attempts at RNAi-mediated P-glycoprotein downregulation for reversal of multidrug resistance in cancer. Med Res Rev 2011. doi:10. 1002/med. 20244.

Abbott GW, Sesti F, Splawski I et al. MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell 1999; 97:175-87.

AbdAlla S, Lother H, Langer A, el Faramawy Y, Quitterer U. Factor XIIIA transglutaminase crosslinks AT1 receptor dimers of monocytes at the onset of atherosclerosis. Cell 2004; 119:343-54.

AbdAlla S, Lother H, Quitterer U. AT (1)-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration. Nature 2000; 407:94-8.

Abdel Halim M, Al-Otaibi T, Gheith O et al. Toxic tacrolimus blood levels with rifampin administration in a renal transplant recipient. Ann Transplant 2010; 15:57-60.

Abdelmalik N, Ruhé HG, Barwari K et al. Effect of the selective serotonin reuptake inhibitor paroxetine on platelet function is modified by a SLC6A4 serotonin transporter polymorphism. Thromb Haemost 2008; 6:2168-74.

Abdelmegeed MA, Moon KH, Chen C, Gonzalez FJ, Song BJ. Role of cytochrome P450 2E1 in protein nitration and ubiquitin-mediated degradation during acetaminophen toxicity. Biochem Pharmacol 2010; 79:57-66.

Abdelmegeed MA, Yoo SH, Henderson LE, Gonzalez FJ, Woodcroft KJ, Song BJ. PPARalpha expression protects male mice from high fat-induced nonalcoholic fatty liver. J Nutr 2011; 141:603-10.

Abdel-Rahman MH, Pilarski R, Massengill JB, Christopher BN, Noss R, Davidorf FH. Melanoma candidate genes CDKN2A/p16/INK4A, p14ARF, and CDK4 sequencing in patients with uveal melanoma with relative high-risk for hereditary cancer predisposition. Melanoma Res 2011; 21:175-9.

Abdel-Rahman SM, Gotschall RR, Kauffman RE, Leeder JS, Kearns GL. Investigation of terbinafine as a CYP2D6 inhibitor in vivo. Clin Pharmacol Ther 1999; 65:465-72.

Abdel-Rahman SM, Jacobs RF, Massarella J et al. Single-dose pharmacokinetics of intravenous itraconazole and hydroxypropyl-beta-cyclodextrin in infants, children, and adolescents. Antimicrob Agents Chemother 2007; 51:2668-73.

Abderrahmani A, Steinmann M, Plaisance V et al. The transcriptional repressor REST determines the cell-specific expression of the human MAPK8IP1 gene encoding IB1 (JIP-1). Molec Cell Biol 2001; 21:7256-627.

Abdollahi MR, Gaunt TR, Syddall HE et al. Angiotensin II type I receptor gene polymorphism: anthropometric and metabolic syndrome traits. J Med Genet 2005; 42:396-401.

Abdollahi MR, Lewis RM, Gaunt TR et al. Quantitated transcript haplotypes (QTH) of AGTR1, reduced abundance of mRNA haplotypes containing 1166C (rs5186:A>C), and relevance to metabolic syndrome traits. Hum Mutat 2007; 28:365-73.

Abdul MI, Jiang X, Williams KM et al. Pharmacokinetic and pharmacodynamic interactions of echinacea and policosanol with warfarin in healthy subjects. Br J Clin Pharmacol 2010; 69:508-15.

Abduljalil K, Frank D, Gaedigk A et al. Assessment of activity levels for CYP2D6*1, CYP2D6*2, and CYP2D6*41 genes by population pharmacokinetics of dextromethorphan. Clin Pharmacol Ther 2010; 88:643-51.

Abduljalil K, Kinzig M, Bulitta J et al. Modeling the autoinhibition of clarithromycin metabolism during repeated oral administration. Antimicrob Agents Chemother 2009; 53:2892-901.

Abdull Razis AF, Bagatta M, de Nicola GR, Iori R, Ioannides C. Intact glucosinolates modulate hepatic cytochrome P450 and phase II conjugation activities and may contribute directly to the chemopreventive activity of cruciferous vegetables. Toxicology 2010; 277:74-85.

Abdull Razis AF, Bagatta M, de Nicola GR, Iori R, Ioannides C. Up-regulation of cytochrome P450 and phase II enzyme systems in rat precision-cut rat lung slices by the intact glucosinolates, glucoraphanin and glucoerucin. Lung Cancer 2011; 71:298-305.

Abdull Razis AF, Iori R, Ioannides C. The natural chemopreventive phytochemical R-sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer. Int J Cancer 2011; 128:2775-82.

Abdullah C, Wang X, Becker D. Expression analysis and molecular targeting of cyclin-dependent kinases in advanced melanoma. Cell Cycle 2011; 10:997-88.

Abe A, Emi N, Tanimoto M, Terasaki H, Marunouchi T, Saito H. Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution. Blood 1997; 90:4271-7.

Abe F, Ueyama J, Kimata A et al. Involvement of multidrug resistance-associated protein 2 (ABCC2/Mrp2) in biliary excretion of micafungin in rats. Life Sci 2008; 83:229-35.

Abe T, Kakyo M, Tokui T et al. Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J Biol Chem 1999; 274:17159-63.

Abe Y, Namba H, Zheng Y, Nawa H. In situ hybridization reveals developmental regulation of ErbB1-4 mRNA expression in mouse midbrain: implication of ErbB receptors for dopaminergic neurons. Neuroscience 2009; 161:95-110.

Abel MH, Huhtaniemi I, Pakarinen P, Kumar TR, Charlton HM. Age-related uterine and ovarian hypertrophy in FSH receptor knockout and FSHbeta subunit knockout mice. Reproduction 2003; 125:165-73.

Abel S, Back DJ, Vourvahis M. Maraviroc: pharmacokinetics and drug interactions. Antivir Ther 2009; 14:607-18.

Abel S, Beaumont KC, Crespi CL et al. Potential role for P-glycoprotein in the non-proportional pharmacokinetics of UK-343,664 in man. Xenobiotica 2001; 31:665-76.

Abel S, Jenkins TM, Whitlock LA, Ridgway CE, Muirhead GJ. Effects of CYP3A4 inducers with and without CYP3A4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers. Br J Clin Pharmacol 2008; 65 Suppl 1:38-46.

Abel S, Russell D, Taylor-Worth RJ, Ridgway CE, Muirhead GJ. Effects of CYP3A4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers. Br J Clin Pharmacol 2008; 65 Suppl 1:27-37.

Abel S, Russell D, Whitlock LA, Ridgway CE, Muirhead GJ. Effect of maraviroc on the pharmacokinetics of midazolam, lamivudine/zidovudine, and ethinyloestradiol/levonorgestrel in healthy volunteers. Br J Clin Pharmacol 2008; 65 Suppl 1:19-26.

Abel S, van der Ryst E, Rosario MC et al. Assessment of the pharmacokinetics, safety and tolerability of maraviroc, a novel CCR5 antagonist, in healthy volunteers. Br J Clin Pharmacol 2008; 65 Suppl 1:5-18.

Abelö A, Andersson TB, Antonsson M, Naudot AK, Skånberg I, Weidolf L. Stereoselective metabolism of omeprazole by human cytochrome P450 enzymes. Drug Metab Dispos 2000; 28:966-72.

Abelö A, Andersson TB, Bredberg U, Skånberg I, Weidolf L. Stereoselective metabolism by human liver CYP enzymes of a substituted benzimidazole. Drug Metab Dispos 2000; 28:58-64.

Abellán R, Mansego ML, Martínez-Hervás S et al. Association of selected ABC gene family single nucleotide polymorphisms with postprandial lipoproteins: results from the population-based Hortega study. Atherosclerosis 2010; 211:203-9.

Abicht A, Lochmüller H. Congenital myasthenic syndromes. In: Pagon RA, Bird TC, Dolan CR, Stephens K (Eds). GeneReviews. University of Washington, Seattle, 1993-2003. Available from: http://www. ncbi. nlm. nih. gov/books/NBK1168/

Aboraia AS, Makowski B, Bahja A et al. Synthesis and CYP24A1 inhibitory activity of (E)-2-(2-substituted benzylidene)- and 2-(2-substituted benzyl)-6-methoxy-tetralones. Eur J Med Chem 2010; 45:4427-34.

Abou-Donia MB, Dechkovskaia AM, Goldstein LB, Abdel-Rahman A, Bullman SL, Khan WA. Co-exposure to pyridostigmine bromide, DEET, and/or permethrin causes sensorimotor deficit and alterations in brain acetylcholinesterase activity. Pharmacol Biochem Behav 2004; 77:253-62.

Abou-Donia MB, El-Masry EM, Abdel-Rahman AA, McLendon RE, Schiffman SS. Splenda alters gut microflora and increases intestinal p-glycoprotein and cytochrome p-450 in male rats. J Toxicol Environ Health A 2008; 71:1415-29.

Aboutabl ME, Zordoky BN, El-Kadi AO. 3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats. Br J Pharmacol 2009; 158:1808-19.

Aboutabl ME, Zordoky BN, Hammock BD, El-Kadi AO. Inhibition of soluble epoxide hydrolase confers cardioprotection and prevents cardiac cytochrome P450 induction by benzo(a)pyrene. J Cardiovasc Pharmacol 2011; 57:273-81.

Abraham I, Jain S, Wu CP et al. Marine sponge-derived sipholane triterpenoids reverse P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells. Biochem Pharmacol 2010; 80:1497-506.

Abraham JE, Maranian MJ, Driver KE et al. CYP2D6 gene variants: association with breast cancer specific survival in a cohort of breast cancer patients from the United Kingdom treated with adjuvant tamoxifen. Breast Cancer Res 2010; 12:64.

Abraham JE, Maranian MJ, Driver KE et al. CYP2D6 gene variants and their association with breast cancer susceptibility. Cancer Epidemiol Biomarkers Prev 2011; 20:1255-8.

Abrahamsson T. The beta 1- and beta 2-adrenoceptor stimulatory effects of alprenolol, oxprenolol and pindolol: a study in the isolated right atrium and uterus of the rat. Br J Pharmacol 1986; 87:657-64.

Abrams AJ, Farooq A, Wang G. S-Nitrosylation of ApoE in Alzheimer's disease. Biochemistry 2011; 50:3405-7.

Abramson DH, Ellsworth RM, Zimmerman LE. Monocular cancer in retinoblastoma survivors. Trans. Am. Acad. Ophthal. Otolaryng 1976; 81:454-7.

Abramsson A, Landgren S, Zetterberg M et al. No association of LOXL1 gene polymorphisms with Alzheimer's disease. Neuromolecular Med 2011; 13:160-6.

Abrhale T, Brodie A, Sabnis G et al. GP88 (PC-Cell Derived Growth Factor, progranulin) stimulates proliferation and confers letrozole resistance to aromatase overexpressing breast cancer cells. BMC Cancer 2011; 11:231.

Abu-Amero KK, Al-Boudari OM, Mohamed GH, Dzimiri N. The Glu27 genotypes of the beta2-adrenergic receptor are predictors for severe coronary artery disease. BMC Med Genet 2006; 7:31.

Abu-Amero KK, Al-Boudari OM, Mousa A et al. The mitochondrial DNA variant 16189T>C is associated with coronary artery disease and myocardial infarction in Saudi Arabs. Genet Test Mol Biomarkers 2010; 14:43-7.

Abu-Duhier FM, Goodeve AC, Wilson GA, Care RS, Peake IR, Reilly JT. Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia. Br J Haematol 2001; 113:983-8.

Abu-Elheiga L, Brinkley WR, Zhong L, Chirala SS, Woldegiorgis G, Wakil SJ. The subcellular localization of acetyl-CoA carboxylase 2. Proc Nat Acad Sci USA 2000; 97:1444-9.

Abu-Elheiga L, Matzuk MM, Kordari P et al. Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal. Proc Nat Acad Sci USA 2005; 102:12011-6.

Abu-Qare AW, Abou-Donia MB. Combined exposure to DEET (N,N-diethyl-m-toluamide) and permethrin: pharmacokinetics and toxicological effects. J Toxicol Environ Health B Crit Rev 2003; 6:41-53.

Abushahin F, Goldman KN, Barbieri E, Milad M, Rademaker A, Bulun SE. Aromatase inhibition for refractory endometriosis-related chronic pelvic pain. Fertil Steril 2011; 96:939-42.

Aceves Avila FJ, Esquivel Nava GA, Gallegos Arreola MP, Gómez Meda B, Zúñiga González G, Ramos-Remus C. Cyclophosphamide boluses induce micronuclei expression in buccal mucosa cells of patients with systemic lupus erythematosus independent of cytochrome P450 2D6 status. J Rheumatol 2004; 31:1335-9.

Acuña-Alonzo V, Flores-Dorantes T, Kruit JK et al. A functional ABCA1 gene variant is associated with low HDL-cholesterol levels and shows evidence of positive selection in Native Americans. Hum Mol Genet 2010; 19:2877-85.

Achira M, Suzuki H, Ito K, Sugiyama Y. Comparative studies to determine the selective inhibitors for P-glycoprotein and cytochrome P4503A4. AAPS PharmSci 1999; 1:18.

Achour B, Barber J, Rostami-Hodjegan A. Cytochrome P450 Pig Liver Pie: Determination of individual cytochrome P450 isoenzyme contents in microsomes from two pig livers using LC MS. Drug Metab Dispos 2011; 39:2130-4.

Ada AO, C Kunak S, Hancer F et al. CYP and GST polymorphisms and survival in advanced non-small cell lung cancer patients. Neoplasma 2010; 57:512-21.

Adachi T, Nakagawa H, Chung I et al. Nrf2-dependent and-independent induction of ABC transporters ABCC1, ABCC2, and ABCG2 in HepG2 cells under oxidative stress. J Exp Ther Oncol 2007; 6:335-48.

Adachi T, Nakagawa H, Hagiya Y, Yasuoka T, Ishikawa T. Transport-metabolism interplay: LXRalpha-mediated induction of human ABC transporter ABCC2 (cMOAT/MRP2) in HepG2 cells. Mol Pharm 2009; 6:1678-88.

Adamo KB, Dent R, Langefeld CD et al. Peroxisome proliferator-activated receptor gamma 2 and acyl-CoA synthetase 5 polymorphisms influence diet response. Obesity 2007; 15:1068-75.

Adamopoulos S, Kolokathis F, Gkouziouta A et al. Cytokine gene polymorphisms are associated with markers of disease severity and prognosis in patients with idiopathic dilated cardiomyopathy. Cytokine 2011; 54:68-73.

Adams CM, Hu CW, Jeng AY et al. The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-beta-hydroxylase. Bioorg Med Chem Lett 2010; 20:4324-7.

Adams LS, Zhang Y, Seeram NP, Heber D, Chen S. Pomegranate ellagitannin-derived compounds exhibit antiproliferative and antiaromatase activity in breast cancer cells in vitro. Cancer Prev Res 2010; 3:108-13.

Adams M, Pieniaszek HJ Jr, Gammaitoni AR, Ahdieh H. Oxymorphone extended release does not affect CYP2C9 or CYP3A4 metabolic pathways. J Clin Pharmacol 2005; 45:337-45.

Adams P, Falek A, Arnold J. Hungtington disease in Georgia: age at onset. Am J Hum Genet 1988; 43:695-794.

Adams VR, Leggas M. Sunitinib malate for the treatment of metastatic renal cell carcinoma and gastrointestinal stromal tumors. Clin Ther 2007; 29:1338-53.

Adamson ED. Two proto-oncogenes that play dual roles in embryonal cell growth and differentiation. Int J Dev Biol 1993; 37:111-6.

Adamson MM, Hutchinson JB, Shelton A, Wagner AD, Taylor JL. Reduced hippocampal activity during encoding in cognitively normal adults carrying the APOE ε4 allele. Neuropsychologia 2011; 49:2448-55.

Addante F, Sancarlo D, Copetti M et al. Effect of obesity, serum lipoproteins, and apolipoprotein e genotypes on mortality in hospitalized elderly patients. Rejuvenation Res 2011; 14:111-8.

Adedoyin A, Arns PA, Richards WO, Wilkinson GR, Branch RA. Selective effect of liver disease on the activities of specific metabolizing enzymes: investigation of cytochromes P450 2C19 and 2D6. Clin Pharmacol Ther 1998; 64:8-17.

Adhikari AS, Agarwal N, Wood BM et al. CD117 and Stro-1 identify osteosarcoma tumor-initiating cells associated with metastasis and drug resistance. Cancer Res 2010; 70:4602-12.

Adinolfi A, Hopkinson DA. Blue sepharose chromatography of human alcohol dehydrogenase: evidence for interlocus and interallelic differences in affinity characteristics. Ann Hum Genet 1978; 41:399-407.

Adjei AA, Gaedigk A, Simon SD, Weinshilboum RM, Leeder JS. Interindividual variability in acetaminophen sulfation by human fetal liver: implications for pharmacogenetic investigations of drug-induced birth defects. Birth Defects Res A Clin Mol Teratol 2008; 82:155-65.

Adjei AA, Thomae BA, Prondzinski JL, Eckloff BW, Wieben ED, Weinshilboum RM. Human estrogen sulfotransferase (SULT1E1) pharmacogenomics: gene resequencing and functional genomics. Br J Pharmacol 2003; 139:1373-82.

Adkison KK, Shachoy-Clark A, Fang L et al. The effects of ritonavir and lopinavir/ritonavir on the pharmacokinetics of a novel CCR5 antagonist, aplaviroc, in healthy subjects. Br J Clin Pharmacol 2006; 62:336-44.

Adli M, Hollinde DL, Stamm T et al. Response to lithium augmentation in depression is associated with the glycogen synthase kinase 3-beta -50T/C single nucleotide polymorphism. Biol Psychiatry 2007; 62:1295-302.

Adorni MP, Favari E, Ronda N et al. Free cholesterol alters macrophage morphology and mobility by an ABCA1 dependent mechanism. Atherosclerosis 2011; 215:70-6.

Adrian K, Bernhard MK, Breitinger HG, Ogilvie A. Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells. Biochim Biophys Res Acta 2000; 1492:127-38.

Adrian K, Strouch MJ, Zeng Q et al. Tgfbr1 haploinsufficiency inhibits the development of murine mutant Kras-induced pancreatic precancer. Cancer Res 2009; 69:9169-74.

Advani A, Johnson SJ, Nicol MR et al. Adult-onset hypogonadotropic hypogonadism caused by aberrant expression of aromatase in an adrenocortical adenocarcinoma. Endocr J 2010; 57:651-6.

Aerssens J, Raeymaekers P, Lilienfeld S, Geerts H, Konings F, Parys W. APOE genotype: no influence on galantamine treatment efficacy nor on rate of decline in Alzheimer's disease. Dement Geriatr Cogn Disord 2001; 22:69-77.

Afrin LB, Afrin JB. Value of preemptive CYP2C19 genotyping in allogeneic stem cell transplant patients considered for pentamidine administration. Clin Transplant 2011; 25:271-5.

Afsar NA, Haenisch S, Mateen A et al. Genotype frequencies of selected drug metabolizing enzymes and ABC drug transporters among breast cancer patients on FAC chemotherapy. Basic Clin Pharmacol Toxicol 2010; 107:570-6.

Afshar M, Thormann W. Validated capillary electrophoresis assay for the simultaneous enantioselective determination of propafenone and its major metabolites in biological samples. Electrophoresis 2006; 27:1517-25.

Afshar M, Thormann W. Capillary electrophoretic investigation of the enantioselective metabolism of propafenone by human cytochrome P-450 SUPERSOMES: Evidence for atypical kinetics by CYP2D6 and CYP3A4. Electrophoresis 2006; 27:1526-36.

Aft R. Bisphosphonates in breast cancer: antitumor effects. Clin Adv Hematol Oncol 2011; 9:292-9.

Afzal AR, Kiechl S, Daryani YP et al. Common CCR5-del32 frameshift mutation associated with serum levels of inflammatory markers and cardiovascular disease risk in the Bruneck population. Stroke 2008; 39:1972-8.

Afzal S, Jensen SA, Vainer B et al. MTHFR polymorphisms and 5-FU-based adjuvant chemotherapy in colorectal cancer. Ann Oncol 2009; 20:1660-6.

Afzelius L, Arnby CH, Broo A et al. State-of-the-art tools for computational site of metabolism predictions: comparative analysis, mechanistical insights, and future applications. Drug Metab Rev 2007; 39:61-86.

Agachan Cakmakoglu B, Attar R, Kahraman OT et al. Cyclooxygenase-2 gene and epithelial ovarian carcinoma risk. Mol Biol Rep 2011; 38:3481-6.

Agalliu I, Salinas CA, Hansten PD, Ostrander EA, Stanford JL. Statin use and risk of prostate cancer: results from a population-based epidemiologic study. Am J Epidemiol 2008; 168:250-60.

Agarwal AK, Arioglu E, de Almeida S et al. AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34. Nat Genet 2002; 31:21-3.

Agarwal AK, Barnes RI, Garg A. Genetic basis of congenital generalized lipodystrophy. Int J Obes Relat Metab Disord 2004; 28:336-9.

Agarwal AK, Garg A. A novel heterozygous mutation in peroxisome proliferator-activated receptor-gamma gene in a patient with familial partial lipodystrophy. J Clin Endocr Metab 2002; 87:408-11.

Agarwal AK, Garg A. Genetic basis of lipodystrophies and management of metabolic complications. Annu Rev Med 2006; 57:297-311.

Agarwal AK, Simha V, Oral EA et al. Phenotypic and genetic heterogeneity in congenital generalized lipodystrophy. J Clin Endocrinol Metab 2003; 88:4840-7.

Agarwal DP, Goedde HW. Pharmacogenetics of alcohol metabolism and alcoholism. Pharmacogenetics 1992; 2:48-62.

Agarwal S, Boddu SH, Jain R, Samanta S, Pal D, Mitra AK. Peptide prodrugs: improved oral absorption of lopinavir, a HIV protease inhibitor. Int J Pharm 2008; 359:7-14.

Agarwal S, Holton KL, Lanza R. Efficient differentiation of functional hepatocytes from human embryonic stem cells. Stem Cells 2008; 26:1117-27.

Agarwal S, Sane R, Gallardo JL, Ohlfest JR, Elmquist WF. Distribution of gefitinib to the brain is limited by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2)-mediated active efflux. J Pharmacol Exp Ther 2010; 334:147-55.

Agarwal S, Sane R, Ohlfest JR, Elmquist WF. The role of the breast cancer resistance protein (ABCG2) in the distribution of sorafenib to the brain. J Pharmacol Exp Ther 2011; 336:223-33.

Agarwal V, Kommaddi RP, Valli K et al. Drug metabolism in human brain: high levels of cytochrome P4503A43 in brain and metabolism of anti-anxiety drug alprazolam to its active metabolite. PLoS One 2008. doi:10. 1371/journal. pone. 0002337.

Agbonon A, Eklu-Gadegbeku K, Aklikokou K et al. In vitro inhibitory effect of West African medicinal and food plants on human cytochrome P450 3A subfamily. J Ethnopharmacol 2010; 128:390-4.

Aggarwal PK, Jain V, Jha V. Endothelial nitric oxide synthase, angiotensin-converting enzyme and angiotensinogen gene polymorphisms in hypertensive disorders of pregnancy. Hypertens Res 2010; 33:473-7.

Aggarwal PK, Jain V, Srinivasan R, Jha V. Maternal EDN1 G5665T polymorphism influences circulating endothelin-1 levels and plays a role in determination of preeclampsia phenotype. J Hypertens 2009; 27:2044-50.

Aghajanova L, Giudice LC. Effect of bisphenol A on human endometrial stromal fibroblasts in vitro. Reprod Biomed Online 2011; 22:249-56.

Aghajanpour L, Mashayekhi F, Rajaei F. Intercellular adhesion molecule-1 (ICAM-1) gene polymorphism and endometriosis in northern Iran. Arch Gynecol Obstet 2011; 283:1035-9.

Agic A, Xu H, Altgassen C et al. Relative expression of 1,25-dihydroxyvitamin D3 receptor, vitamin D 1 alpha-hydroxylase, vitamin D 24-hydroxylase, and vitamin D 25-hydroxylase in endometriosis and gynecologic cancers. Reprod Sci 2007; 14:486-97.

Aglony M, Martínez-Aguayo A, Carvajal CA et al. Frequency of familial hyperaldosteronism type 1 in a hypertensive pediatric population: clinical and biochemical presentation. Hypertension 2011; 57:1117-21.

Ago H, Kanaoka Y, Irikura D et al. Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis. Nature 2007; 448:609-12.

Agomelatine: AGO 178, AGO178, S 20098. Drugs R D 2008; 9:177-83.

Agrawal AK, Hop CE, Pang J et al. In vitro metabolism of a new oxazolidinedione hypoglycemic agent utilizing liver microsomes and recombinant human cytochrome P450 enzymes. J Pharm Biomed Anal 2005; 37:351-8.

Agrawal DK. Pharmacology and clinical efficacy of desloratadine as an anti-allergic and anti-inflammatory drug. Expert Opin Investig Drugs 2001; 10:547-60.

Agrawal K, Onami S, Mortimer JE, Pal SK. Cognitive changes associated with endocrine therapy for breast cancer. Maturitas 2010; 67:209-14.

Agudo J, Ayuso E, Jimenez V et al. IGF-I mediates regeneration of endocrine pancreas by increasing beta cell replication through cell cycle protein modulation in mice. Diabetologia 2008; 51:1862-72.

Aguilar-Salinas CA, Canizales-Quinteros S, Rojas-Martínez R et al. The non-synonymous Arg230Cys variant (R230C) of the ATP-binding cassette transporter A1 is associated with low HDL cholesterol concentrations in Mexican adults: A population based nation wide study. Atherosclerosis 2011; 216:146-50.

Aguilar-Salinas CA, Reyes-Rodríguez E, Ordóñez-Sánchez ML, Torres MA et al. Early-onset type 2 diabetes: metabolic and genetic characterization in the mexican population. J Clin Endocrinol Metab 2001; 86:220-6.

Aguilera DG, Tsimberidou AM. Dasatinib in chronic myeloid leukemia: a review. Ther Clin Risk Manag 2009; 5:281-9.

Agúndez JA. Cytochrome P450 gene polymorphism and cancer. Curr Drug Metab 2004; 5:211-24.

Agúndez JA, Ledesma MC, Ladero JM, Benítez J. Prevalence of CYP2D6 gene duplication and its repercussion on the oxidative phenotype in a white population. Clin Pharmacol Ther 1995; 57:265-9.

Agúndez JA, Martínez C, Ledesma MC, Ladona MG, Ladero JM, Benítez J. Genetic basis for differences in debrisoquin polymorphism between a Spanish and other white populations. Clin Pharmacol Ther 1994; 55:412-7.

Agúndez JA, Martínez C, Pérez-Sala D, Carballo M, Torres MJ, García-Martín E. Pharmacogenomics in aspirin intolerance. Curr Drug Metab 2009; 10:998-1008.

Agúndez JA, Ramirez R, Hernandez M, Llerena A, Benítez J. Molecular heterogeneity at the CYP2D gene locus in Nicaraguans: impact of gene-flow from Europe. Pharmacogenetics 1997; 7:337-40.

Agúndez JA, Rodríguez I, Olivera M et al. CYP2D6, NAT2 and CYP2E1 genetic polymorphisms in nonagenarians. Age Ageing 1997; 26:147-51.

Agurs-Collins T, Fuemmeler BF. Dopamine polymorphisms and depressive symptoms predict foods intake. Results from a nationally representative sample. Appetite 2011; 57:339-48.

Agusa T, Iwata H, Fujihara J et al. Genetic polymorphisms in AS3MT and arsenic metabolism in residents of the Red River Delta, Vietnam. Toxicol Appl Pharmacol 2009; 236:131-41.

Aguzzi A, Brandner S. The genetics of prions-a contradiction in terms? Lancet 1999; 354:22-5.

Aguzzi A, Weissmann C. A suspicious signature. Nature 1996; 383:666-7.

Ahern TP, Christensen M, Cronin-Fenton DP et al. Functional polymorphisms in UDP-glucuronosyl transferases and recurrence in tamoxifen-treated breast cancer survivors. Cancer Epidemiol Biomarkers Prev 2011; 20:1937-43.

Ahern TP, Pedersen L, Cronin-Fenton DP, Sørensen HT, Lash TL. No increase in breast cancer recurrence with concurrent use of tamoxifen and some CYP2D6-inhibiting medications. Cancer Epidemiol Biomarkers Prev 2009; 18:2562-4.

Ahirwar DK, Kesarwani P, Singh R, Ghoshal UC, Mittal RD. Role of tumor necrosis factor-alpha (C-863A) polymorphism in pathogenesis of inflammatory bowel disease in Northern India. J Gastrointest Cancer 2011. doi:10. 1007/s12029-010-9238-9.

Ahles A, Engelhardt S. Polymorphisms determine beta-adrenoceptor conformation: implications for cardiovascular disease and therapy. Trends Pharmacol Sci 2009; 30:188-93.

Ahlstedt I, Engberg S, Smith J et al. Occurrence and pharmacological characterization of four human tachykinin NK2 receptor variants. Biochem Pharmacol 2008; 76:476-81.

Ahlström MM, Zamora I. Characterization of type II ligands in CYP2C9 and CYP3A4. J Med Chem 2008; 51:1755-63.

Ahluwalia TS, Ahuja M, Rai TS et al. ACE variants interact with the RAS pathway to confer risk and protection against type 2 diabetic nephropathy. DNA Cell Biol 2009; 28:141-50.

Ahmad A. Genetics of cerebral venous thrombosis. J Pak Med Assoc 2006; 56:488-90.

Ahmad A, Ali SM, Ahmad MU, Sheikh S, Ahmad I. Orally administered endoxifen is a new therapeutic agent for breast cancer. Breast Cancer Res Treat 2010; 122:579-84.

Ahmad A, Shahabuddin S, Sheikh S et al. Endoxifen, a new cornerstone of breast cancer therapy: demonstration of safety, tolerability, and systemic bioavailability in healthy human subjects. Clin Pharmacol Ther 2010; 88:814-7.

Ahmad I, Shukla S, Kumar A et al. Maneb and paraquat-induced modulation of toxicant responsive genes in the rat liver: comparison with polymorphonuclear leukocytes. Chem Biol Interact 2010; 188:566-79.

Ahmed RR, Holler CJ, Webb RL, Li F, Beckett TL, Murphy MP. BACE1 and BACE2 enzymatic activities in Alzheimer's disease. J Neurochem 2010; 112:1045-53.

Ahn CY, Kim EJ, Kwon JW et al. Effects of cysteine on the pharmacokinetics of intravenous clarithromycin in rats with protein-calorie malnutrition. Life Sci 2003; 73:1783-94.

Ahn D, Ge Y, Stricklett PK et al. Collecting duct-specific knockout of endothelin-1 causes hypertension and sodium retention. J Clin Invest 2004; 114:504-11.

Ahn HJ, Kim KB, Liu KH et al. In vitro metabolism and transport of the new dipeptidyl peptidase 4 inhibitors, KR66222 and KR66223. Xenobiotica 2011; 41:445-55.

Ahn J, Albanes D, Berndt SI et al. Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk. Carcinogenesis 2009; 30:769-76.

Ahn J, Gammon MD, Santella RM et al. Associations between breast cancer risk and the catalase genotype, fruit and vegetable consumption, and supplement use. Am J Epidemiol 2005; 162:943-52.

Ahn J, Gammon MD, Santella RM et al. Effects of glutathione S-transferase A1 (GSTA1) genotype and potential modifiers on breast cancer risk. Carcinogenesis 2006; 27:1876-82.

Ahn J, Nowell S, McCann SE et al. Associations between catalase phenotype and genotype: modification by epidemiologic factors. Cancer Epidemiol Biomarkers Prev 2006; 15:1217-22.

Ahn J, Yu K, Stolzenberg-Solomon R et al. Genome-wide association study of circulating vitamin D levels. Hum Mol Genet 2010; 19:2739-45.

Ahn JH, Park WS, Jun MA et al. Synthesis and biological evaluation of homopiperazine derivatives with beta-aminoacyl group as dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett 2008; 18:6525-9.

Ahn MR, Kim DK, Sheen YY. Trichostatin A, a histone deacetylase inhibitor stimulate CYP3A4 proximal promoter activity in Hepa-I cells. Arch Pharm Res 2004; 27:415-21.

Ahn S, Duke CB 3rd, Barrett CM et al. I-387, a novel antimitotic indole, displays a potent in vitro and in vivo antitumor activity with less neurotoxicity. Mol Cancer Ther 2010; 9:2859-68.

Ahn S, Hwang DJ, Barrett CM et al. A novel bis-indole destabilizes microtubules and displays potent in vitro and in vivo antitumor activity in prostate cancer. Cancer Chemother Pharmacol 2011; 67:293-304.

Ahn S, Kearbey JD, Li CM, Duke CB 3rd, Miller DD, Dalton JT. Biotransformation of a novel antimitotic agent, I-387, by mouse, rat, dog, monkey, and human liver microsomes and in vivo pharmacokinetics in mice. Drug Metab Dispos 2011; 39:636-43.

Ahn SJ, Jeon YH, Lee YJ et al. Enhanced anti-tumor effects of combined MDR1 RNA interference and human sodium/iodide symporter (NIS) radioiodine gene therapy using an adenoviral system in a colon cancer model. Cancer Gene Ther 2010; 17:492-500.

Ahn T, Yun CH. High-level expression of human cytochrome P450 3A4 by co-expression with human molecular chaperone HDJ-1 (Hsp40). Arch Pharm Res 2004; 27:319-23.

Ahn T, Yun CH. Effects of epitope sequence tandem repeat and proline incorporation on polyclonal antibody production against cytochrome 1A2 and 3A4. BMB Rep 2009; 42:418-20.

Ahonen J, Olkkola KT, Neuvonen PJ. Effect of route of administration of fluconazole on the interaction between fluconazole and midazolam. Eur J Clin Pharmacol 1997; 51:415-9.

Ahonen J, Olkkola KT, Takala A, Neuvonen PJ. Interaction between fluconazole and midazolam in intensive care patients. Acta Anaesthesiol Scand 1999; 43:509-14.

Ahrén B, Winzell MS, Wierup N, Sundler F, Burkey B, Hughes TE. DPP-4 inhibition improves glucose tolerance and increases insulin and GLP-1 responses to gastric glucose in association with normalized islet topography in mice with beta-cell-specific overexpression of human islet amyloid polypeptide. Regul Pept 2007; 143:97-103.

Ahsan A, Norboo T, Baig MA, Pasha MAQ. Simultaneous selection of the wild-type genotypes of the G894T and 4B/4A polymorphisms of NOS3 associate with high-altitude adaptation. Ann Hum Genet 2005; 69:260-67.

Ai D, Pang W, Li N et al. Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy. Proc Natl Acad Sci USA 2009; 106:564-9.

Aiba I, Yamasaki T, Shinki T et al. Characterization of rat and human CYP2J enzymes as Vitamin D 25-hydroxylases. Steroids 2006; 71:849-56.

Aiba T, Susa M, Fukumori S, Hashimoto Y. The effects of culture conditions on CYP3A4 and MDR1 mRNA induction by 1alpha,25-dihydroxyvitamin D(3) in human intestinal cell lines, Caco-2 and LS180. Drug Metab Pharmacokinet 2005; 20:268-74.

Aiba T, Takehara Y, Okuno M, Hashimoto Y. Poor correlation between intestinal and hepatic metabolic rates of CYP3A4 substrates in rats. Pharm Res 2003; 20:745-8.

Aichhorn W, Whitworth AB, Weiss EM, Marksteiner J. Second-generation antipsychotics: is there evidence for sex differences in pharmacokinetic and adverse effect profiles? Drug Saf 2006; 29:587-98.

Aigrain L, Pompon D, Moréra S, Truan G. Structure of the open conformation of a functional chimeric NADPH cytochrome P450 reductase. EMBO Rep 2009; 10:742-7.

Aihara T, Suemasu K, Takei H et al. Effects of exemestane, anastrozole and tamoxifen on bone mineral density and bone turnover markers in postmenopausal early breast cancer patients: results of N-SAS BC 04, the TEAM Japan substudy. Oncology 2010; 79:376-81.

Ailhaud G, Fukamizu A, Massiera F, Negrel R, Saint-Marc P, Teboul M. Angiotensinogen, angiotensin II and adipose tissue development. Int J Obes Relat Metab Disord 2000; 24 Suppl 4:33-5.

Aisen PS, Schafer KA, Grundman M et al. Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial. JAMA 2003; 289:2819-26.

Aithal GP, Day CP, Kesteven PJ, Daly AK. Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications. Lancet 1999; 353:717-9.

Aithal GP, Day CP, Leathart JB, Daly AK. Relationship of polymorphism in CYP2C9 to genetic susceptibility to diclofenac-induced hepatitis. Pharmacogenetics 2000; 10:511-8.

Aitken AE, Lee CM, Morgan ET. Roles of nitric oxide in inflammatory downregulation of human cytochromes P450. Free Radic Biol Med 2008; 44:1161-8.

Aitken AE, Morgan ET. Gene-specific effects of inflammatory cytokines on cytochrome P450 2C, 2B6 and 3A4 mRNA levels in human hepatocytes. Drug Metab Dispos 2007; 35:1687-93.

Aiyer HS, Gupta RC. Berries and ellagic acid prevent estrogen-induced mammary tumorigenesis by modulating enzymes of estrogen metabolism. Cancer Prev Res 2010; 3:727-37.

Ajdary S, Ghamilouie MM, Alimohammadian MH, Riazi-Rad F, Pakzad SR. Toll-like receptor 4 polymorphisms predispose to cutaneous leishmaniasis. Microbes Infect 2011; 13:226-31.

Akaba K, Kimura T, Sasaki A et al. Neonatal hyperbilirubinemia and mutation of the bilirubin uridine diphosphate-glucuronosyltransferase gene: a common missense mutation among Japanese, Koreans and Chinese. Biochem Molec Biol Int 1998; 46:21-6.

Akaba K, Kimura T, Sasaki A et al. Neonatal hyperbilirubinemia and a common mutation of the bilirubin uridine diphosphate-glucuronosyltransferase gene in Japanese. J Hum Genet 1999; 44:22-5.

Akamine Y, Miura M, Sunagawa S, Kagaya H, Yasui-Furukori N, Uno T. Influence of drug-transporter polymorphisms on the pharmacokinetics of fexofenadine enantiomers. Xenobiotica 2010; 40:782-9.

Akao T, Sato K, Hanada M. Hepatic contribution to a marked increase in the plasma concentration of baicalin after oral administration of its aglycone, baicalein, in multidrug resistance-associated protein 2-deficient rat. Biol Pharm Bull 2009; 32:2079-82.

Akasaka H, Katsuya T, Saitoh S et al. Effects of angiotensin II type 1 receptor gene polymorphisms on insulin resistance in a Japanese general population: the Tanno-Sobetsu study. Hypertens Res 2006; 29:961-7.

Akasaka K, Kaburagi T, Yasuda S et al. Impact of functional ABCG2 polymorphisms on the adverse effects of gefitinib in Japanese patients with non-small-cell lung cancer. Cancer Chemother Pharmacol 2010; 66:691-8.

Akbas SH, Bilgen T, Keser I et al. The effect of MDR1 (ABCB1) polymorphism on the pharmacokinetic of tacrolimus in Turkish renal transplant recipients. Transplant Proc 2006; 38:1290-2.

Akgül S, Derman O, Alikaşifoğlu M, Aktaş D. CYP1A1 polymorphism in adolescents with polycystic ovary syndrome. Int J Gynaecol Obstet 2011; 112:8-10.

Akhavan S, de Cristofaro R, Peyvandi F, Lavoretano S, Landolfi R, Mannucci PM. Molecular and functional characterization of a natural homozygous Arg67His mutation in the prothrombin gene of a patient with a severe procoagulant defect contrasting with a mild hemorrhagic phenotype. Blood 2002; 100:1347-53.

Akhtar N, Ahad A, Khar RK et al. The emerging role of P-glycoprotein inhibitors in drug delivery: a patent review. Expert Opin Ther Pat 2011; 21:561-76.

Akhtar TA, Orsomando G, Mehrshahi P et al. A central role for gamma-glutamyl hydrolases in plant folate homeostasis. Plant J 2010; 64:256-66.

Akhter MS, Biswas A, Ranjan R, Sharma A, Kumar S, Saxena R. The nitric oxide synthase 3 gene polymorphisms and their association with deep vein thrombosis in Asian Indian patients. Clin Chim Acta 2010; 411:649-52.

Akin C, Metcalfe DD. The biology of Kit in disease and the application of pharmacogenetics. J Allergy Clin Immunol 2004; 114:13-9.

Akin L, Kurtoglu S, Kendirci M, Akin MA, Hartmann MF, Wudy SA. Hook effect: a pitfall leading to misdiagnosis of hypoaldosteronism in an infant with pseudohypoaldosteronism. Horm Res Paediatr 2010; 74:72-5.

Akintoye SO, Kelly MH, Brillante B et al. Pegvisomant for the treatment of gsp-mediated growth hormone excess in patients with McCune-Albright syndrome. J Clin Endocrinol Metab 2006; 91:2960-6.

Akita H, Chiba H, Tsuchihashi K et al. Cholesteryl ester transfer protein gene: two common mutations and their effect on plasma high-density lipoprotein cholesterol content. J Clin Endocr Metab 1994; 79:1615-8.

Akiyama I, Tomiyama K, Sakaguchi M et al. Expression of CYP3A4 by an immortalized human hepatocyte line in a three-dimensional culture using a radial-flow bioreactor. Int J Mol Med 2004; 14:663-8.

Akiyama M, Shimizu H. An update on molecular aspects of the non-syndromic ichthyoses. Exp Dermatol 2008; 17:373-82.

Akk G, Steinbach JH. Galantamine activates muscle-type nicotinic acetylcholine receptors without binding to the acetylcholine-binding site. J Neurosci 2005; 25:1992-2001.

Akkız H, Bayram S, Bekar A, Akgöllü E, Ülger Y. Functional polymorphisms of cyclooxygenase-2 gene and risk for hepatocellular carcinoma. Mol Cell Biochem 2011; 347:201-8.

Akli S, van Pelt CS, Bui T, Meijer L, Keyomarsi K. Cdk2 is required for breast cancer mediated by the low molecular weight isoform of cyclin E. Cancer Res 2011; 71:3377-86.

Aklillu E, Herrlin K, Gustafsson LL, Bertilsson L, Ingelman-Sundberg M. Evidence for environmental influence on CYP2D6-catalysed debrisoquine hydroxylation as demonstrated by phenotyping and genotyping of Ethiopians living in Ethiopia or in Sweden. Pharmacogenetics 2002; 12:375-83.

Aklillu E, Kalow W, Endrenyi L, Harper P, Miura J, Ozdemir V. CYP2D6 and DRD2 genes differentially impact pharmacodynamic sensitivity and time course of prolactin response to perphenazine. Pharmacogenet Genomics 2007; 17:989-93.

Aklillu E, Persson I, Bertilsson L, Johansson I, Rodrigues F, Ingelman-Sundberg M. Frequent distribution of ultrarapid metabolizers of debrisoquine in an Ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles. J Pharmacol Exp Ther 1996; 278:441-6.

Aknin-Seifer IE, Touraine RL, Lejeune H et al. Is the CAG repeat of mitochondrial DNA polymerase gamma (POLG) associated with male infertility? A multi-centre French study. Hum Reprod 2005; 20:736-40.

Akomolafe A, Lunetta KL, Erlich PM et al. Genetic association between endothelial nitric oxide synthase and Alzheimer disease. Clin Genet 2006; 70:49-56.

Akram A, Schmeidler J, Katsel P, Hof PR, Haroutunian V. Increased expression of RXRα in dementia: an early harbinger for the cholesterol dyshomeostasis? Mol Neurodegener 2010; 5:36.

Aksentijevich I, Masters SL, Ferguson PJ et al. An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist. N Engl J Med 2009; 360:2426-37.

Akuffo EL, Davis JB, Fox SM et al. The discovery and early validation of novel plasma biomarkers in mild-to-moderate Alzheimer's disease patients responding to treatment with rosiglitazone. Biomarkers 2008; 13:618-36.

Akune T, Ohba S, Kamekura S et al. PPAR-gamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest 2004; 113:846-55.

Akutsu T, Kobayashi K, Sakurada K, Ikegaya H, Furihata T, Chiba K. Identification of human cytochrome p450 isozymes involved in diphenhydramine N-demethylation. Drug Metab Dispos 2007; 35:72-8.

Al Ahmad A, Taboada CB, Gassmann M, Ogunshola OO. Astrocytes and pericytes differentially modulate blood-brain barrier characteristics during development and hypoxic insult. J Cereb Blood Flow Metab 2011; 31:693-705.

Al Koudsi N, Ahluwalia JS, Lin SK, Sellers EM, Tyndale RF. A novel CYP2A6 allele (CYP2A6*35) resulting in an amino-acid substitution (Asn438Tyr) is associated with lower CYP2A6 activity in vivo. Pharmacogenomics J 2009; 9:274-82.

Al Koudsi N, Tyndale RF. Hepatic CYP2B6 is altered by genetic, physiologic, and environmental factors but plays little role in nicotine metabolism. Xenobiotica 2010; 40:381-92.

Al-Abdulhadi SA, Al-Rabia MW. Linkage and haplotype analysis for chemokine receptors clustered on chromosome 3p21. 3 and transmitted in family pedigrees with asthma and atopy. Ann Saudi Med 2010; 30:115-22.

Alakus H, Mönig SP, Warnecke-Eberz U et al. Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer. World J Gastroenterol 2009; 15:6061-7.

Alakus H, Warnecke-Eberz U, Bollschweiler E et al. GNAS1 T393C polymorphism is associated with histopathological response to neoadjuvant radiochemotherapy in esophageal cancer. Pharmacogenomics J 2009; 9:202-7.

Alam M, Caldwell B, Johnson R, Darlington D, Mains R, Eipper B. Novel proteins that interact with the COOH-terminal cystosolic routing determinants of an integral membrane peptide-processing enzyme. J Biol Chem 1996; 271:28636-40.

Alam M, Johnson R, Darlington D, Hand T, Mains R, Eipper B. Kalirin, a cytosolic protein with spectrin-like and GDP/GTP exchange factor-like domains that interacts with peptigylglycine alpha-amidating monooxygenase, an integral membrane peptide-processing enzyme. J Biol Chem 1997; 272:12667-75.

Alamartine E, Berthoux P, Mariat C, Cambazard F, Berthoux F. Interleukin-10 promoter polymorphisms and susceptibility to skin squamous cell carcinoma after renal transplantation. J Invest Dermatol 2003; 120:99-103.

Alayli G, Cengiz K, Cantürk F, Durmuş D, Akyol Y, Menekşe EB. Acute myopathy in a patient with concomitant use of pravastatin and colchicine. Ann Pharmacother 2005; 39:1358-61.

Albalushi T, Horiuchi Y, Ishiguro H et al. Replication study and meta-analysis of the genetic association of GRM3 gene polymorphisms with schizophrenia in a large Japanese case-control population. Am J Med Genet B Neuropsychiatr Genet 2008; 147:392-6.

Albani D, Polito L, Signorini A, Forloni G. Neuroprotective properties of resveratrol in different neurodegenerative disorders. Biofactors 2010; 36:370-6.

Albani D, Tettamanti M, Batelli S et al. Interleukin-1α, interleukin-1β and tumor necrosis factor-α genetic variants and risk of dementia in the very old: evidence from the "Monzino 80-plus" prospective study. Age (Dordr) 2011. doi:10. 1007/s11357-011-9249-x.

Albano E. Alcohol, oxidative stress and free radical damage. Proc Nutr Soc 2006; 65:278-90.

Albasanz-Puig A, Murray J, Preusch M et al. Oncostatin M is expressed in atherosclerotic lesions: A role for Oncostatin M in the pathogenesis of atherosclerosis. Atherosclerosis 2011; 216:292-8.

Al-Bataineh MM, van der Merwe D, Schultz BD, Gehring R. Tumor necrosis factor alpha increases P-glycoprotein expression in a BME-UV in vitro model of mammary epithelial cells. Biopharm Drug Dispos 2010; 31:506-15.

Al-Belooshi T, John A, Tariq S, Al-Otaiba A, Raza H. Increased mitochondrial stress and modulation of mitochondrial respiratory enzyme activities in acetaminophen-induced toxicity in mouse macrophage cells. Food Chem Toxicol 2010; 48:2624-32.

Albers LJ, Reist C, Helmeste D, Vu R, Tang SW. Paroxetine shifts imipramine metabolism. Psychiatry Res 1996; 59:189-96.

Albers LJ, Reist C, Vu RL et al. Effect of venlafaxine on imipramine metabolism. Psychiatry Res 2000; 96:235-43.

Albert CM, MacRae CA, Chasman DI et al. Common variants in cardiac ion channel genes are associated with sudden cardiac death. Circ Arrhythm Electrophysiol 2010; 3:222-9.

Albert CM, Nam EG, Rimm EB et al. Cardiac sodium channel gene variants and sudden cardiac death in women. Circulation 2008; 117:16-23.

Albert MS, Basu S, Bassett SS et al. Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin. Hum Mol Genet 2003; 12:2765-76.

Albertí JJ, Sentellas S, Salvà M. In vitro liver metabolism of aclidinium bromide in preclinical animal species and humans: identification of the human enzymes involved in its oxidative metabolism. Biochem Pharmacol 2011; 81:761-76.

Alberts R, Lu L, Williams RW, Schughart K. Genome-wide analysis of the mouse lung transcriptome reveals novel molecular gene interaction networks and cell-specific expression signatures. Respir Res 2011; 12:61.

Albertsen H, Plaetke R, Ballard L et al. Genetic mapping of the BRCA1 region on chromosome 17q21. Am J Hum Genet 1994; 54:516-25.

Albin N, Johnson MR, Shahinian H, Wang K, Diasio RB. Initial characterization of the molecular defect in human dihydropyrimidine dehydrogenase deficiency. Proc Am Assoc Cancer Res 1995; 36:211.

Albrecht C, Elliott JI, Sardini A et al. Functional analysis of candidate ABC transporter proteins for sitosterol transport. Biochim Biophys Acta 2002; 1567:133-42.

Albrecht C, McVey JH, Elliott JI et al. A novel missense mutation in ABCA1 results in altered protein trafficking and reduced phosphatidylserine translocation in a patient with Scott syndrome. Blood 2005; 106:542-9.

Albrecht EA, Dhanasekaran SM, Tomlins S. Immediate early inflammatory gene responses of human umbilical vein endothelial cells to hemorrhagic venom. Inflamm Res 2011; 60:213-7.

Albrecht W, Unger A, Nussler AK, Laufer S. In vitro metabolism of 2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl] acetic acid (licofelone, ML3000), an inhibitor of cyclooxygenase-1 and -2 and 5-lipoxygenase. Drug Metab Dispos 2008; 36:894-903.

Albuquerque EX, Pereira EF, Aracava Y et al. Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents. Proc Natl Acad Sci USA 2006; 103:13220-5.

Alcaro S, Arcone R, Vecchio I et al. Molecular modelling and enzymatic studies of acetylcholinesterase and butyrylcholinesterase recognition with paraquat and related compounds. SAR QSAR Environ Res 2007; 18:595-602.

Alcorn J, McNamara PJ. Ontogeny of hepatic and renal systemic clearance pathways in infants: part I. Clin Pharmacokinet 2002; 41:959-98.

Alcorn J, McNamara PJ. Ontogeny of hepatic and renal systemic clearance pathways in infants: part II. Clin Pharmacokinet 2002; 41:1077-94.

Al-Chalabi A, Dürr A, Wood NW et al. Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy. PLoS One 2009. doi:10. 1371/journal. pone. 0007114.

Al-Chalabi A, Enayat ZE, Bakker MC et al. Association of apolipoprotein E e4 allele with bulbar-onset motor neuron disease. Lancet 1996; 347:159-60.

Al-Deeb ID, Arafat TA, Irshaid YM. The effect of licorice drink on the systemic exposure of verapamil in rabbits. Drug Metab Lett 2010; 4:173-9.

Alderman CP, Gebauer MG, Gilbert AL, Condon JT. Possible interaction of zopiclone and nefazodone. Ann Pharmacother 2001; 35:1378-80.

Alderman CP, Hundertmark JD, Soetratma TW. Interaction of serotonin re-uptake inhibitors with perhexiline. Aust N Z J Psychiatry 1997; 31:601-3.

Alderman J. Coadministration of sertraline with cisapride or pimozide: an open-label, nonrandomized examination of pharmacokinetics and corrected QT intervals in healthy adult volunteers. Clin Ther 2005; 27:1050-63.

Alderman J, Preskorn SH, Greenblatt DJ et al. Desipramine pharmacokinetics when coadministered with paroxetine or sertraline in extensive metabolizers. J Clin Psychopharmacol 1997; 17:284-91.

Al-Dosari M, Zhang G, Knapp JE, Liu D. Evaluation of viral and mammalian promoters for driving transgene expression in mouse liver. Biochem Biophys Res Commun 2006; 339:673-8.

Aldrich MC, Selvin S, Hansen HM et al. CYP1A1/2 haplotypes and lung cancer and assessment of confounding by population stratification. Cancer Res 2009; 69:2340-8.

Alebouyeh M, Moussavi F, Haddad-Deylami H, Vossough P. Hydroxyurea in the treatment of major beta-thalassemia and importance of genetic screening. Ann Hematol 2004; 83:430-3.

Aleksa K, Matsell D, Krausz K, Gelboin H, Ito S, Koren G. Cytochrome P450 3A and 2B6 in the developing kidney: implications for ifosfamide nephrotoxicity. Pediatr Nephrol 2005; 20:872-85.

Alenius M, Wadelius M, Dahl ML, Hartvig P, Lindström L, Hammarlund-Udenaes M. Gene polymorphism influencing treatment response in psychotic patients in a naturalistic setting. J Psychiatr Res 2008; 42:884-93.

Alexandrino-Silva C, Nadalini Mauá FH, de Andrade AG, de Toledo Ferraz Alves TC. Hypotension caused by therapeutic doses of venlafaxine: case report and proposed pathophysiological mechanisms. J Psychopharmacol 2008; 22:214-6.

Alexanian A, Rufanova VA, Miller B, Flasch A, Roman RJ, Sorokin A. Down-regulation of 20-HETE synthesis and signaling inhibits renal adenocarcinoma cell proliferation and tumor growth. Anticancer Res 2009; 29:3819-24.

Alexopoulos GS, Streim J, Carpenter D, Docherty JP; Expert Consensus Panel for Using Antipsychotic Drugs in Older Patients. Using antipsychotic agents in older patients. J Clin Psychiatry 2004; 65 Suppl 2:5-99.

Alexopoulos P, Richter-Schmidinger T, Horn M et al. Hippocampal volume differences between healthy young Apolipoprotein E ε2 and ε4 carriers. J Alzheimers Dis 2011; 26:207-10.

Alfakir M, Dawe N, Eyre R et al. The temporal and spatial expression patterns of ABCG2 in the developing human heart. Int J Cardiol 2010. doi:10. 1016/j. ijcard. 2010. 10. 025.

Alfalah M, Parkin ET, Jacob R et al. A point mutation in the juxtamembrane stalk of human angiotensin I-converting enzyme invokes the action of a distinct secretase. J Biol Chem 2001; 276:21105-9.

Alfaras I, Pérez M, Juan ME et al. Involvement of breast cancer resistance protein (BCRP1/ABCG2) in the bioavailability and tissue distribution of trans-resveratrol in knockout mice. J Agric Food Chem 2010; 58:4523-8.

Alfaro CL, Lam YW, Simpson J, Ereshefsky L. CYP2D6 status of extensive metabolizers after multiple-dose fluoxetine,fluvoxamine, paroxetine, or sertraline. J Clin Psychopharmacol 1999; 19:155-63.

Alfaro CL, Lam YW, Simpson J, Ereshefsky L. CYP2D6 inhibition by fluoxetine, paroxetine, sertraline, and venlafaxine in a crossover study: intraindividual variability and plasma concentration correlations. J Clin Pharmacol 2000; 40:58-66.

Alfirevic A, Mills T, Harrington P et al. Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster. Pharmacogenet Genomics 2006; 16:287-96.

Alfirevic A, Vilar FJ, Alsbou M et al. TNF, LTA, HSPA1L and HLA-DR gene polymorphisms in HIV-positive patients with hypersensitivity to cotrimoxazole. Pharmacogenomics 2009; 10:531-40.

Al-Fulaij MA, Ren Y, Beinborn M, Kopin AS. Pharmacological analysis of human D1 and D2 dopamine receptor missense variants. J Mol Neurosci 2008; 34:211-23.

Algeciras-Schimnich A, O'Kane DJ, Snozek CL. Pharmacogenomics of tamoxifen and irinotecan therapies. Clin Lab Med 2008; 28:553-67.

Ali F, Raufi MA, Washington B, Ghali JK. Conivaptan: a dual vasopressin receptor v1a/v2 antagonist [corrected]. Cardiovasc Drug Rev 2007; 25:261-79.

Ali O, Wharton J, Gibbs JS, Howard L, Wilkins MR. Emerging therapies for pulmonary arterial hypertension. Expert Opin Investig Drugs 2007; 16:803-18.

Aliberti J, Serhan C, Sher A. Parasite-induced lipoxin A4 is an endogenous regulator of IL-12 production and immunopathology in Toxoplasma gondii infection. J Exp Med 2002; 196:1253-62.

Aljamali MN, Margaritis P, Schlachterman A et al. Long-term expression of murine activated factor VII is safe, but elevated levels cause premature mortality. J Clin Invest 2008; 118:1825-34.

Al-Jenoobi FI, Al-Thukair AA, Abbas FA et al. Effect of black seed on dextromethorphan O- and N-demethylation in human liver microsomes and healthy human subjects. Drug Metab Lett 2010; 4:51-5.

Alkhatib G. The biology of CCR5 and CXCR4. Curr Opin HIV AIDS 2009; 4:96-103.

Al-Mahdi M, Al Mutair A, Al Balwi M, Hussain K. Successful transfer from insulin to oral sulfonylurea in a 3-year-old girl with a mutation in the KCNJ11 gene. Ann Saudi Med 2010; 30:162-4.

Almeida S, Zandoná MR, Franken N, Callegari-Jacques SM, Osório-Wender MC, Hutz MH. Estrogen-metabolizing gene polymorphisms and lipid levels in women with different hormonal status. Pharmacogenomics J 2005; 5:346-51.

Almkvist O, Jelic V, Amberla K, Hellstrom-Lindahl E, Meurling L, Norberg A. Responder characteristics to a single oral dose of cholinesterase inhibitor: a double-blind placebo-controlled study with tacrine in Alzheimer patients. Dement Geriatr Cogn Disord 2001; 12:22-32.

Alon US. Clinical practice: Fibroblast growth factor (FGF)23: a new hormone. Eur J Pediatr 2011; 170:545-54.

Alonen A, Finel M, Kostiainen R. The human UDP-glucuronosyltransferase UGT1A3 is highly selective towards N2 in the tetrazole ring of losartan, candesartan, and zolarsartan. Biochem Pharmacol 2008; 76:763-72.

Alonen A, Jansson J, Kallonen S et al. Enzyme-assisted synthesis and structure characterization of glucuronic acid conjugates of losartan, candesartan, and zolarsartan. Bioorg Chem 2008; 36:148-55.

Alonso, Grundke-Iqbal I, Iqbal K. Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubles. Nat Med 1996; 2:783-7.

Al-Otaiba A, John A, Al-Belooshi T, Raza H. Redox homeostasis and respiratory metabolism in camels (Camelus dromedaries): comparisons with domestic goats and laboratory rats and mice. J Comp Physiol B 2010; 180:1121-32.

Al-Salami H, Butt G, Tucker I, Mikov M. Influence of the semisynthetic bile acid MKC on the ileal permeation of gliclazide in vitro in healthy and diabetic rats treated with probiotics. Methods Find Exp Clin Pharmacol 2008; 30:107-13.

Al-Shurbaji A, Säwe J. The pharmacokinetics of ketobemidone are not affected by CYP2D6 or CYP2C19 phenotype. Eur J Clin Pharmacol 2002; 57:877-81.

Altare F, Durandy A, Lammas D et al. Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency. Science 1998; 280:1432-5.

Altarescu G, Rachmilewitz D, Zevin S. Relationship between CYP2A6 genetic polymorphism, as a marker of nicotine metabolism, and ulcerative colitis. Isr Med Assoc J 2011; 13:87-90.

Althaus M, Groen Y, Wijers AA et al. Variants of the SLC6A3 (DAT1) polymorphism affect performance monitoring-related cortical evoked potentials that are associated with ADHD. Biol Psychol 2010; 85:19-32.

Althaus M, Retzow A, Castell JV et al. In vitro identification of the cytochrome P450 isoform responsible for the metabolism of alpha-dihydroergocryptine. Xenobiotica 2000; 30:1033-45.

Altinisik J, Balta ZB, Aydin G, Ulutin T, Buyru N. Investigation of glutathione S-transferase M1 and T1 deletions in lung cancer. Mol Biol Rep 2010; 37:263-7.

Altmäe S, Haller K, Peters M et al. Allelic estrogen receptor 1 (ESR1) gene variants predict the outcome of ovarian stimulation in in vitro fertilization. Mol Hum Reprod 2007; 13:521-6.

Altshuler D, Hirschhorn JN, Klannemark M et al. The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 2000; 26:76-80.

Altstiel LD, Greenberg DA, Marin D, Lantz M, Mohs R. Apolipoprotein E genotype and cognition in the very old. Lancet 1997; 349:1451.

Álvarez V, González P, Corao AI et al. The Sp1/Egr1-tandem repeat polymorphism in the 5-lipoxygenase gene promoter is not associated with late onset Alzheimer disease. Alzheimer Dis Assoc Disord 2008; 22:177-80.

Alvarez V, López-Larrea C, Coto E. Mutational analysis of the CCR5 and CXCR4 genes (HIV-1 co-receptors) in resistance to HIV-1 infection and AIDS development among intravenous drug users. Hum Genet 1998; 102:483-6.

Álvarez XA, Cacabelos R, Sampedro C et al. Efficacy and safety of Cerebrolysin in moderate to moderately severe Alzheimer's disease: results of a randomized, double-blind, controlled trial investigating three dosages of Cerebrolysin. Eur J Neurol 2011; 18:59-68.

Álvarez XA, Mouzo R, Pichel V et al. Double-blind placebo-controlled study with citicoline in APOE genotyped Alzheimer's disease patients. Effects on cognitive performance, brain bioelectrical activity, and cerebral perfusion. Methods Find Exp Clin Pharmacol 1999; 21:633-44.

Álvarez XA, Pichel V, Pérez P et al. Double-blind, randomized, placebo-controlled pilot study with anapsos in senile dementia: effects on cognition, brain bioelectrical activity and cerebral hemodynamics. Methods Find Exp Clin Pharmacol 2000; 22:585-94.

Álvarez-Álvarez M, Galdos L, Fernández-Martínez M et al. 5-Hydroxytryptamine 6 receptor (5-HT(6)) receptor and apolipoprotein E (ApoE) polymorphisms in patients with Alzheimer's disease in the Basque Country. Neurosci Lett 2003; 339:85-7.

Alvarez-Gonzalez I, Mojica R, Madrigal-Bujaidar E, Camacho-Carranza R, Escobar-García D, Espinosa-Aguirre JJ. The antigenotoxic effects of grapefruit juice on the damage induced by benzo(a)pyrene and evaluation of its interaction with hepatic and intestinal Cytochrome P450 (Cyp) 1a1. Food Chem Toxicol 2011; 49:807-11.

Alvarez-Guerra M, Bertholom N, Garay RP. Selective blockade by nicergoline of vascular responses elicited by stimulation of alpha 1A-adrenoceptor subtype in the rat. Fundam Clin Pharmacol 1999; 13:50-8.

Álvarez-Lorenzo C, Rey-Rico A, Brea J, Loza MI, Concheiro A, Sosnik A. Inhibition of P-glycoprotein pumps by PEO-PPO amphiphiles: branched versus linear derivatives. Nanomedicine 2010; 5:1371-83.

Alves AJ, Eynon N, Oliveira J, Goldhammer E. RAAS and adrenergic genes in heart failure: Function, predisposition and survival implications. World J Cardiol 2010; 2:187-97.

Alves da Costa C, Dunys J, Brau F, Wilk S, Cappai R, Checler F. 6-Hydroxydopamine but not 1-methyl-4-phenylpyridinium abolishes alpha-synuclein anti-apoptotic phenotype by inhibiting its proteasomal degradation and by promoting its aggregation. J Biol Chem 2006; 281:9824-31.

Alves da Costa C, Mattson MP, Ancolio K, Checler F. The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart. J Biol Chem 2003; 278:12064-9.

Alves Dos Santos R, Teixeira AC, Mayorano MB, Carrara HH, Moreira de Andrade J, Takahashi CS. Variability in estrogen-metabolizing genes and their association with genomic instability in untreated breast cancer patients and healthy women. J Biomed Biotechnol 2011. doi:10. 1155/2011/571784.

Alves L, Hülsmeyer V, Jaggy A, Fischer A, Leeb T, Drögemüller M. Polymorphisms in the ABCB1 gene in phenobarbital responsive and resistant idiopathic epileptic Border Collies. J Vet Intern Med 2011; 25:484-9.

Alvi AJ, Austen B, Weston VJ et al. A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival. Blood 2005; 105:4484-91.

Alzheimer's Disease Collaborative Group. The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families. Nat Genet 1995; 11:219-22.

Allabi AC, Gala JL, Horsmans Y et al. Functional impact of CYP2C95, CYP2C96, CYP2C98, and CYP2C911 in vivo among black Africans. Clin Pharmacol Ther 2004; 76:113-8.

Allabi AC, Gala JL, Horsmans Y. CYP2C9, CYP2C19, ABCB1 (MDR1) genetic polymorphisms and phenytoin metabolism in a Black Beninese population. Pharmacogenet Genomics 2005; 15:779-86.

Allabi AC, Horsmans Y, Alvarez JC et al. Acenocoumarol sensitivity and pharmacokinetic characterization of CYP2C9 *5/*8,*8/*11,*9/*11 and VKORC1*2 in black African healthy Beninese subjects. Eur J Drug Metab Pharmacokinet 2011. doi:10. 1007/s13318-011-0056-7

Allam MF, Serrano del Castillo A, Fernández-Crehuet Navajas R. Smoking and Parkinson's disease: explanatory hypothesis. Int J Neurosci 2002; 112:851-4.

Allan JM, Wild CP, Rollinson S et al. Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapy-induced leukemia. Proc Natl Acad Sci USA 2001; 98:11592-7.

Allayee H, Baylin A, Hartiala J et al. Nutrigenetic association of the 5-lipoxygenase gene with myocardial infarction. Am J Clin Nutr 2008; 88:934-40.

Allayee H, de Bruin TWA, Dominguez KM et al. Genome scan for blood pressure in Dutch dyslipidemic families reveals linkage to a locus on chromosome 4p. Hypertension 2001; 38:773-8.

Allcock RJN, Windsor L, Gut IG et al. High-density SNP genotyping defines 17 distinct haplotypes of the TNF block in the Caucasian population: implications for haplotype tagging. Hum Mutat 2004; 24:517-25.

Allegaert K, de Hoon J, Naulaers G, van de Velde M. Neonatal clinical pharmacology: recent observations of relevance for anaesthesiologists. Acta Anaesthesiol Belg 2008; 59:283-8.

Allegaert K, van den Anker JN, de Hoon JN et al. Covariates of tramadol disposition in the first months of life. Br J Anaesth 2008; 100:525-32.

Allegaert K, van den Anker JN, Debeer A et al. Maturational changes in the in vivo activity of CYP3A4 in the first months of life. Int J Clin Pharmacol Ther 2006; 44:303-8.

Allegaert K, van den Anker JN, Naulaers G, de Hoon J. Determinants of drug metabolism in early neonatal life. Curr Clin Pharmacol 2007; 2:23-9.

Allegaert K, van Schaik RH, Vermeersch S et al. Postmenstrual age and CYP2D6 polymorphisms determine tramadol o-demethylation in critically ill neonates and infants. Pediatr Res 2008; 63:674-9.

Allegaert K, Verbesselt R, Rayyan M, Debeer A, de Hoon J. Urinary metabolites to assess in vivo ontogeny of hepatic drug metabolism in early neonatal life. Methods Find Exp Clin Pharmacol 2007; 29:251-6.

Allen B, Ingram E, Takao M et al. Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein. J Neurosci 2002; 22:9340-51.

Allen NC, Bagade S, McQueen MB et al. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the Sz Gene database. Nat Genet 2008; 40:827-34.

Allikmets R, Gerrard B, Hutchinson A, Dean M. Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. Hum Mol Genet 1996; 5:1649-55.

Allingham-Hawkins DJ, Babul-Hirji R, Chitayat D et al. Fragile X premutation is a significant risk factor for premature ovarian failure: the International Collaborative POF in Fragile X study-preliminary data. Am J Med Genet 1999; 83:322-5.

Allis JW, Zhao G. Quantitative evaluation of bromodichloromethane metabolism by recombinant rat and human cytochrome P450s. Chem Biol Interact 2002; 140:137-53.

Allison JP, Krummel MF. The yin and yang of T cell costimulation. Science 1995; 270:932-3.

Allmyr M, Panagiotidis G, Sparve E, Diczfalusy U, Sandborgh-Englund G. Human exposure to triclosan via toothpaste does not change CYP3A4 activity or plasma concentrations of thyroid hormones. Basic Clin Pharmacol Toxicol 2009; 105:339-44.

Allorge D, Harlow J, Boulet O et al. In-vitro analysis of the contribution of CYP2D6. 35 to ultra-rapid metabolism. Pharmacogenetics 2001; 11:739-41.

Allqvist A, Miura J, Bertilsson L, Mirghani RA. Inhibition of CYP3A4 and CYP3A5 catalyzed metabolism of alprazolam and quinine by ketoconazole as racemate and four different enantiomers. Eur J Clin Pharmacol 2007; 63:173-9.

Aman MG, Vinks AA, Remmerie B et al. Plasma pharmacokinetic characteristics of risperidone and their relationship to saliva concentrations in children with psychiatric or neurodevelopmental disorders. Clin Ther 2007; 29:1476-86.

Amant C, Bauters C, Bodart JC et al. D allele of the angiotensin I-converting enzyme is a major risk factor for restenosis after coronary stenting. Circulation 1997; 96:56-60.

Amant C, Hamon M, Bauters C et al. The angiotensin II type 1 receptor gene polymorphism is associated with coronary artery vasoconstriction. J Am Coll Cardiol 1997; 29:486-90.

Amar L, Azizi M, Menard J, Peyrard S, Watson C, Plouin PF. Aldosterone synthase inhibition with LCI699: a proof-of-concept study in patients with primary aldosteronism. Hypertension 2010; 56:831-8.

Amar MJ, D'Souza W, Turner S et al. 5A apolipoprotein mimetic peptide promotes cholesterol efflux and reduces atherosclerosis in mice. J Pharmacol Exp Ther 2010; 334:634-41.

Ambrose C, Duyao M, Barnes G et al. Structure and expression of the Hungtington's disease gene: evidence against simple inactivation due to an expansed CAG repeat. Somat Cell Molec Genet 1994; 20:27-38.

Ambudkar SV, Dey S, Hrycyna CA, Ramachandra M, Pastan I, Gottesman MM. Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu Rev Pharmacol Toxicol 1999; 39:361-98.

Amchin J, Ereshefsky L, Zarycranski W, Taylor K, Albano D, Klockowski PM. Effect of venlafaxine versus fluoxetine on metabolism of dextromethorphan, a CYP2D6 probe. J Clin Pharmacol 2001; 41:443-51.

Amchin J, Zarycranski W, Taylor KP, Albano D, Klockowski PM. Effect of venlafaxine on the pharmacokinetics of terfenadine. Psychopharmacol Bull 1998; 34:383-9.

Amchin J, Zarycranski W, Taylor KP, Albano D, Klockowski PM. Effect of venlafaxine on the pharmacokinetics of alprazolam. Psychopharmacol Bull 1998; 34:211-9.

Amchin J, Zarycranski W, Taylor KP, Albano D, Klockowski PM. Effect of venlafaxine on the pharmacokinetics of risperidone. J Clin Pharmacol 1999; 39:297-309.

Ames BD, Lee MY, Moody C, Zhang W, Tang Y, Tsai SC. Structural and biochemical characterization of ZhuI Aromatase/Cyclase from the R1128 polyketide pathway. Biochemistry 2011; 50:8392-406.

Ames PR, Margaglione M, Ciampa A et al. Increased warfarin consumption and residual fibrin turnover in thrombotic patients with primary antiphospholipid syndrome. Thromb Res 2011; 127:595-9.

Amet Y, Berthou F, Baird S, Dreano Y, Bail JP, Menez JF. Validation of the (omega-1)-hydroxylation of lauric acid as an in vitro substrate probe for human liver CYP2E1. Biochem Pharmacol 1995; 50:1775-82.

Amin AS, Boink GJ, Atrafi F et al. Facilitatory and inhibitory effects of SCN5A mutations on atrial fibrillation in Brugada syndrome. Europace 2011; 13:968-75.

Amini-Shirazi N, Ghahremani MH, Ahmadkhaniha R et al. Influence of CYP2C9 polymorphism on metabolism of valproate and its hepatotoxin metabolite in Iranian patients. Toxicol Mech Methods 2010; 20:452-7.

Amir E, Seruga B, Niraula S, Carlsson L, Ocaña A. Toxicity of adjuvant endocrine therapy in postmenopausal breast cancer patients: A systematic review and meta-analysis. J Natl Cancer Inst 2011; 103:1299-309.

Amirian ES, Ittmann MM, Scheurer ME. Associations between arachidonic acid metabolism gene polymorphisms and prostate cancer risk. Prostate 2011; 71:1382-9.

Amirimani B, Ning B, Deitz AC, Weber BL, Kadlubar FF, Rebbeck TR. Increased transcriptional activity of the CYP3A4*1B promoter variant. Environ Mol Mutagen 2003; 42:299-305.

Amirzargar A, Shahram F, Nikoopour E et al. Proinflammatory cytokine gene polymorphisms in Behçet's disease. Eur Cytokine Netw 2010; 21:292-6.

Amitay M, Shurki A. The structure of G117H mutant of butyrylcholinesterase: nerve agents scavenger. Proteins 2009; 77:370-7.

Ammon S, Marx C, Behrens C et al. Diclofenac does not interact with codeine metabolism in vivo: a study in healthy volunteers. BMC Clin Pharmacol 2002; 2:2.

Amoêdo ND, Castelo-Branco MT, Paschoal ME et al. Expression of ABC transporters, p53, Bax, Bcl-2 in an archival sample of non-small cell lung cancer bearing a deletion in the EGFR gene. Int J Mol Med 2009; 23:609-14.

Amoroso A, Pirulli D, Florian F et al. AGXT gene mutations and their influence on clinical heterogeneity of type 1 primary hyperoxaluria. J Am Soc Nephrol 2001; 12:2072-9.

Amouyel P, Vidal O, Launay JM, Laplanche JL. The apolipoprotein E alleles as major susceptibility factors for Creutzfeldt-Jakob disease. The French Research Group on Epidemiology of Human Spongiform Encephalopathies. Lancet 1994; 344:1315-8.

Ampasavate C, Sotanaphun U, Phattanawasin P, Piyapolrungroj N. Effects of Curcuma spp. on P-glycoprotein function. Phytomedicine 2010; 17:506-12.

Amstutz U, Farese S, Aebi S, Largiadèr CR. Hypermethylation of the DPYD promoter region is not a major predictor of severe toxicity in 5-fluorouracil based chemotherapy. J Exp Clin Cancer Res 2008; 27:54.

Amstutz U, Farese S, Aebi S, Largiadèr CR. Dihydropyrimidine dehydrogenase gene variation and severe 5-fluorouracil toxicity: a haplotype assessment. Pharmacogenomics 2009; 10:931-44.

An G, Gallegos J, Morris ME. The bioflavonoid kaempferol is an Abcg2 substrate and inhibits Abcg2-mediated quercetin efflux. Drug Metab Dispos 2011; 39:426-32.

An G, Morris ME. Effects of the isoflavonoid biochanin A on the transport of mitoxantrone in vitro and in vivo. Biopharm Drug Dispos 2010; 31:340-50.

An G, Wu F, Morris ME. 5,7-Dimethoxyflavone and multiple flavonoids in combination alter the ABCG2-mediated tissue distribution of mitoxantrone in mice. Pharm Res 2011; 28:1090-9.

An J, Yin L, Shang Y et al. The combined effects of BDE47 and BaP on oxidatively generated DNA damage in L02 cells and the possible molecular mechanism. Mutat Res 2011; 721:192-8.

An JH, Kim DS, Lee YH et al. Proteomic analysis of the protective effects of Platycodi Radix in liver of chronically alcoholic rats. J Med Food 2009; 12:1190-8.

An P, Vlahov D, Margolick JB et al. A tumor necrosis factor-alpha-inducible promoter variant of interferon-gamma accelerates CD4+ T cell depletion in human immunodeficiency virus-1-infected individuals. J Infect Dis 2003; 188:228-31.

An S, Jang YS, Park JS, Kwon BM, Paik YK, Jeong TS. Inhibition of acyl-coenzyme A: cholesterol acyltransferase stimulates cholesterol efflux from macrophages and stimulates farnesoid X receptor in hepatocytes. Exp Mol Med 2008; 40:407-17.

An Y, Ongkeko WM. ABCG2: the key to chemoresistance in cancer stem cells? Expert Opin Drug Metab Toxicol 2009; 5:1529-42.

An Y, Yao J, Wei JS et al. Establish a gemcitabine-resistant pancreatic cancer cell line SW1990/GZ and research the relationship between SW1990/GZ and pancreatic cancer stem cell. Zhonghua Wai Ke Za Zhi 2010; 48:999-1003.

Anagnostopoulou K, Kolovou G, Kostakou P, Mihas C, Mikhailidis D, Cokkinos DV. Pharmacogenetic study of cholesteryl ester transfer protein gene and simvastatin treatment in hypercholesterolaemic subjects. Expert Opin Pharmacother 2007; 8:2459-63.

Anakk S, Watanabe M, Ochsner SA, McKenna NJ, Finegold MJ, Moore DD. Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis. J Clin Invest 2011; 121:86-95.

Anania MC, Sensi M, Radaelli E et al. TIMP3 regulates migration, invasion and in vivo tumorigenicity of thyroid tumor cells. Oncogene 2011; 30:3011-23.

Ananth J, Parameswaran S, Gunatilake S, Burgoyne K, Sidhom T. Neuroleptic malignant syndrome and atypical antipsychotic drugs. J Clin Psychiatry 2004; 65:464-70.

Ananth S, Zhuang L, Gopal E et al. Diclofenac-induced stimulation of SMCT1 (SLC5A8) in a heterologous expression system: a RPE specific phenomenon. Biochem Biophys Res Commun 2010; 394:75-80.

Anantharaman D, Samant TA, Sen S, Mahimkar MB. Polymorphisms in tobacco metabolism and DNA repair genes modulate oral precancer and cancer risk. Oral Oncol 2011; 47:866-72.

Anapolsky A, Teng S, Dixit S, Piquette-Miller M. The role of pregnane X receptor in 2-acetylaminofluorene-mediated induction of drug transport and -metabolizing enzymes in mice. Drug Metab Dispos 2006; 34:405-9.

Anastasi E, Campese AF, Bellavia D et al. Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes. J Immunol 2003; 171:4504-11.

Ancrenaz V, Daali Y, Fontana P et al. Impact of genetic polymorphisms and drug-drug interactions on clopidogrel and prasugrel response variability. Curr Drug Metab 2010; 11:667-77.

Andersen V, Ernst A, Christensen J et al. The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study. BMC Med Genet 2010; 11:82.

Andersen V, Ostergaard M, Christensen J, Overvad K, Tjønneland A, Vogel U. Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study. BMC Cancer 2009; 9:407.

Andersen V, Pedersen N, Larsen NE, Sonne J, Larsen S. Intestinal first pass metabolism of midazolam in liver cirrhosis -effect of grapefruit juice. Br J Clin Pharmacol 2002; 54:120-4.

Andersohn F, Schmedt N, Weinmann S, Willich SN, Garbe E. Priapism associated with antipsychotics: role of alpha1 adrenoceptor affinity. J Clin Psychopharmacol 2010; 30:68-71.

Anderson BM, Schnetz-Boutaud NC, Bartlett J et al. Examination of association of genes in the serotonin system to autism. Neurogenetics 2009; 10:209-16.

Anderson DH, Ozaki S, Nealon M et al. Local cellular sources of apolipoprotein E in the human and retinal pigmented epithelium: implications for the process of drusen formation. Am J Ophthal 2001; 131:767-81.

Anderson GD. A mechanistic approach to antiepileptic drug interactions. Ann Pharmacother 1998; 32:554-63.

Anderson GD. Pregnancy-induced changes in pharmacokinetics: a mechanistic-based approach. Clin Pharmacokinet 2005; 44:989-1008.

Anderson GD. Using pharmacokinetics to predict the effects of pregnancy and maternal-infant transfer of drugs during lactation. Expert Opin Drug Metab Toxicol 2006; 2:947-60.

Anderson GD. Gender differences in pharmacological response. Int Rev Neurobiol 2008; 83:1-10.

Anderson GD. Developmental pharmacokinetics. Semin Pediatr Neurol 2010; 17:208-13.

Anderson GD, Rosito G, Mohustsy MA, Elmer GW. Drug interaction potential of soy extract and Panax ginseng. J Clin Pharmacol 2003; 43:643-8.

Anderson LE, Dring AM, Hamel LD, Stoner MA. Modulation of constitutive androstane receptor (CAR) and pregnane X receptor (PXR) by 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives, ligands of peripheral benzodiazepine receptor (PBR). Toxicol Lett 2011; 202:148-54.

Anderson PL, Lamba J, Aquilante CL, Schuetz E, Fletcher CV. Pharmacogenetic characteristics of indinavir, zidovudine, and lamivudine therapy in HIV-infected adults: a pilot study. J Acquir Immune Defic Syndr 2006; 42:441-9.

Anderson SF, Schlegel BP, Nakajima T, Wolpin ES, Parvin JD. BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A. Nat Genet 1998; 19:254-6.

Andersson H, Garscha U, Brittebo E. Effects of PCB126 and 17β-oestradiol on endothelium-derived vasoactive factors in human endothelial cells. Toxicology 2011; 285:46-56.

Andersson P, McGuire J, Rubio C et al. A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors. Proc Nat Acad Sci USA 2002; 99:9990-5.

Andersson T, Hassan-Alin M, Hasselgren G, Röhss K, Weidolf L. Pharmacokinetic studies with esomeprazole, the (S)-isomer of omeprazole. Clin Pharmacokinet 2001; 40:411-26.

Andersson T, Hassan-Alin M, Hasselgren G, Röhss K. Drug interaction studies with esomeprazole, the (S)-isomer of omeprazole. Clin Pharmacokinet 2001; 40:523-37.

Andersson T, Miners JO, Veronese ME et al. Identification of human liver cytochrome P450 isoforms mediating omeprazole metabolism. Br J Clin Pharmacol 1993; 36:521-30.

Ando H, Tsuruoka S, Yanagihara H et al. Effects of grapefruit juice on the pharmacokinetics of pitavastatin and atorvastatin. Br J Clin Pharmacol 2005; 60:494-7.

Ando Y, Shimizu T, Nakamura K et al. Potent and non-specific inhibition of cytochrome P450 by JM216, a new oral platinum agent. Br J Cancer 1998; 78:1170-4.

Andorfer C, Kress Y, Espinoza M et al. Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms. J Neurochem 2003; 86:582-90.

Andrade LC, de Almeida MJ, Neves MA, Dinis TC, Sá e Melo ML. 6beta-Methyl-B-norandrostenedione. Acta Crystallogr C 2010; 66:185-6.

Andrade LC, Paixão JA, de Almeida MJ, Neves MA, Sá e Melo ML. 6-[(4-Fluorophenyl)(1H-imidazol-1-yl)methyl]-1,3-benzodioxol-5-ol and 6-[(4-methoxyphenyl)(1H-imidazol-1-yl)methyl]-1,3-benzodioxol-5-ol. Acta Crystallogr C 2010; 66:499-502.

Andrade RA, Evans RT, Hamill RJ, Zerai T, Giordano TP. Clinical evidence of interaction between itraconazole and nonnucleoside reverse transcriptase inhibitors in HIV-infected patients with disseminated histoplasmosis. Ann Pharmacother 2009; 43:908-13.

Andrade RJ, Agúndez JA, Lucena MI, Martínez C, Cueto R, García-Martín E. Pharmacogenomics in drug induced liver injury. Curr Drug Metab 2009; 10:956-70.

Andreadis A, Brown WM, Kosik KS. Structure and novel exons of the human tau gene. Biochemistry 1992; 31:10626-33.

Andreasen AH, Brøsen K, Damkier P. A comparative pharmacokinetic study in healthy volunteers of the effect of carbamazepine and oxcarbazepine on cyp3a4. Epilepsia 2007; 48:490-6.

Andreassen TN, Eftedal I, Klepstad P et al. Do CYP2D6 genotypes reflect oxycodone requirements for cancer patients treated for cancer pain? A cross-sectional multicentre study. Eur J Clin Pharmacol 2011. doi:10. 1007/s00228-011-1093-5.

Andreassi MG, Botto N, Maffei S. Factor V Leiden, prothrombin G20210A substitution and hormone therapy: indications for molecular screening. Clin Chem Lab Med 2006; 44:514-21.

Andrén L, Andreasson A, Eggertsen R. Interaction between a commercially available St. John's wort product (Movina) and atorvastatin in patients with hypercholesterolemia. Eur J Clin Pharmacol 2007; 63:913-6.

Andreotti G, Boffetta P, Rosenberg PS et al. Variants in blood pressure genes and the risk of renal cell carcinoma. Carcinogenesis 2010; 31:614-20.

Andres MA, Feger U, Nath A, Munsaka S, Jiang CS, Chang L. APOE ε4 allele and CSF APOE on cognition in HIV-infected subjects. J Neuroimmune Pharmacol 2011; 6:389-98.

Andreutti-Zaugg C, Scott RJ, Iggo R. Inhibition of nonsense-mediated messenger RNA decay in clinical samples facilitates detection of human MSH2 mutations with an in vivo fusion protein assay and conventional techniques. Cancer Res 1997; 57:3288-93.

Andrew AS, Burgess JL, Meza MM et al. Arsenic exposure is associated with decreased DNA repair in vitro and in individuals exposed to drinking water arsenic. Environ Health Perspect 2006; 114:1193-8.

Andrew S, Goldberg Y, Kremer B et al. Hungtington disease without CAG expansion: phenocopies or errors in assignment? Am J Hum Genet 1994; 54:852-63.

Andrews E, Damle BD, Fang A et al. Pharmacokinetics and tolerability of voriconazole and a combination oral contraceptive co-administered in healthy female subjects. Br J Clin Pharmacol 2008; 65:531-9.

Andrews E, Glue P, Fang J, Crownover P, Tressler R, Damle B. Assessment of the pharmacokinetics of co-administered maraviroc and raltegravir. Br J Clin Pharmacol 2010; 69:51-7.

Andrews J, Abd-Ellah MF, Randolph NL et al. Comparative study of the metabolism of drug substrates by human cytochrome P450 3A4 expressed in bacterial, yeast and human lymphoblastoid cells. Xenobiotica 2002; 32:937-47.

Andrews ZB, Horvath TL. Uncoupling protein-2 regulates lifespan in mice. Am J Physiol Endocrinol Metab 2009; 296:621-7.

Androutsopoulos VP, Papakyriakou A, Vourloumis D, Spandidos DA. Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids. Bioorg Med Chem 2011; 19:2842-9.

Andrulionyte L, Laukkanen O, Chiasson JL, Laakso M; STOP-NIDDM Study Group. Single nucleotide polymorphisms of the HNF4alpha gene are associated with the conversion to type 2 diabetes mellitus: the STOP-NIDDM trial. J Mol Med 2006; 84:701-8.

Andrulionyte L, Peltola P, Chiasson JL, Laakso M; STOP-NIDDM Study Group. Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial. Diabetes 2006; 55:2148-52.

Angelastro JM, Lamé MW. Overexpression of CD133 promotes drug resistance in C6 glioma cells. Mol Cancer Res 2010; 8:1105-15.

Angelini A, di Ilio C, Castellani ML, Conti P, Cuccurullo F. Modulation of multidrug resistance p-glycoprotein activity by flavonoids and honokiol in human doxorubicin- resistant sarcoma cells (MES-SA/DX-5): implications for natural sedatives as chemosensitizing agents in cancer therapy. J Biol Regul Homeost Agents 2010; 24:197-205.

Angelini S, Kumar R, Carbone F et al. Inherited susceptibility to bleomycin-induced micronuclei: correlating polymorphisms in GSTT1, GSTM1 and DNA repair genes with mutagen sensitivity. Mutat Res 2008; 638:90-7.

Anger GJ, Magomedova L, Piquette-Miller M. Impact of acute streptozotocin-induced diabetes on ABC transporter expression in rats. Chem Biodivers 2009; 6:1943-59.

Angiolillo DJ, Fernandez-Ortiz A, Bernardo E et al. 807 C/T Polymorphism of the glycoprotein Ia gene and pharmacogenetic modulation of platelet response to dual antiplatelet treatment. Blood Coagul Fibrinolysis 2004; 15:427-33.

Angiolillo DJ, Fernandez-Ortiz A, Bernardo E et al. Lack of association between the P2Y12 receptor gene polymorphism and platelet response to clopidogrel in patients with coronary artery disease. Thromb Res 2005; 116:491-7.

Angiolillo DJ, Fernández-Ortiz A, Bernardo E et al. Contribution of gene sequence variations of the hepatic cytochrome P450 3A4 enzyme to variability in individual responsiveness to clopidogrel. Arterioscler Thromb Vasc Biol 2006; 26:1895-900.

Angiolillo DJ, Gibson CM, Cheng S et al. Differential effects of omeprazole and pantoprazole on the pharmacodynamics and pharmacokinetics of clopidogrel in healthy subjects: randomized, placebo-controlled, crossover comparison studies. Clin Pharmacol Ther 2011; 89:65-74.

Anglicheau D, Le Corre D, Lechaton S et al. Consequences of genetic polymorphisms for sirolimus requirements after renal transplant in patients on primary sirolimus therapy. Am J Transplant 2005; 5:595-603.

Anglicheau D, Legendre C, Beaune P, Thervet E. Cytochrome P450 3A polymorphisms and immunosuppressive drugs: an update. Pharmacogenomics 2007; 8:835-49.

Aninat C, Seguin P, Descheemaeker PN, Morel F, Malledant Y, Guillouzo A. Catecholamines induce an inflammatory response in human hepatocytes. Crit Care Med 2008; 36:848-54.

Anji A, Kumari M. Supplementing the liquid alcohol diet with chow enhances alcohol intake in C57 BL/6 mice. Drug Alcohol Depend 2008; 97:86-93.

Ankley GT, Cavallin JE, Durhan EJ et al. Temporal evaluation of effects of a model 3β-hydroxysteroid dehydrogenase inhibitor on endocrine function in the fathead minnow. Environ Toxicol Chem 2011; 30:2094-102.

Annaert W, de Strooper B. Presenilins: molecular switches between proteolysis and signal transduction. Trend Neurosci 1999; 22:439-43.

Annas A, Carlström K, Alván G, AL-Shurbaji A. The effect of ketoconazole and diltiazem on oestrogen metabolism in postmenopausal women after single dose oestradiol treatment. Br J Clin Pharmacol 2003; 56:334-6.

Anovazzi G, Kim YJ, Viana AC et al. Polymorphisms and haplotypes in the interleukin-4 gene are associated with chronic periodontitis in a Brazilian population. J Periodontol 2010; 81:392-402.

Ansari A, Arenas M, Greenfield S et al. Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease. Aliment Pharmacol Ther 2008; 28:973-83.

Ansari M, Lauzon-Joset JF, Vachon MF et al. Influence of GST gene polymorphisms on busulfan pharmacokinetics in children. Bone Marrow Transplant 2010; 45:261-7.

Ansari M, Sauty G, Labuda M et al. Polymorphisms in multidrug resistance-associated protein gene 4 is associated with outcome in childhood acute lymphoblastic leukemia. Blood 2009; 114:1383-6.

Ansari-Lari MA, Muzny DM, Lu J et al. A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13. Genome Res 1996; 6:314-26.

Anson BD, Ackerman MJ, Tester DJ et al. Molecular and functional characterization of common polymorphisms in HERG (KCNH2) potassium channels. Am J Physiol Heart Circ Physiol 2004; 286:2434-41.

Antherieu S, Chesne C, Li R et al. Stable expression, activity and inducibility of cytochromes P450 in differentiated HepaRG cells. Drug Metab Dispos 2010; 38:516-25.

Anthony IC, Norrby KE, Dingwall T et al. Predisposition to accelerated Alzheimer-related changes in the brains of human immunodeficiency virus negative opiate abusers. Brain 2010; 133:3685-98.

Anthony M, Berg MJ. Biologic and molecular mechanisms for sex differences in pharmacokinetics, pharmacodynamics, and pharmacogenetics: Part I. J Womens Health Gend Based Med 2002; 11:601-15.

Anthony M, Romero K, Malone DC et al. Warfarin interactions with substances listed in drug information compendia and in the FDA-Approved label for warfarin sodium. Clin Pharmacol Ther 2009; 86:425-9.

Antia U. 'Party pill' drugs-BZP and TFMPP. N Z Med J 2009; 122:55-68.

Antia U, Tingle MD, Russell BR. Metabolic interactions with piperazine-based 'party pill' drugs. J Pharm Pharmacol 2009; 61:877-82.

Antila S, Honkanen T, Lehtonen L, Neuvonen PJ. The CYP3A4 inhibitor intraconazole does not affect the pharmacokinetics of a new calcium-sensitizing drug levosimendan. Int J Clin Pharmacol Ther 1998; 36:446-9.

Antolino Lobo I, Meulenbelt J, Nijmeijer SM, Scherpenisse P, van den Berg M, van Duursen MB. Differential roles of phase I and phase II enzymes in 3,4-methylendioxymethamphetamine-induced cytotoxicity. Drug Metab Dispos 2010; 38:1105-12.

Anton RF, Oroszi G, O'Malley S et al. An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study. Arch Gen Psychiatry 2008; 65:135-44.

Antonić J, Grabnar I, Milčinski L et al. Influence of P-glycoprotein inhibition on secretion of ivermectin and doramectin by milk in lactating sheep. Vet Parasitol 2011; 179:159-66.

Antoniou A, Pharoah PDP, Narod S et al. Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: a combined analysis of 22 studies. Am J Hum Genet 2003; 72:1117-30.

Antoniou AC, Spurdle AB, Sinilnikova OM et al. Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers. Am J Hum Genet 2008; 82:937-48.

Antoniou T, Tseng AL. Interactions between antiretrovirals and antineoplastic drug therapy. Clin Pharmacokinet 2005; 44:111-45.

Antony S, Kohlhagen G, Agama K et al. Cellular topoisomerase I inhibition and antiproliferative activity by MJ-III-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison. Mol Pharmacol 2005; 67:523-30.

Anttila AK, Rasanen L, Leinonen EV. Fluvoxamine augmentation increases serum mirtazapine concentrations three-to fourfold. Ann Pharmacother 2001; 35:1221-3.

Anttila S, Hukkanen J, Hakkola J et al. Expression and localization of CYP3A4 and CYP3A5 in human lung. Am J Respir Cell Mol Biol 1997; 16:242-9.

Anttila SA, Leinonen EV. A review of the pharmacological and clinical profile of mirtazapine. CNS Drug Rev 2001; 7:249-64.

Antuna-Puente B, Boutet E, Vigouroux C et al. Higher adiponectin levels in patients with Berardinelli-Seip congenital lipodystrophy due to seipin as compared with 1-acylglycerol-3-phosphate-o-acyltransferase-2 deficiency. J Clin Endocrinol Metab 2010; 95:1463-8.

Antunes-Fernandes EC, Bovee TF, Daamen FE, Helsdingen RJ, van den Berg M, van Duursen MB. Some OH-PCBs are more potent inhibitors of aromatase activity and (anti-) glucocorticoids than non-dioxin like (NDL)-PCBs and MeSO(2)-PCBs. Toxicol Lett 2011; 206:158-65.

Antzelevitch C. Drug-induced spatial dispersion of repolarization. Cardiol J 2008; 15:100-21.

Anvari M, Khalilzadeh O, Esteghamati A et al. Graves' disease and gene polymorphism of TNF-α, IL-2, IL-6, IL-12, and IFN-γ. Endocrine 2010; 37:344-8.

Anzenbacherová E, Bec N, Anzenbacher P et al. Flexibility and stability of the structure of cytochromes P450 3A4 and BM-3. Eur J Biochem 2000; 267:2916-20.

Aoki J, Ikeda K, Murayama O, Yoshihara E, Ogai Y, Iwahashi K. The association between personality, pain threshold and a single nucleotide polymorphism (rs3813034) in the 3'-untranslated region of the serotonin transporter gene (SLC6A4). J Clin Neurosci 2010; 17:574-8.

Aoki T, Hirota T, Tamari M et al. An association between asthma and TNF-308G/A polymorphism: meta-analysis. J Hum Genet 2006; 51:677-85.

Aomori T, Yamamoto K, Oguchi-Katayama A et al. Rapid single-nucleotide polymorphism detection of cytochrome P450 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genes for the warfarin dose adjustment by the SMart-amplification process version 2. Clin Chem 2009; 55:804-12.

Aono S, Adachi Y, Uyama E et al. Analysis of genes for bilirubin UDP-glucuronosyltransferase in Gilbert's syndrome. Lancet 1995; 346:314-5.

Aono S, Yamada Y, Keino H et al. Identification of defect in the genes for bilirubin UDP-glucuronosyl-transferase in a patient with Crigler-Najjar syndrome type II. Biochem Biophys Res Commun 1993; 197:1239-44.

Aono S, Yamada Y, Keino H et al. A new type of defect in the gene for bilirubin uridine 5'-diphosphate-glucuronosyltransferase in a patient with Crigler-Najjar syndrome type I. Pediatr Res 1994; 35:629-32.

Aouali N, El Btaouri H, Dumontet C et al. Accumulation of lactosylceramide and overexpression of a PSC833-resistant P-glycoprotein in multidrug-resistant human sarcoma cells. Oncol Rep 2011; 25:1161-7.

Aoyagi T, Koshimizu TA, Tanoue A. Vasopressin regulation of blood pressure and volume: findings from V1a receptor-deficient mice. Kidney Int 2009; 76:1035-9.

Aoyagi Y, Nagata S, Kudo T et al. Peroxisome proliferator-activated receptor γ 2 mutation may cause a subset of ulcerative colitis. Pediatr Int 2010; 52:729-34.

Aoyama K, Yoshinari K, Kim HJ, Nagata K, Yamazoe Y. Simultaneous expression of plural forms of human cytochrome P450 at desired ratios in HepG2 cells: adenovirus-mediated tool for cytochrome P450 reconstitution. Drug Metab Pharmacokinet 2009; 24:209-17.

Aoyama T, Yamano S, Waxman DJ et al. Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine. J Biol Chem 1989; 264:10388-95.

Apáti A, Orbán TI, Varga N et al. High level functional expression of the ABCG2 multidrug transporter in undifferentiated human embryonic stem cells. Biochim Biophys Acta 2008; 1778:2700-9.

Apetoh L, Ghiringhelli F, Tesniere A et al. Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med 2007; 13:1050-9.

Apinan R, Tassaneeyakul W, Mahavorasirikul W et al. The influence of CYP2A6 polymorphisms and cadmium on nicotine metabolism in Thai population. Environ Toxicol Pharmacol 2009; 28:420-4.

Aplenc R, Glatfelter W, Han P et al. CYP3A genotypes and treatment response in paediatric acute lymphoblastic leukaemia. Br J Haematol 2003; 122:240-4.

Apostolov EO, Ray D, Savenka AV, Shah SV, Basnakian AG. Chronic uremia stimulates LDL carbamylation and atherosclerosis. J Am Soc Nephrol 2010; 21:1852-7.

Appel-Dingemanse S. Clinical pharmacokinetics of tegaserod, a serotonin 5-HT(4) receptor partial agonist with promotile activity. Clin Pharmacokinet 2002; 41:1021-42.

Apperley JF, Gardembas M, Melo JV et al. Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta. N Engl J Med 2002; 347:481-7.

Appiah-Opong R, Commandeur JN, Axson C, Vermeulen NP. Interactions between cytochromes P450, glutathione S-transferases and Ghanaian medicinal plants. Food Chem Toxicol 2008; 46:3598-603.

Appiah-Opong R, Commandeur JN, van Vugt-Lussenburg B, Vermeulen NP. Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products. Toxicology 2007; 235:83-91.

Appiah-Opong R, de Esch I, Commandeur JN, Andarini M, Vermeulen NP. Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues. Eur J Med Chem 2008; 43:1621-31.

Applebaum KM, Karagas MR, Hunter DJ et al. Polymorphisms in nucleotide excision repair genes, arsenic exposure, and non-melanoma skin cancer in New Hampshire. Environ Health Perspect 2007; 115:1231-6.

Apte U, Singh S, Zeng G et al. Beta-catenin activation promotes liver regeneration after acetaminophen-induced injury. Am J Pathol 2009; 175:1056-65.

Aquilante CL, Yarandi HN, Cavallari LH et al. Beta-adrenergic receptor gene polymorphisms and hemodynamic response to dobutamine during dobutamine stress echocardiography. Pharmacogenomics J 2008; 8:408-15.

Aquino-Galvez A, Camarena A, Montaño M et al. Transporter associated with antigen processing (TAP) 1 gene polymorphisms in patients with hypersensitivity pneumonitis. Exp Mol Pathol 2008; 84:173-7.

Arab JP, Ramírez C, Muñoz P et al. Effects of Japanese herbal medicine Inchin-ko-to on endotoxin-induced cholestasis in the rat. Ann Hepatol 2009; 8:228-33.

Arab-Alameddine M, di Iulio J, Buclin T et al. Pharmacogenetics-based population pharmacokinetic analysis of efavirenz in HIV-1-infected individuals. Clin Pharmacol Ther 2009; 85:485-94.

Aragonès G, Guardiola M, Barreda M et al. Measurement of serum PON-3 concentration: method evaluation, reference values, and influence of genotypes in a population-based study. J Lipid Res 2011; 52:1055-61.

Arai H, Higuchi S, Muramatsu T, Iwarsubo T, Sasaki H, Trojanowski Q. Apolipoprotein E gene in diffuse Lewy body disease with or without co-existing Alzheimer's disease. Lancet 1994; 344:1307.

Arai T, Kim HJ, Chiba H, Matsumoto A. Interaction of fenofibrate and fish oil in relation to lipid metabolism in mice. J Atheroscler Thromb 2009; 16:283-91.

Araki K, Yasui-Furukori N, Fukasawa T et al. Inhibition of the metabolism of etizolam by itraconazole in humans: evidence for the involvement of CYP3A4 in etizolam metabolism. Eur J Clin Pharmacol 2004; 60:427-30.

Araki N, Tsuruoka S, Wang N et al. Human CYP3A4-introduced HepG2 cells: in vitro screening system of new chemicals for the evaluation of CYP3A4-inhibiting activity. Xenobiotica 2008; 38:1355-64.

Araki S, Koya D, Makiishi T et al. APOE polymorphism and the progression of diabetic nephropathy in Japanese subjects with type 2 diabetes: results of a prospective observational follow-up study. Diabetes Care 2003; 26:2416-20.

Arashiro R, Katsuren K, Fukuyama S, Ohta T. Effect of Trp64Arg mutation of the beta3-adrenergic receptor gene and C161T substitution of the peroxisome proliferator activated receptor gamma gene on obesity in Japanese children. Pediatr Int 2003; 45:135-41.

Araújo MA, Goulart LR, Cordeiro ER et al. Genotypic interactions of renin-angiotensin system genes in myocardial infarction. Int J Cardiol 2005; 103:27-32.

Araújo MA, Menezes BS, Lourenço C, Cordeiro ER, Gatti RR, Goulart LR. The A1166C polymorphism of the angiotensin II type-1 receptor in acute myocardial infarction. Arq Bras Cardiol 2004; 83:409-13; 404-8.

Araújo-Vilar D, Lattanzi G, González-Méndez B et al. Site-dependent differences in both prelamin A and adipogenic genes in subcutaneous adipose tissue of patients with type 2 familial partial lipodystrophy. J Med Genet 2009; 46:40-8.

Araya Z, Wikvall K. 6alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes. Biochim Biophys Acta 1999; 1438:47-54.

Arayne MS, Sultana N, Bibi Z. Grape fruit juice-drug interactions. Pak J Pharm Sci 2005; 18:45-57.

Arbini AA, Mannucci M, Bauer KA. A Thr359Met mutation in factor VII of a patient with a hereditary deficiency causes defective secretion of the molecule. Blood 1996; 87:5085-94.

Arbini AA, Pollak ES, Bayleran JK, High KA, Bauer KA. Severe factor VII deficiency due to a mutation disrupting a hepatocyte nuclear factor 4 binding site in the factor VII promoter. Blood 1997; 89:176-82.

Arbus C, Benyamina A, Llorca PM et al. Characterization of human cytochrome P450 enzymes involved in the metabolism of cyamemazine. Eur J Pharm Sci 2007; 32:357-66.

Arbustini E, Grasso M, Fasani R et al. Angiotensin converting enzyme gene deletion allele is independently and strongly associated with coronary atherosclerosis and myocardial infarction. Brit Heart J 1995; 74:584-91.

Arch DD, Bergeron M, Hathaway L, Kushner JP, Phillips JD, Franklin MR. Longitudinal study of a mouse model of familial porphyria cutanea tarda. Cell Mol Biol 2009; 55:46-54.

Ardies CM, Smith TJ, Kim S, Yang CS. Induction of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) activation in rat lung microsomes by chronic ethanol consumption and repeated running exercise. Cancer Lett 1996; 103:209-18.

Arellano C, Philibert C, Vachoux C, Woodley J, Houin G. The metabolism of midazolam and comparison with other CYP enzyme substrates during intestinal absorption: in vitro studies with rat everted gut sacs. J Pharm Pharm Sci 2007; 10:26-36.

Arenaz I, Vicente J, Fanlo A et al. Haplotype structure and allele frequencies of CYP2B6 in Spaniards and Central Americans. Fundam Clin Pharmacol 2010; 24:247-53.

Arendash GW, Lewis J, Leighty RE et al. Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer's disease: linkage of poorer cognitive performance to tau pathology in forebrain. Brain Res 2004; 1012:29-41.

Arendt J, Rajaratnam SM. Melatonin and its agonists: an update. Br J Psychiatry 2008; 193:267-9.

Argani H, Ghorbanihaghjo A, Aghaeishahsavari M et al. Effects of losartan and enalapril on high-sensitivity C-reactive protein and total antioxidant in renal transplant recipients with Renin-Angiotensin system polymorphisms. Transplant Proc 2008; 40:16-21.

Argikar UA, Remmel RP. Variation in glucuronidation of lamotrigine in human liver microsomes. Xenobiotica 2009; 39:355-63.

Argikar UA, Remmel RP. Effect of aging on glucuronidation of valproic acid in human liver microsomes and the role of UDP-glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10. Drug Metab Dispos 2009; 37:229-36.

Argikar UA, Senekeo-Effenberger K, Larson EE, Tukey RH, Remmel RP. Studies on induction of lamotrigine metabolism in transgenic UGT1 mice. Xenobiotica 2009; 39:826-35.

Argov M, Bod T, Batra S, Margalit R. Novel steroid carbamates reverse multidrug-resistance in cancer therapy and show linkage among efficacy, loci of drug action and P-glycoprotein's cellular localization. Eur J Pharm Sci 2010; 41:53-9.

Arias A, Villanueva SS, Ruiz ML et al. Regulation of expression and activity of rat intestinal multidrug resistance-associated protein 2 by cholestatic estrogens. Drug Metab Dispos 2009; 37:1277-85.

Arias B, Gutiérrez B, Pintor L, Gastó C, Fañanás L. Variability in the 5-HT(2A) receptor gene is associated with seasonal pattern in major depression. Mol Psychiatry 2001; 6:239-42.

Arias B, Serretti A, Mandelli L et al. Dysbindin gene (DTNBP1) in major depression: association with clinical response to selective serotonin reuptake inhibitors. Pharmacogenet Genomics 2009; 19:121-8.

Arikuma T, Yoshikawa S, Azuma R, Watanabe K, Matsumura K, Konagaya A. Drug interaction prediction using ontology-driven hypothetical assertion framework for pathway generation followed by numerical simulation. BMC Bioinformatics 2008; 9 Suppl 6:11.

Arima K, Kowalska A, Hasegawa M et al. Two brothers with frontotemporal dementia and parkinsonism with an N279K mutation of the tau gene. Neurology 2000; 54:1787-95.

Arimoto R, Prasad MA, Gifford EM. Development of CYP3A4 inhibition models: comparisons of machine-learning techniques and molecular descriptors. J Biomol Screen 2005; 10:197-205.

Arinami T, Ishikawa M, Inoue A et al. Chromosomal assignments of the human endothelin family genes: the endothelin-1 gene (EDN1) to 6p23-p24, the endothelin-2 gene (EDN2) to 1p34, and the endothelin-3 gene (EDN3) to 20q13. 2-q13. 3. Am J Hum Genet 1991; 48:990-6.

Ariyoshi N, Iga Y, Hirata K et al. Enhanced susceptibility of HLA-mediated ticlopidine-induced idiosyncratic hepatotoxicity by CYP2B6 polymorphism in Japanese. Drug Metab Pharmacokinet 2010; 25:298-306.

Ariyoshi N, Ohara M, Kaneko M et al. Gln172His replacement overcomes effects on the metabolism of cyclophosfamide and efavirenz caused by CYP2B6 variant with Arg262. Drug Metab Dispos 2011; 39:2045-8.

Ariyoshi N, Sawamura Y, Kamataki T. A novel single nucleotide polymorphism altering stability and activity of CYP2a6. Biochem Biophys Res Commun 2001; 281:810-4.

Ariyoshi N, Sekine H, Nakayama K, Saito K, Miyamoto A, Kamataki T. Identification of deletion-junction site of CYP2A6*4B allele lacking entire coding region of CYP2A6 in Japanese. Pharmacogenetics 2004; 14:701-5.

Ariyoshi N, Sekine H, Saito K, Kamataki T. Characterization of a genotype previously designated as CYP2A6 D-type: CYP2A6*4B, another entire gene deletion allele of the CYP2A6 gene in Japanese. Pharmacogenetics 2002; 12:501-4.

Ariyoshi N, Takahashi Y, Miyamoto M et al. Structural characterization of a new variant of the CYP2A6 gene (CYP2A6*1B) apparently diagnosed as heterozygotes of CYP2A6*1A and CYP2A6*4C. Pharmacogenetics 2000; 10:687-93.

Arkwright PD, McDermott MF, Houten SM et al. Hyper IgD syndrome (HIDS) associated with in vitro evidence of defective monocyte TNFRSF1A shedding and partial response to TNF receptor blockade with etanercept. Clin Exp Immunol 2002; 130:484-8.

Arlander E, Ekström G, Alm C et al. Metabolism of ropivacaine in humans is mediated by CYP1A2 and to a minor extent by CYP3A4: an interaction study with fluvoxamine and ketoconazole as in vivo inhibitors. Clin Pharmacol Ther 1998; 64:484-91.

Arman A, Yüksel B, Coker A, Sarioz O, Temiz F, Topaloglu AK. Novel growth hormone receptor gene mutation in a patient with Laron syndrome. J Pediatr Endocrinol Metab 2010; 23:407-14.

Armani A, Marzolla V, Rosano GM, Fabbri A, Caprio M. Phosphodiesterase type 5 (PDE5) in the adipocyte: a novel player in fat metabolism? Trends Endocrinol Metab 2011; 22:404-11.

Armanios M, Chen JL, Chang YP et al. Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita. Proc Natl Acad Sci USA 2005; 102:15960-4.

Armbruster D, Mueller A, Strobel A, Kirschbaum C, Lesch KP, Brocke B. Influence of functional tryptophan hydroxylase 2 gene variation and sex on the startle response in children, young adults, and older adults. Biol Psychol 2010; 83:214-21.

Armstrong AJ, Gebre AK, Parks JS, Hedrick CC. ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation. J Immunol 2010; 184:173-83.

Armstrong RA. Density and spatial pattern of β-amyloid (Aβ) deposits in corticobasal degeneration. Folia Neuropathol 2011; 49:14-20.

Armstrong SA, Mabon ME, Silverman LB et al. FLT3 mutations in childhood acute lymphoblastic leukemia. Blood 2004; 103:3544-6.

Armstrong SC, Wynn GH, Sandson NB. Pharmacokinetic drug interactions of synthetic opiate analgesics. Psychosomatics 2009; 50:169-76.

Arnaud MJ. Pharmacokinetics and metabolism of natural methylxanthines in animal and man. Handb Exp Pharmacol 2011:33-91.

Arnaud O, Boumendjel A, Gèze A et al. The acridone derivative MBLI-87 sensitizes breast cancer resistance protein-expressing xenografts to irinotecan. Eur J Cancer 2011; 47:640-8.

Arnaud O, Koubeissi A, Ettouati L et al. Potent and fully noncompetitive peptidomimetic inhibitor of multidrug resistance P-glycoprotein. J Med Chem 2010; 53:6720-9.

Arnedo M, Taffé P, Sahli R et al. Contribution of 20 single nucleotide polymorphisms of 13 genes to dyslipidemia associated with antiretroviral therapy. Pharmacogenet Genomics 2007; 17:755-64.

Arnett DK, Davis BR, Ford CE et al. Pharmacogenetic association of the angiotensin-converting enzyme insertion/deletion polymorphism on blood pressure and cardiovascular risk in relation to antihypertensive treatment: the Genetics of Hypertension-Associated Treatment (GenHAT) study. Circulation 2005; 111:3374-83.

Arnold C, Konkel A, Fischer R, Schunck WH. Cytochrome P450-dependent metabolism of omega-6 and omega-3 long-chain polyunsaturated fatty acids. Pharmacol Rep 2010; 62:536-47.

Arnold SE, Joo E, Martinoli MG et al. Apoliprotein E genotype in schizophrenia: Frequency, age and onset, and neurophathological features. Neuroreport 1997; 8:1523-6.

Arnoldi A, Crimella C, Tenderini E et al. Clinical phenotype variability in patients with hereditary spastic paraplegia type 5 associated with CYP7B1 mutations. Clin Genet 2011. doi:10. 1111/j. 1399-0004. 2011. 01624. x.

Arnoux JB, de Lonlay P, Ribeiro MJ et al. Congenital hyperinsulinism. Early Hum Dev 2010; 86:287-94.

Arold G, Donath F, Maurer A et al. No relevant interaction with alprazolam, caffeine, tolbutamide, and digoxin by treatment with a low-hyperforin St John's wort extract. Planta Med 2005; 71:331-7.

Aronin N, Chase K, Young C et al. CAG expansion affects the expression of mutant hungtingtin in Huntington's disease brain. Neuron 1995; 15:1193-201.

Aron-Wisnewsky J, Julia Z, Poitou C et al. Effect of bariatric surgery-induced weight loss on SR-BI-, ABCG1-, and ABCA1-mediated cellular cholesterol efflux in obese women. J Clin Endocrinol Metab 2011; 96:1151-9.

Arora V, Cate ML, Ghosh C, Iversen PL. Phosphorodiamidate morpholino antisense oligomers inhibit expression of human cytochrome P450 3A4 and alter selected drug metabolism. Drug Metab Dispos 2002; 30:757-62.

Arora V, Iversen PL. Redirection of drug metabolism using antisense technology. Curr Opin Mol Ther 2001; 3:249-57.

Arosio B, Mastronardi L, Vergani C, Annoni G. Intereleukin-10 promoter polymorphism in mild cognitive impairment and in its clinical evolution. Int J Alzheimers Dis 2010. doi:10. 4061/2010/854527

Arráiz N, Bermúdez V, Rondon N et al. Novel mutations identification in exon 4 of LDLR gene in patients with moderate hypercholesterolemia in a Venezuelan population. Am J Ther 2010; 17:325-9.

Arranz MJ, Dawson E, Shaikh S et al. Cytochrome P4502D6 genotype does not determine response to clozapine. Br J Clin Pharmacol 1995; 39:417-20.

Arrington-Sanders R, Hutton N, Siberry GK. Ritonavir-fluticasone interaction causing Cushing syndrome in HIV-infected children and adolescents. Pediatr Infect Dis J 2006; 25:1044-8.

Arrizabalaga J, Rodriguez-Alcántara F, Castañer JL et al. Prevalence of HLA-B*5701 in HIV-infected patients in Spain (results of the EPI Study). HIV Clin Trials 2009; 10:48-51.

Arsenault J, Lehoux J, Lanthier L et al. A single-nucleotide polymorphism of alanine to threonine at position 163 of the human angiotensin II type 1 receptor impairs Losartan affinity. Pharmacogenet Genomics 2010; 20:377-88.

Arthur AT, Armati PJ, Bye C et al. Genes implicated in multiple sclerosis pathogenesis from consilience of genotyping and expression profiles in relapse and remission. BMC Med Genet 2008; 19:9:17.

Artico M, Riganò R, Buttari B et al. Protective role of parnaparin in reducing systemic inflammation and atherosclerotic plaque formation in ApoE-/- mice. Int J Mol Med 2011; 27:561-5.

Arukwe A. Modulation of brain steroidogenesis by affecting transcriptional changes of steroidogenic acute regulatory (StAR) protein and cholesterol side chain cleavage (P450scc) in juvenile Atlantic salmon (Salmo salar) is a novel aspect of nonylphenol toxicity. Environ Sci Technol 2005; 39:9791-8.

Arun Kumar AS, Chakradhara Rao US, Umamaheswaran G et al. Haplotype structures of common variants of CYP2C8, CYP2C9, and ADRB1 genes in a South Indian population. Genet Test Mol Biomarkers 2011; 15:407-13.

Asada T, Kariya T, Yamagata Z, Kinoshita T, Asaka A. ApoE epsilon-4 and cognitive decline in patients with Alzheimer's disease. Neurology 1996; 47:603.

Asadullah K, Eskdale J, Wiese A, Gallagher G, Friedrich M, Sterry W. Interleukin-10 promoter polymorphism in psoriasis. J Invest Dermatol 2001; 116:975-8.

Asakawa C, Ogawa M, Kumata K et al. [(11)C]Sorafenib: Radiosynthesis and preliminary PET study of brain uptake in P-gp/Bcrp knockout mice. Bioorg Med Chem Lett 2011; 21:2220-3.

Asano K, Yamada-Yamasawa W, Kudoh H et al. Association between beta-adrenoceptor gene polymorphisms and relative response to beta 2-agonists and anticholinergic drugs in Japanese asthmatic patients. Respirology 2010; 15:849-54.

Asano T, Kushida H, Sadakane C et al. Metabolism of ipecac alkaloids cephaeline and emetine by human hepatic microsomal cytochrome P450s, and their inhibitory effects on P450 enzyme activities. Biol Pharm Bull 2001; 24:678-82.

Asano T, Takahashi KA, Fujioka M et al. Genetic analysis of steroid-induced osteonecrosis of the femoral head. J Orthop Sci 2003; 8:329-33.

Asano T, Takahashi KA, Fujioka M et al. ABCB1 C3435T and G2677T/A polymorphism decreased the risk for steroid-induced osteonecrosis of the femoral head after kidney transplantation. Pharmacogenetics 2003; 13:675-82.

Asberg A. Interactions between cyclosporin and lipid-lowering drugs: implications for organ transplant recipients. Drugs 2003; 63:367-78.

Aschim EL, Nordenskjöld A, Giwercman A et al. Linkage between cryptorchidism, hypospadias, and GGN repeat length in the androgen receptor gene. J Clin Endocrinol Metab 2004; 89:5105-9.

Asghar A, Gorski JC, Haehner-Daniels B, Hall SD. Induction of multidrug resistance-1 and cytochrome P450 mRNAs in human mononuclear cells by rifampin. Drug Metab Dispos 2002; 30:20-6.

Ashbee HR, Gilleece MH. Has the era of individualised medicine arrived for antifungals? A review of antifungal pharmacogenomics. Bone Marrow Transplant 2011. doi:10. 1038/bmt. 2011. 146.

Ashcroft FM. ATP-sensitive potassium channelopathies: focus on insulin secretion. J Clin Invest 2005; 115:2047-58.

Asher G, Tsvetkov P, Kahana C, Shaul Y. A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73. Genes Dev 2005; 19:316-21.

Ashford JW. APOE genotype effects on Alzheimer's disease onset and epidemiology. J Mol Neurosci 2004; 23:157-65.

Ashiru-Oredope DA, Patel N, Forbes B, Patel R, Basit AW. The effect of polyoxyethylene polymers on the transport of ranitidine in Caco-2 cell monolayers. Int J Pharm 2011; 409:164-8.

Ashkar S, Mesentsev A, Zhang WX, Mastyugin V, Dunn MW, Laniado-Schwartzman M. Retinoic acid induces corneal epithelial CYP4B1 gene expression and stimulates the synthesis of inflammatory 12-hydroxyeicosanoids. J Ocul Pharmacol Ther 2004; 20:65-74.

Ashley-Koch AE, Elliott L, Kail ME et al. Identification of genetic polymorphisms associated with risk for pulmonary hypertension in sickle cell disease. Blood 2008; 111:5721-6.

Ashraf J, Thompson EB. Identification of the activation-labile gene: a single point mutation in the human glucocorticoid receptor presents as two distinct receptor phenotypes. Mol Endocrinol 1993; 7:631-42.

Ashrafian H, Horowitz JD, Frenneaux MP. Perhexiline. Cardiovasc Drug Rev 2007; 25:76-97.

Ashton KA, Proietto A, Otton G et al. Polymorphisms in genes of the steroid hormone biosynthesis and metabolism pathways and endometrial cancer risk. Cancer Epidemiol 2010; 34:328-37.

Asiedu C, Biggs J, Lilly M, Kraft AS. Inhibition of leukemic cell growth by the protein kinase C activator bryostatin 1 correlates with the dephosphorylation of cyclin-dependent kinase 2. Cancer Res 1995; 55:3716-20.

Asimus S, Elsherbiny D, Hai TN et al. Artemisinin antimalarials moderately affect cytochrome P450 enzyme activity in healthy subjects. Fundam Clin Pharmacol 2007; 21:307-16.

Asleh R, Levy AP. In vivo and in vitro studies establishing haptoglobin as a major susceptibility gene for diabetic vascular disease. Vasc Health Risk Manag 2005; 1:19-28.

Asp V, Ullerås E, Lindström V, Bergström U, Oskarsson A, Brandt I. Biphasic hormonal responses to the adrenocorticolytic DDT metabolite 3-methylsulfonyl-DDE in human cells. Toxicol Appl Pharmacol 2010; 242:281-9.

Assaraf YG. The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis. Drug Resist Updat 2006; 9:227-46.

Asselta R, Peyvandi F. Factor V deficiency. Semin Thromb Hemost 2009; 35:382-9.

Assenat E, Gerbal-Chaloin S, Larrey D et al. Interleukin 1beta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance. Hepatology 2004; 40:951-60.

Aste N, Watanabe Y, Harada N, Saito N. Distribution and sex differences in aromatase-producing neurons in the brain of Japanese quail embryos. J Chem Neuroanat 2010; 39:272-88.

Atack JR. GABA(A) receptor subtype-selective efficacy: TPA023, an alpha2/alpha3 selective non-sedating anxiolytic and alpha5IA, an alpha5 selective cognition enhancer. CNS Neurosci Ther 2008; 14:25-35.

Atalay C, Demirkazik A, Gunduz U. Role of ABCB1 and ABCC1 gene induction on survival in locally advanced breast cancer. J Chemother 2008; 20:734-9.

Atanasova SY, von Ahsen N, Toncheva DI, Dimitrov TG, Oellerich M, Armstrong VW. Genetic polymorphisms of cytochrome P450 among patients with Balkan endemic nephropathy (BEN). Clin Biochem 2005; 38:223-8.

Ateeq B, Tomlins SA, Chinnaiyan AM. AGTR1 as a therapeutic target in ER-positive and ERBB2-negative breast cancer cases. Cell Cycle 2009; 8:3794-5.

Ateş NA, Tamer L, Ateş C et al. Glutathione S-transferase M1, T1, P1 genotypes and risk for development of colorectal cancer. Biochem Genet 2005; 43:149-63.

Ates O, Dalyan L, Hatemi G, Hamuryudan V, Topal-Sarikaya A. Genetic susceptibility to Behçet's syndrome is associated with NRAMP1 (SLC11A1) polymorphism in Turkish patients. Rheumatol Int 2009; 29:787-91.

Ates O, Dalyan L, Müsellim B et al. NRAMP1 (SLC11A1) gene polymorphisms that correlate with autoimmune versus infectious disease susceptibility in tuberculosis and rheumatoid arthritis. Int J Immunogenet 2009; 36:15-29.

Ates O, Dolek B, Dalyan L, Musellim B, Ongen G, Topal-Sarikaya A. The association between BsmI variant of vitamin D receptor gene and susceptibility to tuberculosis. Mol Biol Rep 2011; 38:2633-6.

Athippozhy A, Huang L, Wooton-Kee CR et al. Differential gene expression in liver and small intestine from lactating rats compared to age-matched virgin controls detects increased mRNA of cholesterol biosynthetic genes. BMC Genomics 2011; 12:95.

Athyros VG, Papageorgiou AA, Hatzikonstandinou HA, Athyrou VV, Kontopoulos AG. Effect of atorvastatin versus simvastatin on lipid profile and plasma fibrinogen in patients with hypercholesterolaemia: A Pilot, Randomised, Double-Blind, Dose-Titrating Study. Clin Drug Investig 1998; 16:219-27.

Atkinson SH, Mwangi TW, Uyoga SM et al. The haptoglobin 2-2 genotype is associated with a reduced incidence of Plasmodium falciparum malaria in children on the coast of Kenya. Clin Infect Dis 2007; 44:802-9.

Atkinson SH, Rockett K, Sirugo G et al. Seasonal childhood anaemia in West Africa is associated with the haptoglobin 2-2 genotype. PLoS Med 2006. doi:10. 1371/journal. pmed. 0030172.

Atshaves BP, McIntosh AL, Martin GG et al. Overexpression of sterol carrier protein-2 differentially alters hepatic cholesterol accumulation in cholesterol-fed mice. J Lipid Res 2009; 50:1429-47.

Attar-Herzberg D, Apel A, Gang N, Dvir D, Mayan H. The serotonin syndrome: initial misdiagnosis. Isr Med Assoc J 2009; 11:367-70.

Attie T, Pelet A, Edery P et al. Diversity of RET proto-oncogene mutations in familial and sporadic Hirschsprung disease. Hum Molec Genet 1995; 4:1381-6.

Au N, Rettie AE. Pharmacogenomics of 4-hydroxycoumarin anticoagulants. Drug Metab Rev 2008; 40:355-75.

Au WY, Lam CC, Chan EC, Kwong YL. Two novel factor VII gene mutations in a Chinese family with factor VII deficiency. Br J Haematol 2000; 111:143-5.

Aubert J, Begriche K, Knockaert L, Robin MA, Fromenty B. Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: Mechanisms and pathophysiological role. Clin Res Hepatol Gastroenterol 2011; 35:630-7.

Audero E, Coppi E, Mlinar B et al. Sporadic autonomic dysregulation and death associated with excessive serotonin autoinhibition. Science 2008; 321:130-3.

Audí L, Carrascosa A, Esteban C et al. The exon 3-deleted/full-length growth hormone receptor polymorphism does not influence the effect of puberty or growth hormone therapy on glucose homeostasis in short non-growth hormone-deficient small-for-gestational-age children: results from a two-year controlled prospective study. J Clin Endocrinol Metab 2008; 93:2709-15.

Audi L, Fernández-Cancio M, Carrascosa A et al. Novel (60%) and recurrent (40%) androgen receptor gene mutations in a series of 59 patients with a 46,XY disorder of sex development. J Clin Endocrinol Metab 2010; 95:1876-88.

Auerbach SS, Dekeyser JG, Stoner MA, Omiecinski CJ. CAR2 displays unique ligand binding and RXRalpha heterodimerization characteristics. Drug Metab Dispos 2007; 35:428-39.

Auerbach SS, Stoner MA, Su S, Omiecinski CJ. Retinoid X receptor-alpha-dependent transactivation by a naturally occurring structural variant of human constitutive androstane receptor (NR1I3). Mol Pharmacol 2005; 68:1239-53.

Auerbach W, Hulbert M, Hilditch-Maguire P et al. The HD mutation causes progressive lethal neurogical disease in mice expressing reduced levels of huntingtin. Hum Molec Genet 2001; 10:2515-23.

Aulchenko YS, Ripatti S, Lindqvist I et al. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet 2009; 41:47-55.

Ault BH, Schmidt BZ, Fowler NL et al. Human factor H deficiency. Mutations in framework cysteine residues and block in H protein secretion and intracellular catabolism. J Biol Chem 1997; 272:25168-75.

Auner V, Sehouli J, Oskay-Oezcelik G, Horvat R, Speiser P, Zeillinger R. ABC transporter gene expression in benign and malignant ovarian tissue. Gynecol Oncol 2010; 117:198-201.

Aung GL, O'Brien JG, Tien PG, Kawamoto LS. Increased aripiprazole concentrations in an HIV-positive male concurrently taking duloxetine, darunavir, and ritonavir. Ann Pharmacother 2010; 44:1850-4.

Aung HH, Lame MW, Gohil K et al. Comparative gene responses to collected ambient particles in vitro: endothelial responses. Physiol Genomics 2011; 43:917-29.

Aurade RM, Jayalakshmi SK, Sreeramulu K. Modulatory effects of natural curcuminoids on P-glycoprotein ATPase of insecticide-resistant pest Helicoverpa armigera (Lepidopetera: Noctüidae). J Membr Biol 2010; 236:271-8.

Aurade RM, Jayalakshmi SK, Sreeramulu K. P-glycoprotein ATPase from the resistant pest, Helicoverpa armigera: purification, characterization and effect of various insecticides on its transport function. Biochim Biophys Acta 2010; 1798:1135-43.

Aureli A, del Beato T, Sebastiani P et al. Attention-deficit hyperactivity disorder and intellectual disability: a study of association with brain-derived neurotrophic factor gene polymorphisms. Int J Immunopathol Pharmacol 2010; 23:873-80.

Aurich H, Sgodda M, Kaltwasser P et al. Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo. Gut 2009; 58:570-81.

Auro K, Alanne M, Kristiansson K et al. Combined effects of thrombosis pathway gene variants predict cardiovascular events. PLoS Genet 2007. doi:10. 1371/journal. pgen. 0030120.

Austin SA, Santhanam AV, Katusic ZS. Endothelial nitric oxide modulates expression and processing of amyloid precursor protein. Circ Res 2010; 107:1498-502.

Austinat M, Braeuninger S, Pesquero JB et al. Blockade of bradykinin receptor B1 but not bradykinin receptor B2 provides protection from cerebral infarction and brain edema. Stroke 2009; 40:285-93.

Avdesh A, Wong P, Martins RN, Martin-Iverson MT. Memory function in a mouse genetic model of Alzheimer's disease. J Alzheimers Dis 2011; 25:433-44.

Avenoso A, Spinà E, Campo G et al. Interaction between fluoxetine and haloperidol: pharmacokinetic and clinical implications. Pharmacol Res 1997; 35:335-9.

Avent KM, DeVoss JJ, Gillam EM. Cytochrome P450-mediated metabolism of haloperidol and reduced haloperidol to pyridinium metabolites. Chem Res Toxicol 2006; 19:914-20.

Aversa A, Caprio M, Antelmi A et al. Exposure to phosphodiesterase type 5 inhibitors stimulates aromatase expression in human adipocytes in vitro. J Sex Med 2011; 8:696-704.

Avizienyte E, Ward RA, Garner AP. Comparison of the EGFR resistance mutation profiles generated by EGFR-targeted tyrosine kinase inhibitors and the impact of drug combinations. Biochem J 2008; 415:197-206.

Avramovich Y, Amit T, Youdim MB. Non-steroidal anti-inflammatory drugs stimulate secretion of non-amyloidogenic precursor protein. J Biol Chem 2002; 277:31466-73.

Avti PK, Vaiphei K, Pathak CM, Khanduja KL. Involvement of various molecular events in cellular injury induced by smokeless tobacco. Chem Res Toxicol 2010; 23:1163-74.

Awata T, Inoue K, Kurihara S et al. A common polymorphism in the 5'-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes. Diabetes 2002; 51:1635-9.

Ayajiki K, Fujioka H, Toda N et al. Mediation of arachidonic acid metabolite(s) produced by endothelial cytochrome P-450 3A4 in monkey arterial relaxation. Hypertens Res 2003; 26:237-43.

Aycan Z, Onder A, Cetinkaya S. Eight-year follow-up of a girl with McCune-Albright syndrome. J Clin Res Pediatr Endocrinol 2011; 3:40-2.

Aydin M, Oktar S, Ozkan OV, Alçin E, Oztürk OH, Nacar A. Letrozole induces hepatotoxicity without causing oxidative stress: the protective effect of melatonin. Gynecol Endocrinol 2011; 27:209-15.

Aye IL, Waddell BJ, Mark PJ, Keelan JA. Placental ABCA1 and ABCG1 transporters efflux cholesterol and protect trophoblasts from oxysterol induced toxicity. Biochim Biophys Acta 2010; 1801:1013-24.

Ayed-Boussema I, Pascussi JM, Maurel P, Bacha H, Hassen W. Zearalenone activates pregnane X receptor, constitutive androstane receptor and aryl hydrocarbon receptor and corresponding phase I target genes mRNA in primary cultures of human hepatocytes. Environ Toxicol Pharmacol 2011; 31:79-87.

Ayed-Boussema I, Pascussi JM, Zaied C, Maurel P, Bacha H, Hassen W. Ochratoxin A induces CYP3A4, 2B6, 3A5, 2C9, 1A1, and CYP1A2 gene expression in primary cultured human hepatocytes: a possible activation of nuclear receptors. Drug Chem Toxicol 2011. doi:10. 3109/01480545. 2011. 589438.

Aylin Arici M, Kilinc E, Demir O, Ates M, Yesilyurt A, Gelal A. Interactions between verapamil and digoxin in Langendorff-perfused rat hearts: The role of inhibition of P-glycoprotein in the heart. Basic Clin Pharmacol Toxicol 2010. doi:10. 1111/j. 1742-7843. 2010. 00574. x.

Aymerich I, Duflot S, Fernández-Veledo S et al. The concentrative nucleoside transporter family (SLC28): new roles beyond salvage? Biochem Soc Trans 2005; 33:216-9.

Aynacioglu AS, Brockmöller J, Bauer S et al. Frequency of cytochrome P450 CYP2C9 variants in a Turkish population and functional relevance for phenytoin. Br J Clin Pharmacol 1999; 48:409-15.

Ayodo G, Price AL, Keinan A et al. Combining evidence of natural selection with association analysis increases power to detect malaria-resistance variants. Am J Hum Genet 2007; 81:234-42.

Ayoub N, Lucas C, Kaddoumi A. Genomics and pharmacogenomics of breast cancer: current knowledge and trends. Asian Pac J Cancer Prev 2011; 12:1127-40.

Azarpira N, Ashraf MJ, Khademi B, Darai M, Hakimzadeh A, Abedi E. Study the polymorphism of CYP3A5 and CYP3A4 loci in Iranian population with laryngeal squamous cell carcinoma. Mol Biol Rep 2011; 38:5443-8.

Azarpira N, Namazi S, Hendijani F, Banan M, Darai M. Investigation of allele and genotype frequencies of CYP2C9, CYP2C19 and VKORC1 in Iran. Pharmacol Rep 2010; 62:740-6.

Azcoitia I, Yague JG, García-Segura LM. Estradiol synthesis within the human brain. Neuroscience 2011; 191:139-47.

Azizi E, Massoud A, Amirzargar AA et al. Association of CTLA4 gene polymorphism in Iranian patients with ankylosing spondylitis. J Clin Immunol 2010; 30:268-71.

Azizi M, Hallouin MC, Jeunemaitre X, Guyene TT, Menard J. Influence of the M235T polymorphism of human angiotensinogen (AGT) on plasma AGT and renin concentrations after ethinylestradiol administration. J Clin Endocr Metab 2000; 85:4331-7.

Azizi Z, Noroozian M, Kaini-Moghaddam Z, Majlessi N. Association between NOS3 gene G894T polymorphism and late-onset Alzheimer disease in a sample from Iran. Alzheimer Dis Assoc Disord 2010; 24:204-8.

Azmanov DN, Dimitrova S, Florez L et al. LTBP2 and CYP1B1 mutations and associated ocular phenotypes in the Roma/Gypsy founder population. Eur J Hum Genet 2011; 19:326-33.

Azrak RG, Yu J, Pendyala L et al. Irinotecan pharmacokinetic and pharmacogenomic alterations induced by methylselenocysteine in human head and neck xenograft tumors. Mol Cancer Ther 2005; 4:843-54.

Azuma J, Hasunuma T, Kubo M et al. The relationship between clinical pharmacokinetics of aripiprazole and CYP2D6 genetic polymorphism: effects of CYP enzyme inhibition by coadministration of paroxetine or fluvoxamine. Eur J Clin Pharmacol 2011. doi:10. 1007/s00228-011-1094-4.

Azuma J, Nonen S. Chronic heart failure: beta-blockers and pharmacogenetics. Eur J Clin Pharmacol 2009; 65:3-17.

Azzato EM, Chen RA, Wacholder S, Chanock SJ, Klebanoff MA, Caporaso NE. Maternal EPHX1 polymorphisms and risk of phenytoin-induced congenital malformations. Pharmacogenet Genomics 2010; 20:58-63.

Baba T, Touchi A, Ito K et al. Effects of serum albumin and liver cytosol on CYP2C9- and CYP3A4-mediated drug metabolism. Drug Metab Pharmacokinet 2002; 17:522-31.

Babalola CP, Adejumo O, Ung D et al. Cytochrome P450 CYP2C19 genotypes in Nigerian sickle-cell disease patients and normal controls. J Clin Pharm Ther 2010; 35:471-7.

Babalola CP, Kolade YT, Olaniyi AA, Adedapo A, Scriba GK. Effect of fluconazole on the pharmacokinetics of halofantrine in healthy volunteers. J Clin Pharm Ther 2009; 34:677-82.

Babaoglu MO, Ocal T, Bayar B, Kayaalp SO, Bozkurt A. Frequency and enzyme activity of the butyrylcholinesterase K-variant in a Turkish population. Eur J Clin Pharmacol 2004; 59:875-7.

Babaoglu MO, Yasar U, Sandberg M et al. CYP2C9 genetic variants and losartan oxidation in a Turkish population. Eur J Clin Pharmacol 2004; 60:337-42.

Babbar S, Chanda S, Bley K. Inhibition and induction of human cytochrome P450 enzymes in vitro by capsaicin. Xenobiotica 2010; 40:807-16.

Babenko AP, Polak M, Cavé H et al. Activating mutations in the ABCC8 gene in neonatal diabetes mellitus. N Engl J Med 2006; 355:456-66.

Babić Z, Kucisec-Tepes N, Troskot R, Dorosulić Z, Svoboda-Beusan I. The importance of P-glycoprotein multidrug transporter activity measurement in patients with Helicobacter pylori infection. Coll Antropol 2009; 33:1145-50.

Babic Z, Svoboda-Beusan I, Kucisec-Tepes N, Dekaris D, Troskot R. Increased activity of Pgp multidrug transporter in patients with Helicobacter pylori infection. World J Gastroenterol 2005; 11:2720-5.

Babron MC, Nilsson S, Adamovic S et al. Meta and pooled analysis of European coeliac disease data. Eur J Hum Genet 2003; 11:828-34.

Babu E, Takeda M, Narikawa S et al. Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol 2002; 88:69-76.

Baccarelli A, Calista D, Minghetti P et al. XPD gene polymorphism and host characteristics in the association with cutaneous malignant melanoma risk. Br J Cancer 2004; 90:497-502.

Bäck M. Inhibitors of the 5-lipoxygenase pathway in atherosclerosis. Curr Pharm Des 2009; 15:3116-32.

Backman JT, Granfors MT, Neuvonen PJ. Rifampicin is only a weak inducer of CYP1A2-mediated presystemic and systemic metabolism: studies with tizanidine and caffeine. Eur J Clin Pharmacol 2006; 62:451-61.

Backman JT, Kyrklund C, Kivistö KT, Wang JS, Neuvonen PJ. Plasma concentrations of active simvastatin acid are increased by gemfibrozil. Clin Pharmacol Ther 2000; 68:122-9.

Backman JT, Mäenpää J, Belle DJ, Wrighton SA, Kivistö KT, Neuvonen PJ. Lack of correlation between in vitro and in vivo studies on the effects of tangeretin and tangerine juice on midazolam hydroxylation. Clin Pharmacol Ther 2000; 67:382-90.

Backman JT, Olkkola KT, Neuvonen PJ. Rifampin drastically reduces plasma concentrations and effects of oral midazolam. Clin Pharmacol Ther 1996; 59:7-13.

Backman JT, Wang JS, Wen X, Kivistö KT, Neuvonen PJ. Mibefradil but not isradipine substantially elevates the plasma concentrations of the CYP3A4 substrate triazolam. Clin Pharmacol Ther 1999; 66:401-7.

Bacher I, Wu B, Shytle DR, George TP. Mecamylamine - a nicotinic acetylcholine receptor antagonist with potential for the treatment of neuropsychiatric disorders. Expert Opin Pharmacother 2009; 10:2709-21.

Bachleda P, Vrzal R, Dvorák Z. Activation of MAPKs influences the expression of drug-metabolizing enzymes in primary human hepatocytes. Gen Physiol Biophys 2009; 28:316-20.

Bachleda P, Vrzal R, Pivnicka J, Cvek B, Dvorak Z. Examination of Zolpidem effects on AhR- and PXR-dependent expression of drug-metabolizing cytochromes P450 in primary cultures of human hepatocytes. Toxicol Lett 2009; 191:74-8.

Bachmakov I, Glaeser H, Fromm MF, König J. Interaction of oral antidiabetic drugs with hepatic uptake transporters: focus on organic anion transporting polypeptides and organic cation transporter 1. Diabetes 2008; 57:1463-9.

Bachman ES, Dhillon H, Zhang CY et al. Beta-AR signaling required for diet-induced thermogenesis and obesity resistance. Science 2002; 297:843-5.

Bachmann K, He Y, Sarver JG, Peng N. Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of ethosuximide by human hepatic microsomal enzymes. Xenobiotica 2003; 33:265-76.

Bachmann K, Jauregui L, Chandra R, Thakker K. Influence of a 3-day regimen of azithromycin on the disposition kinetics of cyclosporine A in stable renal transplant patients. Pharmacol Res 2003; 47:549-54.

Bachmeier C, Beaulieu-Abdelahad D, Mullan M, Paris D. Selective dihydropyiridine compounds facilitate the clearance of β-amyloid across the blood-brain barrier. Eur J Pharmacol 2011; 659:124-9.

Bachmeier CJ, Beaulieu-Abdelahad D, Ganey NJ, Mullan MJ, Levin GM. Induction of drug efflux protein expression by venlafaxine but not desvenlafaxine. Biopharm Drug Dispos 2011; 32:233-44.

Bachus R, Bickel U, Thomsen T, Roots I, Kewitz H. The O-demethylation of the antidementia drug galanthamine is catalysed by cytochrome P450 2D6. Pharmacogenetics 1999; 9:661-8.

Badagnani I, Castro RA, Taylor TR et al. Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants. J Pharmacol Exp Ther 2006; 318:521-9.

Badal S, Williams SA, Huang G et al. Cytochrome P450 1 enzyme inhibition and anticancer potential of chromene amides from Amyris plumieri. Fitoterapia 2011; 82:230-6.

Badaracco MA. Keeping our depressed patients in the right treatment long enough for them to get better: some hopeful findings. Am J Psychiatry 2007; 164:1136-9.

Badawi AF, Cavalieri EL, Rogan EG. Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16alpha-hydroxylation of 17beta-estradiol. Metabolism 2001; 50:1001-3.

Bader A, Hansen T, Kirchner G, Allmeling C, Haverich A, Borlak JT. Primary porcine enterocyte and hepatocyte cultures to study drug oxidation reactions. Br J Pharmacol 2000; 129:331-42.

Bader MI, Wober J, Kretzschmar G, Zierau O, Vollmer G. Comparative assessment of estrogenic responses with relevance to the metabolic syndrome and to menopausal symptoms in wild-type and aromatase-knockout mice. J Steroid Biochem Mol Biol 2011. doi:10. 1016/j. jsbmb. 2011. 05. 004.

Badruddin A, Gorelick PB. Antiplatelet therapy for prevention of recurrent stroke. Curr Treat Options Neurol 2009; 11:452-9.

Badyal DK, Dadhich AP. Cytochrome P450 and drug interactions. Indian J of Pharmacol 2001; 33:248-59.

Bae JW, Choi CI, Jang CG, Lee SY. Effects of CYP2C9*1/*13 on the pharmacokinetics and pharmacodynamics of meloxicam. Br J Clin Pharmacol 2011; 71:550-5.

Bae JW, Choi CI, Kim MJ et al. Frequency of CYP2C9 alleles in Koreans and their effects on losartan pharmacokinetics. Acta Pharmacol Sin 2011; 32:1303-8.

Bae JW, Choi CI, Lee JH, Jang CG, Chung MW, Lee SY. Effects of UDP-glucuronosyltransferase polymorphisms on the pharmacokinetics of ezetimibe in healthy subjects. Eur J Clin Pharmacol 2011; 67:39-45.

Bae JW, Jang CG, Lee SY. Effects of clopidogrel on the pharmacokinetics of sibutramine and its active metabolites. J Clin Pharmacol 2011. doi:10. 1177/0091270010388651.

Bae JW, Kim JH, Choi CI et al. Effect of CYP2C9*3 allele on the pharmacokinetics of naproxen in Korean subjects. Arch Pharm Res 2009; 32:269-73.

Bae SH, Bae SK, Lee MG. Effect of hepatic CYP inhibitors on the metabolism of sildenafil and formation of its metabolite, N-desmethylsildenafil, in rats in vitro and in vivo. J Pharm Pharmacol 2009; 61:1637-42.

Bae SH, Sung SH, Cho EJ et al. Concerted action of sulfiredoxin and peroxiredoxin I protects against alcohol-induced oxidative injury in mouse liver. Hepatology 2011; 53:945-53.

Bae SK, Cao S, Seo KA et al. Cytochrome P450 2B6 catalyzes the formation of pharmacologically active sibutramine (N-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N,N-dimethylamine) metabolites in human liver microsomes. Drug Metab Dispos 2008; 36:1679-88.

Baede-van Dijk PA, Hugen PW, Verweij-van Wissen CP, Koopmans PP, Burger DM, Hekster YA. Analysis of variation in plasma concentrations of nelfinavir and its active metabolite M8 in HIV-positive patients. AIDS 2001; 15:991-8.

Baede-van Dijk PA, van Galen E, Lekkerkerker JF. Drug interactions of Hypericum perforatum (St. John's wort) are potentially hazardous. Ned Tijdschr Geneeskd 2000; 144:811-2.

Baek MS, Kim JY, Myung SW, Yim YH, Jeong JH, Kim DH. Metabolism of dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate (DDB) by human liver microsomes: characterization of metabolic pathways and of cytochrome P450 isoforms involved. Drug Metab Dispos 2001; 29:381-8.

Baek SH, Ohgi KA, Rose DW, Koo EH, Glass CK, Rosenfeld MG. Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappa-B and beta-amyloid precursor protein. Cell 2002; 110:55-67.

Baer BR, Rettie AE, Henne KR. Bioactivation of 4-ipomeanol by CYP4B1: adduct characterization and evidence for an enedial intermediate. Chem Res Toxicol 2005; 18:855-64.

Baer BR, Rettie AE. CYP4B1: an enigmatic P450 at the interface between xenobiotic and endobiotic metabolism. Drug Metab Rev 2006; 38:451-76.

Baer BR, Wienkers LC, Rock DA. Time-dependent inactivation of P450 3A4 by raloxifene: identification of Cys239 as the site of apoprotein alkylation. Chem Res Toxicol 2007; 20:954-64.

Bafica A, Scanga CA, Serhan C et al. Host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase-dependent lipoxin production. J Clin Invest 2005; 115:1601-6.

Baghdasaryan A, Claudel T, Kosters A et al. Curcumin improves sclerosing cholangitis in Mdr2-/- mice by inhibition of cholangiocyte inflammatory response and portal myofibroblast proliferation. Gut 2010; 59:521-30.

Bagnoli F, de Oliveira VM, da Silva MA, Taromaru GC, Rinaldi JF, Aoki T. The interaction between aromatase, metalloproteinase 2,9 and CD44 in breast cancer. Rev Assoc Med Bras 2010; 56:472-7.

Bagriantsev S, Liebman S. Modulation of Aβ42 low-n oligomerization using a novel yeast reporter system. BMC Biol 2006; 4:32.

Baguley BC. Multiple drug resistance mechanisms in cancer. Mol Biotechnol 2010; 46:308-16.

Bah J, Quach H, Ebstein RP et al. Maternal transmission disequilibrium of the glutamate receptor GRIK2 in schizophrenia. Neuroreport 2004; 15:1987-91.

Bahadur N, Leathart JB, Mutch E et al. CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6alpha-hydroxylase activity in human liver microsomes. Biochem Pharmacol 2002; 64:1579-89.

Bahar AY, Taylor PJ, Andrews L et al. The frequency of founder mutations in the BRCA1, BRCA2, and APC genes in Australian Ashkenazi Jews: implications for the generality of U. S. population data. Cancer 2001; 92:440-5.

Bahia L, Aguiar LG, Villela N, Bottino D, Godoy-Matos AF, Bouskela E. Effects of rosiglitazone on endothelial function in non-diabetic subjects with metabolic syndrome. Arq Bras Cardiol 2006; 86:366-73.

Bahn A, Prawitt D, Buttler D et al. Genomic structure and in vivo expression of the human organic anion transporter 1 (hOAT1) gene. Biochem Biophys Res Commun 2000; 275:623-30.

Bahn S, Mimmack M, Ryan M et al. Neuronal target of the neuron-restrictive silencer factor in neuropheres derived from fetuses with Down's syndrome: a gene expression study. Lancet 2002; 359:310-5.

Bahrami F, Yousefpour M, Mehrani H et al. Type of cell death and the role of acetylcholinesterase activity in neurotoxicity induced by paraoxon in cultured rat hippocampal neurons. Acta Biol Hung 2009; 60:1-13.

Bai C, Matsui E, Ohnishi H et al. A novel polymorphism, E254K, in the 5-lipoxygenase gene associated with bronchial asthma. Int J Mol Med 2008; 21:139-44.

Bai N, Kido T, Suzuki H et al. Changes in atherosclerotic plaques induced by inhalation of diesel exhaust. Atherosclerosis 2011; 216:299-306.

Bai S, Stepkowski SM, Kahan BD, Brunner LJ. Metabolic interaction between cyclosporine and sirolimus. Transplantation 2004; 77:1507-12.

Bai Y, Yu Y, Yu B et al. Association of vitamin D receptor polymorphisms with the risk of prostate cancer in the Han population of Southern China. BMC Med Genet 2009; 10:125.

Bai YM, Chen TT, Liou YJ, Hong CJ, Tsai SJ. Association between HTR2C polymorphisms and metabolic syndrome in patients with schizophrenia treated with atypical antipsychotics. Schizophr Res 2011; 125:179-86.

Baier LJ, Sacchettini JC, Knowler WC et al. An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance. J Clin Invest 1995; 95:1281-7.

Baigent A, Lashen H. Ovarian hyperstimulation syndrome in a patient treated with tamoxifen for breast cancer. Fertil Steril 2011; 95:2429.

Bailey DG, Bend JR, Arnold JM, Tran LT, Spence JD. Erythromycin-felodipine interaction: magnitude, mechanism, and comparison with grapefruit juice. Clin Pharmacol Ther 1996; 60:25-33.

Bailey DG, Dresser GK, Bend JR. Bergamottin, lime juice, and red wine as inhibitors of cytochrome P450 3A4 activity: comparison with grapefruit juice. Clin Pharmacol Ther 2003; 73:529-37.

Bailey DG, Dresser GK, Kreeft JH, Munoz C, Freeman DJ, Bend JR. Grapefruit-felodipine interaction: effect of unprocessed fruit and probable active ingredients. Clin Pharmacol Ther 2000; 68:468-77.

Bailey DG, Dresser GK, Leake BF, Kim RB. Naringin is a major and selective clinical inhibitor of organic anion-transporting polypeptide 1A2 (OATP1A2) in grapefruit juice. Clin Pharmacol Ther 2007; 81:495-502.

Bailey DG, Dresser GK. Interactions between grapefruit juice and cardiovascular drugs. Am J Cardiovasc Drugs 2004; 4:281-97.

Bailey DG, Malcolm J, Arnold O, Spence JD. Grapefruit juice-drug interactions. Br J Clin Pharmacol 1998; 46:101-10.

Bailey KM, Romaine SP, Jackson BM et al. Hepatic metabolism and transporter gene variants enhance response to rosuvastatin in patients with acute myocardial infarction: the GEOSTAT-1 Study. Circ Cardiovasc Genet 2010; 3:276-85.

Bailey LR, Roodi N, Dupont WD, Parl FF. Association of cytochrome P450 1B1 (CYP1B1) polymorphism with steroid receptor status in breast cancer. Cancer Res 1998; 58:5038-41.

Bains OS, Karkling MJ, Grigliatti TA, Reid RE, Riggs KW. Two nonsynonymous single nucleotide polymorphisms of human carbonyl reductase 1 demonstrate reduced in vitro metabolism of daunorubicin and doxorubicin. Drug Metab Dispos 2009; 37:1107-14.

Baird JK, Hoffman SL. Primaquine therapy for malaria. Clin Infect Dis 2004; 39:1336-45.

Baird PN, Guida E, Chu DT, Vu HT, Guymer RH. The epsilon2 and epsilon4 alleles of the apolipoprotein gene are associated with age-related macular degeneration. Invest Ophthalmol Vis Sci 2004; 45:1311-5.

Baitsch D, Bock HH, Engel T et al. Apolipoprotein e induces antiinflammatory phenotype in macrophages. Arterioscler Thromb Vasc Biol 2011; 31:1160-8.

Bajaj G, Rodriguez-Proteau R, Venkataraman A, Fan Y, Kioussi C, Ishmael JE. MDR1 function is sensitive to the phosphorylation state of myosin regulatory light chain. Biochem Biophys Res Commun 2010; 398:7-12.

Bajgai SP, Prachyawarakorn V, Mahidol C, Ruchirawat S, Kittakoop P. Hybrid flavan-chalcones, aromatase and lipoxygenase inhibitors, from Desmos cochinchinensis. Phytochemistry 2011; 72:2062-7.

Bajgar J, Fusek J, Kassa J, Jun D, Kuca K, Hajek P. An attempt to assess functionally minimal acetylcholinesterase activity necessary for survival of rats intoxicated with nerve agents. Chem Biol Interact 2008; 175:281-5.

Bajgar J, Fusek J, Kuca K, Bartosova L, Jun D. Treatment of organophosphate intoxication using cholinesterase reactivators: facts and fiction. Mini Rev Med Chem 2007; 7:461-6.

Bajgar J, Hajek P, Slizova D et al. Changes of acetylcholinesterase activity in different rat brain areas following intoxication with nerve agents: biochemical and histochemical study. Chem Biol Interact 2007; 165:14-21.

Bajpai M, Roskos LK, Shen DD, Levy RH. Roles of cytochrome P4502C9 and cytochrome P4502C19 in the stereoselective metabolism of phenytoin to its major metabolite. Drug Metab Dispos 1996; 24:1401-3.

Bajrami B, Zhao L, Schenkman JB, Rusling JF. Rapid LC-MS drug metabolite profiling using microsomal enzyme bioreactors in a parallel processing format. Anal Chem 2009; 81:9921-9.

Bajt ML, Ramachandran A, Yan HM et al. Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity. Toxicol Sci 2011; 122:598-605.

Bak S, Tsiropoulos I, Kjaersgaard JO et al. Selective serotonin reuptake inhibitors and the risk of stroke: a population-based case-control study. Stroke 2002; 33:1465-73.

Bakare-Odunola MT, Enemali I, Garba M, Obodozie OO, Mustapha KB. The influence of lamivudine, stavudine and nevirapine on the pharmacokinetics of chlorpropamide in human subjects. Eur J Drug Metab Pharmacokinet 2008; 33:165-71.

Baker AD, Malur A, Barna BP, Kavuru MS, Malur AG, Thomassen MJ. PPARgamma regulates the expression of cholesterol metabolism genes in alveolar macrophages. Biochem Biophys Res Commun 2010; 393:682-7.

Baker DE. Loperamide: a pharmacological review. Rev Gastroenterol Disord 2007; 7 Suppl 3:11-8.

Baker EK, El-Osta A. Epigenetic regulation of multidrug resistance 1 gene expression: profiling CpG methylation status using bisulphite sequencing. Methods Mol Biol 2010; 596:183-98.

Baker JR, Best AM, Pade PA, McCance-Katz EF. Effect of buprenorphine and antiretroviral agents on the QT interval in opioid-dependent patients. Ann Pharmacother 2006; 40:392-6.

Baker JR, Edwards RJ, Lasker JM, Moore MR, Satarug S. Renal and hepatic accumulation of cadmium and lead in the expression of CYP4F2 and CYP2E1. Toxicol Lett 2005; 159:182-91.

Baker JR, Satarug S, Reilly PE et al. Relationships between non-occupational cadmium exposure and expression of nine cytochrome P450 forms in human liver and kidney cortex samples. Biochem Pharmacol 2001; 62:713-21.

Baker M, Litvan I, Houlden H et al. Association of an extended haplotype in the tau gene with progressive supranuclear palsy. Hum Mol Genet 1999; 8:711-5.

Baker M, Rahman T, Hall D et al. The C-532T polymorphism of the angiotensinogen gene is associated with pulse pressure: a possible explanation for heterogeneity in genetic association studies of AGT and hypertension. Int J Epidemiol 2007; 36:1356-62.

Baker MT, Olson MJ, Wang Y, Ronnenberg WC Jr, Johnson JT, Brady AN. Isoflurane-chlorodifluoroethene interaction in human liver microsomes. Role of cytochrome P4502B6 in potentiation of haloethene metabolism. Drug Metab Dispos 1995; 23:60-4.

Baker SD, van Schaik RH, Rivory LP et al. Factors affecting cytochrome P-450 3A activity in cancer patients. Clin Cancer Res 2004; 10:8341-50.

Baker SD, Verweij J, Cusatis GA et al. Pharmacogenetic pathway analysis of docetaxel elimination. Clin Pharmacol Ther 2009; 85:155-63.

Baker SS, Baker RD, Liu W, Nowak NJ, Zhu L. Role of alcohol metabolism in non-alcoholic steatohepatitis. PLoS One 2010. doi:10. 1371/journal. pone. 0009570.

Bakken GV, Rudberg I, Christensen H, Molden E, Refsum H, Hermann M. Metabolism of quetiapine by CYP3A4 and CYP3A5 in presence or absence of cytochrome B5. Drug Metab Dispos 2009; 37:254-8.

Balabanov S, Gontarewicz A, Keller G et al. Abcg2 overexpression represents a novel mechanism for acquired resistance to the multi-kinase inhibitor danusertib in BCR-ABL-positive cells in vitro. PLoS One 2011. doi:10. 1371/journal. pone. 0019164.

Balakin KV, Ekins S, Bugrim A et al. Kohonen maps for prediction of binding to human cytochrome P450 3A4. Drug Metab Dispos 2004; 32:1183-9.

Balakin KV, Ekins S, Bugrim A et al. Quantitative structure-metabolism relationship modeling of metabolic N-dealkylation reaction rates. Drug Metab Dispos 2004; 32:1111-20.

Balakumar P, Kaur J. Arsenic exposure and cardiovascular disorders: an overview. Cardiovasc Toxicol 2009; 9:169-76.

Balant-Gorgia AE, Gex-Fabry M, Genet C, Balant LP. Therapeutic drug monitoring of risperidone using a new, rapid HPLC method: reappraisal of interindividual variability factors. Ther Drug Monit 1999; 21:105-15.

Balasubramanian D, Scacheri PC. Functional studies of menin through genetic manipulation of the Men1 homolog in mice. Adv Exp Med Biol 2009; 668:105-15.

Balasubramanian M, Shield JP, Acerini CL et al. Pancreatic hypoplasia presenting with neonatal diabetes mellitus in association with congenital heart defect and developmental delay. Am J Med Genet A 2010; 152:340-6.

Balcerczak E, Panczyk M, Piaskowski S, Pasz-Walczak G, Sałagacka A, Mirowski M. ABCB1/MDR1 gene polymorphisms as a prognostic factor in colorectal cancer. Int J Colorectal Dis 2010; 25:1167-76.

Balding J, Kane D, Livingstone W et al. Cytokine gene polymorphisms: association with psoriatic arthritis susceptibility and severity. Arthritis Rheum 2003; 48:1408-13.

Balducci C, Beeg M, Stravalaci M et al. Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein. Proc Natl Acad Sci USA 2010; 107:2295-300.

Balic I, Graham ST, Troyer DA et al. Androgen receptor length polymorphism associated with prostate cancer risk in Hispanic men. J Urol 2002; 168:2245-8.

Balistreri CR, Grimaldi MP, Vasto S et al. Association between the polymorphism of CCR5 and Alzheimer's disease: results of a study performed on male and female patients from Northern Italy. Ann N Y Acad Sci 2006; 1089:454-61.

Baloira A, Vilariño C, Leiro V, Valverde D. Mutations in the gene encoding bone morphogenetic protein receptor 2 in patients with idiopathic pulmonary arterial hypertension. Arch Bronconeumol 2008; 44:29-34.

Baltes MR, Dubois JG, Hanocq M. Application to drug-food interactions of living cells as in vitro model expressing cytochrome P450 activity: enzyme inhibition by lemon juice. Talanta 2001; 54:983-7.

Baltes S, Fedrowitz M, Tortós CL, Potschka H, Löscher W. Valproic acid is not a substrate for P-glycoprotein or multidrug resistance proteins 1 and 2 in a number of in vitro and in vivo transport assays. J Pharmacol Exp Ther 2007; 320:331-43.

Balunas MJ, Su B, Riswan S et al. Isolation and characterization of Aromatase inhibitors from Brassaiopsis glomerulata (Araliaceae). Phytochem Lett 2009; 2:29-33.

Ball SE, Ahern D, Scatina J, Kao J. Venlafaxine: in vitro inhibition of CYP2D6 dependent imipramine and desipramine metabolism; comparative studies with selected SSRIs, and effects on human hepatic CYP3A4, CYP2C9 and CYP1A2. Br J Clin Pharmacol 1997; 43:619-26.

Ball SE, Maurer G, Zollinger M, Ladona M, Vickers AE. Characterization of the cytochrome P-450 gene family responsible for the N-dealkylation of the ergot alkaloid CQA 206-291 in humans. Drug Metab Dispos 1992; 20:56-63.

Ball SE, Scatina J, Kao J et al. Population distribution and effects on drug metabolism of a genetic variant in the 5' promoter region of CYP3A4. Clin Pharmacol Ther 1999; 66:288-94.

Ballard JE, Prueksaritanont T, Tang C. Hepatic metabolism of MK-0457, a potent aurora kinase inhibitor: interspecies comparison and role of human cytochrome P450 and flavin-containing monooxygenase. Drug Metab Dispos 2007; 35:1447-51.

Ballarè E, Persani L, Lania AG et al. Mutation of somatostatin receptor type 5 in an acromegalic patient resistant to somatostatin analog treatment. J Clin Endocrinol Metab 2001; 86:3809-14.

Ballatori N, Fang F, Christian WV, Li N, Hammond CL. Ostalpha-Ostbeta is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver. Am J Physiol Gastrointest Liver Physiol 2008; 295:179-86.

Ballatori N, Krance SM, Notenboom S, Shi S, Tieu K, Hammond CL. Glutathione dysregulation and the etiology and progression of human diseases. Biol Chem 2009; 390:191-214.

Ballent M, Lifschitz A, Virkel G, Mate L, Lanusse C. Pretreatment with the inducers rifampicin and phenobarbital alters ivermectin gastrointestinal disposition. J Vet Pharmacol Ther 2010; 33:252-9.

Ballent M, Lifschitz A, Virkel G, Sallovitz J, Maté L, Lanusse C. Gender-related differences on P-glycoprotein-mediated drug intestinal transport in rats. J Pharm Pharmacol 2011; 63:619-626.

Balliet RM, Chen G, Dellinger RW, Lazarus P. UDP-glucuronosyltransferase 1A10: activity against the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, and a potential role for a novel UGT1A10 promoter deletion polymorphism in cancer susceptibility. Drug Metab Dispos 2010; 38:484-90.

Ballon N, Leroy S, Roy C et al. (AAT)n repeat in the cannabinoid receptor gene (CNR1): association with cocaine addiction in an African-Caribbean population. Pharmacogenomics J 2006; 6:126-30.

Bamba Y, Yun YS, Kunugi A, Inoue H. Compounds isolated from Curcuma aromatica Salisb. inhibit human P450 enzymes. J Nat Med 2011; 65:583-7.

Bambha K, Kim WR, Rosen CB et al. Endothelial nitric oxide synthase gene variation associated with chronic kidney disease after liver transplant. Mayo Clin Proc 2010; 85:814-20.

Bamburowicz-Klimkowska M, Zywiec K, Potentas A, Szutowski M. Impact of the changes in P-glycoprotein activity on domperidone pharmacokinetics in rat plasma. Pharmacol Rep 2007; 59:752-6.

Ban H, Andoh A, Imaeda H et al. The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease. J Gastroenterol 2010; 45:1014-21.

Ban S, Kondo T, Ishizuka M et al. Using microarray analysis to evaluate genetic polymorphisms involved in the metabolism of environmental chemicals. Fukuoka Igaku Zasshi 2007; 98:208-14.

Banaschewski T, Becker K, Scherag S, Franke B, Coghill D. Molecular genetics of attention-deficit/hyperactivity disorder: an overview. Eur Child Adolesc Psychiatry 2010; 19:237-57.

Bandmann O, Nygaard TG, Surtees R, Marsden CD, Wood NW, Harding AE. Dopa-responsive dystonia in British patients: new mutations of the GTP-cyclohydrolase I gene and evidence for genetic heterogeneity. Hum Mol Genet 1996; 5:403-6.

Bandulik S, Penton D, Barhanin J, Warth R. TASK1 and TASK3 potassium channels: determinants of aldosterone secretion and adrenocortical zonation. Horm Metab Res 2010; 42:450-7.

Bandur S, Petrasek J, Hribova P, Novotna E, Brabcova I, Viklicky O. Haplotypic structure of ABCB1/MDR1 gene modifies the risk of the acute allograft rejection in renal transplant recipients. Transplantation 2008; 86:1206-13.

Bandyopadhyay S, Huang X, Lahiri DK, Rogers JT. Novel drug targets based on metallobiology of Alzheimer's disease. Expert Opin Ther Targets 2010; 14:1177-97.

Banerjee I, Skae M, Flanagan SE et al. The contribution of rapid KATP channel gene mutation analysis to the clinical management of children with congenital hyperinsulinism. Eur J Endocrinol 2011; 164:733-40.

Banerjee S, A'Hern R, Detre S et al. Biological evidence for dual antiangiogenic-antiaromatase activity of the VEGFR inhibitor PTK787/ZK222584 in vivo. Clin Cancer Res 2010; 16:4178-87.

Banfield C, Herron J, Keung A, Padhi D, Affrime M. Desloratadine has no clinically relevant electrocardiographic or pharmacodynamic interactions with ketoconazole. Clin Pharmacokinet 2002; 41 Suppl 1:37-44.

Banfield C, Hunt T, Reyderman L, Statkevich P, Padhi D, Affrime M. Lack of clinically relevant interaction between desloratadine and erythromycin. Clin Pharmacokinet 2002; 41 Suppl 1:29-35.

Banfield DK, MacGillivray RT. Partial characterization of vertebrate prothrombin cDNAs: amplification and sequence analysis of the B chain of thrombin from nine different species. Proc Natl Acad Sci USA 1992; 89:2779-83.

Bang L, Goa K. Oxcarbazepine: a review of its use in children with epilepsy. Paediatr Drugs 2003; 5:557-73.

Bang LM, Goa KL. Spotlight on oxcarbazepine in epilepsy. CNS Drugs 2004; 18:57-61.

Bangsi D, Zhou J, Sun Y et al. Impact of a genetic variant in CYP3A4 on risk and clinical presentation of prostate cancer among white and African-American men. Urol Oncol 2006; 24:21-7.

Banning AM. Respiratory depression following medication change from tramadol to morphine. Ugeskr Laeger 1999; 161:6500-1.

Bannister SC, Smith CA, Roeszler KN, Doran TJ, Sinclair AH, Tizard ML. Manipulation of estrogen synthesis alters MIR202* expression in embryonic chicken gonads. Biol Reprod 2011; 85:22-30.

Bansal I, Waghmare CK, Anand T, Gupta AK, Bhattacharya BK. Differential mRNA expression of acetylcholinesterase in the central nervous system of rats with acute and chronic exposure of sarin & physostigmine. J Appl Toxicol 2009; 29:386-94.

Bansal R, Guleria S, Ries C, Hartmann RW. Synthesis and antineoplastic activity of O-alkylated derivatives of 7-hydroximinoandrost-5-ene steroids. Arch Pharm 2010; 343:377-83.

Bansal R, Guleria S, Thota S, Hartmann RW, Zimmer C. Synthesis and biological evaluation of 16E-arylidenosteroids as cytotoxic and anti-aromatase agents. Chem Pharm Bull 2011; 59:327-31.

Bansal S, Liu CP, Sepuri NB et al. Mitochondria-targeted cytochrome P450 2E1 induces oxidative damage and augments alcohol-mediated oxidative stress. J Biol Chem 2010; 285:24609-19.

Bansal SS, Vadhanam MV, Gupta RC. Development and in vitro-in vivo evaluation of polymeric implants for continuous systemic delivery of curcumin. Pharm Res 2011; 28:1121-30.

Bantis C, Heering P, Aker S, Kuhr N, Grabensee B, Ivens K. Influence of cytokine gene polymorphisms on IgA nephropathy. Ren Fail 2008; 2:135-40.

Bantis C, Heering PJ, Siekierka-Harreis M et al. Impact of aldosterone synthase gene C-344T polymorphism on IgA nephropathy. Ren Fail 2011; 33:393-7.

Bantis C, Heering PJ, Stangou M et al. Influence of aldosterone synthase gene C-344T polymorphism on focal segmental glomerulosclerosis. Nephrology 2011. doi:10. 1111/j. 1440-1797. 2011. 01497. x.

Bantis C, Ivens K, Kreusser W et al. Influence of genetic polymorphisms of the renin-angiotensin system on IgA nephropathy. Am J Nephrol 2004; 24:258-67.

Bantubungi K, Jacquard C, Greco A et al. Minocycline in phenotypic models of Huntington's disease. Neurobiol Dis 2005; 18:206-17.

Banu H, Renuka N, Vasanthakumar G. Reduced catalytic activity of human CYP2C9 natural alleles for gliclazide: molecular dynamics simulation and docking studies. Biochimie 2011; 93:1028-36.

Bányász I, Bokodi G, Vásárhelyi B et al. Genetic polymorphisms for vascular endothelial growth factor in perinatal complications. Eur Cytokine Netw 2006; 174:266-70.

Bao L, Haque A, Jackson K et al. Increased expression of P-glycoprotein is associated with doxorubicin chemoresistance in the metastatic 4T1 breast cancer model. Am J Pathol 2011; 178:838-52.

Bapat B, Xia L, Madlensky L et al. The genetic basis of Muir-Torre syndrome includes the hMLH1 locus. Am J Hum Genet 1996; 59:736-9.

Bapiro TE, Egnell AC, Hasler JA, Masimirembwa CM. Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s. Drug Metab Dispos 2001; 29:30-5.

Bapiro TE, Hasler JA, Ridderström M, Masimirembwa CM. The molecular and enzyme kinetic basis for the diminished activity of the cytochrome P450 2D6. 17 (CYP2D6. 17) variant. Potential implications for CYP2D6 phenotyping studies and the clinical use of CYP2D6 substrate drugs in some African populations. Biochem Pharmacol 2002; 64:1387-98.

Baptista R, Rebelo M, Decq-Mota J et al. Apolipoprotein E epsilon-4 polymorphism is associated with younger age at referral to a lipidology clinic and a poorer response to lipid-lowering therapy. Lipids Health Dis 2011; 10:48.

Baradaran-Rahimi H, Radvar M, Arab HR, Tavakol-Afshari J, Ebadian AR. Association of interleukin-1 receptor antagonist gene polymorphisms with generalized aggressive periodontitis in an Iranian population. J Periodontol 2010; 81:1342-6.

Baranczewski P, Möller L. Relationship between content and activity of cytochrome P450 and induction of heterocyclic amine DNA adducts in human liver samples in vivo and in vitro. Cancer Epidemiol Biomarkers Prev 2004; 13:1071-8.

Baranzini SE, Wang J, Gibson RA et al. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. Hum Mol Genet 2009; 18:767-78.

Barash H, R Gross E, Edrei Y et al. Accelerated carcinogenesis following liver regeneration is associated with chronic inflammation-induced double-strand DNA breaks. Proc Natl Acad Sci USA 2010; 107:2207-12.

Barattin R, Perrotton T, Trompier D et al. Iodination of verapamil for a stronger induction of death, through GSH efflux, of cancer cells overexpressing MRP1. Bioorg Med Chem 2010; 18:6265-74.

Barau C, Blouin P, Creput C, Taburet AM, Durrbach A, Furlan V. Effect of coadministered HIV-protease inhibitors on tacrolimus and sirolimus blood concentrations in a kidney transplant recipient. Fundam Clin Pharmacol 2009; 23:423-5.

Barbalić M, Skarić-Jurić T, Cambien F et al. Gene polymorphisms of the renin-angiotensin system and early development of hypertension. Am J Hypertens 2006; 19:837-42.

Barbato E, Berger A, Delrue L et al. GLU-27 variant of beta2-adrenergic receptor polymorphisms is an independent risk factor for coronary atherosclerotic disease. Atherosclerosis 2007; 194:80-6.

Barbato E, Penicka M, Delrue L et al. Thr164Ile polymorphism of beta2-adrenergic receptor negatively modulates cardiac contractility: implications for prognosis in patients with idiopathic dilated cardiomyopathy. Heart 2007; 93:856-61.

Barbaux S, Kluijtmans LA, Whitehead AS. Accurate and rapid "multiplex heteroduplexing" method for genotyping key enzymes involved in folate/homocysteine metabolism. Clin Chem 2000; 46:907-12.

Barberger-Gateau P, Samieri C, Féart C, Plourde M. Dietary Omega 3 polyunsaturated fatty acids and Alzheimer's disease: interaction with Apolipoprotein E genotype. Curr Alzheimer Res 2011; 8:479-91.

Barbieri I, Pensa S, Pannellini T et al. Constitutively active Stat3 enhances neu-mediated migration and metastasis in mammary tumors via upregulation of Cten. Cancer Res 2010; 70:2558-67.

Barbosa EJ, Palming J, Glad CA et al. Influence of the exon 3-deleted/full-length growth hormone (GH) receptor polymorphism on the response to GH replacement therapy in adults with severe GH deficiency. J Clin Endocrinol Metab 2009; 94:639-44.

Barcelos AL, Chies R, Almeida SE et al. Association of CYP7A1 -278A>C polymorphism and the response of plasma triglyceride after dietary intervention in dyslipidemic patients. Braz J Med Biol Res 2009; 42:487-93.

Barclay ML, Sawyers SM, Begg EJ et al. Correlation of CYP2D6 genotype with perhexiline phenotypic metabolizer status. Pharmacogenetics 2003; 13:627-32.

Bardag-Gorce F, Oliva J, Wong W et al. S-adenosylmethionine decreases the peak blood alcohol levels 3 h after an acute bolus of ethanol by inducing alcohol metabolizing enzymes in the liver. Exp Mol Pathol 2010; 89:217-21.

Bardag-Gorce F. Proteasome inhibitor treatment in alcoholic liver disease. World J Gastroenterol 2011; 17:2558-62.

Bardia A, Olson JE, Vachon CM et al. Effect of aspirin and other NSAIDs on postmenopausal breast cancer incidence by hormone receptor status: results from a prospective cohort study. Breast Cancer Res Treat 2011; 126:149-55.

Bardowell SA, Stec DE, Parker RS. Common variants of cytochrome P450 4F2 exhibit altered vitamin E-{omega}-hydroxylase specific activity. J Nutr 2010; 140:1901-6.

Barecki ME, Casciano CN, Johnson WW, Clement RP. In vitro characterization of the inhibition profile of loratadine, desloratadine, and 3-OH-desloratadine for five human cytochrome P-450 enzymes. Drug Metab Dispos 2001; 29:1173-5.

Bareggi SR, Braida D, Pollera C et al. Effects of clioquinol on memory impairment and the neurochemical modifications induced by scrapie infection in golden hamsters. Brain Res 2009; 1280:195-200.

Bareggi SR, Mundo E, Dell'Osso B, Altamura AC. The use of escitalopram beyond major depression: pharmacological aspects, efficacy and tolerability in anxiety disorders. Expert Opin Drug Metab Toxicol 2007; 3:741-53.

Barghorn S, Davies P, Mandelkow E. Tau paired helical filaments from Alzheimer's disease brain and assembled in vitro are based on beta-structure in the core domain. Biochemistry 2004; 43:1694-703.

Baririan N, Desager JP, Petit M, Horsmans Y. CYP3A4 activity in four different animal species liver microsomes using 7-benzyloxyquinoline and HPLC/spectrofluorometric determination. J Pharm Biomed Anal 2006; 40:211-4.

Baririan N, Horsmans Y, Desager JP et al. Alfentanil-induced miosis clearance as a liver CYP3A4 and 3A5 activity measure in healthy volunteers: improvement of experimental conditions. J Clin Pharmacol 2005; 45:1434-41.

Baririan N, van Obbergh L, Desager JP et al. Alfentanil-induced miosis as a surrogate measure of alfentanil pharmacokinetics in patients with mild and moderate liver cirrhosis. Clin Pharmacokinet 2007; 46:261-70.

Barker ML, Hathaway LB, Arch DD et al. Hyper- and hypo-induction of cytochrome P450 activities with Aroclor 1254 and 3-methylcholanthrene in Cyp1a2(-/-) mice. Chem Biol Interact 2009; 182:220-6.

Barkhordari E, Rezaei N, Ansaripour B et al. Proinflammatory cytokine gene polymorphisms in irritable bowel syndrome. J Clin Immunol 2010; 30:74-9.

Barkin RL. Zolpidem extended-release: a single insomnia treatment option for sleep induction and sleep maintenance symptoms. Am J Ther 2007; 14:299-305.

Barnby G, Abbott A, Sykes N et al. Candidate-gene screening and association analysis at the autism-susceptibility locus on chromosome 16p: evidence of association at GRIN2A and ABAT. Am J Hum Genet 2005; 76:950-66.

Barner EL, Gray SL. Donepezil use in Alzheimer disease. Ann Pharmacother 1998; 32:70-7.

Barnes PF, Fong SJ, Brennan PJ, Twomey PE, Mazumder A, Modlin RL. Local production of tumor necrosis factor and IFN-gamma in tuberculous pleuritis. J Immun 1990; 145:149-54.

Baroja A, de la Hoz C, Álvarez A et al. Polyploidization and exit from cell cycle as mechanisms of cultured melanoma cell resistance to methotrexate. Life Sci 1998; 62:2275-82.

Baron JM, Goh LB, Yao D, Wolf CR, Friedberg T. Modulation of P450 CYP3A4-dependent metabolism by P-glycoprotein: implications for P450 phenotyping. J Pharmacol Exp Ther 2001; 296:351-8.

Barone GW, Gurley BJ, Ketel BL, Lightfoot ML, Abul-Ezz SR. Drug interaction between St. John's wort and cyclosporine. Ann Pharmacother 2000; 34:1013-6.

Barone I, Brusco L, Fuqua SA. Estrogen receptor mutations and changes in downstream gene expression and signaling. Clin Cancer Res 2010; 16:2702-8.

Barque JP, Abahamid A, Flinois JP, Beaune P, Bonaly J. Constitutive overexpression of immunoidentical forms of PCP-induced Euglena gracilis CYP-450. Biochem Biophys Res Commun 2002; 298:277-81.

Barraclough KA, Lee KJ, Staatz CE. Pharmacogenetic influences on mycophenolate therapy. Pharmacogenomics 2010; 11:369-90.

Barragan E, Collado M, Cervera J et al. The GST deletions and NQO1*2 polymorphism confers interindividual variability of response to treatment in patients with acute myeloid leukemia. Leuk Res 2007; 31:947-53.

Barrio R, Bellanné-Chantelot C, Moreno JC et al. Nine novel mutations in maturity-onset diabetes of the young (MODY) candidate genes in 22 Spanish families. J Clin Endocrinol Metab 2002; 87:2532-9.

Barron AM, Fuller SJ, Verdile G, Martins RN. Reproductive hormones modulate oxidative stress in Alzheimer's disease. Antioxid Redox Signal 2006; 8:2047-59.

Barros SA, Srimaroeng C, Perry JL et al. Activation of protein kinase Czeta increases OAT1 (SLC22A6)- and OAT3 (SLC22A8)-mediated transport. J Biol Chem 2009; 284:2672-9.

Barroso I, Luan J, Wheeler E et al. Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies. Diabetes 2008; 57:3161-5.

Barry KH, Zhang Y, Lan Q et al. Genetic variation in metabolic genes, occupational solvent exposure, and risk of non-hodgkin lymphoma. Am J Epidemiol 2011; 173:404-13.

Barst RJ. Sitaxsentan: a selective endothelin-A receptor antagonist, for the treatment of pulmonary arterial hypertension. Expert Opin Pharmacother 2007; 8:95-109.

Bart G, Heilig M, LaForge KS et al. Substantial attributable risk related to a functional mu-opioid receptor gene polymorphism in association with heroin addiction in central Sweden. Mol Psychiatry 2004; 9:547-9.

Bart G, Kreek MJ, Ott J et al. Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden. Neuropsychopharmacology 2005; 30:417-22.

Bartels AL, de Klerk OL, Kortekaas R, de Vries JJ, Leenders KL. 11C-verapamil to assess P-gp function in human brain during aging, depression and neurodegenerative disease. Curr Top Med Chem 2010; 10:1775-84.

Bartels LE, Hvas CL, Agnholt J, Dahlerup JF, Agger R. Human dendritic cell antigen presentation and chemotaxis are inhibited by intrinsic 25-hydroxy vitamin D activation. Int Immunopharmacol 2010; 10:922-8.

Barthe L, Woodley J, Houin G. Gastrointestinal absorption of drugs: methods and studies. Fundam Clin Pharmacol 1999; 13:154-68.

Barthel H, Gertz HJ, Dresel S et al. Cerebral amyloid-β PET with florbetaben ((18)F) in patients with Alzheimer's disease and healthy controls: a multicentre phase 2 diagnostic study. Lancet Neurol 2011; 10:424-35.

Bartik L, Whitfield GK, Kaczmarska M et al. Curcumin: a novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention. J Nutr Biochem 2010; 21:1153-61.

Bartley GE, Yokoyama W, Young SA et al. Hypocholesterolemic effects of hydroxypropyl methylcellulose are mediated by altered gene expression in hepatic bile and cholesterol pathways of male hamsters. J Nutr 2010; 140:1255-60.

Bartmann H, Fuest C, la Fougere C et al. Imaging of P-glycoprotein-mediated pharmacoresistance in the hippocampus: proof-of-concept in a chronic rat model of temporal lobe epilepsy. Epilepsia 2010; 51:1780-90.

Bartolomucci A, La Corte G, Possenti R et al. TLQP-21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesity. Proc Nat Acad Sci USA 2006; 103:14584-9.

Bartolomucci A, Possenti R, Levi A, Pavone F, Moles A. The role of the vgf gene and VGF-derived peptides in nutrition and metabolism. Genes Nutr 2007; 2:169-80.

Bartram CR. Molecular genetic aspects of myelodysplastic syndromes. Hematol Oncol Clin North Am 1992; 6:557-70.

Bartsch H, Dally H, Popanda O, Risch A, Schmezer P. Genetic risk profiles for cancer susceptibility and therapy response. Recent Results Cancer Res 2007; 174:19-36.

Bartsch R, Wenzel C, Zielinski CC, Steger GG. HER-2-positive breast cancer: hope beyond trastuzumab. BioDrugs 2007; 21:69-77.

Barwick JL, Quattrochi LC, Mills AS, Potenza C, Tukey RH, Guzelian PS. Trans-species gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human CYP3A4 and rabbit CYP3A6 in primary cultures of adult rat and rabbit hepatocytes. Mol Pharmacol 1996; 50:10-6.

Barzilai N, Atzmon G, Derby CA, Bauman JM, Lipton RB. A genotype of exceptional longevity is associated with preservation of cognitive function. Neurology 2006; 67:2170-5.

Basavarajappa MS, Craig ZR, Hernández-Ochoa I, Paulose T, Leslie TC, Flaws JA. Methoxychlor reduces estradiol levels by altering steroidogenesis and metabolism in mouse antral follicles in vitro. Toxicol Appl Pharmacol 2011; 253:161-9.

Basi GS, Hemphill S, Brigham EF et al. Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease. Alzheimers Res Ther 2010; 2:36.

Basic S, Hajnsek S, Bozina N et al. The influence of C3435T polymorphism of ABCB1 gene on penetration of phenobarbital across the blood-brain barrier in patients with generalized epilepsy. Seizure 2008; 17:524-30.

Basmaison O, Rolland MO, Cochat P, Bozon D. Identification of 5 novel mutations in the AGXT gene. Hum Mutat 2000; 15:577.

Bass SE, Sienkiewicz P, Macdonald CJ et al. Novel dithiolethione-modified nonsteroidal anti-inflammatory drugs in human hepatoma HepG2 and colon LS180 cells. Clin Cancer Res 2009; 15:1964-72.

Bassiouny AR, Zaky A, Neenaa HM. Synergistic effect of celecoxib on 5-fluorouracil-induced apoptosis in hepatocellular carcinoma patients. Ann Hepatol 2010; 9:410-8.

Basso AD, Doll RJ. Inhibition of cyclin-dependent kinases - a review of the recent patent literature. Recent Pat Anticancer Drug Discov 2006; 1:357-67.

Bastepe M, Jüppner H. GNAS locus and pseudohypoparathyroidism. Horm Res 2005; 63:65-74.

Bastepe M. The GNAS locus and pseudohypoparathyroidism. Adv Exp Med Biol 2008; 626:27-40.

Bastianetto S, Krantic S, Chabot JG, Quirion R. Possible involvement of programmed cell death pathways in the neuroprotective action of polyphenols. Curr Alzheimer Res 2011; 8:445-51.

Basu K, Palmer CN, Tavendale R, Lipworth BJ, Mukhopadhyay S. Adrenergic beta(2)-receptor genotype predisposes to exacerbations in steroid-treated asthmatic patients taking frequent albuterol or salmeterol. J Allergy Clin Immunol 2009; 124:1188-94.

Basu NK, Ciotti M, Hwang MS et al. Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Bio Chem 2004; 279:1429-41.

Basun H, Lind B, Nordberg M, Nordström M, Björkstén KS, Winblad B. Cadmium in blood in Alzheimer's disease and non-demented subjects: results from a population-based study. Biometals 1994; 7:130-4.

Batar B, Güven M, Bariş S, Celkan T, Yildiz I. DNA repair gene XPD and XRCC1 polymorphisms and the risk of childhood acute lymphoblastic leukemia. Leuk Res 2009; 33:759-63.

Batchu SN, Law E, Brocks DR, Falck JR, Seubert JM. Epoxyeicosatrienoic acid prevents postischemic electrocardiogram abnormalities in an isolated heart model. J Mol Cell Cardiol 2009; 46:67-74.

Bate C, Tayebi M, Diomede L, Salmona M, Williams A. Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells. BMC Biol 2008; 6:39.

Batel P, Houchi H, Daoust M, Ramoz N, Naassila M, Gorwood P. A haplotype of the DRD1 gene is associated with alcohol dependence. Alcohol Clin Exp Res 2008; 32:567-72.

Bates DE, Herman RJ. Carbamazepine toxicity induced by lopinavir/ritonavir and nelfinavir. Ann Pharmacother 2006; 40:1190-5.

Bates G, Mangiarini L, Mahal A, Davies S. Transgenic model of Huntingston's disease. Hum Molec Genet 1997; 6:1633-7.

Bates SE, Zhan Z, Steadman K et al. Laboratory correlates for a phase II trial of romidepsin in cutaneous and peripheral T-cell lymphoma. Br J Haematol 2010; 148:256-67.

Bathum L, Skjelbo E, Mutabingwa TK, Madsen H, Hørder M, Brøsen K. Phenotypes and genotypes for CYP2D6 and CYP2C19 in a black Tanzanian population. Br J Clin Pharmacol 1999; 48:395-401.

Batourina E, Gim S, Bello N et al. Vitamin A controls epithelial/mesenchymal interactions through Ret expression. Nat Genet 2001; 27:74-8.

Batra CM, Gupta N, Atwal G, Gupta V. Transient neonatal diabetes due to activating mutation in the ABCC8 gene encoding SUR1. Indian J Pediatr 2009; 76:1169-72.

Battino D, Croci D, Rossini A, Messina S, Mamoli D, Perucca E. Serum carbamazepine concentrations in elderly patients: a case-matched pharmacokinetic evaluation based on therapeutic drug monitoring data. Epilepsia 2003; 44:923-9.

Battochio A, Mohammed S, Winthrop D et al. Detection of c-KIT and PDGFRA gene mutations in gastrointestinal stromal tumors: comparison of DHPLC and DNA sequencing methods using a single population-based cohort. Am J Clin Pathol 2010; 133:149-55.

Batty KT, Davis TM, Ilett KF, Dusci LJ, Langton SR. The effect of ciprofloxacin on theophylline pharmacokinetics in healthy subjects. Br J Clin Pharmacol 1995; 39:305-11.

Baudhuin LM, Miller WL, Train L et al. Relation of ADRB1, CYP2D6, and UGT1A1 polymorphisms with dose of, and response to, carvedilol or metoprolol therapy in patients with chronic heart failure. Am J Cardiol 2010; 106:402-8.

Baudin B. Angiotensin I-converting enzyme gene polymorphism and drug response. Clin Chem Lab Med 2000; 38:853-6.

Baudin B. Angiotensin II receptor polymorphisms in hypertension. Pharmacogenomic considerations. Pharmacogenomics 2002; 3:65-73.

Baudin B. Polymorphism in angiotensin II receptor genes and hypertension. Exp Physiol 2005; 90:277-82.

Bauer F, Kuntner C, Bankstahl JP et al. Synthesis and in vivo evaluation of [11C]tariquidar, a positron emission tomography radiotracer based on a third-generation P-glycoprotein inhibitor. Bioorg Med Chem 2010; 18:5489-97.

Bauer M, Karch R, Neumann F et al. Assessment of regional differences in tariquidar-induced P-glycoprotein modulation at the human blood-brain barrier. J Cereb Blood Flow Metab 2010; 30:510-5.

Bauer T, Bouman HJ, van Werkum JW, Ford NF, Ten Berg JM, Taubert D. Impact of CYP2C19 variant genotypes on clinical efficacy of antiplatelet treatment with clopidogrel: systematic review and meta-analysis. BMJ 2011. doi:10. 1136/bmj. d4588.

Bauerfeind A, Knoblauch H, Costanza MC et al. Concordant association of lipid gene variation with a combined HDL/LDL-cholesterol phenotype in two European populations. Hum Hered 2006; 61:123-31.

Bauerfeind I, Elling D, Heinemann V. Lapatinib in the treatment of hormone receptor-positive/ErbB2-positive breast cancer. Breast Care 2010; 5:13-15.

Baulac M, Leppik IE. Efficacy and safety of adjunctive zonisamide therapy for refractory partial seizures. Epilepsy Res 2007; 75:75-83.

Baulac S, Gourfinkel-An I, Picard F et al. A second locus for familial generalized epilepsy with febrile seizures plus maps to chromosome 2q21-q33. Am J Hum Genet 1999; 65:1078-85.

Baum CE, Ockers SB, English BC, Price DK, Sartor O, Figg WD. Androgen receptor sequence and variations in several common prostate cancer cell lines. Cancer Biol Ther 2010; 9:383-8.

Bauman JN, Frederick KS, Sawant A et al. Comparison of the bioactivation potential of the antidepressant and hepatotoxin nefazodone with aripiprazole, a structural analog and marketed drug. Drug Metab Dispos 2008; 36:1016-29.

Baumann C, Davies B, Peters M, Kaufmann-Reiche U, Lessl M, Theuring F. AKR1B7 (mouse vas deferens protein) is dispensable for mouse development and reproductive success. Reproduction 2007; 134:97-109.

Baumann P. Pharmacokinetic-pharmacodynamic relationship of the selective serotonin reuptake inhibitors. Clin Pharmacokinet 1996; 31:444-69.

Baumann P. Care of depression in the elderly: comparative pharmacokinetics of SSRIs. Int Clin Psychopharmacol 1998; 13 Suppl 5:35-43.

Baumann P, Mandl-Weber S, Völkl A et al. Dihydroorotate dehydrogenase inhibitor A771726 (leflunomide) induces apoptosis and diminishes proliferation of multiple myeloma cells. Mol Cancer Ther 2009; 8:366-75.

Baumann P, Rochat B. Comparative pharmacokinetics of selective serotonin reuptake inhibitors: a look behind the mirror. Int Clin Psychopharmacol 1995; 10 Suppl 1:15-21.

Baumhäkel M, Kasel D, Rao-Schymanski RA et al. Screening for inhibitory effects of antineoplastic agents on CYP3A4 in human liver microsomes. Int J Clin Pharmacol Ther 2001; 39:517-28.

Baune BT, Dannlowski U, Domschke K et al. The interleukin 1 beta (IL1B) gene is associated with failure to achieve remission and impaired emotion processing in major depression. Biol Psychiatry 2010; 67:543-9.

Baune BT, Hohoff C, Berger K et al. Association of the COMT Val158Met variant with antidepressant treatment response in major depression. Neuropsychopharmacology 2008; 33:924-32.

Bavadekar SA, Hong SS, Lee SI, Miller DD, Feller DR. Bioisosteric phentolamine analogs as selective human alpha(2)- versus alpha(1)-adrenoceptor ligands. Eur J Pharmacol 2008; 590:53-60.

Bavisotto LM, Ellis DJ, Milner PG, Combs DL, Irwin I, Canafax DM. Tecarfarin, a novel vitamin K reductase antagonist, is not affected by CYP2C9 and CYP3A4 inhibition following concomitant administration of fluconazole in healthy participants. J Clin Pharmacol 2011; 51:561-74.

Båvner A, Shafaati M, Hansson M et al. On the mechanism of accumulation of cholestanol in the brain of mice with a disruption of sterol 27-hydroxylase. J Lipid Res 2010; 51:2722-30.

Bax DA, Gaspar N, Little SE et al. EGFRvIII deletion mutations in pediatric high-grade glioma and response to targeted therapy in pediatric glioma cell lines. Clin Cancer Res 2009; 15:5753-61.

Baxter LC, Caselli RJ, Johnson SC, Reiman E, Osborne D. Apolipoprotein E epsilon4 affects new learning in cognitively normal individuals at risk for Alzheimer disease. Neurobiol Aging 2003; 24:947-52

Bayer AU, Keller ON, Ferrari F, Maag KP. Association of glaucoma with neurodegenerative diseases with apoptotic cell death: Alzheimer's disease and Parkinson's disease. Am J Ophthal 2002; 133:135-7.

Bayne S, Li H, Jones ME et al. Estrogen deficiency reversibly induces telomere shortening in mouse granulosa cells and ovarian aging in vivo. Protein Cell 2011; 2:333-46.

Bazargani A, Khoramrooz SS, Kamali-Sarvestani E, Taghavi SA, Saberifiroozi M. Association between peroxisome proliferator-activated receptor-γ gene polymorphism (Pro12Ala) and Helicobacter pylori infection in gastric carcinogenesis. Scand J Gastroenterol 2010; 45:1162-7.

Bazo AP, Salvadori D Jr, Salvadori RA et al. DNA repair gene polymorphism is associated with the genetic basis of atherosclerotic coronary artery disease. Cardiovasc Pathol 2011; 20:9-15.

B'chir F, Pavanello S, Knani J, Boughattas S, Arnaud MJ, Saguem S. CYP1A2 genetic polymorphisms and adenocarcinoma lung cancer risk in the Tunisian population. Life Sci 2009; 84:779-84.

Beaird SL. HMG-CoA reductase inhibitors: assessing differences in drug interactions and safety profiles. J Am Pharm Assoc 2000; 40:637-44.

Beamer BA, Yen CJ, Andersen RE et al. Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-gamma2 gene with obesity in two Caucasian populations. Diabetes 1998; 47:1806-8.

Bearden DT, Neuhauser MM, Garey KW. Telithromycin: an oral ketolide for respiratory infections. Pharmacotherapy 2001; 21:1204-22.

Beauclair S, Formento P, Fischel JL et al. Role of the HER2 [Ile655Val] genetic polymorphism in tumorogenesis and in the risk of trastuzumab-related cardiotoxicity. Ann Oncol 2007; 18:1335-41.

Beaumont KA, Newton RA, Smit DJ, Leonard JH, Stow JL, Sturm RA. Altered cell surface expression of human MC1R variant receptor alleles associated with red hair and skin cancer risk. Hum Mol Genet 2005; 14:2145-54.

Beaver KM, DeLisi M, Vaughn MG, Barnes JC. Monoamine oxidase A genotype is associated with gang membership and weapon use. Compr Psychiatry 2010; 51:130-4.

Bebawy M, Chetty M. Gender differences in p-glycoprotein expression and function: effects on drug disposition and outcome. Curr Drug Metab 2009; 10:322-8.

Bebawy M, Rasmussen C, Sambasivam S, Bao S. Dietary nucleotide supplements in infant formula modify the expression of P-glycoprotein in the intestinal epithelium in vitro. Int J Vitam Nutr Res 2009; 79:381-7.

Bebia Z, Buch SC, Wilson JW et al. Bioequivalence revisited: influence of age and sex on CYP enzymes. Clin Pharmacol Ther 2004; 76:618-27.

Beck M, Brückner MK, Holzer M et al. Guinea-pig primary cell cultures provide a model to study expression and amyloidogenic processing of endogenous amyloid precursor protein. Neuroscience 2000; 95:243-54.

Becker C, Bray-French K, Drewe J. Pharmacokinetic evaluation of idebenone. Expert Opin Drug Metab Toxicol 2010; 6:1437-44.

Becker LE, Koleganova N, Piecha G et al. Effect of paricalcitol and calcitriol on aortic wall remodeling in uninephrectomized ApoE knockout mice. Am J Physiol Renal Physiol 2011; 300:772-82.

Becker ML, Visser LE, van Schaik RH, Hofman A, Uitterlinden AG, Stricker BH. Common genetic variation in the ABCB1 gene is associated with the cholesterol-lowering effect of simvastatin in males. Pharmacogenomics 2009; 10:1743-51.

Becker ML, Visser LE, van Schaik RH, Hofman A, Uitterlinden AG, Stricker BH. Genetic variation in the organic cation transporter 1 is associated with metformin response in patients with diabetes mellitus. Pharmacogenomics J 2009; 9:242-7.

Becker ML, Visser LE, van Schaik RH, Hofman A, Uitterlinden AG, Stricker BH. Influence of genetic variation in CYP3A4 and ABCB1 on dose decrease or switching during simvastatin and atorvastatin therapy. Pharmacoepidemiol Drug Saf 2010; 19:75-81.

Becker RM, da Silva VK, Machado Fda S et al. Association between environmental quality, stress and APOE gene variation in fibromyalgia susceptibility determination. Rev Bras Reumatol 2010; 50:617-24.

Becker SL. The role of pharmacological enhancement in protease inhibitor-based highly active antiretroviral therapy. Expert Opin Investig Drugs 2003; 12:401-12.

Beckers MM, Ruven HJ, Haas FJ et al. Single nucleotide polymorphisms in inflammation-related genes are associated with venous thromboembolism. Eur J Intern Med 2010; 21:289-92.

Beckman DR, Hoganson G, Berlow S, Gilbert EF. Pathological findings in 5,10-methylene tetrahydrofolate reductase deficiency. Birth Defects Orig Artic Ser 1987; 23:47-64.

Beckmann-Knopp S, Rietbrock S, Weyhenmeyer R et al. Inhibitory effects of trospium chloride on cytochrome P450 enzymes in human liver microsomes. Pharmacol Toxicol 1999; 85:299-304.

Beckmann-Knopp S, Rietbrock S, Weyhenmeyer R et al. Inhibitory effects of silibinin on cytochrome P-450 enzymes in human liver microsomes. Pharmacol Toxicol 2000; 86:250-6.

Becquemont L, Camus M, Eschwege V et al. Lymphocyte P-glycoprotein expression and activity before and after rifampicin in man. Fundam Clin Pharmacol 2000; 14:519-25.

Becquemont L, Chazouilleres O, Serfaty L et al. Effect of interferon alpha-ribavirin bitherapy on cytochrome P450 1A2 and 2D6 and N-acetyltransferase-2 activities in patients with chronic active hepatitis C. Clin Pharmacol Ther 2002; 71:488-95.

Becquemont L, Glaeser H, Drescher S et al. Effects of ursodeoxycholic acid on P-glycoprotein and cytochrome P450 3A4-dependent pharmacokinetics in humans. Clin Pharmacol Ther 2006; 79:449-60.

Becquemont L, Mouajjah S, Escaffre O, Beaune P, Funck-Brentano C, Jaillon P. Cytochrome P-450 3A4 and 2C8 are involved in zopiclone metabolism. Drug Metab Dispos 1999; 27:1068-73.

Beedanagari SR, Bebenek I, Bui P, Hankinson O. Resveratrol inhibits dioxin-induced expression of human CYP1A1 and CYP1B1 by inhibiting recruitment of the aryl hydrocarbon receptor complex and RNA polymerase II to the regulatory regions of the corresponding genes. Toxicol Sci 2009; 110:61-7.

Beedanagari SR, Taylor RT, Bui P, Wang F, Nickerson DW, Hankinson O. Role of epigenetic mechanisms in differential regulation of the dioxin-inducible human CYP1A1 and CYP1B1 genes. Mol Pharmacol 2010; 78:608-16.

Beedanagari SR, Taylor RT, Hankinson O. Differential regulation of the dioxin-induced Cyp1a1 and Cyp1b1 genes in mouse hepatoma and fibroblast cell lines. Toxicol Lett 2010; 194:26-33.

Beedham C, Miceli JJ, Obach RS. Ziprasidone metabolism, aldehyde oxidase, and clinical implications. J Clin Psychopharmacol 2003; 23:229-32.

Beedholm-Ebsen R, van de Wetering K, Hardlei T, Nexø E, Borst P, Moestrup SK. Identification of multidrug resistance protein 1 (MRP1/ABCC1) as a molecular gate for cellular export of cobalamin. Blood 2010; 115:1632-9.

Beeks E, Kessels AG, Kroon AA, van der Klauw MM, de Leeuw PW. Genetic predisposition to salt-sensitivity: a systematic review. J Hypertens 2004; 22:1243-9.

Beel AJ, Sakakura M, Barrett PJ, Sanders CR. Direct binding of cholesterol to the amyloid precursor protein: An important interaction in lipid-Alzheimer's disease relationships? Biochim Biophys Acta 2010; 1801:975-82.

Been LF, Ralhan S, Wander GS et al. Variants in KCNQ1 increase type II diabetes susceptibility in South Asians: A study of 3,310 subjects from India and the US. BMC Med Genet 2011; 12:18.

Beghin D, Forestier F, Noël-Hudson MS et al. Modulation of endocrine and transport functions in human trophoblasts by saquinavir and nelfinavir. Eur J Obstet Gynecol Reprod Biol 2010; 152:55-9.

Begré S, von Bardeleben U, Ladewig D et al. Paroxetine increases steady-state concentrations of (R)-methadone in CYP2D6 extensive but not poor metabolizers. J Clin Psychopharmacol 2002; 22:211-5.

Beher D, Fricker M, Nadin A et al. In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand. Biochemistry 2003; 42:8133-42.

Behre HM, Greb RR, Mempel A et al. Significance of a common single nucleotide polymorphism in exon 10 of the follicle-stimulating hormone (FSH) receptor gene for the ovarian response to FSH: a pharmacogenetic approach to controlled ovarian hyperstimulation. Pharmacogenet Genomics 2005; 15:451-6.

Behrens A, Aguzzi A. Small is not beatiful: antagonizing functions for the prion protein PrP(C) and its homologue Dpl. Trends in Neurosci 2002; 25:150-4.

Bei T, Tilkeridis C, Garantziotis S et al. A novel, non-functional, COL1A1 polymorphism is not associated with lumbar disk disease in young male Greek subjects unlike that of the Sp1 site. Hormones 2008; 7:251-4.

Beierle I, Meibohm B, Derendorf H. Gender differences in pharmacokinetics and pharmacodynamics. Int J Clin Pharmacol Ther 1999; 37:529-47.

Beil W, Sewing KF, Kromer W. Basic aspects of selectivity of pantoprazole and its pharmacological actions. Drugs Today 1999; 35:753-64.

Beilke LD, Aleksunes LM, Holland RD et al. Constitutive androstane receptor-mediated changes in bile acid composition contributes to hepatoprotection from lithocholic acid-induced liver injury in mice. Drug Metab Dispos 2009; 37:1035-45.

Beinema M, Brouwers JR, Schalekamp T, Wilffert B. Pharmacogenetic differences between warfarin, acenocoumarol and phenprocoumon. Thromb Haemost 2008; 100:1052-7.

Beitelshees AL, Finck BN, Leone TC et al. Interaction between the UCP2 -866 G>A polymorphism, diabetes, and beta-blocker use among patients with acute coronary syndromes. Pharmacogenet Genomics 2010; 20:231-8.

Beitelshees AL, Johnson JA, Hames ML et al. Aromatase gene polymorphisms are associated with survival among patients with cardiovascular disease in a sex-specific manner. PLoS One 2010. doi:10. 1371/journal. pone. 0015180.

Beitelshees AL, Zineh I, Yarandi HN, Pauly DF, Johnson JA. Influence of phenotype and pharmacokinetics on beta-blocker drug target pharmacogenetics. Pharmacogenomics J 2006; 6:174-8.

Belbin O, Carrasquillo MM, Crump M et al. Investigation of 15 of the top candidate genes for late-onset Alzheimer's disease. Hum Genet 2011; 129:273-82.

Belenkov YN, Privalova EV, Kaplunova VY, Stambol'skiĭ DV, Fomin AA. Analysis of morpho-functional parameters of the heart and polymorphisms of renin-angiotensin-aldosterone system genes in patients with different variants of the course of hypertrophic cardiomyopathy. Kardiologiia 2010; 50:27-34.

Belfer I, Buzas B, Evans C et al. Haplotype structure of the beta adrenergic receptor genes in US Caucasians and African Americans. Eur J Hum Genet 2005; 13:341-51.

Belin de Chantemèle EJ, Retailleau K, Pinaud F et al. Notch3 is a major regulator of vascular tone in cerebral and tail resistance arteries. Arterioscler Thromb Vasc Biol 2008; 28:2216-24.

Belinsky MG, Chen ZS, Shchaveleva I, Zeng H, Kruh GD. Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6). Cancer Res 2002; 62:6172-7.

Belpaire FM, Wijnant P, Temmerman A, Rasmussen BB, Brøsen K. The oxidative metabolism of metoprolol in human liver microsomes: inhibition by the selective serotonin reuptake inhibitors. Eur J Clin Pharmacol 1998; 54:261-4.

Beltinger J, Haschke M, Kaufmann P, Michot M, Terracciano L, Krähenbühl S. Hepatic veno-occlusive disease associated with immunosuppressive cyclophosphamide dosing and roxithromycin. Ann Pharmacother 2006; 40:767-70.

Bell DA, Taylor JA, Butler MA et al. Genotype/phenotype discordance for human arylamine N-acetyltransferase (NAT2) reveals a new slow-acetylator allele common in African-Americans. Carcinogenesis 1993; 14:1689-92.

Bell DW, Gore I, Okimoto RA et al. Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR. Nat Genet 2005; 37:1315-6.

Bell EC, Ravis WR, Chan HM, Lin YJ. Lack of pharmacokinetic interaction between St. John's wort and prednisone. Ann Pharmacother 2007; 41:1819-24.

Bell LN, Molleston JP, Morton MJ et al. Hepatic lipid peroxidation and cytochrome P-450 2E1 in pediatric nonalcoholic fatty liver disease and its subtypes. J Clin Gastroenterol 2011; 45:800-7.

Bell LN, Temm CJ, Saxena R et al. Bariatric surgery-induced weight loss reduces hepatic lipid peroxidation levels and affects hepatic cytochrome P-450 protein content. Ann Surg 2010; 251:1041-8.

Bellanger N, Orsoni A, Julia Z et al. Atheroprotective reverse cholesterol transport pathway is defective in familial hypercholesterolemia. Arterioscler Thromb Vasc Biol 2011; 31:1675-81.

Bellanné-Chantelot C, Saint-Martin C, Ribeiro MJ et al. ABCC8 and KCNJ11 molecular spectrum of 109 patients with diazoxide-unresponsive congenital hyperinsulinism. J Med Genet 2010; 47:752-9.

Belle DJ, Ernest CS, Sauer JM, Smith BP, Thomasson HR, Witcher JW. Effect of potent CYP2D6 inhibition by paroxetine on atomoxetine pharmacokinetics. J Clin Pharmacol 2002; 42:1219-27.

Bellec G, Dréano Y, Lozach P, Ménez JF, Berthou F. Cytochrome P450 metabolic dealkylation of nine N-nitrosodialkylamines by human liver microsomes. Carcinogenesis 1996; 17:2029-34.

Bellili NM, Foucan L, Fumeron F et al. Associations of the -344 T>C and the 3097 G>A polymorphisms of CYP11B2 gene with hypertension, type 2 diabetes, and metabolic syndrome in a French population. Am J Hypertens 2010; 23:660-7.

Bellincampi L, Ballerini S, Bernardini S et al. Glutathione transferase P1 polymorphism in neuroblastoma studied by endonuclease restriction mapping. Clin Chem Lab Med 2001; 39:830-5.

Belloc C, Baird S, Cosme J et al. Human cytochromes P450 expressed in Escherichia coli: production of specific antibodies. Toxicology 1996; 106:207-19.

Bellocq D, Molina J, Rathahao-Paris E, Taché S, Pierre F, Paris A. Metabolic bioactivation of oestradiol-17beta (E2beta) in mouse colon epithelial cells bearing ApcMin mutation. Steroids 2010; 75:665-75.

Bellon A, Perez-Garcia G, Coverdale JH, Chacko RC. Seizures associated with levofloxacin: case presentation and literature review. Eur J Clin Pharmacol 2009; 65:959-62.

Bellucci A, Westwood AJ, Ingram E, Casamenti F, Goedert M, Spillantini MG. Induction of inflammatory mediators and microglial activation in mice transgenic for mutant human P301S tau protein. Am J Pathol 2004; 165:1643-52.

Bellusci CP, Rocco CA, Aulicino PC et al. MDR1 3435T and 1236T alleles delay disease progression to pediatric AIDS but have no effect on HIV-1 vertical transmission. AIDS 2010; 24:833-40.

Ben Dhifallah I, Karray EF, Sassi F, Hamzaoui K. Intercellular adhesion molecule 1 K469E gene polymorphism is associated with presence of skin lesions in Tunisian Behçet's disease patients. Tissue Antigens 2010; 75:74-8.

Benayoun L, Granot E, Rizel L, Allon-Shalev S, Behar DM, Ben-Yosef T. Abetalipoproteinemia in Israel: evidence for a founder mutation in the Ashkenazi Jewish population and a contiguous gene deletion in an Arab patient. Molec Genet Metab 2007; 90:453-57.

Bendardaf R, Lamlum H, Ristamäki R, Korkeila E, Syrjänen K, Pyrhönen S. Thymidylate synthase and microsatellite instability in colorectal cancer: implications for disease free survival, treatment response and survival with metastases. Acta Oncol 2008; 47:1046-53.

Bendel SD, Bona R, Baker WL. Dabigatran: an oral direct thrombin inhibitor for use in atrial fibrillation. Adv Ther 2011; 28:460-72.

Benedetti F, Bernasconi A, Lorenzi C et al. A single nucleotide polymorphism in glycogen synthase kinase 3-beta promoter gene influences onset of illness in patients affected by bipolar disorder. Neurosci Lett 2004; 355:37-40.

Benedetti F, Serretti A, Pontiggia A et al. Long-term response to lithium salts in bipolar illness is influenced by the glycogen synthase kinase 3-beta -50 T/C SNP. Neurosci Lett 2005; 376:51-5.

Benedetti MS. Enzyme induction and inhibition by new antiepileptic drugs: a review of human studies. Fundam Clin Pharmacol 2000; 14:301-19.

Benedetti MS, Whomsley R, Canning M. Drug metabolism in the paediatric population and in the elderly. Drug Discov Today 2007; 12:599-610.

Benedetto A, Squadrone S, Prearo M, Elia AC, Giorgi I, Abete MC. Evaluation of ABC efflux transporters genes expression in kidney of rainbow trout (Oncorhynchus mykiss) fed with melamine and cyanuric acid diets. Chemosphere 2011; 84:727-30.

Benet LZ, Cummins CL, Wu CY. Transporter-enzyme interactions: implications for predicting drug-drug interactions from in vitro data. Curr Drug Metab 2003; 4:393-8.

Benet LZ, Cummins CL, Wu CY. Unmasking the dynamic interplay between efflux transporters and metabolic enzymes. Int J Pharm 2004; 277:3-9.

Benet LZ, Izumi T, Zhang Y, Silverman JA, Wacher VJ. Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery. J Control Release 1999; 62:25-31.

Benetos A, Cambien F, Gautier S et al. Influence of the angiotensin II type 1 receptor gene polymorphism on the effects of perindopril and nitrendipine on arterial stiffness in hypertensive individuals. Hypertension 1996; 28:1081-4.

Benetton SA, Borges VM, Chang TK, McErlane KM. Role of individual human cytochrome P450 enzymes in the in vitro metabolism of hydromorphone. Xenobiotica 2004; 34:335-44.

Benetton SA, Fang C, Yang YO et al. P450 phenotyping of the metabolism of selegiline to desmethylselegiline and methamphetamine. Drug Metab Pharmacokinet 2007; 22:78-87.

Bengtsson K, Melander O, Orho-Melander M et al. Polymorphism in the beta(1)-adrenergic receptor gene and hypertension. Circulation 2001; 104:187-90.

Bengtsson K, Orho-Melander M, Lindblad U et al. Polymorphism in the angiotensin converting enzyme but not in the angiotensinogen gene is associated with hypertension and type 2 diabetes: the Skaraborg Hypertension and diabetes project. J Hypertens 1999; 17:1569-75.

Benhamou S, Sarasin A. ERCC2 /XPD gene polymorphisms and lung cancer: a HuGE review. Am J Epidemiol 2005; 161:1-14.

Benhamou S, Sarasin A. ERCC2/XPD gene polymorphisms and cancer risk. Mutagenesis 2002; 17:463-9.

Benites J, Valderrama JA, Taper H, Buc Calderon P. An in vitro comparative study with furyl-1,4-quinones endowed with anticancer activities. Invest New Drugs 2011; 29:760-7.

Benjafield AV, Wang WY, Morris BJ. No association of angiotensin-converting enzyme 2 gene (ACE2) polymorphisms with essential hypertension. Am J Hypertens 2004; 17:624-8.

Benjamin J, Li L, Patterson C, Greenberg BD, Murphy DL, Hamer DH. Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking. Nat Genet 1996; 12:81-4.

Benjamin R, Leake A, McArthur FK et al. Propective effect of apoE e2 in Alzheimer's disease. Lancet 1994; 334:473-4.

Benn M, Tybjærg-Hansen A, Stender S, Frikke-Schmidt R, Nordestgaard BG. Low-density lipoprotein cholesterol and the risk of cancer: a mendelian randomization study. J Natl Cancer Inst 2011; 103:508-19.

Bennet AM, Reynolds CA, Eriksson UK et al. Genetic association of sequence variants near AGER/NOTCH4 and dementia. J Alzheimers Dis 2011; 24:475-84.

Bennet C, Crawford F, Osborne A et al. Evidence that the APOE locus influences rate of disease progression in late onset familial Alzheimer's disease but is not causative. Am J Med Genet 1995; 60:1-6.

Bennett CL, Price DK, Kim S et al. Racial variation in CAG repeat lengths within the androgen receptor gene among prostate cancer patients of lower socioeconomic status. J Clin Oncol 2002; 20:3599-604.

Bennett DA, Wilson RS, Schneider JA et al. Apolipoprotein E epsilon-4 allele, AD pathology, and the clinical expression of Alzheimer's disease. Neurology 2003; 60:246-52.

Bennett K, James C, Hussain K. Pancreatic β-cell KATP channels: Hypoglycaemia and hyperglycaemia. Rev Endocr Metab Disord 2010; 11:157-63.

Benod C, Subra G, Nahoum V et al. N-1H-benzimidazol-5-ylbenzenesulfonamide derivatives as potent hPXR agonists. Bioorg Med Chem 2008; 16:3537-49.

Benoit E, Delatour P, Olivier L, Caldwell J. (-)-R-fenoprofen: formation of fenoprofenyl-coenzyme A by rat liver microsomes. Biochem Pharmacol 1995; 49:1717-20.

Benoit-Biancamano MO, Connelly J, Villeneuve L, Caron P, Guillemette C. Deferiprone glucuronidation by human tissues and recombinant UDP glucuronosyltransferase 1A6: an in vitro investigation of genetic and splice variants. Drug Metab Dispos 2009; 37:322-9.

Benson AM, Hunkeler MJ, Talalay P. Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity. Proc Natl Acad Sci USA 1980; 77:5216-20.

Benson C, White J, de Bono J et al. A phase I trial of the selective oral cyclin-dependent kinase inhibitor seliciclib (CYC202; R-Roscovitine), administered twice daily for 7 days every 21 days. Br J Cancer 2007; 96:29-37.

Benusiglio PR, Lesueur F, Luccarini C et al. Common ERBB2 polymorphisms and risk of breast cancer in a white British population: a case-control study. Breast Cancer Res 2005; 7:204-9.

Benz-de Bretagne I, Respaud R, Vourc'h P et al. Urinary elimination of coproporphyrins is dependent on ABCC2 polymorphisms and represents a potential biomarker of MRP2 activity in humans. J Biomed Biotechnol 2011. doi:10. 1155/2011/498757.

Benzon Larsen S, Vogel U, Christensen J et al. Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer. Cancer Lett 2010; 295:191-7.

Bepler G. Phase II pharmacogenomics-based adjuvant therapy trial in patients with non-small-cell lung cancer: Southwest Oncology Group Trial 0720. Clin Lung Cancer 2007; 8:509-11.

Beraza N, Ofner-Ziegenfuss L, Ehedego H et al. Nor-ursodeoxycholic acid reverses hepatocyte-specific nemo-dependent steatohepatitis. Gut 2011; 60:387-96.

Berbée JF, Vanmierlo T, Abildayeva K et al. Apolipoprotein CI knock-out mice display impaired memory functions. J Alzheimers Dis 2011; 23:567-98.

Berbel García A, Latorre Ibarra A, Porta Etessam J et al. Protease inhibitor-induced carbamazepine toxicity. Clin Neuropharmacol 2000; 23:216-8.

Berce V, Potocnik U. Association of Q551R polymorphism in the interleukin 4 receptor gene with nonatopic asthma in Slovenian children. Wien Klin Wochenschr 2010; 122 Suppl 2:11-8.

Berce V, Potocnik U. Functional polymorphism in CTLA4 gene influences the response to therapy with inhaled corticosteroids in Slovenian children with atopic asthma. Biomarkers 2010; 15:158-66.

Bercovitch L, Martin L, Chassaing N et al. Acquired pseudoxanthoma elasticum presenting after liver transplantation. J Am Acad Dermatol 2011; 64:873-8.

Berecz R, de la Rubia A, Dorado P, Fernández-Salguero P, Dahl ML, Llerena A. Thioridazine steady-state plasma concentrations are influenced by tobacco smoking and CYP2D6, but not by the CYP2C9 genotype. Eur J Clin Pharmacol 2003; 59:45-50.

Berecz R, Dorado P, de la Rubia A, Cáceres MC, Degrell I, Llerena A. The role of cytochrome P450 enzymes in the metabolism of risperidone and its clinical relevance for drug interactions. Curr Drug Targets 2004; 5:573-9.

Bereczky Z, Kovács KB, Muszbek L. Protein C and protein S deficiencies: similarities and differences between two brothers playing in the same game. Clin Chem Lab Med 2010; 48 Suppl 1:53-66.

Berg V, Lyche JL, Karlsson C et al. Accumulation and effects of natural mixtures of persistent organic pollutants (POP) in Zebrafish after two generations of exposure. J Toxicol Environ Health A 2011; 74:407-23.

Bergamaschi L, Leone MA, Fasano ME et al. HLA-class I markers and multiple sclerosis susceptibility in the Italian population. Genes Immun 2010; 11:173-80.

Berge KE, Leren TP. Mutations in APOA-I and ABCA1 in Norwegians with low levels of HDL cholesterol. Clin Chim Acta 2010; 411:2019-23.

Berge M, Chevalier P, Benammar M et al. Safe management of tacrolimus together with posaconazole in lung transplant patients with cystic fibrosis. Ther Drug Monit 2009; 31:396-9.

Berge M, Guillemain R, Boussaud V et al. Voriconazole pharmacokinetic variability in cystic fibrosis lung transplant patients. Transpl Infect Dis 2009; 11:211-9.

Berge M, Guillemain R, Trégouet DA et al. Effect of cytochrome P450 2C19 genotype on voriconazole exposure in cystic fibrosis lung transplant patients. Eur J Clin Pharmacol 2011; 67:253-60.

Bergen AA, Plomp AS, Schuurman EJ et al. Mutations in ABCC6 cause pseudoxanthoma elasticum. Nat Genet 2000; 25:228-31.

Bergen AW, van den Bree MB, Yeager M et al. Candidate genes for anorexia nervosa in the 1p33-36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa. Mol Psychiatry 2003; 8:397-406.

Berger EA, Murphy PM, Farber JM. Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease. Annu Rev Immunol 1999; 17:657-700.

Berger K, Stogbauer F, Stoll M et al. The Glu298Asp polymorphism in the nitric oxide synthase 3 gene is associated with the risk of ischemic stroke in two large independent case-control studies. Hum Genet 2007; 121:169-78.

Berger R, Mezey E, Clancy KP et al. Analysis of aldehyde oxidase and xanthine dehydrogenase/oxidase as possible candidate genes for autosomal recessive familial amyotrophic lateral sclerosis. Somat Cell Molec Genet 1995; 21:121-31.

Berges R, Gsur A, Feik E et al. Association of polymorphisms in CYP19A1 and CYP3A4 genes with lower urinary tract symptoms, prostate volume, uroflow and PSA in a population-based sample. World J Urol 2011; 29:143-8.

Berggren S, Gall C, Wollnitz N et al. Gene and protein expression of P-glycoprotein, MRP1, MRP2, and CYP3A4 in the small and large human intestine. Mol Pharm 2007; 4:252-7.

Berggren S, Lennernäs P, Ekelund M, Weström B, Hoogstraate J, Lennernäs H. Regional transport and metabolism of ropivacaine and its CYP3A4 metabolite PPX in human intestine. J Pharm Pharmacol 2003; 55:963-72.

Bergheim I, Bode C, Parlesak A. Decreased expression of cytochrome P450 protein in non-malignant colonic tissue of patients with colonic adenoma. BMC Gastroenterol 2005; 5:34.

Bergheim I, Bode C, Parlesak A. Distribution of cytochrome P450 2C, 2E1, 3A4, and 3A5 in human colon mucosa. BMC Clin Pharmacol 2005; 5:4.

Bergheim I, Wolfgarten E, Bollschweiler E, Hölscher AH, Bode C, Parlesak A. Cytochrome P450 levels are altered in patients with esophageal squamous-cell carcinoma. World J Gastroenterol 2007; 13:997-1002.

Berginc K, Trdan T, Trontelj J, Kristl A. HIV protease inhibitors: garlic supplements and first-pass intestinal metabolism impact on the therapeutic efficacy. Biopharm Drug Dispos 2010; 31:495-505.

Berginc K, Trontelj J, Kristl A. The influence of aged garlic extract on the uptake of saquinavir and darunavir into HepG2 cells and rat liver slices. Drug Metab Pharmacokinet 2010; 25:307-13.

Berginc K, Žakelj S, Kristl A. In vitro interactions between aged garlic extract and drugs used for the treatment of cardiovascular and diabetic patients. Eur J Nutr 2010; 49:373-84.

Bergman A, Einbeigi Z, Olofsson U et al. The western Swedish BRCA1 founder mutation 3171ins5; a 3. 7 cM conserved haplotype of today is a reminiscence of a 1500-year-old mutation. Eur J Hum Genet 2001; 9:787-93.

Bergman A, Mistry GC, Luo WL et al. Dose-proportionality of a final market image sitagliptin formulation, an oral dipeptidyl peptidase-4 inhibitor, in healthy volunteers. Biopharm Drug Dispos 2007; 28:307-13.

Bergmann TK, Brasch-Andersen C, Gréen H et al. Impact of CYP2C8*3 on paclitaxel clearance: a population pharmacokinetic and pharmacogenomic study in 93 patients with ovarian cancer. Pharmacogenomics J 2011; 11:113-20.

Bergmann TK, Gréen H, Brasch-Andersen C et al. Retrospective study of the impact of pharmacogenetic variants on paclitaxel toxicity and survival in patients with ovarian cancer. Eur J Clin Pharmacol 2011; 67:693-700.

Berle JØ, Steen VM, Aamo TO, Breilid H, Zahlsen K, Spigset O. Breastfeeding during maternal antidepressant treatment with serotonin reuptake inhibitors: infant exposure, clinical symptoms, and cytochrome p450 genotypes. J Clin Psychiatry 2004; 65:1228-34.

Berlin DS, Sangkuhl K, Klein TE, Altman RB. PharmGKB summary: cytochrome P450, family 2, subfamily J, polypeptide 2: CYP2J2. Pharmacogenet Genomics 2011; 21:308-11.

Berlin M, Ting PC, Vaccaro WD et al. Reduction of CYP450 inhibition in the 4-[(1H-imidazol-4-yl)methyl]piperidine series of histamine H3 receptor antagonists. Bioorg Med Chem Lett 2006; 16:989-94.

Bermúdez-Fajardo A, Oviedo-Orta E. Influenza vaccination promotes stable atherosclerotic plaques in apoE knockout mice. Atherosclerosis 2011; 217:97-105.

Bernardi CC, Ribeiro Ede S, Cavalli IJ, Chautard-Freire-Maia EA, Souza RL. Amplification and deletion of the ACHE and BCHE cholinesterase genes in sporadic breast cancer. Cancer Genet Cytogenet 2010; 197:158-65.

Bernardi F, Castaman G, Redaelli R et al. Topologically equivalent mutations causing dysfunctional coagulation factors VII (294Ala→Val) and X (334Ser→Pro). Hum Mol Genet 1994; 3:1175-7.

Bernardi RE, Lattal KM. A role for alpha-adrenergic receptors in extinction of conditioned fear and cocaine conditioned place preference. Behav Neurosci 2010; 124:204-10.

Bernauer U, Heinrich-Hirsch B, Tönnies M, Peter-Matthias W, Gundert-Remy U. Characterisation of the xenobiotic-metabolizing Cytochrome P450 expression pattern in human lung tissue by immunochemical and activity determination. Toxicol Lett 2006; 164:278-88.

Berndt SI, Chatterjee N, Huang WY et al. Variant in sex hormone-binding globulin gene and the risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 2007; 16:165-8.

Berneburg M, Lehmann AR. Xeroderma pigmentosum and related disorders: defects in DNA repair and transcription. Adv Genet 2001; 43:71-102.

Bernini F, Poli A, Paoletti R. Safety of HMG-CoA reductase inhibitors: focus on atorvastatin. Cardiovasc Drugs Ther 2001; 15:211-8.

Bernsdorf A, Giessmann T, Modess C et al. Simvastatin does not influence the intestinal P-glycoprotein and MPR2, and the disposition of talinolol after chronic medication in healthy subjects genotyped for the ABCB1, ABCC2 and SLCO1B1 polymorphisms. Br J Clin Pharmacol 2006; 61:440-50.

Bernstein D, Fajardo G, Zhao M et al. Differential cardioprotective/cardiotoxic effects mediated by beta-adrenergic receptor subtypes. Am J Physiol Heart Circ Physiol 2005; 289:2441-9.

Bernstein RA, Gibbs M, Hunt Batjer H. Clinical diagnosis and successful treatment of inflammatory cerebral amyloid angiopathy. Neurocrit Care 2011; 14:453-5.

Berr C, Richard F, Dufouil C, Amant C, Alperovitch A, Amouyel P. Polymorphism of the prion protein is associated with cognitive impairment in the elderly: the EVA study. Neurology 1998; 51:734-7.

Berr C, Vercambre MN, Bonenfant S, Manoux AS, Zins M, Goldberg M. Occupational exposure to solvents and cognitive performance in the GAZEL cohort: preliminary results. Dement Geriatr Cogn Disord 2010; 30:12-9.

Berrettini WH, Wileyto EP, Epstein L et al. Catechol-O-methyltransferase (COMT) gene variants predict response to bupropion therapy for tobacco dependence. Biol Psychiatry 2007; 61:111-8.

Berriman J, Serpell LC, Oberg KA, Fink AL, Goedert M, Crowther RA. Tau filaments from human brain and from in vitro assembly of recombinant protein show cross-beta structure. Proc Natl Acad Sci USA 2003; 100:9034-8.

Berrougui H, Khalil A. Age-associated decrease of high-density lipoprotein-mediated reverse cholesterol transport activity. Rejuvenation Res 2009; 12:117-26.

Berry BW, Jamali F. Presystemic and systemic chiral inversion of R-(-)-fenoprofen in the rat. J Pharmacol Exp Ther 1991; 258:695-701.

Berry LM, Zhao Z. An examination of IC50 and IC50-shift experiments in assessing time-dependent inhibition of CYP3A4, CYP2D6 and CYP2C9 in human liver microsomes. Drug Metab Lett 2008; 2:51-9.

Berstein LM, Koskela A, Boyarkina MP, Adlercreutz H. Excretion of estrogens, catecholestrogens and phytoestrogens in carriers of BRCA1 gene mutations: effects of metformin. Neoplasma 2010; 57:333-8.

Berstein LM, Yue W, Wang JP, Santen RJ. Isolated and combined action of tamoxifen and metformin in wild-type, tamoxifen-resistant, and estrogen-deprived MCF-7 cells. Breast Cancer Res Treat 2011; 128:109-17.

Bertelsen KM, Venkatakrishnan K, von Moltke LL, Obach RS, Greenblatt DJ. Apparent mechanism-based inhibition of human CYP2D6 in vitro by paroxetine: comparison with fluoxetine and quinidine. Drug Metab Dispos 2003; 31:289-93.

Bertelli M, Cecchin S, Lapucci C et al. Study of the adenosinergic system in the brain of HPRT knockout mouse (Lesch-Nyhan disease). Clin Chim Acta 2006; 373:104-7.

Berthier MT, Paradis AM, Tchernof A et al. The interleukin 6-174G/C polymorphism is associated with indices of obesity in men. J Hum Genet 2003; 48:14-9.

Berthou F, Dreano Y, Belloc C, Kangas L, Gautier JC, Beaune P. Involvement of cytochrome P450 3A enzyme family in the major metabolic pathways of toremifene in human liver microsomes. Biochem Pharmacol 1994; 47:1883-95.

Bertilsson G, Berkenstam A, Blomquist P. Functionally conserved xenobiotic responsive enhancer in cytochrome P450 3A7. Biochem Biophys Res Commun 2001; 280:139-44.

Bertilsson L. Geographical/interracial differences in polymorphic drug oxidation. Current state of knowledge of cytochromes P450 (CYP) 2D6 and 2C19. Clin Pharmacokinet 1995; 29:192-209.

Bertilsson L, Dahl ML, Tybring G. Pharmacogenetics of antidepressants: clinical aspects. Acta Psychiatr Scand Suppl 1997; 391:14-21.

Bertilsson L, Tybring G, Widén J, Chang M, Tomson T. Carbamazepine treatment induces the CYP3A4 catalysed sulphoxidation of omeprazole, but has no or less effect on hydroxylation via CYP2C19. Br J Clin Pharmacol 1997; 44:186-9.

Bertilsson PM, Olsson P, Magnusson KE. Cytokines influence mRNA expression of cytochrome P450 3A4 and MDRI in intestinal cells. J Pharm Sci 2001; 90:638-46.

Bertini I, Rosato A. Menkes disease. Cell Mol Life Sci 2008; 65:89-91.

Bertolino A, Caforio G, Blasi G et al. COMT Val158Met polymorphism predicts negative symptoms response to treatment with olanzapine in schizophrenia. Schizophr Res 2007; 95:253-5.

Bertolino A, Fazio L, Caforio G et al. Functional variants of the dopamine receptor D2 gene modulate prefronto-striatal phenotypes in schizophrenia. Brain 2009; 132:417-25.

Bertolotti M, Gabbi C, Anzivino C et al. Age-related changes in bile acid synthesis and hepatic nuclear receptor expression. Eur J Clin Invest 2007; 37:501-8.

Bertram L, McQueen MB, Mullin K, Blacker D, Tanzi RE. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat Genet 2007; 39:17-23.

Bertrand J, Treluyer JM, Panhard X et al. Influence of pharmacogenetics on indinavir disposition and short-term response in HIV patients initiating HAART. Eur J Clin Pharmacol 2009; 65:667-78.

Bertrand-Thiebault C, Ferrari L, Boutherin-Falson O et al. Cytochromes P450 are differently expressed in normal and varicose human saphenous veins: linkage with varicosis. Clin Exp Pharmacol Physiol 2004; 31:295-301.

Berwaerts J, Cleton A, Herben V et al. The effects of paroxetine on the pharmacokinetics of paliperidone extended-release tablets. Pharmacopsychiatry 2009; 42:158-63.

Besemer J, Harant H, Wang S et al. Selective inhibition of cotranslational translocation of vascular cell adhesion molecule 1. Nature 2005; 436:290-3.

Bessadok A, Garcia E, Jacquet H et al. Recognition of sulfonylurea receptor (ABCC8/9) ligands by the multidrug resistance transporter P-glycoprotein (ABCB1): functional similarities based on common structural features between two multispecific ABC proteins. J Biol Chem 2011; 286:3552-69.

Bessho Y, Oguri T, Ozasa H et al. ABCC10/MRP7 is associated with vinorelbine resistance in non-small cell lung cancer. Oncol Rep 2009; 21:263-8.

Besson A, Salemi S, Deladoëy J et al. Short stature caused by a biologically inactive mutant growth hormone (GH-C53S). J Clin Endocrinol Metab 2005; 90:2493-9.

Bestue-Cardiel M, Sáenz de Cabezón-Alvarez A, Capablo-Liesa JL et al. Congenital endplate acetylcholinesterase deficiency responsive to ephedrine. Neurology 2005; 65:144-6.

Beszłej JA, Grzesiak M, Milejski P. Acute dyskinetic syndrome during chloropromazine treatment of a female patient with CYP2D6 poor metabolism phenotype. Psychiatr Pol 2007; 41:495-501.

Betard C, Robitaille Y, Gee M et al. Apo E allele frequencies in Alzheimer's disease, Lewy body dementia, Alzheimer's disease with cerebrovascular disease and vascular dementia. Neuroreport 1994; 1893-6.

Bethke L, Webb E, Sellick G et al. Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1 and colorectal cancer risk. BMC Cancer 2007; 7:123.

Beukelaers P, Vandenbosch R, Caron N et al. Cdk6-dependent regulation of G(1)Length controls adult neurogenesis. Stem Cells 2011; 29:713-24.

Beulz-Riché D, Grudé P, Puozzo C et al. Characterization of human cytochrome P450 isoenzymes involved in the metabolism of vinorelbine. Fundam Clin Pharmacol 2005; 19:545-53.

Beulz-Riché D, Robert J, Riché C, Ratanasavanh D. Effects of paclitaxel, cyclophosphamide, ifosfamide, tamoxifen and cyclosporine on the metabolism of methoxymorpholinodoxorubicin in human liver microsomes. Cancer Chemother Pharmacol 2002; 49:274-80.

Beuten J, Gelfond JA, Franke JL et al. Single and multigenic analysis of the association between variants in 12 steroid hormone metabolism genes and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 2009; 18:1869-80.

Beutler E, Duparc S; G6PD Deficiency Working Group. Glucose-6-phosphate dehydrogenase deficiency and antimalarial drug development. Am J Trop Med Hyg 2007; 77:779-89.

Beutler E, Gelbart T, Demina A. Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism? Proc Natl Acad Sci USA 1998; 95:8170-4.

Beutler E, Gelbart T, Pegelow C. Erythrocyte glutathione synthetase deficiency leads not only to glutathione but also to glutathione-S-transferase deficiency. J Clin Invest 1986; 77:38-41.

Bevelander GS, Pinto ES, Canario AV, Spanings T, Flik G. CYP27A1 expression in gilthead sea bream (Sparus auratus, L. ): effects of calcitriol and parathyroid hormone-related protein. J Endocrinol 2008; 196:625-35.

Beyeler C, Frey BM, Bird HA. Urinary 6 beta-hydroxycortisol excretion in rheumatoid arthritis. Br J Rheumatol 1997; 36:54-8.

Beyer K, Lao JI, Álvarez XA, Cacabelos R. Different implications of APOE E4 in Alzheimer's disease and vascular dementia in the Spanish population. Alzheimer Res 1996; 2:215-20.

Beyer K, Lao JI, Cacabelos R. Molecular genetics and genotyping in Alzheimer's disease. Ann Psychiatry 1996; 6:173-87.

Beyer K, Lao JI, Carrato C et al. Cystathionine beta synthase as a risk factor for Alzheimer disease. Curr Alzheimer Res 2004; 1:127-33.

Beyer K, Lao-Villadóniga JI, Vecino-Bilbao B, Cacabelos R, de la Fuente-Fernández R. A novel point mutation in the GTP cyclohydrolase I gene in a Spanish family with hereditary progressive and dopa responsive dystonia. J Neurol Neurosurg Psychiatry 1997; 62:420-1.

Beyreuther K, Masters CL. Catching the culprit prion. Nature 1994; 370:419-20.

Bezerra FJ, do Vale NB, de Oliveira Macedo B, Rezende AA, Almeida MG. Evaluation of antioxidant parameters in rats treated with sevoflurane. Rev Bras Anestesiol 2010; 60:162-9, 93-7.

Bezzina CR, Verkerk AO, Busjahn A et al. A common polymorphism in KCNH2 (HERG) hastens cardiac repolarization. Cardiovasc Res 2003; 59:27-36.

Bhagavath B, Carson SA. Ovulation induction in women with polycystic ovary syndrome: an update. Am J Obstet Gynecol 2011. doi:10. 1016/j. ajog. 2011. 06. 007.

Bhandaru M, Kempe DS, Rotte A, Rexhepaj R, Kuhl D, Lang F. Hyperaldosteronism, hypervolemia, and increased blood pressure in mice expressing defective APC. Am J Physiol Regul Integr Comp Physiol 2009; 297:571-5.

Bharadwaj D, Iino M, Kontoyianni M, Smith KJ, Foster DC, Kisiel W. Factor VII central. A novel mutation in the catalytic domain that reduces tissue factor binding, impairs activation by factor Xa, and abolishes amidolytic and coagulant activity. J Biol Chem 1996; 271:30685-91.

Bhardwaj RK, Glaeser H, Becquemont L, Klotz U, Gupta SK, Fromm MF. Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther 2002; 302:645-50.

Bharucha AE, Skaar T, Andrews CN et al. Relationship of cytochrome P450 pharmacogenetics to the effects of yohimbine on gastrointestinal transit and catecholamines in healthy subjects. Neurogastroenterol Motil 2008; 20:891-9.

Bhaskar V, Yin J, Mirza AM et al. Monoclonal antibodies targeting IL-1 beta reduce biomarkers of atherosclerosis in vitro and inhibit atherosclerotic plaque formation in Apolipoprotein E-deficient mice. Atherosclerosis 2011; 216:313-20.

Bhasker CR, Miners JO, Coulter S, Birkett DJ. Allelic and functional variability of cytochrome P4502C9. Pharmacogenetics 1997; 7:51-8.

Bhatnagar S, Damron HA, Hillgartner FB. Fibroblast growth factor-19, a novel factor that inhibits hepatic fatty acid synthesis. J Biol Chem 2009; 284:10023-33.

Bhatnagar V, Garcia EP, O'Connor DT et al. CYP3A4 and CYP3A5 polymorphisms and blood pressure response to amlodipine among African-American men and women with early hypertensive renal disease. Am J Nephrol 2010; 31:95-103.

Bhattacharjee A, Banerjee D, Mookherjee S et al. Leu432Val polymorphism in CYP1B1 as a susceptible factor towards predisposition to primary open-angle glaucoma. Mol Vis 2008; 14:841-50.

Bhattacharjee PS, Huq TS, Mandal TK et al. A novel peptide derived from human apolipoprotein E is an inhibitor of tumor growth and ocular angiogenesis. PLoS One. 2011. doi:10. 1371/journal. pone. 0015905.

Bhattacharya S, Macdonald ST, Farthing CR. Molecular mechanisms controlling the coupled development of myocardium and coronary vasculature. Clin Sci 2006; 111:35-46.

Bhavani V, Srinivasulu M, Ahuja YR, Hasan Q. Role of BRCA1, HSD17B1 and HSD17B2 methylation in breast cancer tissue. Cancer Biomark 2009; 5:207-13.

Bhave VS, Donthamsetty S, Latendresse JR, Cunningham ML, Mehendale HM. Secretory phospholipase A2-mediated progression of hepatotoxicity initiated by acetaminophen is exacerbated in the absence of hepatic COX-2. Toxicol Appl Pharmacol 2011; 251:173-80.

Bhuiyan AR, Chen W, Srinivasan SR et al. G-6A polymorphism of angiotensinogen gene modulates the effect of blood pressure on carotid intima-media thickness. The Bogalusa Heart Study. Am J Hypertens 2007; 20:1073-8.

Bhuiyan MJ, Do HV, Mun S et al. Hypocholesterolemic and hypoglycemic effects of enzymatically modified carbohydrates from rice in high-fat-fed C57BL/6J mice. Mol Nutr Food Res 2011; 55 Suppl 2:214-26.

Bhuiyan ZA, van den Berg MP, van Tintelen JP et al. Expanding spectrum of human RYR2-related disease: new electrocardiographic, structural, and genetic features. Circulation 2007; 116:1569-76.

Bhumbra NA, Sahloff EG, Oehrtman SJ, Horner JM. Exogenous Cushing syndrome with inhaled fluticasone in a child receiving lopinavir/ritonavir. Ann Pharmacother 2007; 41:1306-9.

Bhutia YD, Hung SW, Patel B, Lovin D, Govindarajan R. CNT1 expression influences proliferation and chemosensitivity in drug-resistant pancreatic cancer cells. Cancer Res 2011; 71:1825-35.

Bialecka M, Klodowska-Duda G, Honczarenko K et al. Polymorphisms of catechol-0-methyltransferase (COMT), monoamine oxidase B (MAOB), N-acetyltransferase 2 (NAT2) and cytochrome P450 2D6 (CYP2D6) gene in patients with early onset of Parkinson's disease. Parkinsonism Relat Disord 2007; 13:224-9.

Biancalana M, Koide S. Molecular mechanism of Thioflavin-T binding to amyloid fibrils. Biochim Biophys Acta 2010; 1804:1405-12

Bianchi A, Giustina A, Cimino V et al. Influence of growth hormone receptor d3 and full-length isoforms on biochemical treatment outcomes in acromegaly. J Clin Endocrinol Metab 2009; 94:2015-22.

Bianchino G, Cittadini A, Grieco V et al. Polymorphisms of the CYP1A1, CYP2E1 and XRCC1 genes and cancer risk in a Southern Italian population: a case-control study. Anticancer Res 2011; 31:1359-65.

Biasiotto G, Goldwurm S, Finazzi D et al. HFE gene mutations in a population of Italian Parkinson's disease patients. Parkinsonism Relat Disord 2008; 14:426-30.

Bible KC, Lensing JL, Nelson SA et al. Phase 1 trial of flavopiridol combined with cisplatin or carboplatin in patients with advanced malignancies with the assessment of pharmacokinetic and pharmacodynamic end points. Clin Cancer Res 2005; 11:5935-41.

Bidlack WR, Brown RC, Mohan C. Nutritional parameters that alter hepatic drug metabolism, conjugation, and toxicity. Fed Proc 1986; 45:142-8.

Bidstrup TB, Bjørnsdottir I, Sidelmann UG, Thomsen MS, Hansen KT. CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide. Br J Clin Pharmacol 2003; 56:305-14.

Bidstrup TB, Damkier P, Olsen AK, Ekblom M, Karlsson A, Brøsen K. The impact of CYP2C8 polymorphism and grapefruit juice on the pharmacokinetics of repaglinide. Br J Clin Pharmacol 2006; 61:49-57.

Bidstrup TB, Stilling N, Damkier P, Scharling B, Thomsen MS, Brøsen K. Rifampicin seems to act as both an inducer and an inhibitor of the metabolism of repaglinide. Eur J Clin Pharmacol 2004; 60:109-14.

Bidwell LC, Garrett ME, McClernon FJ et al. A preliminary analysis of interactions between genotype, retrospective ADHD symptoms, and initial reactions to smoking in a sample of young adults. Nicotine Tob Res 2011. doi:10. 1093/ntr/ntr125.

Bièche I, Narjoz C, Asselah T et al. Reverse transcriptase-PCR quantification of mRNA levels from cytochrome (CYP)1, CYP2 and CYP3 families in 22 different human tissues. Pharmacogenet Genomics 2007; 17:731-42.

Biegon A, Kim SW, Alexoff DL et al. Unique distribution of aromatase in the human brain: in vivo studies with PET and [N-methyl-11C]vorozole. Synapse 2010; 64:801-7.

Biegon A, Kim SW, Logan J, Hooker JM, Muench L, Fowler JS. Nicotine blocks brain estrogen synthase (aromatase): in vivo positron emission tomography studies in female baboons. Biol Psychiatry 2010; 67:774-7.

Bielarczyk H, Tomaszewicz M, Madziar B, Cwikowska J, Pawełczyk T, Szutowicz A. Relationships between cholinergic phenotype and acetyl-CoA level in hybrid murine neuroblastoma cells of septal origin. J Neurosci Res 2003; 73:717-21.

Bieler CA, Arlt VM, Wiessler M, Schmeiser HH. DNA adduct formation by the environmental contaminant 3-nitrobenzanthrone in V79 cells expressing human cytochrome P450 enzymes. Cancer Lett 2003; 200:9-18.

Bielohuby M, Roemmler J, Manolopoulou J et al. Chronic growth hormone excess is associated with increased aldosterone: a study in patients with acromegaly and in growth hormone transgenic mice. Exp Biol Med 2009; 234:1002-9.

Bien-Ly N, Andrews-Zwilling Y, Xu Q, Bernardo A, Wang C, Huang Y. C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-beta (Abeta) and acts in concert with Abeta to elicit neuronal and behavioral deficits in mice. Proc Natl Acad Sci USA 2011; 108:4236-41.

Bierau J, Lindhout M, Bakker JA. Pharmacogenetic significance of inosine triphosphatase. Pharmacogenomics 2007; 8:1221-8.

Bierman WF, Scheffer GL, Schoonderwoerd A et al. Protease inhibitors atazanavir, lopinavir and ritonavir are potent blockers, but poor substrates, of ABC transporters in a broad panel of ABC transporter-overexpressing cell lines. J Antimicrob Chemother 2010; 65:1672-80.

Biffi A, Plourde A, Shen Y et al. Screening for familial APP mutations in sporadic cerebral amyloid angiopathy. PLoS One 2010. doi:10. 1371/journal. pone. 0013949.

Biffi A, Sonni A, Anderson CD et al. Variants at APOE influence risk of deep and lobar intracerebral hemorrhage. Ann Neurol 2010; 68:934-43.

Biggs JS, Wan J, Cutler NS et al. Transcription factor binding to a putative double E-box motif represses CYP3A4 expression in human lung cells. Mol Pharmacol 2007; 72:514-25.

Bigler J, Sibert JG, Poole EM, Carlson CS, Potter JD, Ulrich CM. Polymorphisms predicted to alter function in prostaglandin E2 synthase and prostaglandin E2 receptors. Pharmacogenet Genomics 2007; 17:221-7.

Bijl MJ, Luijendijk HJ, van den Berg JF et al. Association between the CYP2D6*4 polymorphism and depression or anxiety in the elderly. Pharmacogenomics 2009; 10:541-7.

Bijl MJ, van Schaik RH, Lammers LA et al. The CYP2D6*4 polymorphism affects breast cancer survival in tamoxifen users. Breast Cancer Res Treat 2009; 118:125-30.

Bijl MJ, Visser LE, Hofman A et al. Influence of the CYP2D6*4 polymorphism on dose, switching and discontinuation of antidepressants. Br J Clin Pharmacol 2008; 65:558-64.

Bijl MJ, Visser LE, van Schaik RH et al. Genetic variation in the CYP2D6 gene is associated with a lower heart rate and blood pressure in beta-blocker users. Clin Pharmacol Ther 2009; 85:45-50.

Bijl N, van Roomen CP, Triantis V et al. Reduction of glycosphingolipid biosynthesis stimulates biliary lipid secretion in mice. Hepatology 2009; 49:637-45.

Bijland S, Rensen PC, Pieterman EJ et al. Perfluoroalkyl sulfonates cause alkyl chain length-dependent hepatic steatosis and hypolipidemia mainly by impairing lipoprotein production in APOE*3-Leiden. CETP mice. Toxicol Sci 2011; 123:290-303.

Bilbao E, Raingeard D, de Cerio OD et al. Effects of exposure to Prestige-like heavy fuel oil and to perfluorooctane sulfonate on conventional biomarkers and target gene transcription in the thicklip grey mullet Chelon labrosus. Aquat Toxicol 2010; 98:282-96.

Bilgi N, Bell K, Ananthakrishnan AN, Atallah E. Imatinib and Panax ginseng: a potential interaction resulting in liver toxicity. Ann Pharmacother 2010; 44:926-8.

Billestrup N, Swanson LW, Vale W. Growth hormone-releasing factor stimulates proliferation of somatotrophs in vitro. Proc Natl Acad Sci USA 1986; 83:6854-7.

Billet S, Bardin S, Verp S et al. Gain-of-function mutant of angiotensin II receptor, type 1A, causes hypertension and cardiovascular fibrosis in mice. J Clin Invest 2007; 117:1914-25.

Binder EB, Bradley RG, Liu W et al. Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. JAMA 2008; 299:1291-305.

Binder EB, Salyakina D, Lichtner P et al. Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. Nat Genet 2004; 36:1319-25.

Bingham TC, Fisher EA, Parathath S, Reiss AB, Chan ES, Cronstein BN. A2A adenosine receptor stimulation decreases foam cell formation by enhancing ABCA1-dependent cholesterol efflux. J Leukoc Biol 2010; 87:683-90.

Bingham TC, Parathath S, Tian H et al. Cholesterol 27-hydroxylase but not Apolipoprotein apoE contributes to A(2A) adenosine receptor stimulated reverse cholesterol transport. Inflammation 2011. doi:10. 1007/s10753-010-9288-y.

Binkhathlan Z, Hamdy DA, Brocks DR, Lavasanifar A. Pharmacokinetics of PSC 833 (valspodar) in its Cremophor EL formulation in rat. Xenobiotica 2010; 40:55-61.

Biolo A, Clausell N, Santos KG et al. Impact of beta1-adrenergic receptor polymorphisms on susceptibility to heart failure, arrhythmogenesis, prognosis, and response to beta-blocker therapy. Am J Cardiol 2008; 102:726-32.

Bird MG, Wetmore BA, Letinski DJ et al. Influence of toluene co-exposure on the metabolism and genotoxicity of benzene in mice using continuous and intermittent exposures. Chem Biol Interact 2010; 184:233-9.

Birks J, Grimley Evans J, Iakovidou V, Tsolaki M, Holt FE. Rivastigmine for Alzheimer's disease. Cochrane Database Syst Rev 2009; CD001191.

Birks J. Cholinesterase inhibitors for Alzheimer's disease. Cochrane Database Syst Rev 2006: CD005593.

Birmann BM, Tamimi RM, Giovannucci E et al. Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myeloma. Cancer Epidemiol Biomarkers Prev 2009; 18:282-8.

Biron CA, Byron KS, Sullivan JL. Severe herpesvirus infections in an adolescent without natural killer cells. N Engl J Med 1989; 320:1731-5.

Bis JC, Smith NL, Psaty BM et al. Angiotensinogen Met235Thr polymorphism, angiotensin-converting enzyme inhibitor therapy, and the risk of nonfatal stroke or myocardial infarction in hypertensive patients. Am J Hypertens 2003; 16:1011-7.

Bisaga A, Kos T, Wójcikowski J, Daniel WA, Popik P. Brain levels of dextromethorphan and the intensity of opioid withdrawal in mice. Drug Alcohol Depend 2008; 95:147-51.

Bischoff E. Vardenafil preclinical trial data: potency, pharmacodynamics, pharmacokinetics, and adverse events. Int J Impot Res 2004; 16 Suppl 1:34-7.

Bishop GM, Robinson SR, Liu Q, Perry G, Atwood CS, Smith MA. Iron: a pathological mediator of Alzheimer disease? Dev Neurosci 2002; 24:184-7.

Bishop JR, Bishop DL. Iloperidone for the treatment of schizophrenia. Drugs Today 2010; 46:567-79.

Bishop JR, Ellingrod VL, Moline J, Miller D. Association between the polymorphic GRM3 gene and negative symptom improvement during olanzapine treatment. Schizophr Res 2005; 77:253-60.

Bishop JR, Miller DD, Ellingrod VL, Holman T. Association between type-three metabotropic glutamate receptor gene (GRM3) variants and symptom presentation in treatment refractory schizophrenia. Hum Psychopharmacol 2011. doi:10. 1002/hup. 1163.

Bistrup C, Nielsen FT, Jeppesen UE, Dieperink H. Effect of grapefruit juice on Sandimmun Neoral absorption among stable renal allograft recipients. Nephrol Dial Transplant 2001; 16:373-7.

Biundo R, Gardini S, Caffarra P et al. Influence of APOE status on lexical-semantic skills in mild cognitive impairment. J Int Neuropsychol Soc 2011; 17:1-8.

Bixby D, Talpaz M. Mechanisms of resistance to tyrosine kinase inhibitors in chronic myeloid leukemia and recent therapeutic strategies to overcome resistance. Hematology Am Soc Hematol Educ Program 2009:461-76.

Bjelajac A, Goo AK, Weart CW. Prevention and regression of atherosclerosis: effects of HMG-CoA reductase inhibitors. Ann Pharmacother 1996; 30:1304-15.

Bjork JA, Lau C, Chang SC, Butenhoff JL, Wallace KB. Perfluorooctane sulfonate-induced changes in fetal rat liver gene expression. Toxicology 2008; 251:8-20.

Björkhem I, Hansson M. Cerebrotendinous xanthomatosis: an inborn error in bile acid synthesis with defined mutations but still a challenge. Biochem Biophys Res Commun 2010; 396:46-9.

Björkman S. Prediction of drug disposition in infants and children by means of physiologically based pharmacokinetic (PBPK) modelling: theophylline and midazolam as model drugs. Br J Clin Pharmacol 2005; 59:691-704.

Björkman S. Prediction of cytochrome p450-mediated hepatic drug clearance in neonates, infants and children: how accurate are available scaling methods? Clin Pharmacokinet 2006; 45:1-11.

Bjørnerheim R, Frøysaker T, Hansson V. Effects of chronic amiodarone treatment on human myocardial beta adrenoceptor density and adenylate cyclase response. Cardiovasc Res 1991; 25:503-9.

Blaas L, Kornfeld JW, Schramek D et al. Disruption of the growth hormone-signal transducer and activator of transcription 5-insulinlike growth factor 1 axis severely aggravates liver fibrosis in a mouse model of cholestasis. Hepatology 2010; 51:1319-26.

Black JL, Litzow MR, Hogan WJ et al. Correlation of CYP2B6, CYP2C19, ABCC4 and SOD2 genotype with outcomes in allogeneic blood and marrow transplant patients. Leuk Res 2011. doi:10. 1016/j. leukres. 2011. 06. 020.

Black MP, Balthazart J, Baillien M, Grober MS. Rapid increase in aggressive behavior precedes the decrease in brain aromatase activity during socially mediated sex change in Lythrypnus dalli. Gen Comp Endocrinol 2011; 170:119-24.

Blacker D, Laird NM, Wilcox MA et al. Alpha-2 macroglobulin is genetically associated with Alzheimer disease. Nat Genet 1998; 19:357-60.

Blagodatskikh KA, Evdokimova MA, Agapkina IuV et al. Gene IL6 G(-174)C and gene IL10 G(-1082)A polymorphisms are associated with unfavourable outcomes in patients with acute coronary syndrome. Mol Biol 2010; 44:839-46.

Blagojevic A, Delaney JA, Lévesque LE, Dendukuri N, Boivin JF, Brophy JM. Investigation of an interaction between statins and clopidogrel after percutaneous coronary intervention: a cohort study. Pharmacoepidemiol Drug Saf 2009; 18:362-9.

Blaisdell J, Jorge-Nebert LF, Coulter S et al. Discovery of new potentially defective alleles of human CYP2C9. Pharmacogenetics 2004; 14:527-37.

Blaisdell J, Mohrenweiser H, Jackson J et al. Identification and functional characterization of new potentially defective alleles of human CYP2C19. Pharmacogenetics 2002; 12:703-11.

Blake JA, Pritchard M, Ding S et al. Coexpression of a human P450 (CYP3A4) and P450 reductase generates a highly functional monooxygenase system in Escherichia coli. FEBS Lett 1996; 397:210-4.

Blake MJ, Abdel-Rahman SM, Pearce RE, Leeder JS, Kearns GL. Effect of diet on the development of drug metabolism by cytochrome P-450 enzymes in healthy infants. Pediatr Res 2006; 60:717-23.

Blake MJ, Gaedigk A, Pearce RE et al. Ontogeny of dextromethorphan O- and N-demethylation in the first year of life. Clin Pharmacol Ther 2007; 81:510-6.

Blakely EL, Trip SA, Swalwell H et al. A new mitochondrial transfer RNAPro gene mutation associated with myoclonic epilepsy with ragged-red fibers and other neurological features. Arch Neurol 2009; 66:399-402.

Blakemore AI, Cox A, Gonzalez AM et al. Interleukin-1 receptor antagonist allele (IL1RN*2) associated with nephropathy in diabetes mellitus. Hum Genet 1996; 97:369-74.

Blakey GE, Lockton JA, Perrett J et al. Pharmacokinetic and pharmacodynamic assessment of a five-probe metabolic cocktail for CYPs 1A2, 3A4, 2C9, 2D6 and 2E1. Br J Clin Pharmacol 2004; 57:162-9.

Blanco JG, Edick MJ, Hancock ML et al. Genetic polymorphisms in CYP3A5, CYP3A4 and NQO1 in children who developed therapy-related myeloid malignancies. Pharmacogenetics 2002; 12:605-11.

Blanco JG, Harrison PL, Evans WE, Relling MV. Human cytochrome P450 maximal activities in pediatric versus adult liver. Drug Metab Dispos 2000; 28:379-82.

Bland TM, Haining RL, Tracy TS, Callery PS. CYP2C-catalyzed delta9-tetrahydrocannabinol metabolism: kinetics, pharmacogenetics and interaction with phenytoin. Biochem Pharmacol 2005; 70:1096-103.

Blando JM, Carbajal S, Abel E et al. Cooperation between Stat3 and Akt signaling leads to prostate tumor development in transgenic mice. Neoplasia 2011; 13:254-65.

Blank MC, Stefanescu RN, Masuda E et al. Decreased transcription of the human FCGR2B gene mediated by the -343 G/C promoter polymorphism and association with systemic lupus erythematosus. Hum Genet 2005; 117:220-7.

Blanpain C, Lee B, Tackoen M et al. Multiple nonfunctional alleles of CCR5 are frequent in various human populations. Blood 2000; 96:1638-45.

Blanpain C, Libert F, Vassart G, Parmentier M. CCR5 and HIV infection. Receptors Channels 2002; 8:19-31.

Blasi G, Bertolino A. Imaging genomics and response to treatment with antipsychotics in schizophrenia. NeuroRx 2006; 3:117-30.

Blasko I, Kemmler G, Jungwirth S et al. Prospective study on association between plasma amyloid beta-42 and atherosclerotic risk factors. J Neural Transm 2011; 118:663-72.

Bleasby K, Castle JC, Roberts CJ et al. Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: a resource for investigations into drug disposition. Xenobiotica 2006; 36:963-88.

Bleasby K, Hall LA, Perry JL, Mohrenweiser HW, Pritchard JB. Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6). J Pharmacol Exp Ther 2005; 314:923-31.

Blech S, Ludwig-Schwellinger E, Gräfe-Mody EU, Withopf B, Wagner K. The metabolism and disposition of the oral dipeptidyl peptidase-4 inhibitor, linagliptin, in humans. Drug Metab Dispos 2010; 38:667-78.

Bleecker ER, Nelson HS, Kraft M et al. Beta2-receptor polymorphisms in patients receiving salmeterol with or without fluticasone propionate. Am J Respir Crit Care Med 2010; 181:676-87.

Bleecker ER, Postma DS, Lawrance RM, Meyers DA, Ambrose HJ, Goldman M. Effect of ADRB2 polymorphisms on response to longacting beta2-agonist therapy: a pharmacogenetic analysis of two randomised studies. Lancet 2007; 370:2118-25.

Bleecker ER, Yancey SW, Baitinger LA et al. Salmeterol response is not affected by beta2-adrenergic receptor genotype in subjects with persistent asthma. J Allergy Clin Immunol 2006; 118:809-16.

Blevins-Primeau AS, Sun D, Chen G et al. Functional significance of UDP-glucuronosyltransferase variants in the metabolism of active tamoxifen metabolites. Cancer Res 2009; 69:1892-900.

Bleyer AJ, Zivná M, Hulková H et al. Clinical and molecular characterization of a family with a dominant renin gene mutation and response to treatment with fludrocortisone. Clin Nephrol 2010; 74:411-22.

Bliek BJ, van Schaik RH, van der Heiden IP et al. Maternal medication use, carriership of the ABCB1 3435C > T polymorphism and the risk of a child with cleft lip with or without cleft palate. Am J Med Genet A 2009; 149:2088-92.

Bliesath H, Huber R, Steinijans VW, Koch HJ, Kunz K, Wurst W. Pantoprazole does not interact with nifedipine in man under steady-state conditions. Int J Clin Pharmacol Ther 1996; 34:51-5.

Bloch B, Reshef A, Cohen T et al. Preliminary effects of bupropion and the promoter region (HTTLPR) serotonin transporter (SLC6A4) polymorphism on smoking behavior in schizophrenia. Psychiatry Res 2010; 175:38-42.

Blokzijl H, van der Borght S, Bok LI et al. Decreased P-glycoprotein (P-gp/MDR1) expression in inflamed human intestinal epithelium is independent of PXR protein levels. Inflamm Bowel Dis 2007; 13:710-20.

Blom TS, Linder MD, Snow K et al. Defective endocytic trafficking of NPC1 and NPC2 underlying infantile Niemann-Pick type C disease. Hum Mol Genet 2003; 12:257-72.

Blomberg Jensen M, Andersen CB, Nielsen JE et al. Expression of the vitamin D receptor, 25-hydroxylases, 1alpha-hydroxylase and 24-hydroxylase in the human kidney and renal clear cell cancer. J Steroid Biochem Mol Biol 2010; 121:376-82.

Blomberg Jensen M, Nielsen JE, Jørgensen A et al. Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract. Hum Reprod 2010; 25:1303-11.

Blonk MI, van der Velde N, van den Bemt PM, van Schaik RH, van der Cammen TJ. CYP2D6*4, CYP3A5*3 and ABCB1 3435T polymorphisms and drug-related falls in elderly people. Pharm World Sci 2010; 32:26-9.

Bloom J, Hinrichs AL, Wang JC et al. The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans. Pharmacogenet Genomics 2011; 21:403-16.

Blum M, Suzuki A, Ajani JA. A comprehensive review of S-1 in the treatment of advanced gastric adenocarcinoma. Future Oncol 2011; 7:715-26.

Blum S, Milman U, Shapira C et al. Dual therapy with statins and antioxidants is superior to statins alone in decreasing the risk of cardiovascular disease in a subgroup of middle-aged individuals with both diabetes mellitus and the haptoglobin 2-2 genotype. Arterioscler Thromb Vasc Biol 2008; 28:18-20.

Blume H, Donath F, Warnke A, Schug BS. Pharmacokinetic drug interaction profiles of proton pump inhibitors. Drug Saf 2006; 29:769-84.

Blume N, Leonard J, Xu ZJ, Watanabe O, Remotti H, Fishman J. Characterization of Cyp2d22, a novel cytochrome P450 expressed in mouse mammary cells. Arch Biochem Biophys 2000; 381:191-204.

Boada M, Antunez C, López-Arrieta J et al. Estrogen receptor alpha gene variants are associated with Alzheimer's disease. Neurobiol Aging 2010. doi:10. 1016/j. neurobiolaging. 2010. 06. 016.

Board PG, Shaw DC. Determination of the amino acid substitution in human prothrombin type 3 (157 Glu leads to Lys) and the localization of a third thrombin cleavage site. Br J Haematol 1983; 54:245-54.

Bobrowska-Hägerstrand M, Wróbel A, Rychlik B, Ohman I, Hägerstrand H. Flow cytometric monitoring of multidrug drug resistance protein 1 (MRP1/ABCC1) -mediated transport of 2',7'-bis-(3-carboxypropyl)-5-(and-6)-carboxyfluorescein (BCPCF) into human erythrocyte membrane inside-out vesicles. Mol Membr Biol 2007; 24:485-95.

Bocca C, Bozzo F, Bassignana A, Miglietta A. Antiproliferative effects of COX-2 inhibitor celecoxib on human breast cancer cell lines. Mol Cell Biochem 2011; 350:59-70.

Bock KW, Schrenk D, Forster A et al. The influence of environmental and genetic factors on CYP2D6, CYP1A2 and UDP-glucuronosyltransferases in man using sparteine, caffeine, and paracetamol as probes. Pharmacogenetics 1994; 4:209-18.

Boctor AM, Eickholt M, Pugsley TA. Meclofenamate sodium is an inhibitor of both the 5-lipoxygenase and cyclooxygenase pathways of the arachidonic acid cascade in vitro. Prostaglandins Leukot Med 1986; 23:229-38.

Bochud M, Eap CB, Maillard M et al. Association of ABCB1 genetic variants with renal function in Africans and in Caucasians. BMC Med Genomics 2008; 1:21.

Bochud PY, Chien JW, Marr KA et al. Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation. N Engl J Med 2008; 359:1766-77.

Bode KA, Donner MG, Leier I, Keppler D. Inhibition of transport across the hepatocyte canalicular membrane by the antibiotic fusidate. Biochem Pharmacol 2002; 64:151-8.

Bodin K, Bretillon L, Aden Y et al. Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4. J Biol Chem 2001; 276:38685-9.

Bodin K, Lindbom U, Diczfalusy U. Novel pathways of bile acid metabolism involving CYP3A4. Biochim Biophys Acta 2005; 1687:84-93.

Bodin L, Perdu J, Diry M, Horellou MH, Loriot MA. Multiple genetic alterations in vitamin K epoxide reductase complex subunit 1 gene (VKORC1) can explain the high dose requirement during oral anticoagulation in humans. J Thromb Haemost 2008; 6:1436-9.

Bodin L, Verstuyft C, Tregouet DA et al. Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity. Clin Pharmacol Ther 2007; 2:185-93.

Boeckmann L, Nickel AC, Kuschal C et al. Temozolomide chemoresistance heterogeneity in melanoma with different treatment regimens: DNA damage accumulation contribution. Melanoma Res 2011; 21:206-16.

Boeckmann L, Schirmer M, Rosenberger A et al. Effect of DNA repair host factors on temozolomide or dacarbazine melanoma treatment in Caucasians. Pharmacogenet Genomics 2009; 19:760-9.

Boehnke M, Conneally P, Lange K. Two models for a maternal factor in the inheritance of Huntington disease. Am J Hum Genet 1983; 35:845-60.

Boek-Dohalská L, Hodek P, Sulc M, Stiborová M. alpha-Naphthoflavone acts as activator and reversible or irreversible inhibitor of rabbit microsomal CYP3A6. Chem Biol Interact 2001; 138:85-106.

Boekhout AH, Beijnen JH, Schellens JH. Trastuzumab. Oncologist 2011; 16:800-10.

Bogaards JJ, van Ommen B, Wolf CR, van Bladeren PJ. Human cytochrome P450 enzyme selectivities in the oxidation of chlorinated benzenes. Toxicol Appl Pharmacol 1995; 132:44-52.

Bogaards JJ, Venekamp JC, van Bladeren PJ. The biotransformation of isoprene and the two isoprene monoepoxides by human cytochrome P450 enzymes, compared to mouse and rat liver microsomes. Chem Biol Interact 1996; 102:169-82.

Bogachev O, Majdalawieh A, Pan X, Zhang L, Ro HS. AEBP1, a novel macrophage proinflammatory mediator, over-expression promotes and ablation attenuates atherosclerosis in ApoE(-)(/)(-) and LDLR(-)(/)(-) mice. Mol Med 2011; 17:1056-64.

Bogard C, Daveau M, Deybach JC et al. Heme and acute inflammation role in vivo of heme in the hepatic expression of positive acute-phase reactants in rats. Eur J Biochem 1999; 261:190-6.

Bogman K, Silkey M, Chan SP, Tomlinson B, Weber C. Influence of CYP2C19 genotype on the pharmacokinetics of R483, a CYP2C19 substrate, in healthy subjects and type 2 diabetes patients. Eur J Clin Pharmacol 2010; 66:1005-15.

Bogner JR, Lutz B, Klein HG, Pollerer C, Troendle U, Goebel FD. Association of highly active antiretroviral therapy failure with chemokine receptor 5 wild type. HIV Med 2004; 5:264-72.

Bogush TA, Dudko EA, Bogush EA, Kirsanov VIu, Antonov VG. Glutoxime-an inhibitor of multiple drug resistance phenotype associated with Pgp expression. Antibiot Khimioter 2010; 55:18-23.

Bohan A, Chen WS, Denson LA, Held MA, Boyer JL. Tumor necrosis factor alpha-dependent up-regulation of Lrh-1 and Mrp3(Abcc3) reduces liver injury in obstructive cholestasis. J Biol Chem 2003; 278:36688-98.

Bohan KH, Mansuri TF, Wilson NM. Anticonvulsant hypersensitivity syndrome: implications for pharmaceutical care. Pharmacotherapy 2007; 27:1425-39.

Bohanec Grabar P, Grabnar I, Rozman B et al. Investigation of the influence of CYP1A2 and CYP2C19 genetic polymorphism on 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide (A77 1726) pharmacokinetics in leflunomide-treated patients with rheumatoid arthritis. Drug Metab Dispos 2009; 37:2061-8.

Bohanec Grabar P, Rozman B, Tomsic M, Suput D, Logar D, Dolzan V. Genetic polymorphism of CYP1A2 and the toxicity of leflunomide treatment in rheumatoid arthritis patients. Eur J Clin Pharmacol 2008; 64:871-6.

Bohets H, Lavrijsen K, Hendrickx J et al. Identification of the cytochrome P450 enzymes involved in the metabolism of cisapride: in vitro studies of potential co-medication interactions. Br J Pharmacol 2000; 129:1655-67.

Böhmer G, Gleiter CH, Hünnemeyer A, Lahu G, Bethke TD. Study investigating pharmacokinetic interaction between theophylline and roflumilast in healthy adults. Int J Clin Pharmacol Ther 2011; 49:451-60.

Böhmer GM, Drollmann A, Gleiter CH, Nave R. Effect of coadministered ketoconazole, a strong cytochrome P450 3A4 enzyme inhibitor, on the pharmacokinetics of ciclesonide and its active metabolite desisobutyryl-ciclesonide. Clin Pharmacokinet 2008; 47:343-9.

Böhmer GM, Gleiter CH, Mörike K, Nassr N, Walz A, Lahu G. No dose adjustment on coadministration of the PDE4 inhibitor roflumilast with a weak CYP3A, CYP1A2, and CYP2C19 inhibitor: an investigation using cimetidine. J Clin Pharmacol 2011; 51:594-602.

Bohn M, Berge KE, Bakken A, Erikssen J, Berg K. Insertion/deletion (I/D) polymorphism at the locus for angiotensin I-converting enzyme and parental history of myocardial infarction. Clin Genet 1993; 44:298-301.

Bohnenstengel F, Hofmann U, Eichelbaum M, Kroemer HK. Characterization of the cytochrome P450 involved in side-chain oxidation of cyclophosphamide in humans. Eur J Clin Pharmacol 1996; 51:297-301.

Bois C, Delalande C, Nurmio M et al. Age- and cell-related gene expression of aromatase and estrogen receptors in the rat testis. J Mol Endocrinol 2010; 45:147-59.

Bojanic DD, Tarr PT, Gale GD et al. Differential expression and function of ABCG1 and ABCG4 during development and aging. J Lipid Res 2010; 51:169-81.

Bokesch HR, Cartner LK, Fuller RW et al. Inhibition of ABCG2-mediated drug efflux by naphthopyrones from marine crinoids. Bioorg Med Chem Lett 2010; 20:3848-50.

Bolbrinker J, Beige J, Huber M et al. Role of CYP2C9 genetic variants for salt sensitivity and the regulation of the renin-angiotensin-aldosterone system in normotensive men. J Hypertens 2011; 29:56-61.

Bolk GS, Salomon R, Pelet A et al. Segregation at three loci explains familial and population risk in Hirschsprung disease. Nat Genet 2002; 31:89-93.

Bolognin S, Messori L, Drago D, Gabbiani C, Cendron L, Zatta P. Aluminum, copper, iron and zinc differentially alter amyloid-Aβ(1-42) aggregation and toxicity. Int J Biochem Cell Biol 2011; 43:877-85.

Bolt HM, Selinski S, Dannappel D, Blaszkewicz M, Golka K. Re-investigation of the concordance of human NAT2 phenotypes and genotypes. Arch Toxicol 2005; 79:196-200.

Bolt HM. Rifampicin, a keystone inducer of drug metabolism: from Herbert Remmer's pioneering ideas to modern concepts. Drug Metab Rev 2004; 36:497-509.

Bolufer P, Barragan E, Collado M, Cervera J, López JA, Sanz MA. Influence of genetic polymorphisms on the risk of developing leukemia and on disease progression. Leuk Res 2006; 30:1471-91.

Bolufer P, Collado M, Barragán E et al. The potential effect of gender in combination with common genetic polymorphisms of drug-metabolizing enzymes on the risk of developing acute leukemia. Haematologica 2007; 92:308-14.

Bolufer P, Collado M, Barragan E et al. Profile of polymorphisms of drug-metabolising enzymes and the risk of therapy-related leukaemia. Br J Haematol 2007; 136:590-6.

Bolland MJ, Bagg W, Thomas MG, Lucas JA, Ticehurst R, Black PN. Cushing's syndrome due to interaction between inhaled corticosteroids and itraconazole. Ann Pharmacother 2004; 38:46-9.

Bombail V, Taylor K, Gibson GG, Plant N. Role of Sp1, C/EBP alpha, HNF3, and PXR in the basal- and xenobiotic-mediated regulation of the CYP3A4 gene. Drug Metab Dispos 2004; 32:525-35.

Bomsien S, Aderjan R, Mattern R, Skopp G. Effect of psychotropic medication on the in vitro metabolism of buprenorphine in human cDNA-expressed cytochrome P450 enzymes. Eur J Clin Pharmacol 2006; 62:639-43.

Bomsien S, Skopp G. An in vitro approach to potential methadone metabolic-inhibition interactions. Eur J Clin Pharmacol 2007; 63:821-7.

Bonagura TW, Zhou H, Babischkin JS, Pepe GJ, Albrecht ED. Expression of P-450 aromatase, estrogen receptor α and β, and α-inhibin in the fetal baboon testis after estrogen suppression during the second half of gestation. Endocrine 2011; 39:75-82.

Bonapace G, Concolino D, Formicola S, Strisciuglio P. A novel mutation in a patient with insulin-like growth factor 1 (IGF1) deficiency. J Med Genet 2003; 40:913-7.

Bonaventure P, Umans L, Bakker MH et al. Humanization of mouse 5-hydroxytryptamine1B receptor gene by homologous recombination: in vitro and in vivo characterization. Mol Pharmacol 1999; 56:54-67.

Bondiolotti G, Sala M, Pollera C et al. Pharmacokinetics and distribution of clioquinol in golden hamsters. J Pharm Pharmacol 2007; 59:387-93.

Bondolfi G, Chautems C, Rochat B, Bertschy G, Baumann P. Non-response to citalopram in depressive patients: pharmacokinetic and clinical consequences of a fluvoxamine augmentation. Psychopharmacology 1996; 128:421-5.

Bondolfi G, Eap CB, Bertschy G, Zullino D, Vermeulen A, Baumann P. The effect of fluoxetine on the pharmacokinetics and safety of risperidone in psychotic patients. Pharmacopsychiatry 2002; 35:50-6.

Bongaerts BW, de Goeij AF, Wouters KA et al. Alcohol consumption, alcohol dehydrogenase 1C (ADH1C) genotype, and risk of colorectal cancer in the Netherlands Cohort Study on diet and cancer. Alcohol 2011; 45:217-25.

Boni J, Abbas R, Leister C et al. Disposition of desipramine, a sensitive cytochrome P450 2D6 substrate, when coadministered with intravenous temsirolimus. Cancer Chemother Pharmacol 2009; 64:263-70.

Boni J, Leister C, Burns J, Cincotta M, Hug B, Moore L. Pharmacokinetic profile of temsirolimus with concomitant administration of cytochrome p450-inducing medications. J Clin Pharmacol 2007; 47:1430-9.

Boni JP, Hug B, Leister C, Sonnichsen D. Intravenous temsirolimus in cancer patients: clinical pharmacology and dosing considerations. Semin Oncol 2009; 36 Suppl 3:18-25.

Boni JP, Leister C, Burns J, Hug B. Differential effects of ketoconazole on exposure to temsirolimus following intravenous infusion of temsirolimus. Br J Cancer 2008; 98:1797-802.

Boni R, Vortmeyer AO, Pack S et al. Somatic mutations of the MEN1 tumor suppressor gene detected in sporadic angiofibromas. J Invest Derm 1998; 111:539-40.

Bonkovsky HL, Naishadham D, Lambrecht RW et al. Roles of iron and HFE mutations on severity and response to therapy during retreatment of advanced chronic hepatitis C. Gastroenterology 2006; 131:1440-51.

Bonn B, Masimirembwa CM, Aristei Y, Zamora I. The molecular basis of CYP2D6-mediated N-dealkylation: balance between metabolic clearance routes and enzyme inhibition. Drug Metab Dispos 2008; 36:2199-210.

Bonn B, Masimirembwa CM, Castagnoli N Jr. Exploration of catalytic properties of CYP2D6 and CYP3A4 through metabolic studies of levorphanol and levallorphan. Drug Metab Dispos 2010; 38:187-99.

Bonnabry P, Leemann T, Dayer P. Role of human liver microsomal CYP2C9 in the biotransformation of lornoxicam. Eur J Clin Pharmacol 1996; 49:305-8.

Bonnabry P, Sievering J, Leemann T, Dayer P. Quantitative drug interactions prediction system (Q-DIPS): a computer-based prediction and management support system for drug metabolism interactions. Eur J Clin Pharmacol 1999; 55:341-7.

Bonnardeaux A, Davies E, Jeunemaitre X et al. Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension. Hypertension 1994; 24:63-9.

Bonnefond A, Durand E, Sand O et al. Molecular diagnosis of neonatal diabetes mellitus using next-generation sequencing of the whole exome. PLoS One 2010. doi:10. 1371/journal. pone. 0013630.

Bonner-Jackson A, Okonkwo O, Tremont G; the Alzheimer's Disease Neuroimaging Initiative. Apolipoprotein E ε2 and Functional Decline in Amnestic Mild Cognitive Impairment and Alzheimer Disease. Am J Geriatr Psychiatry 2011; 19:607-17.

Bonnet U. Moclobemide: therapeutic use and clinical studies. CNS Drug Rev 2003; 9:97-140.

Bonnycastle LL, Yu CE, Wijsman EM et al. The c-fos gene and early-onset familial Alzheimer's disease. Neurosci Lett 1993; 160:33-6.

Bono M, Cases A, Calls J et al. Effect of antihypertensive treatment on the increased beta 2-adrenoceptor density in patients with essential hypertension. Am J Hypertens 1995; 8:487-93.

Bonomini F, Rodella LF, Moghadasian M, Lonati C, Coleman R, Rezzani R. Role of apolipoprotein E in renal damage protection. Histochem Cell Biol 2011; 135:571-9.

Bonora-Centelles A, Jover R, Mirabet V et al. Sequential hepatogenic transdifferentiation of adipose tissue-derived stem cells: relevance of different extracellular signaling molecules, transcription factors involved and expression of new key marker genes. Cell Transplant 2009; 18:1319-40.

Bönsch D, Lederer T, Reulbach U, Hothorn T, Kornhuber J, Bleich S. Joint analysis of the NACP-REP1 marker within the alpha synuclein gene concludes association with alcohol dependence. Hum Mol Genet 2005; 14:967-71.

Bonvicini C, Minelli A, Scassellati C et al. Serotonin transporter gene polymorphisms and treatment-resistant depression. Prog Neuropsychopharmacol Biol Psychiatry 2010; 34:934-9.

Boobis AR, McKillop D, Robinson DT, Adams DA, McCormick DJ. Interlaboratory comparison of the assessment of P450 activities in human hepatic microsomal samples. Xenobiotica 1998; 28:493-506.

Boocock DJ, Brown K, Gibbs AH, Sánchez E, Turteltaub KW, White IN. Identification of human CYP forms involved in the activation of tamoxifen and irreversible binding to DNA. Carcinogenesis 2002; 23:1897-901.

Boon WC, Horne MK. Aromatase and its inhibition in behaviour, obsessive compulsive disorder and parkinsonism. Steroids 2011; 76:816-9.

Boquoi A, Chen T, Enders GH. Chemoprevention of mouse intestinal tumorigenesis by the cyclin-dependent kinase inhibitor SNS-032. Cancer Prev Res 2009; 2:800-6.

Boraska Jelavić T, Barisić M, Drmic Hofman I et al. Microsatelite GT polymorphism in the toll-like receptor 2 is associated with colorectal cancer. Clin Genet 2006; 70:156-60.

Borg A, Isola J, Chen J et al. Germline BRCA1 and HMLH1 mutations in a family with male and female breast carcinoma. Int J Cancer 2000; 85:796-800.

Borgaonkar DS, Schmidt LC, Martin SE et al. Linkage of late-onset Alzheimer's disease with apolipoprotein E type 4 on chromosome 19. Lancet 1993; 342:625.

Börgel J, Bulut D, Hanefeld C et al. The CYP2J2 G-50T polymorphism and myocardial infarction in patients with cardiovascular risk profile. BMC Cardiovasc Disord 2008; 8:41.

Borggreve SE, Hillege HL, Wolffenbuttel BHR et al. The effect of cholesterol ester transfer protein -629C-A promoter polymorphism on high-density lipoprotein cholesterol is dependent on serum triglycerides. J Clin Endocr Metab 2005; 90:4198-202.

Borghese B, Barbaux S, Mondon F et al. Research resource: genome-wide profiling of methylated promoters in endometriosis reveals a subtelomeric location of hypermethylation. Mol Endocrinol 2010; 24:1872-85.

Borgiani P, Ciccacci C, Forte V et al. CYP4F2 genetic variant (rs2108622) significantly contributes to warfarin dosing variability in the Italian population. Pharmacogenomics 2009; 10:261-6.

Boriani G, Biffi M, Diemberger I, Domenichini G, Marziali A, Martignani C. Atrial fibrillation: Adverse effects of "pill-in-the-pocket" treatment and propafenone-carvedilol interaction. Int J Cardiol 2010; 140:242-3.

Borkowska E, Binka-Kowalska A, Constantinou M, Nawrocka A, Matych J, Kałuzewski B. P53 mutations in urinary bladder cancer patients from Central Poland. J Appl Genet 2007; 48:177-83.

Borlak J, Walles M, Levsen K, Thum T. Verapamil: metabolism in cultures of primary human coronary arterial endothelial cells. Drug Metab Dispos 2003; 31:888-91.

Borlak J, Zwadlo C. Expression of drug-metabolizing enzymes, nuclear transcription factors and ABC transporters in Caco-2 cells. Xenobiotica 2003; 33:927-43.

Borlak JT, Harsany V, Schneble H, Haegele KD. pNAT and CYP2D6 gene polymorphism in epileptic patients. Biochem Pharmacol 1994; 48:1717-20.

Borobia AM, Novalbos J, Guerra-López P et al. Influence of sex and CYP2D6 genotype on mirtazapine disposition, evaluated in Spanish healthy volunteers. Pharmacol Res 2009; 59:393-8.

Borowiec M, Liew CW, Thompson R et al. Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction. Proc Natl Acad Sci USA 2009; 106:14460-5.

Borozdenkova S, Smith J, Marshall S, Yacoub M, Rose M. Identification of ICAM-1 polymorphism that is associated with protection from transplant associated vasculopathy after cardiac transplantation. Hum Immunol 2001; 62:247-55.

Borrelli F, Izzo AA. Herb-drug interactions with St John's wort (Hypericum perforatum): an update on clinical observations. AAPS J 2009; 11:710-27.

Borroni B, Grassi M, Archetti S et al. Genetic background predicts poor prognosis in frontotemporal lobar degeneration. Neurodegener Dis 2011; 8:289-95.

Borska S, Sopel M, Chmielewska M, Zabel M, Dziegiel P. Quercetin as a potential modulator of P-glycoprotein expression and function in cells of human pancreatic carcinoma line resistant to daunorubicin. Molecules 2010; 15:857-70.

Borst P, Evers R, Kool M, Wijnholds J. A family of drug transporters: the multidrug resistance-associated proteins. J Natl Cancer Inst 2000; 92:1295-302.

Bort R, Gómez-Lechón MJ, Castell JV, Jover R. Role of hepatocyte nuclear factor 3 gamma in the expression of human CYP2C genes. Arch Biochem Biophys 2004; 426:63-72.

Bort R, Macé K, Boobis A, Gómez-Lechón MJ, Pfeifer A, Castell J. Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways. Biochem Pharmacol 1999; 58:787-96.

Bortezomib: new indication. Second-line treatment of myeloma: limited efficacy, major risks. Prescrire Int 2006; 15:98-100.

Bosco P, Caraci F, Copani A et al. The CDC2 I-G-T haplotype associated with the APOE epsilon4 allele increases the risk of sporadic Alzheimer's disease in Sicily. Neurosci Lett 2007; 419:195-8.

Bosch TM, Deenen M, Pruntel R et al. Screening for polymorphisms in the PXR gene in a Dutch population. Eur J Clin Pharmacol 2006; 62:395-9.

Bosch TM, Doodeman VD, Smits PH, Meijerman I, Schellens JH, Beijnen JH. Pharmacogenetic screening for polymorphisms in drug-metabolizing enzymes and drug transporters in a Dutch population. Mol Diagn Ther 2006; 10:175-85.

Bosch TM, Meijerman I, Beijnen JH, Schellens JH. Genetic polymorphisms of drug-metabolising enzymes and drug transporters in the chemotherapeutic treatment of cancer. Clin Pharmacokinet 2006; 45:253-85.

Bose PD, Sarma MP, Medhi S, Das BC, Husain SA, Kar P. Role of polymorphic N-acetyl transferase2 and cytochrome P4502E1 gene in antituberculosis treatment-induced hepatitis. J Gastroenterol Hepatol 2011; 26:312-8.

Bosia M, Anselmetti S, Pirovano A et al. HTTLPR functional polymorphism in schizophrenia: executive functions vs. sustained attention dissociation. Prog Neuropsychopharmacol Biol Psychiatry 2010; 34:81-5.

Bosma PJ, Chowdhury JR, Bakker C et al. The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome. N Engl J Med 1995; 333:1171-5.

Bosma PJ, Chowdhury JR, Huang TJ et al. Mechanisms of inherited deficiencies of multiple UDP-glucuronosyltransferase isoforms in two patients with Crigler-Najjar syndrome, type I. FASEB J 1992; 6:2859-63.

Bosma PJ, Chowdhury NR, Goldhoorn BG et al. Sequence of exons and the flanking regions of human bilirubin-UDP-glucuronosyltransferase gene complex and identification of a genetic mutation in a patient with Crigler-Najjar syndrome, type I. Hepatology 1992; 15:941-7.

Bosma PJ, Goldhoorn B, Oude Elferink RP, Sinaasappel M, Oostra BA, Jansen PL. A mutation in bilirubin uridine 5'-diphosphate-glucuronosyltransferase isoform 1 causing Crigler-Najjar syndrome type II. Gastroenterology 1993; 105:288-93.

Bosron WF, Magnes LJ, Li TK. Human liver alcohol dehydrogenase: ADH(Indianapolis) results from genetic polymorphism at the ADH-2 gene locus. Biochem Genet 1983; 21:735-44.

Bossé Y, Lemire M, Poon AH et al. Asthma and genes encoding components of the vitamin D pathway. Respir Res 2009; 10:98.

Bossé Y, Vohl MC, Dumont M et al. Influence of the angiotensin-converting enzyme gene insertion/deletion polymorphism on lipoprotein/lipid response to gemfibrozil. Clin Genet 2002; 62:45-52.

Bosso JA, Liu Q, Evans WE, Relling MV. CYP2D6, N-acetylation, and xanthine oxidase activity in cystic fibrosis. Pharmacotherapy 1996; 16:749-53.

Bot I, Jukema JW, Lankhuizen IM, van Berkel TJ, Biessen EA. Atorvastatin inhibits plaque development and adventitial neovascularization in ApoE deficient mice independent of plasma cholesterol levels. Atherosclerosis 2011; 214:295-300.

Bothe H, Gassmann K, Götz C, Fritsche E, Abel J, Haarmann-Stemmann T. Epigallocatechin-3-gallate does not affect the activity of enzymes involved in metabolic activation and cellular excretion of benzo[a]pyrene in human colon carcinoma cells. Toxicol Lett 2011; 203:258-64.

Bothe H, Götz C, Stobbe-Maicherski N, Fritsche E, Abel J, Haarmann-Stemmann T. Luteolin enhances the bioavailability of benzo(a)pyrene in human colon carcinoma cells. Arch Biochem Biophys 2010; 498:111-8.

Botsch S, Gautier JC, Beaune P, Eichelbaum M, Kroemer HK. Identification and characterization of the cytochrome P450 enzymes involved in N-dealkylation of propafenone: molecular base for interaction potential and variable disposition of active metabolites. Mol Pharmacol 1993; 43:120-6.

Böttiger Y. Use of omeprazole sulfone in a single plasma sample as a probe for CYP3A4. Eur J Clin Pharmacol 2006; 62:621-5.

Böttiger Y, Säwe J, Brattström C et al. Pharmacokinetic interaction between single oral doses of diltiazem and sirolimus in healthy volunteers. Clin Pharmacol Ther 2001; 69:32-40.

Böttiger Y, Tybring G, Götharson E, Bertilsson L. Inhibition of the sulfoxidation of omeprazole by ketoconazole in poor and extensive metabolizers of S-mephenytoin. Clin Pharmacol Ther 1997; 62:384-91.

Bottini N, de Luca D, Saccucci P et al. Autism: evidence of association with adenosine deaminase genetic polymorphism. Neurogenetics 2001; 3:111-3.

Bottke D, Koychev D, Busse A et al. Fractionated irradiation can induce functionally relevant multidrug resistance gene and protein expression in human tumor cell lines. Radiat Res 2008; 170:41-8.

Botton MR, Bandinelli E, Rohde LE, Amon LC, Hutz MH. Influence of genetic, biological and pharmacological factors on warfarin dose in a Southern Brazilian population of European ancestry. Br J Clin Pharmacol 2011; 72:442-50.

Bottorff MB. Statin safety and drug interactions: clinical implications. Am J Cardiol 2006; 97:27-31.

Bottova I, Sauder U, Olivieri V, Hehl AB, Sonda S. The P-glycoprotein inhibitor GF120918 modulates Ca2+-dependent processes and lipid metabolism in Toxoplasma gondii. PLoS One 2010. doi:10. 1371/journal. pone. 0010062.

Bouamar R, Hesselink DA, van Schaik RH et al. Polymorphisms in CYP3A5, CYP3A4, and ABCB1 are not associated with cyclosporine pharmacokinetics nor with cyclosporine clinical end points after renal transplantation. Ther Drug Monit 2011; 33:178-84.

Bouchard L, Faucher G, Tchernof A et al. Comprehensive genetic analysis of the dipeptidyl peptidase-4 gene and cardiovascular disease risk factors in obese individuals. Acta Diabetol 2009; 46:13-21.

Bouchet BP, Galmarini CM. Cabazitaxel, a new taxane with favorable properties. Drugs Today 2010; 46:735-42.

Boudinot E, Bernard V, Camp S et al. Influence of differential expression of acetylcholinesterase in brain and muscle on respiration. Respir Physiol Neurobiol 2009; 165:40-8.

Bouguerne B, Belkheiri N, Bedos-Belval F et al. Antiatherogenic effect of bisvanillyl-hydralazone, a new hydralazine derivative with antioxidant, carbonyl scavenger, and antiapoptotic properties. Antioxid Redox Signal 2011; 14:2093-106.

Bouhali K, Dipietromaria A, Fontaine A et al. Allelic reduction of Dlx5 and Dlx6 results in early follicular depletion: a new mouse model of primary ovarian insufficiency. Hum Mol Genet 2011; 20:2642-50.

Boulange-Lecomte C, Geraudie P, Forget-Leray J, Gerbron M, Minier C. Ligula intestinalis infection is associated with alterations of both brain and gonad aromatase expression in roach (Rutilus rutilus). J Helminthol 2011; 85:339-44.

Boulton DW, Arnaud P, DeVane CL. Pharmacokinetics and pharmacodynamics of methadone enantiomers after a single oral dose of racemate. Clin Pharmacol Ther 2001; 70:48-57.

Boulton DW, deVane CL, Liston HL, Markowitz JS. In vitro P-glycoprotein affinity for atypical and conventional antipsychotics. Life Sci 2002; 71:163-9.

Boumpas DT, Anastassiou ED, Older SA, Tsokos GC, Nelson DL, Balow JE. Dexamethasone inhibits human interleukin 2 but not interleukin 2 receptor gene expression in vitro at the level of nuclear transcription. J Clin Invest 1991; 87:1739-47.

Bounhar Y, Zhang Y, Goodyer CG, LeBlanc A. Prion protein protects human neurons against Bax-mediated apoptosis. J Biol Chem 2001; 276:39145-9.

Bouquié R, Deslandes G, Renaud C, Dailly E, Haloun A, Jolliet P. Colchicine-induced rhabdomyolysis in a heart/lung transplant patient with concurrent use of cyclosporin, pravastatin, and azithromycin. J Clin Rheumatol 2011; 17:28-30.

Bouraïma-Lelong H, Vanneste M, Delalande C, Zanatta L, Wolczynski S, Carreau S. Aromatase gene expression in immature rat Sertoli cells: age-related changes in the FSH signalling pathway. Reprod Fertil Dev 2010; 22:508-15.

Bourcier K, Hyland R, Kempshall S et al. Investigation into UDP-glucuronosyltransferase (UGT) enzyme kinetics of imidazole- and triazole-containing antifungal drugs in human liver microsomes and recombinant UGT enzymes. Drug Metab Dispos 2010; 38:923-9.

Bourdeaut F, Hérault A, Gentien D et al. Mosaicism for oncogenic G12D KRAS mutation associated with epidermal nevus, polycystic kidneys and rhabdomyosarcoma. J Med Genet 2010; 47:859-62.

Bourguinat C, Kamgno J, Boussinesq M, Mackenzie CD, Prichard RK, Geary TG. Analysis of the mdr-1 gene in patients co-infected with Onchocerca volvulus and Loa loa who experienced a post-ivermectin serious adverse event. Am J Trop Med Hyg 2010; 83:28-32.

Bourguinat C, Keller K, Blagburn B, Schenker R, Geary TG, Prichard RK. Correlation between loss of efficacy of macrocyclic lactone heartworm anthelmintics and P-glycoprotein genotype. Vet Parasitol 2011; 176:374-81.

Bourguinat C, Keller K, Prichard RK, Geary TG. Genetic polymorphism in Dirofilaria immitis. Vet Parasitol 2011; 176:368-73.

Bourkiza R, Joyce S, Patel H et al. Cerebrotendinous xanthomatosis (CTX): an association of pulverulent cataracts and pseudo-dominant developmental delay in a family with a splice site mutation in CYP27A1-a case report. Ophthalmic Genet 2010; 31:73-6.

Bournique B, Lambert N, Boukaiba R, Martinet M. In vitro metabolism and drug interaction potential of a new highly potent anti-cytomegalovirus molecule, CMV423 (2-chloro 3-pyridine 3-yl 5,6,7,8-tetrahydroindolizine I-carboxamide). Br J Clin Pharmacol 2001; 52:53-63.

Bournique B, Petry M, Gousset G. Usefulness of statistic experimental designs in enzymology: example with recombinant hCYP3A4 and 1A2. Anal Biochem 1999; 276:18-26.

Bournissen FG, Moretti ME, Juurlink DN, Koren G, Walker M, Finkelstein Y. Polymorphism of the MDR1/ABCB1 C3435T drug-transporter and resistance to anticonvulsant drugs: a meta-analysis. Epilepsia 2009; 50:898-903.

Bourquard N, Ng CJ, Reddy ST. Impaired hepatic insulin signalling in PON2-deficient mice: a novel role for the PON2/apoE axis on the macrophage inflammatory response. Biochem J 2011; 436:91-100.

Bourrié M, Meunier V, Berger Y, Fabre G. Cytochrome P450 isoform inhibitors as a tool for the investigation of metabolic reactions catalyzed by human liver microsomes. J Pharmacol Exp Ther 1996; 277:321-32.

Bourrié M, Meunier V, Berger Y, Fabre G. Role of cytochrome P-4502C9 in irbesartan oxidation by human liver microsomes. Drug Metab Dispos 1999; 27:288-96.

Bousquet L, Pruvost A, Guyot AC, Farinotti R, Mabondzo A. Combination of tenofovir and emtricitabine plus efavirenz: in vitro modulation of ABC transporter and intracellular drug accumulation. Antimicrob Agents Chemother 2009; 53:896-902.

Boutros PC, Yao CQ, Watson JD et al. Hepatic transcriptomic responses to TCDD in dioxin-sensitive and dioxin-resistant rats during the onset of toxicity. Toxicol Appl Pharmacol 2011; 251:119-29.

Bouvard B, Hoppé E, Soulié P et al. High prevalence of vertebral fractures in women with breast cancer starting aromatase inhibitor therapy. Ann Oncol 2011. doi:10. 1093/annonc/mdr356.

Bouwman AC, Bovenhuis H, Visker MH, van Arendonk JA. Genome-wide association of milk fatty acids in Dutch dairy cattle. BMC Genet 2011; 12:43.

Bowen WP, Carey JE, Miah A et al. Measurement of cytochrome P450 gene induction in human hepatocytes using quantitative real-time reverse transcriptase-polymerase chain reaction. Drug Metab Dispos 2000; 28:781-8.

Bowers DJ, Calvano JE, Alvarez SM et al. Polymorphisms of heat shock protein-70 (HSPA1B and HSPA1L loci) do not influence infection or outcome risk in critically ill surgical patients. Shock 2006; 25:117-22.

Bowers JM, Waddell J, McCarthy MM. A developmental sex difference in hippocampal neurogenesis is mediated by endogenous oestradiol. Biol Sex Differ 2010; 1:8.

Boyd RA, Stern RH, Stewart BH et al. Atorvastatin coadministration may increase digoxin concentrations by inhibition of intestinal P-glycoprotein-mediated secretion. J Clin Pharmacol 2000; 40:91-8.

Boyer SH, Sun Z, Jiang H et al. Synthesis and characterization of a novel liver-targeted prodrug of cytosine-1-beta-D-arabinofuranoside monophosphate for the treatment of hepatocellular carcinoma. J Med Chem 2006; 49:7711-20.

Boyle J, Kill IR, Parris CN. Heterogeneity of dimer excision in young and senescent human dermal fibroblasts. Aging Cell 2005; 4:247-55.

Bozdag G, Alp A, Saribas Z, Tuncer S, Aksu T, Gurgan T. CYP17 and CYP2C19 gene polymorphisms in patients with endometriosis. Reprod Biomed Online 2010; 20:286-90.

Bozina N, Bradamante V, Lovrić M. Genetic polymorphism of metabolic enzymes P450 (CYP) as a susceptibility factor for drug response, toxicity, and cancer risk. Arh Hig Rada Toksikol 2009; 60:217-42.

Bozina N, Jovanović N, Lovrić M, Medved V. Clinical significance of a CYP2D6 poor metabolizer-a patient with schizophrenia on risperidone treatment. Ther Drug Monit 2008; 30:748-51.

Bozina N, Kuzman MR, Medved V, Jovanovic N, Sertic J, Hotujac L. Associations between MDR1 gene polymorphisms and schizophrenia and therapeutic response to olanzapine in female schizophrenic patients. J Psychiatr Res 2008; 42:89-97.

Bozkurt O, de Boer A, Grobbee DE et al. Variation in Renin-Angiotensin system and salt-sensitivity genes and the risk of diabetes mellitus associated with the use of thiazide diuretics. Am J Hypertens 2009; 22:545-51.

Bozkurt O, de Boer A, Grobbee DE, Heerdink ER, Burger H, Klungel OH. Pharmacogenetics of glucose-lowering drug treatment: a systematic review. Mol Diagn Ther 2007; 11:291-302.

Bozkurt O, Verschuren WM, van Wieren-de Wijer BM et al. Genetic variation in the renin-angiotensin system modifies the beneficial effects of ACE inhibitors on the risk of diabetes mellitus among hypertensives. J Hum Hypertens 2008; 22:774-80.

Bozovic-Spasojevic I, Azambuja E, McCaskill-Stevens W, Dinh P, Cardoso F. Chemoprevention for breast cancer. Cancer Treat Rev 2011. doi:10. 1016/j. ctrv. 2011. 07. 005.

Bozzuto G, Colone M, Toccacieli L, Stringaro A, Molinari A. Tea tree oil might combat melanoma. Planta Med 2011; 77:54-6.

Braam W, van Geijlswijk I, Keijzer H, Smits MG, Didden R, Curfs LM. Loss of response to melatonin treatment is associated with slow melatonin metabolism. J Intellect Disabil Res 2010; 54:547-55.

Bracale R, Pasanisi F, Labruna G et al. Metabolic syndrome and ADRB3 gene polymorphism in severely obese patients from South Italy. Eur J Clin Nutr 2007; 61:1213-9.

Brackbill ML, Kidd RS, Abdoo AD, Warner JG Jr, Harralson AF. Frequency of CYP3A4, CYP3A5, CYP2C9, and CYP2C19 variant alleles in patients receiving clopidogrel that experience repeat acute coronary syndrome. Heart Vessels 2009; 24:73-8.

Brackenbury WJ, Davis TH, Chen C et al. Voltage-gated Na+ channel beta1 subunit-mediated neurite outgrowth requires Fyn kinase and contributes to postnatal CNS development in vivo. J Neurosci 2008; 28:3246-56.

Brackett CC, Bloch JD. Phenytoin as a possible cause of acetaminophen hepatotoxicity: case report and review of the literature. Pharmacotherapy 2000; 20:229-33.

Bracht K, Liebeke M, Ritter CA, Grünert R, Bednarski PJ. Correlations between the activities of 19 standard anticancer agents, antioxidative enzyme activities and the expression of ATP-binding cassette transporters: comparison with the National Cancer Institute data. Anticancer Drugs 2007; 18:389-404.

Brachtendorf L, Jetter A, Beckurts KT, Hölscher AH, Fuhr U. Cytochrome P450 enzymes contributing to demethylation of maprotiline in man. Pharmacol Toxicol 2002; 90:144-9.

Bradberry SM, Cage SA, Proudfoot AT, Vale JA. Poisoning due to pyrethroids. Toxicol Rev 2005; 24:93-106.

Bradbury PA, Kulke MH, Heist RS et al. Cisplatin pharmacogenetics, DNA repair polymorphisms, and esophageal cancer outcomes. Pharmacogenet Genomics 2009; 19:613-25.

Bradbury PA, Zhai R, Ma C et al. Vascular endothelial growth factor polymorphisms and esophageal cancer prognosis. Clin Cancer Res 2009; 15:4680-5.

Bradford J, Shin JY, Roberts M, Wang CE, Li X-J, Li SH. Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms. Proc. Natl. Acad. Sci USA 2009; 106:22480-5.

Bradford J, Shin JY, Roberts M, Wang CE, Li X-J, Li SH. Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice. J Biol Chem 2010; 285:10653-61.

Bradford LD. CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants. Pharmacogenomics 2002; 3:229-43.

Braeuning A, Köhle C, Buchmann A, Schwarz M. Coordinate regulation of cytochrome P450 1A1 expression in mouse liver by the aryl hydrocarbon receptor and the {beta}-catenin pathway. Toxicol Sci 2011; 122:16-25.

Brainard DM, Kassahun K, Wenning LA et al. Lack of a clinically meaningful pharmacokinetic effect of rifabutin on raltegravir: in vitro/in vivo correlation. J Clin Pharmacol 2011; 51:943-50.

Brakensiek K, Frye-Boukhriss H, Mälzer M et al. Detection of a significant association between mutations in the ACVRL1 gene and hepatic involvement in German patients with hereditary haemorrhagic telangiectasia. Clin Genet 2008; 74:171-7.

Bram EE, Stark M, Raz S, Assaraf YG. Chemotherapeutic drug-induced ABCG2 promoter demethylation as a novel mechanism of acquired multidrug resistance. Neoplasia 2009; 11:1359-70.

Brancati F, Valente EM, Castori M et al. Role of the dopamine D5 receptor (DRD5) as a susceptibility gene for cervical dystonia. J Neurol Neurosurg Psychiatry 2003; 74:665-6.

Branch RA, Adedoyin A, Frye RF, Wilson JW, Romkes M. In vivo modulation of CYP enzymes by quinidine and rifampin. Clin Pharmacol Ther 2000; 68:401-11.

Branch RA, Chern HD, Adedoyin A et al. The procarcinogen hypothesis for bladder cancer: activities of individual drug metabolizing enzymes as risk factors. Pharmacogenetics 1995; 5 Spec No:S97-102.

Brand E, Chatelain N, Paillard F et al. Detection of putative functional angiotensinogen (AGT) gene variants controlling plasma AGT levels by combined segregation-linkage analysis. Eur J Hum Genet 2002; 10:715-23.

Brand W, Boersma MG, Bik H et al. Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples. Drug Metab Dispos 2010; 38:617-25.

Brand W, Padilla B, van Bladeren PJ, Williamson G, Rietjens IM. The effect of co-administered flavonoids on the metabolism of hesperetin and the disposition of its metabolites in Caco-2 cell monolayers. Mol Nutr Food Res 2010; 54:851-60.

Brand W, van der Wel PA, Rein MJ et al. Metabolism and transport of the citrus flavonoid hesperetin in Caco-2 cell monolayers. Drug Metab Dispos 2008; 36:1794-802.

Brandel JP, Preece M, Brown P et al. Distribution of codon 129 genotype in human growth hormone-treated CJD patients in France and the UK. Lancet 2003; 326:128-30.

Brandes LJ. N,N-diethyl-2-[4-(phenylmethyl) phenoxy] ethanamine (DPPE; tesmilifene), a chemopotentiating agent with hormetic effects on DNA synthesis in vitro, may improve survival in patients with metastatic breast cancer. Hum Exp Toxicol 2008; 27:143-7.

Brandes LJ, Queen GM, LaBella FS. N,N-diethyl-2-[4-(phenylmethyl)phenoxy] ethanamine (DPPE) a chemopotentiating and cytoprotective agent in clinical trials: interaction with histamine at cytochrome P450 3A4 and other isozymes that metabolize antineoplastic drugs. Cancer Chemother Pharmacol 2000; 45:298-304.

Brandhorst G, Tenderich G, Zittermann A et al. Everolimus exposure in cardiac transplant recipients is influenced by concomitant calcineurin inhibitor. Ther Drug Monit 2008; 30:113-6.

Brandin H, Myrberg O, Rundlöf T, Arvidsson AK, Brenning G. Adverse effects by artificial grapefruit seed extract products in patients on warfarin therapy. Eur J Clin Pharmacol 2007; 63:565-70.

Brandin H, Viitanen E, Myrberg O, Arvidsson AK. Effects of herbal medicinal products and food supplements on induction of CYP1A2, CYP3A4 and MDR1 in the human colon carcinoma cell line LS180. Phytother Res 2007; 21:239-44.

Brandon EF, Sparidans RW, Guijt KJ et al. In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis, Trabectidin), a novel marine anti-cancer drug. Invest New Drugs 2006; 24:3-14.

Brandon EF, Sparidans RW, Meijerman I, Manzanares I, Beijnen JH, Schellens JH. In vitro characterization of the biotransformation of thiocoraline, a novel marine anti-cancer drug. Invest New Drugs 2004; 22:241-51.

Brandon EF, Sparidans RW, van Ooijen RD et al. In vitro characterization of the human biotransformation pathways of aplidine, a novel marine anti-cancer drug. Invest New Drugs 2007; 25:9-19.

Brandon-Warner E, Sugg JA, Schrum LW, McKillop IH. Silibinin inhibits ethanol metabolism and ethanol-dependent cell proliferation in an in vitro model of hepatocellular carcinoma. Cancer Lett 2010; 291:120-9.

Brandstätter A, Lamina C, Kiechl S et al. Sex and age interaction with genetic association of atherogenic uric acid concentrations. Atherosclerosis 2010; 210:474-8.

Brandt JT, Close SL, Iturria SJ et al. Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel. J Thromb Haemost 2007; 5:2429-36.

Brandt S. TERT over-expression affects the growth of myocardial tissue derived from mouse embryonic stem cells. Differentiation 2010; 79:1-8.

Branford S, Melo JV, Hughes TP. Selecting optimal second-line tyrosine kinase inhibitor therapy for chronic myeloid leukemia patients after imatinib failure: does the BCR-ABL mutation status really matter? Blood 2009; 114:5426-35.

Branford S, Rudzki Z, Walsh S et al. High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance. Blood 2002; 99:3472-5.

Brannan MD, Reidenberg P, Radwanski E et al. Loratadine administered concomitantly with erythromycin: pharmacokinetic and electrocardiographic evaluations. Clin Pharmacol Ther 1995; 58:269-78.

Brant SR, Panhuysen CIM, Nicolae D et al. MDR1 Ala893 polymorphism is associated with inflammatory bowel disease. Am J Hum Genet 2003; 73:282-92.

Brantley MA Jr, Fang AM, King JM, Tewari A, Kymes SM, Shiels A. Association of complement factor H and LOC387715 genotypes with response of exudative age-related macular degeneration to intravitreal bevacizumab. Ophthalmology 2007; 114:2168-73.

Braoudaki M, Karpusas M, Katsibardi K et al. Frequency of FLT3 mutations in childhood acute lymphoblastic leukemia. Med Oncol 2009; 26:460-2.

Brasch-Andersen C, Møller MU, Christiansen L et al. A candidate gene study of serotonergic pathway genes and pain relief during treatment with escitalopram in patients with neuropathic pain shows significant association to serotonin receptor2C (HTR2C). Eur J Clin Pharmacol 2011; 67:1131-7.

Brasier AR, Li J. Mechanisms for inducible control of angiotensinogen gene transcription. Hypertension 1996; 27:465-75.

Bratton SM, Mosher CM, Khallouki F et al. Analysis of R- and S-Hydroxywarfarin glucuronidation catalyzed by human liver microsomes and recombinant UDP-glucuronosyltransferases. J Pharmacol Exp Ther 2011. doi:10. 1124/jpet. 111. 184721.

Brauch H, Jordan VC. Targeting of tamoxifen to enhance antitumour action for the treatment and prevention of breast cancer: the 'personalised' approach? Eur J Cancer 2009; 45:2274-83.

Brauch H, Mürdter TE, Eichelbaum M, Schwab M. Pharmacogenomics of tamoxifen therapy. Clin Chem 2009; 55:1770-82.

Braun A, Kammerer S, Bohme E, Muller B, Roscher AA. Identification of polymorphic sites of the human bradykinin B (2) receptor gene. Biochem Biophys Res Commun 1995; 211:234-40.

Braun MS, Richman SD, Quirke P et al. Predictive biomarkers of chemotherapy efficacy in colorectal cancer: results from the UK MRC FOCUS trial. J Clin Oncol 2008; 26:2690-8.

Braun MS, Richman SD, Thompson L et al. Association of molecular markers with toxicity outcomes in a randomized trial of chemotherapy for advanced colorectal cancer: the FOCUS trial. J Clin Oncol 2009; 27:5519-28.

Brave M, Goodman V, Kaminskas E et al. Sprycel for chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia resistant to or intolerant of imatinib mesylate. Clin Cancer Res 2008; 14:352-9.

Bravo CF, Curtis LR, Myers MS et al. Biomarker responses and disease susceptibility in juvenile rainbow trout Oncorhynchus mykiss fed a high molecular weight PAH mixture. Environ Toxicol Chem 2011; 30:704-14.

Bray J, Sludden J, Griffin MJ et al. Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide. Br J Cancer 2010; 102:1003-9.

Bray NJ, Preece A, Williams NM et al. Haplotypes at the dystrobrevin binding protein 1 (DTNBP1) gene locus mediate risk for schizophrenia through reduced DTNBP1 expression. Hum Mol Genet 2005; 14:1947-54.

Bray PF, Cannon CP, Goldschmidt-Clermont P et al. The platelet Pl(A2) and angiotensin-converting enzyme (ACE) D allele polymorphisms and the risk of recurrent events after acute myocardial infarction. Am J Cardiol 2001; 88:347-52.

Brazier MW, Volitakis I, Kvasnicka M et al. Manganese chelation therapy extends survival in a mouse model of M1000 prion disease. J Neurochem 2010; 114:440-51.

Breast and Prostate Cancer Cohort Consortium; Cox DG, Bretsky P et al. Haplotypes of the estrogen receptor beta gene and breast cancer risk. Int J Cancer 2008; 122:387-92.

Breast Cancer Linkage Consortium. Pathology of familial breast cancer: differences between breast cancers in carriers of BRCA1 or BRCA2 mutations and sporadic cases. Lancet 1997; 349:1505-10.

Brechbuhl HM, Gould N, Kachadourian R, Riekhof WR, Voelker DR, Day BJ. Glutathione transport is a unique function of the ATP-binding cassette protein ABCG2. J Biol Chem 2010; 285:16582-7.

Brecht WJ, Harris FM, Chang S et al. Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice. J Neurosci 2004; 24:2527-34.

Bredberg E, Andersson TB, Frison L et al. Ximelagatran, an oral direct thrombin inhibitor, has a low potential for cytochrome P450-mediated drug-drug interactions. Clin Pharmacokinet 2003; 42:765-77.

Bredschneider M, Klein K, Mürdter TE et al. Genetic polymorphisms of glutathione S-transferase A1, the major glutathione S-transferase in human liver: consequences for enzyme expression and busulfan conjugation. Clin Pharmacol Ther 2002; 71:479-87.

Breedveld P, Pluim D, Cipriani G et al. The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models. Mol Pharmacol 2007; 71:240-9.

Breinholt VM, Offord EA, Brouwer C, Nielsen SE, Brøsen K, Friedberg T. In vitro investigation of cytochrome P450-mediated metabolism of dietary flavonoids. Food Chem Toxicol 2002; 40:609-16.

Breitling LP, Dahmen N, Mittelstraß K et al. Association of nicotinic acetylcholine receptor subunit alpha4 polymorphisms with nicotine dependence in 5500 Germans. Pharmacogenomics J 2009; 19:657-9.

Bremer T, Diamond C, McKinney R et al. The pharmacogenetics of lithium response depends upon clinical co-morbidity. Mol Diagn Ther 2007; 11:161-70.

Brennan B, Chiu Y, Berthelon L, Kolis S, Davies B. Effect of age and gender on the pharmacokinetics of R667, a novel agent for the treatment of emphysema, in healthy volunteers. J Pharm Pharm Sci 2007; 10:9-16.

Brennan BJ, Brown AB, Kolis SJ, Rutman O, Gooden C, Davies BE. Effect of R667, a novel emphysema agent, on the pharmacokinetics of midazolam in healthy men. J Clin Pharmacol 2006; 46:222-8.

Brennan P, Lewis S, Hashibe M et al. Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE review. Am J Epidemiol 2004; 159:1-16.

Brennan RM, Burrows SR. A mechanism for the HLA-A*01-associated risk for EBV+ Hodgkin lymphoma and infectious mononucleosis. Blood 2008; 112:2589-90.

Brenner SS, Herrlinger C, Dilger K et al. Influence of age and cytochrome P450 2C9 genotype on the steady-state disposition of diclofenac and celecoxib. Clin Pharmacokinet 2003; 42:283-92.

Brent D, Melhem N, Ferrell R et al. Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study. Am J Psychiatry 2010; 167:190-7.

Bressler R. Grapefruit juice and drug interactions. Exploring mechanisms of this interaction and potential toxicity for certain drugs. Geriatrics 2006; 61:12-8.

Breuer MA, Schmidt B, Schuphan I. Utility of Nicotiana tabacum cell suspension cultures expressing human CYP1A1, CYP1A2 and CYP3A4 to study the oxidative metabolism of the herbicide 14C-fluometuron. Drug Metab Lett 2009; 3:18-27.

Breyer-Pfaff U. The metabolic fate of amitriptyline, nortriptyline and amitriptylinoxide in man. Drug Metab Rev 2004; 36:723-46.

Bridges CC, Joshee L, Zalups RK. MRP2 and the DMPS- and DMSA-mediated elimination of mercury in TR(-) and control rats exposed to thiol S-conjugates of inorganic mercury. Toxicol Sci 2008; 105:211-20.

Bridges CC, Joshee L, Zalups RK. MRP2 and the handling of mercuric ions in rats exposed acutely to inorganic and organic species of mercury. Toxicol Appl Pharmacol 2011; 251:50-8.

Bridges SL Jr, Kelley JM, Hughes LB. The HLA-DRB1 shared epitope in Caucasians with rheumatoid arthritis: a lesson learned from tic-tac-toe. Arthritis Rheum 2008; 58:1211-5.

Briest S, Stearns V. Tamoxifen metabolism and its effect on endocrine treatment of breast cancer. Clin Adv Hematol Oncol 2009; 7:185-92.

Brigelius-Flohé R. Vitamin E and drug metabolism. Biochem Biophys Res Commun 2003; 305:737-40.

Brigelius-Flohé R. Induction of drug metabolizing enzymes by vitamin E. J Plant Physiol 2005; 162:797-802.

Brignac-Huber L, Reed JR, Backes WL. Organization of NADPH-cytochrome P450 reductase and CYP1A2 in the endoplasmic reticulum-microdomain localization affects monooxygenase function. Mol Pharmacol 2011; 79:549-57.

Brill S, Zimmermann C, Berger K, Drewe J, Gutmann H. In vitro interactions with repeated grapefruit juice administration-to peel or not to peel? Planta Med 2009; 75:332-5.

Brimer C, Dalton JT, Zhu Z et al. Creation of polarized cells coexpressing CYP3A4, NADPH cytochrome P450 reductase and MDR1/P-glycoprotein. Pharm Res 2000; 17:803-10.

Brinkman A, de Jong D, Tuinman S, Azaouagh N, van Agthoven T, Dorssers LC. The substrate domain of BCAR1 is essential for anti-estrogen-resistant proliferation of human breast cancer cells. Breast Cancer Res Treat 2010; 120:401-8.

Brinks H, Koch WJ. Targeting G protein-coupled receptor kinases (GRKs) in Heart Failure. Drug Discov Today Dis Mech 2010; 7:129-34.

Brionne TC, Tesseur I, Masliah E, Wyss-Coray T. Loss of TGF-beta-1 leads to increased neuronal cell death and microgliosis in mouse brain. Neuron 2003; 40:1133-45.

Brisson D, Ledoux K, Bossé Y et al. Effect of apolipoprotein E, peroxisome proliferator-activated receptor alpha and lipoprotein lipase gene mutations on the ability of fenofibrate to improve lipid profiles and reach clinical guideline targets among hypertriglyceridemic patients. Pharmacogenetics 2002; 12:313-20.

Bristow MR, Murphy GA, Krause-Steinrauf H et al. An alpha2C-adrenergic receptor polymorphism alters the norepinephrine-lowering effects and therapeutic response of the beta-blocker bucindolol in chronic heart failure. Circ Heart Fail 2010; 3:21-8.

Brito DD, Fernandes AP, Gomes KB et al. Apolipoprotein A5-1131T>C polymorphism, but not APOE genotypes, increases susceptibility for dyslipidemia in children and adolescents. Mol Biol Rep 2011; 38:4381-8.

Britten AC, Mijovic CH, Barnett AH, Kelly MA. Differential expression of HLA-DQ alleles in peripheral blood mononuclear cells: alleles associated with susceptibility to and protection from autoimmune type 1 diabetes. Int J Immunogenet 2009; 36:47-57.

Britzi M, Bialer M, Arcavi L, Shachbari A, Kapitulnik T, Soback S. Genetic polymorphism of CYP2D6 and CYP2C19 metabolism determined by phenotyping Israeli ethnic groups. Ther Drug Monit 2000; 22:510-6.

Broccatelli F, Carosati E, Neri A et al. A Novel approach for predicting P-glycoprotein (ABCB1) inhibition using molecular interaction fields. J Med Chem 2011; 54:1740-51.

Brocic M, Supic G, Zeljic K et al. Genetic polymorphisms of ADH1C and CYP2E1 and risk of oral squamous cell carcinoma. Otolaryngol Head Neck Surg 2011; 145:586-93.

Brock MV, Hooker CM, Ota-Machida E et al. DNA methylation markers and early recurrence in stage I lung cancer. N Engl J Med 2008; 358:1118-28.

Brock O, Douhard Q, Baum MJ, Bakker J. Reduced prepubertal expression of progesterone receptor in the hypothalamus of female aromatase knockout mice. Endocrinology 2010; 151:1814-21.

Brockman R, Bunick D, Mahoney MM. Estradiol deficiency during development modulates the expression of circadian and daily rhythms in male and female aromatase knockout mice. Horm Behav 2011; 60:439-47.

Brockmöller J, Kirchheiner J, Schmider J et al. The impact of the CYP2D6 polymorphism on haloperidol pharmacokinetics and on the outcome of haloperidol treatment. Clin Pharmacol Ther 2002; 72:438-52.

Brockmöller J, Meineke I, Kirchheiner J. Pharmacokinetics of mirtazapine: enantioselective effects of the CYP2D6 ultrarapid metabolizer genotype and correlation with adverse effects. Clin Pharmacol Ther 2007; 81:699-707.

Brodde OE. The functional importance of beta 1 and beta 2 adrenoceptors in the human heart. Am J Cardiol 1988; 62:24-9.

Brodde OE. Beta-1 and beta-2 adrenoceptor polymorphisms: functional importance, impact on cardiovascular diseases and drug responses. Pharmacol Ther 2008; 117:1-29.

Brodde OE. Beta1- and beta2-adrenoceptor polymorphisms and cardiovascular diseases. Fundam Clin Pharmacol 2008; 22:107-25.

Brodde OE, Kroemer HK. Drug-drug interactions of beta-adrenoceptor blockers. Arzneimittelforschung 2003; 53:814-22.

Broderick J, Lu M, Jackson C et al. Apolipoprotein E, phenotype and the efficacy of intravenous tissue plasminogen activator in acute ischemic stroke. Ann Neurol 2001; 49:736-44.

Brody LC, Conley M, Cox C et al. A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: report of the Birth Defects Research Group. Am J Hum Genet 2002; 71:1207-15.

Broide DH. Immunologic and inflammatory mechanisms that drive asthma progression to remodeling. J Allergy Clin Immunol 2008; 3:560-70.

Broly F, Gaedigk A, Heim M, Eichelbaum M, Morike K, Meyer UA. Debrisoquine/sparteine hydroxylation genotype and phenotype: analysis of common mutations and alleles of CYP2D6 in a European population. DNA Cell Biol 1991; 10:545-58.

Broly F, Libersa C, Lhermitte M, Dupuis B. Inhibitory studies of mexiletine and dextromethorphan oxidation in human liver microsomes. Biochem Pharmacol 1990; 39:1045-53.

Broly F, Marez D, Lo Guidice JM et al. A nonsense mutation in the cytochrome P450 CYP2D6 gene identified in a Caucasian with an enzyme deficiency. Hum Genet 1995; 96:601-3.

Broly F, Meyer UA. Debrisoquine oxidation polymorphism: phenotypic consequences of a 3-base-pair deletion in exon 5 of the CYP2D6 gene. Pharmacogenetics 1993; 3:123-30.

Bronner IM, Hoogendijk JE, de Visser M et al. Association of the leukocyte immunoglobulin G (Fcgamma) receptor IIIa-158V/F polymorphism with inflammatory myopathies in Dutch patients. Tissue Antigens 2009; 73:586-9.

Bronson NW, Hamilton JS, Han M et al. LOXL null mice demonstrate selective dentate structural changes but maintain dentate granule cell and CA1 pyramidal cell potentiation in the hippocampus. Neurosci Lett 2005; 390:118-22.

Brooks AM, Gillies WE. Ocular beta-blockers in glaucoma management. Clinical pharmacological aspects. Drugs Aging 1992; 2:208-21.

Brooks TA, Kennedy DR, Gruol DJ, Ojima I, Baer MR, Bernacki RJ. Structure-activity analysis of taxane-based broad-spectrum multidrug resistance modulators. Anticancer Res 2004; 24:409-15.

Brooks-Wilson A, Marcil M, Clee SM et al. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. Nat Genet 1999; 22:336-45.

Brophy DF, Israel DS, Pastor A et al. Pharmacokinetic interaction between amprenavir and clarithromycin in healthy male volunteers. Antimicrob Agents Chemother 2000; 44:978-84.

Brophy JM, Babapulle MN, Costa V, Rinfret S. A pharmacoepidemiology study of the interaction between atorvastatin and clopidogrel after percutaneous coronary intervention. Am Heart J 2006; 152:263-9.

Brøsen K. Drug-metabolizing enzymes and therapeutic drug monitoring in psychiatry. Ther Drug Monit 1996; 18:393-6.

Brøsen K. Differences in interactions of SSRIs. Int Clin Psychopharmacol 1998; 13 Suppl 5:45-7.

Brøsen K. Some aspects of genetic polymorphism in the biotransformation of antidepressants. Therapie 2004; 59:5-12.

Brøsen K, Hansen JG, Nielsen KK, Sindrup SH, Gram LF. Inhibition by paroxetine of desipramine metabolism in extensive but not in poor metabolizers of sparteine. Eur J Clin Pharmacol 1993; 44:349-55.

Brøsen K, Naranjo CA. Review of pharmacokinetic and pharmacodynamic interaction studies with citalopram. Eur Neuropsychopharmacol 2001; 11:275-83.

Brøsen K, Zeugin T, Meyer UA. Role of P450IID6, the target of the sparteine-debrisoquin oxidation polymorphism, in the metabolism of imipramine. Clin Pharmacol Ther 1991; 49:609-17.

Brouillette C, Bossé Y, Pérusse L, Gaudet D, Vohl MC. Effect of liver fatty acid binding protein (FABP) T94A missense mutation on plasma lipoprotein responsiveness to treatment with fenofibrate. J Hum Genet 2004; 49:424-32.

Brousseau DC, McCarver DG, Drendel AL, Divakaran K, Panepinto JA. The effect of CYP2D6 polymorphisms on the response to pain treatment for pediatric sickle cell pain crisis. J Pediatr 2007; 150:623-6.

Brousseau ME, Goldkamp AL, Collins D et al. Polymorphisms in the gene encoding lipoprotein lipase in men with low HDL-C and coronary heart disease: the Veterans Affairs HDL Intervention Trial. J Lipid Res 2004; 45:1885-91.

Brousseau ME, Schaefer EJ, Wolfe ML et al. Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol. New Eng J Med 2004; 350:1505-15.

Broussolle E, Thobois S. Genetics and environmental factors of Parkinson disease. Rev Neurol 2002; 158:11-23.

Brouwer KC, Lal RB, Mirel LB et al. Polymorphism of Fc receptor IIa for IgG in infants is associated with susceptibility to perinatal HIV-1 infection. AIDS 2004; 18:1187-94.

Brouwers EE, Söhne M, Kuipers S et al. Ciprofloxacin strongly inhibits clozapine metabolism: two case reports. Clin Drug Investig 2009; 29:59-63.

Brouwers N, van Cauwenberghe C, Engelborghs S et al. Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites. Mol Psychiatry 2011. doi:10. 1038/mp. 2011. 24.

Brown AR, Bickley LK, Le Page G et al. Are toxicological responses in laboratory (inbred) zebrafish representative of those in outbred (wild) populations? - A case study with an endocrine disrupting chemical. Environ Sci Technol 2011; 45:4166-72.

Brown B, Huang MH, Karlamangla A, Seeman T, Kado D. Do the effects of APOE-ε4 on cognitive function and decline depend upon vitamin status? MacArthur Studies of Successful Aging. J Nutr Health Aging 2011; 15:196-201.

Brown CS, Farmer RG, Soberman JE, Eichner SF. Pharmacokinetic factors in the adverse cardiovascular effects of antipsychotic drugs. Clin Pharmacokinet 2004; 43:33-56.

Brown HS, Galetin A, Hallifax D, Houston JB. Prediction of in vivo drug-drug interactions from in vitro data: factors affecting prototypic drug-drug interactions involving CYP2C9, CYP2D6 and CYP3A4. Clin Pharmacokinet 2006; 45:1035-50.

Brown HS, Ito K, Galetin A, Houston JB. Prediction of in vivo drug-drug interactions from in vitro data: impact of incorporating parallel pathways of drug elimination and inhibitor absorption rate constant. Br J Clin Pharmacol 2005; 60:508-18.

Brown J, Lantos PL, Roques P, Fidani L, Rossor MN. Familial dementia with swollen achromatic neurons and corticobasal inclusion bodies: a clinical and pathological study. J Neurol Sci 1996; 135:21-30.

Brown KA, Hunger NI, Docanto M, Simpson ER. Metformin inhibits aromatase expression in human breast adipose stromal cells via stimulation of AMP-activated protein kinase. Breast Cancer Res Treat 2010; 123:591-6.

Brown KM, Bujac SR, Mann ET, Campbell DA, Stubbins MJ, Blundell JE. Further evidence of association of OPRD1 & HTR1D polymorphisms with susceptibility to anorexia nervosa. Biol Psychiatry 2007; 61:367-73.

Brown MA, Edwards S, Hoyle E et al. Polymorphisms of the CYP2D6 gene increase susceptibility to ankylosing spondylitis. Hum Molec Genet 2000; 9:1563-6.

Brown MD, Sun F, Wallace DC. Clustering of Caucasian Leber hereditary optic neuropathy patients containing the 11778 or 14484 mutations on an mtDNA lineage. Am J Hum Genet 1997; 60:381-7.

Brown MD, Voljavec AS, Lott MT, Torroni A, Yang CC, Wallace DC. Mitochondrial DNA complex I and III mutations associated with Leber's hereditary optic neuropathy. Genetics 1992; 130:163-73.

Brown MD, Wallace DC. Molecular basis of mitochondrial DNA disease. J Bioenerg Biomembr 1994; 26:273-89.

Brown SD. Benefit-risk assessment of telithromycin in the treatment of community-acquired pneumonia. Drug Saf 2008; 31:561-75.

Browning SL, Tarekegn A, Bekele E, Bradman N, Thomas MG. CYP1A2 is more variable than previously thought: a genomic biography of the gene behind the human drug-metabolizing enzyme. Pharmacogenet Genomics 2010; 20:647-64.

Broyl A, Corthals SL, Jongen JL et al. Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: a prospective analysis of data from the HOVON-65/GMMG-HD4 trial. Lancet Oncol 2010; 11:1057-65.

Brozzetti A, Marzotti S, Tortoioli C et al. Cytotoxic T lymphocyte antigen-4 Ala17 polymorphism is a genetic marker of autoimmune adrenal insufficiency: Italian association study and meta-analysis of European studies. Eur J Endocrinol 2010; 162:361-9.

Bruandet A, Richard F, Tzourio C et al. Haplotypes across ACE and the risk of Alzheimer's disease: the three-city study. J Alzheimers Dis 2008; 13:333-9.

Bruck H, Leineweber K, Park J et al. Human beta2-adrenergic receptor gene haplotypes and venodilation in vivo. Clin Pharmacol Ther 2005; 78:232-8.

Bruchova H, Vasikova A, Merkerova M et al. Effect of maternal tobacco smoke exposure on the placental transcriptome. Placenta 2010; 31:186-91.

Brüggemann LW, Schoenmakers SH, Groot AP, Reitsma PH, Spek CA. Role of the factor V Leiden mutation in septic peritonitis assessed in factor V Leiden transgenic mice. Crit Care Med 2006; 34:2201-6.

Brugts JJ, de Maat MP, Boersma E et al. The rationale and design of the PERindopril GENEtic association study (PERGENE): a pharmacogenetic analysis of angiotensin-converting enzyme inhibitor therapy in patients with stable coronary artery disease. Cardiovasc Drugs Ther 2009; 23:171-81.

Brugts JJ, Isaacs A, Boersma E et al. Genetic determinants of treatment benefit of the angiotensin-converting enzyme-inhibitor perindopril in patients with stable coronary artery disease. Eur Heart J 2010; 31:1854-64.

Brugts JJ, Yetgin T, Hoeks SE et al. The benefits of statins in people without established cardiovascular disease but with cardiovascular risk factors: meta-analysis of randomised controlled trials. BMJ 2009; 338:2376.

Bruin GJ, Faller T, Wiegand H et al. Pharmacokinetics, distribution, metabolism, and excretion of deferasirox and its iron complex in rats. Drug Metab Dispos 2008; 36:2523-38.

Brumme ZL, Chan KJ, Dong W et al. CCR5Delta32 and promoter polymorphisms are not correlated with initial virological or immunological treatment response. AIDS 2001; 15:2259-66.

Brumme ZL, Henrick BM, Brumme CJ, Hogg RS, Montaner JS, Harrigan PR. Short communication. Association of the CCR5delta32 mutation with clinical response and >5-year survival following initiation of first triple antiretroviral regimen. Antivir Ther 2005; 10:849-53.

Brunden KR, Yao Y, Potuzak JS et al. The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies. Pharmacol Res 2011; 63:341-51.

Brunham LR, Kruit JK, Iqbal J et al. Intestinal ABCA1 directly contributes to HDL biogenesis in vivo. J Clin Invest 2006; 116:1052-62.

Brunham LR, Kruit JK, Pape TD et al. Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment. Nat Med 2007; 13:340-7.

Brunham LR, Lansberg PJ, Zhang L et al. Differential effect of the rs4149056 variant in SLCO1B1 on myopathy associated with simvastatin and atorvastatin. Pharmacogenomics J 2011. doi:10. 1038/tpj. 2010. 92.

Brunner HG, Nelen M, Breakefield XO, Ropers HH, van Oost BA. Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science 1993; 262:578-80.

Bruns S, Stark Y, Röker S et al. Collagen biomaterial doped with colominic acid for cell culture applications with regard to peripheral nerve repair. J Biotechnol 2007; 131:335-45.

Brüss M, Bönisch H, Bühlen M, Nöthen MM, Propping P, Göthert M. Modified ligand binding to the naturally occurring Cys-124 variant of the human serotonin 5-HT1B receptor. Pharmacogenetics 1999; 9:95-102.

Bruyère A, Declèves X, Bouzom F et al. Effect of variations in the amounts of P-glycoprotein (ABCB1), BCRP (ABCG2) and CYP3A4 along the human small intestine on PBPK models for predicting intestinal first pass. Mol Pharm 2010; 7:1596-607.

Bruyne SD, Wyffels L, Moerman L et al. Radiosynthesis and in vivo evaluation of [(11)C]MC80 for P-glycoprotein imaging. Bioorg Med Chem 2010; 18:6489-95.

Bryan A, Watters C, Koenig L et al. Human transcriptome analysis reveals a potential role for active transport in the metabolism of Pseudomonas aeruginosa autoinducers. Microbes Infect 2010; 12:1042-50.

Bryan J, Muñoz A, Zhang X et al. ABCC8 and ABCC9: ABC transporters that regulate K+ channels. Pflugers Arch 2007; 453:703-18.

Bryant CD, Graham ME, Distler MG et al. A role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetamine. Psychopharmacology 2009; 203:703-11.

Brynedal B, Duvefelt K, Jonasdottir G et al. HLA-A confers an HLA-DRB1 independent influence on the risk of multiple sclerosis. PLoS One 2007. doi:10. 1371/journal. pone. 0000664.

Brynne N, Böttiger Y, Hallén B, Bertilsson L. Tolterodine does not affect the human in vivo metabolism of the probe drugs caffeine, debrisoquine and omeprazole. Br J Clin Pharmacol 1999; 47:145-50.

Brynne N, Forslund C, Hallén B, Gustafsson LL, Bertilsson L. Ketoconazole inhibits the metabolism of tolterodine in subjects with deficient CYP2D6 activity. Br J Clin Pharmacol 1999; 48:564-72.

Brynne N, Svanström C, Aberg-Wistedt A, Hallén B, Bertilsson L. Fluoxetine inhibits the metabolism of tolterodine-pharmacokinetic implications and proposed clinical relevance. Br J Clin Pharmacol 1999; 48:553-63.

Bryson GL, Wyand A, Wozny D, Rees L, Taljaard M, Nathan H. A prospective cohort study evaluating associations among delirium, postoperative cognitive dysfunction, and apolipoprotein E genotype following open aortic repair. Can J Anaesth 2011; 58:246-55.

Bu FX, Armas L, Lappe J et al. Comprehensive association analysis of nine candidate genes with serum 25-hydroxy vitamin D levels among healthy Caucasian subjects. Hum Genet 2010; 128:549-56.

Bu HZ. A literature review of enzyme kinetic parameters for CYP3A4-mediated metabolic reactions of 113 drugs in human liver microsomes: structure-kinetics relationship assessment. Curr Drug Metab 2006; 7:231-49.

Bu HZ, Knuth K, Magis L, Teitelbaum P. High-throughput cytochrome P450 inhibition screening via cassette probe-dosing strategy. IV. Validation of a direct injection on-line guard cartridge extraction/tandem mass spectrometry method for simultaneous CYP3A4, 2D6 and 2E1 inhibition assessment. Rapid Commun Mass Spectrom 2000; 4:1943-8.

Bu HZ, Pool WF, Wu EY, Raber SR, Amantea MA, Shetty BV. Metabolism and excretion of capravirine, a new non-nucleoside reverse transcriptase inhibitor, alone and in combination with ritonavir in healthy volunteers. Drug Metab Dispos 2004; 32:689-98.

Bu HZ, Zhao P, Kang P, Pool WF, Wu EY, Shetty BV. Evaluation of capravirine as a CYP3A probe substrate: in vitro and in vivo metabolism of capravirine in rats and dogs. Drug Metab Dispos 2007; 35:1593-602.

Bu HZ, Zhao P, Kang P, Pool WF, Wu EY. Identification of enzymes responsible for primary and sequential oxygenation reactions of capravirine in human liver microsomes. Drug Metab Dispos 2006; 34:1798-802.

Bu X, Xing G, Yan M. Audiological and molecular findings in a large family with maternally inherited sensorineural hearing loss. J Audiol Med 2000; 9:61-9.

Bucaretchi F, de Capitani EM, Mello SM et al. Serotonin syndrome following sibutramine poisoning in a child, with sequential quantification of sibutramine and its primary and secondary amine metabolites in plasma. Clin Toxicol 2009; 47:598-601.

Buck D, Diefenbach K, Penzel T, Malzahn U, Roots I, Fietze I. Genetic polymorphisms in endothelin-receptor-subtype-a-gene as susceptibility factor for obstructive sleep apnea syndrome. Sleep Med 2010; 11:213-7.

Buczko W, Hermanowicz JM. Pharmacokinetics and pharmacodynamics of aliskiren, an oral direct renin inhibitor. Pharmacol Rep 2008; 60:623-31.

Buch S, Schafmayer C, Völzke H et al. Loci from a genome-wide analysis of bilirubin levels are associated with gallstone risk and composition. Gastroenterology 2010; 139:1942-51.

Buch T, Uthoff-Hachenberg C, Waisman A. Protection from autoimmune brain inflammation in mice lacking IFN-regulatory factor-1 is associated with Th2-type cytokines. Int Immunol 2003; 15:855-9.

Buchanan FF, Myles PS, Cicuttini F. Patient sex and its influence on general anaesthesia. Anaesth Intensive Care 2009; 37:207-18.

Buchard A, Linnet K, Johansen SS, Munkholm J, Fregerslev M, Morling N. Postmortem blood concentrations of R-and S-enantiomers of methadone and EDDP in drug users: influence of co-medication and P-glycoprotein genotype. J Forensic Sci 2010; 55:457-63.

Buchkowsky SS, Partovi N, Ensom MH. Clinical pharmacokinetic monitoring of itraconazole is warranted in only a subset of patients. Ther Drug Monit 2005; 27:322-33.

Buda G, Ricci D, Huang CC et al. Polymorphisms in the multiple drug resistance protein 1 and in P-glycoprotein 1 are associated with time to event outcomes in patients with advanced multiple myeloma treated with bortezomib and pegylated liposomal doxorubicin. Ann Hematol 2010; 89:1133-40.

Budinsky RA, LeCluyse EL, Ferguson SS, Rowlands JC, Simon T. Human and rat primary hepatocyte CYP1A1 and 1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, and 2,3,4,7,8-pentachlorodibenzofuran. Toxicol Sci 2010; 118:224-35.

Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000; 7:273-82.

Budzinski JW, Trudeau VL, Drouin CE, Panahi M, Arnason JT, Foster BC. Modulation of human cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp) in Caco-2 cell monolayers by selected commercial-source milk thistle and goldenseal products. Can J Physiol Pharmacol 2007; 85:966-78.

Buehler BA, Delimont D, van Waes M, Finnell RH. Prenatal prediction of risk of the fetal hydantoin syndrome. N Engl J Med 1990; 322:1567-72.

Buervenich S, Carmine A, Galter D et al. A rare truncating mutation in ADH1C (G78stop) shows significant association with Parkinson disease in a large international sample. Arch Neurol 2005; 62:74-8.

Buetow K, Shiang R, Yang P et al. A detailed multipoint map of human chromosome 4 provides evidence for linkage heterogeneity and position-specific recombination-specific recombination rates. Am J Hum Genet 1991; 48:911-25.

Buhler MM, Craig M, Donaghue KC et al. CCR5 genotyping in an Australian and New Zealand type 1 diabetes cohort. Autoimmunity 2002; 35:457-61.

Bui P, Imaizumi S, Beedanagari SR, Reddy ST, Hankinson O. Human CYP2S1 metabolizes cyclooxygenase- and lipoxygenase-derived eicosanoids. Drug Metab Dispos 2011; 39:180-90.

Bui PH, Hsu EL, Hankinson O. Fatty acid hydroperoxides support cytochrome P450 2S1-mediated bioactivation of benzo[a]pyrene-7,8-dihydrodiol. Mol Pharmacol 2009; 76:1044-52.

Bui PH, Quesada A, Handforth A, Hankinson O. The mibefradil derivative NNC55-0396, a specific T-type calcium channel antagonist, exhibits less CYP3A4 inhibition than mibefradil. Drug Metab Dispos 2008; 36:1291-9.

Buisson M, Anczukow O, Zetoune AB, Ware MD, Mazoyer S. The 185delAG mutation (c. 68_69delAG) in the BRCA1 gene triggers translation reinitiation at a downstream AUG codon. Hum Mutat 2006; 27:1024-9.

Bulchandani DG, Nachnani JS, Nookala A et al. Treatment with omega-3 fatty acids but not exendin-4 improves hepatic steatosis. Eur J Gastroenterol Hepatol 2010; 22:1245-52.

Bulotta A, Ludovico O, Coco A et al. The common -866G/A polymorphism in the promoter region of the UCP-2 gene is associated with reduced risk of type 2 diabetes in Caucasians from Italy. J Clin Endocrinol Metab 2005; 90:1176-80.

Bullido MJ, Artiga MJ, Recuero M et al. A polymorphism in the regulatory region of APOE association with risk for Alzheimer's dementia. Nat Genet 1998; 18:69-71.

Bullock P, Pearce R, Draper A et al. Induction of liver microsomal cytochrome P450 in cynomolgus monkeys. Drug Metab Dispos 1995; 23:736-48.

Bunce C, Hitchings RA, Bhattacharya SS, Lehmann OJ. Single-nucleotide polymorphisms and glaucoma severity. Am J Hum Genet 2003; 72:1593-4.

Bunce D, Anstey KJ, Burns R, Christensen H, Easteal S. Does possession of apolipoprotein E ε4 benefit cognitive function in healthy young adults? Neuropsychologia 2011; 49:1693-7.

Bunten H, Liang WJ, Pounder DJ, Seneviratne C, Osselton D. OPRM1 and CYP2B6 gene variants as risk factors in methadone-related deaths. Clin Pharmacol Ther 2010; 88:383-9.

Bunten H, Liang WJ, Pounder D, Seneviratne C, Osselton MD. CYP2B6 and OPRM1 gene variations predict methadone-related deaths. Addict Biol 2011; 16:142-4.

Buoni S, Orrico A, Galli L et al. SCN1A (2528delG) novel truncating mutation with benign outcome of severe myoclonic epilepsy of infancy. Neurology 2006; 66:606-7.

Buqué X, Martínez MJ, Cano A et al. A subset of dysregulated metabolic and survival genes is associated with severity of hepatic steatosis in obese Zucker rats. J Lipid Res 2010; 51:500-13.

Buraczynska M, Ksiazek P, Drop A, Zaluska W, Spasiewicz D, Ksiazek A. Genetic polymorphisms of the renin-angiotensin system in end-stage renal disease. Nephrol Dial Transplant 2006; 21:979-83.

Buraczyńska M, Pijanowski Z, Spasiewicz D et al. Renin-angiotensin system gene polymorphisms: assessment of the risk of coronary heart disease. Kardiol Pol 2003; 58:1-9.

Buratti FM, de Angelis G, Ricceri L, Venerosi A, Calamandrei G, Testai E. Foetal and neonatal exposure to chlorpyrifos: biochemical and metabolic alterations in the mouse liver at different developmental stages. Toxicology 2011; 280:98-108.

Buratti FM, Leoni C, Testai E. Foetal and adult human CYP3A isoforms in the bioactivation of organophosphorothionate insecticides. Toxicol Lett 2006; 167:245-55.

Buratti FM, Testai E. Evidences for CYP3A4 autoactivation in the desulfuration of dimethoate by the human liver. Toxicology 2007; 241:33-46.

Buratti FM, Volpe MT, Meneguz A, Vittozzi L, Testai E. CYP-specific bioactivation of four organophosphorothioate pesticides by human liver microsomes. Toxicol Appl Pharmacol 2003; 186:143-54.

Burckart GJ, Amur S. Update on the clinical pharmacogenomics of organ transplantation. Pharmacogenomics 2010; 11:227-36.

Burdette-Radoux S, Tozer RG, Lohmann RC et al. Phase II trial of flavopiridol, a cyclin dependent kinase inhibitor, in untreated metastatic malignant melanoma. Invest New Drugs 2004; 22:315-22.

Burdick KE, DeRosse P, Kane JM, Lencz T, Malhotra AK. Association of genetic variation in the MET proto-oncogene with schizophrenia and general cognitive ability. Am J Psychiatry 2010; 167:436-43.

Burdick KE, Goldberg TE, Funke B et al. DTNBP1 genotype influences cognitive decline in schizophrenia. Schizophr Res 2007; 89:169-72.

Burdon KP, Hewitt AW, Mackey DA, Mitchell P, Craig JE. Tag SNPs detect association of the CYP1B1 gene with primary open angle glaucoma. Mol Vis 2010; 16:2286-93.

Burdon KP, Langefeld CD, Wagenknecht LE et al. Association analysis of genes in the renin-angiotensin system with subclinical cardiovascular disease in families with Type 2 diabetes mellitus: the Diabetes Heart Study. Diabet Med 2006; 23:228-34.

Burger H, den Bakker MA, Kros JM et al. Activating mutations in c-KIT and PDGFRalpha are exclusively found in gastrointestinal stromal tumors and not in other tumors overexpressing these imatinib mesylate target genes. Cancer Biol Ther 2005; 4:1270-4.

Burger H, Foekens JA, Look MP et al. RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: correlation with chemotherapeutic response. Clin Cancer Res 2003; 9:827-36.

Burgess B, Naus K, Chan J et al. Overexpression of human ABCG1 does not affect atherosclerosis in fat-fed ApoE-deficient mice. Arterioscler Thromb Vasc Biol 2008; 28:1731-7.

Burgess BL, Parkinson PF, Racke MM et al. ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo. J Lipid Res 2008; 49:1254-67.

Burgess JK, Lindeman R, Chesterman CN, Chong BH. Single amino acid mutation of Fc gamma receptor is associated with the development of heparin-induced thrombocytopenia. Br J Haematol 1995; 91:761-6.

Burhenne J, Matthée AK, Pasáková I et al. No evidence for induction of ABC transporters in peripheral blood mononuclear cells in humans after 14 days of efavirenz treatment. Antimicrob Agents Chemother 2010; 54:4185-91.

Burk O, Arnold KA, Nussler AK et al. Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor. Mol Pharmacol 2005; 67:1954-65.

Burk O, Brenner SS, Hofmann U et al. The impact of thyroid disease on the regulation, expression, and function of ABCB1 (MDR1/P glycoprotein) and consequences for the disposition of digoxin. Clin Pharmacol Ther 2010; 88:685-94.

Burk O, Koch I, Raucy J et al. The induction of cytochrome P450 3A5 (CYP3A5) in the human liver and intestine is mediated by the xenobiotic sensors pregnane X receptor (PXR) and constitutively activated receptor (CAR). J Biol Chem 2004; 279:38379-85.

Burk O, Tegude H, Koch I et al. Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine. J Biol Chem 2002; 277:24280-8.

Burke JR, Enghild JJ, Martin ME et al. Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH. Nat Med 1996; 2:347-50.

Burke KT, Horn PS, Tso P, Heubi JE, Woollett LA. Hepatic bile acid metabolism in the neonatal hamster: expansion of the bile acid pool parallels increased Cyp7a1 expression levels. Am J Physiol Gastrointest Liver Physiol 2009; 297:144-51.

Burmester JK, Berg RL, Glurich I, Yale SH, Schmelzer JR, Caldwell MD. Absence of novel CYP4F2 and VKORC1 coding region DNA variants in patients requiring high warfarin doses. Clin Med Res 2011. doi:10. 3121/cmr. 2011. 951.

Burnell JC, Carr LG, Dwulet FE, Edenberg HJ, Li TK, Bosron WF. The human beta(3) alcohol dehydrogenase subunit differs from beta-1 by a cys for Arg-369 substitution which decreases NAD(H) binding. Biochem Biophys Res Commun 1987; 146:1227-33.

Burns JC, Shimizu C, Gonzalez E et al. Genetic variations in the receptor-ligand pair CCR5 and CCL3L1 are important determinants of susceptibility to Kawasaki disease. J Infect Dis 2005; 192:344-9.

Buroker NE, Ning XH, Zhou ZN et al. Genetic associations with mountain sickness in Han and Tibetan residents at the Qinghai-Tibetan Plateau. Clin Chim Acta 2010; 411:1466-73.

Burris RL, Xie CH, Thampi P, Wu X, Melnyk SB, Nagarajan S. Dietary rice protein isolate attenuates atherosclerosis in apoE-deficient mice by upregulating antioxidant enzymes. Atherosclerosis 2010; 212:107-15.

Burstein AH, Horton RL, Dunn T, Alfaro RM, Piscitelli SC, Theodore W. Lack of effect of St John's Wort on carbamazepine pharmacokinetics in healthy volunteers. Clin Pharmacol Ther 2000; 68:605-12.

Burstein AH, Reiss WG, Kantor E, Anderson GD. Cytochrome P450 3A4 activity in premenopausal and postmenopausal women, based on 6-beta-hydroxycortisol:cortisol ratios. Pharmacotherapy 1998; 18:1271-6.

Burt HJ, Galetin A, Houston JB. IC50-based approaches as an alternative method for assessment of time-dependent inhibition of CYP3A4. Xenobiotica 2010; 40:331-43.

Burton JR, Burton I, Pearson GJ. Clopidogrel-precipitated rhabdomyolysis in a stable heart transplant patient. Ann Pharmacother 2007; 41:133-7.

Burul-Bozkurt N, Pekiner C, Kelicen P. Diabetes alters aromatase enzyme levels in gonadal tissues of rats. Naunyn Schmiedebergs Arch Pharmacol 2010; 382:33-41.

Busby WF Jr, Ackermann JM, Crespi CL. Effect of methanol, ethanol, dimethyl sulfoxide, and acetonitrile on in vitro activities of cDNA-expressed human cytochromes P-450. Drug Metab Dispos 1999; 27:246-9.

Busby WF Jr, Penman BW, Crespi CL. Human cell mutagenicity of mono- and dinitropyrenes in metabolically competent MCL-5 cells. Mutat Res 1994; 322:233-42.

Busch RM, Floden D, Lineweaver TT et al. Effect of apolipoprotein ε4 allele on hippocampal and brain volume in intractable temporal lobe epilepsy. Epilepsy Behav 2011; 21:88-90.

Bush AI. The metallobiology of Alzheimer's disease. Trends Neurosci 2003; 26:207-14.

Busi F, Cresteil T. CYP3A5 mRNA degradation by nonsense-mediated mRNA decay. Mol Pharmacol 2005; 68:808-15.

Businaro R, Fabrizi C, Fumagalli L, Lauro GM. Role of alpha-2-macroglobulin in regulating amyloid beta-protein neurotoxicity: protective or detrimental effect? J Neurochem 2001; 78:406-12.

Busse D, Cosme J, Beaune P, Kroemer HK, Eichelbaum M. Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans. Naunyn Schmiedebergs Arch Pharmacol 1995; 353:116-21.

Busse KH, Penzak SR. Darunavir: a second-generation protease inhibitor. Am J Health Syst Pharm 2007; 64:1593-602.

Buster EH, van Vuuren HJ, Zondervan PE, Metselaar HJ, Tilanus HW, de Man RA. Thiopurine-methyltransferase and inosine triphosphate pyrophosphatase polymorphism in a liver transplant recipient developing nodular regenerative hyperplasia on low-dose azathioprine. Eur J Gastroenterol Hepatol 2008; 1:68-72.

Busti AJ, Hall RG, Margolis DM. Atazanavir for the treatment of human immunodeficiency virus infection. Pharmacotherapy 2004; 24:1732-47.

But WM, Lo IF, Shek CC, Tse WY, Lam ST. Ambiguous genitalia, impaired steroidogenesis, and Antley-Bixler syndrome in a patient with P450 oxidoreductase deficiency. Hong Kong Med J 2010; 16:59-62.

Buters JT, Korzekwa KR, Kunze KL, Omata Y, Hardwick JP, Gonzalez FJ. cDNA-directed expression of human cytochrome P450 CYP3A4 using baculovirus. Drug Metab Dispos 1994; 22:688-92.

Buters JTM, Tang BK, Pineau T, Gelboin HV, Kimura S, Gonzalez FJ. Role of CYP1A2 in caffeine pharmacokinetics and metabolism: studies using mice deficient in CYP1A2. Pharmacogenetics 1996; 6:291-6.

Butkiewicz D, Krześniak M, Vaitiekunaite R et al. A functional analysis of G23A polymorphism and the alternative splicing in the expression of the XPA gene. Cell Mol Biol Lett 2010; 15:611-29.

Butler AM, Murray M. Biotransformation of parathion in human liver: participation of CYP3A4 and its inactivation during microsomal parathion oxidation. J Pharmacol Exp Ther 1997; 280:966-73.

Butler MA, Iwasaki M, Guengerich FP, Kadlubar FF. Human cytochrome P-450(PA) (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines. Proc Nat Acad Sci USA 1989; 86:7696-700.

Butovsky O, Koronyo-Hamaoui M, Kunis G et al. Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1. Proc Natl Acad Sci USA 2006; 103:11784-9.

Buxbaum JN, Reixach N. Transthyretin: the servant of many masters. Cell Mol Life Sci 2009; 66:3095-101.

Buyske S, Williams TA, Mars AE et al. Analysis of case-parent trios at a locus with a deletion allele: association of GSTM1 with autism. BMC Genet 2006; 7:8.

Buzdar AU, Robertson JF. Fulvestrant: pharmacologic profile versus existing endocrine agents for the treatment of breast cancer. Ann Pharmacother 2006; 40:1572-83.

Buzi F, Mella P, Pilotta A et al. Growth hormone receptor polymorphisms. Endocr Dev 2007; 11:28-35.

Buzzetti R, Petrone A, Ribaudo MC et al. The common PPAR-gamma-2 pro12-to-ala variant is associated with greater insulin sensitivity. Europ J Hum Genet 2004; 12:1050-4.

Bylund J, Kunz T, Valmsen K, Oliw EH. Cytochromes P450 with bisallylic hydroxylation activity on arachidonic and linoleic acids studied with human recombinant enzymes and with human and rat liver microsomes. J Pharmacol Exp Ther 1998; 284:51-60.

Bynoté KK, Hackenberg JM, Korach KS, Lubahn DB, Lane PH, Gould KA. Estrogen receptor-alpha deficiency attenuates autoimmune disease in (NZB x NZW)F1 mice. Genes Immun 2008; 9:137-52.

Byrd JC, Lin TS, Dalton JT et al. Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia. Blood 2007; 109:399-404.

Byrski T, Gronwald J, Huzarski T et al. Pathologic complete response rates in young women with BRCA1-positive breast cancers after neoadjuvant chemotherapy. J Clin Oncol 2010; 28:375-9.

Byrum RS, Goulet JL, Snouwaert JN, Griffiths RJ, Koller BH. Determination of the contribution of cysteinyl leukotrienes and leukotriene B4 in acute inflammatory responses using 5-lipoxygenase- and leukotriene A4 hydrolase-deficient mice. J Immunol 1999; 163:6810-9.

Byun E, Caillier SJ, Montalban X et al. Genome-wide pharmacogenomic analysis of the response to interferon beta therapy in multiple sclerosis. Arch Neurol 2008; 65:337-44.

Caballero F, Fernández A, de Lacy AM, Fernández-Checa JC, Caballería J, García-Ruiz C. Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH. J Hepatol 2009; 50:789-96.

Cabaret O, Puel O, Botterel F et al. Metabolic detoxication pathways for sterigmatocystin in primary tracheal epithelial cells. Chem Res Toxicol 2010; 23:1673-81.

Cable EE, Finn PD, Stebbins JW et al. Reduction of hepatic steatosis in rats and mice after treatment with a liver-targeted thyroid hormone receptor agonist. Hepatology 2009; 49:407-17.

Caboni P, Sammelson RE, Casida JE. Phenylpyrazole insecticide photochemistry, metabolism, and GABAergic action: ethiprole compared with fipronil. J Agric Food Chem 2003; 51:7055-61.

Cabrera SE, Santos D, Valverde MP et al. Influence of the cytochrome P450 2B6 genotype on population pharmacokinetics of efavirenz in human immunodeficiency virus patients. Antimicrob Agents Chemother 2009; 53:2791-8.

Cacabelos R. Dementia. In: Jobe TH, Gaviria M, Kovilparambil A (Eds). Clinical Neuropsychiatry. Blackwell Science, Massachussetts, 1997:73-122.

Cacabelos R. Neurogeriatrics Handbook. Alzheimer's disease and other dementias. Epidemiology and Genetics. Masson, Barcelona, 1999.

Cacabelos R. Psychogeriatric research. A conceptual introduction to geriatric neuroscience. Psychogeriatrics 2001; 1:158-88.

Cacabelos R. Pharmacogenomics in Alzheimer's disease. Mini Rev Med Chem 2002; 2:59-84.

Cacabelos R. Pharmacogenomics for the treatment of dementia. Ann Med 2002; 34:357-79.

Cacabelos R. The application of functional genomics to Alzheimer's disease. Pharmacogenomics 2003; 4:597-621.

Cacabelos R. Genomic characterization of Alzheimer's disease and genotype-related phenotypic analysis of biological markers in dementia. Pharmacogenomics 2004; 5:1049-105.

Cacabelos R. Pharmacogenomics, nutrigenomics and therapeutic optimization in Alzheimer's disease. Aging Health 2005; 1:303-48.

Cacabelos R. Pharmacogenomics and therapeutic prospects in Alzheimer's disease. Exp Opin Pharmacother 2005; 6:1967-87.

Cacabelos R. Molecular genetics of Alzheimer's disease and aging. Methods Find Exper Clin Pharmacol 2005; 27 Suppl A:1-573.

Cacabelos R. Donepezil in Alzheimer's disease: From conventional trials to pharmacogenetics. Neuropsychiat Dis Treat 2007; 3:303-33.

Cacabelos R. Pharmacogenetic basis for therapeutic optimization in Alzheimer's disease. Mol Diagn Ther 2007; 11:385-405.

Cacabelos R. Molecular pathology and pharmacogenomics in Alzheimer's disease: polygenic-related effects of multifactorial treatments on cognition, anxiety, and depression. Methods Find Exper Clin Pharmacol 2007; 29(Suppl B):1-91.

Cacabelos R. Pharmacogenomics in Alzheimer's disease. Methods Mol Biol 2008; 448:213-357.

Cacabelos R. Pharmacogenomics and therapeutic prospect in dementia. Eur Arch Psychiatry Clin Neurosci 2008; 258 Suppl 1:28-47.

Cacabelos R. Pharmacogenomics and therapeutic strategies for dementia. Expert Rev Mol Diagn 2009; 9:567-611.

Cacabelos R, Álvarez A, Fernández-Novoa L, Lombardi VRM. A pharmacogenomic approach to Alzheimer's disease. Acta Neurol Scand Suppl 2000; 176:12-9.

Cacabelos R, Álvarez XA, Franco-Maside A, Fernández-Novoa L, Caamaño J. Effect of CDP-choline on cognition and immune function in Alzheimer's disease and multi-infarct dementia. Ann N Y Acad Sci 1993; 695:321-3.

Cacabelos R, Álvarez XA, Lombardi V et al. Pharmacological treatment of Alzheimer disease: From phychotropic drugs and cholinesterase inhibitors to pharmacogenomics. Drugs Today 2000; 36:415-99.

Cacabelos R, Corzo L, Fernández-Novoa L, Lombardi V. Histamine in Alzheimer's disease pathogenesis: Biochemistry and functional genomics. Methods Find Exper Clin Pharmacol 2004; 26(Suppl 2):9-16.

Cacabelos R, Fernández-Novoa L, Álvarez A et al. Cholinesterase inhibitors in dementia. Tem years of Donepezil in Alzheimer's disease and CNS disorders (1996-2006): Therapeutic assessment and pharmacogenetics. Gen-T EuroEspes J 2007; (Suppl 1):1-52.

Cacabelos R, Fernández-Novoa L, Corzo L et al. Phenotypic profiles and functional genomics in Alzheimer's disease and in dementia with a vascular component. Neurol Res 2004; 26:459-80.

Cacabelos R, Fernández-Novoa L, Corzo L et al. Phenotypic profiles and functional genomics in dementia with a vascular component. Neurol Res 2004; 26:459-80.

Cacabelos R, Fernández-Novoa L, Corzo L, Pichel V, Lombardi V, Kubota Y. Genomics and phenotypic profiles in dementia: implications for pharmacological treatment. Methods Find Exp Clin Pharmacol 2004; 26:421-44.

Cacabelos R, Fernández-Novoa L, Kubota Y, Lombardi V, Takeda M. Molecular genetics of Alzheimer's disease and aging. Methods Find Exp Clin Pharmacol 2005; 27:1-573.

Cacabelos R, Fernández-Novoa L, Lombardi V, Corzo L, Pichel V, Kubota Y. Cerebrovascular risk factors in Alzheimer's disease: Brain hemodynamics and pharmacogenomic implications. Neurol Res 2003; 25:567-80.

Cacabelos R, Fernández-Novoa L, Lombardi V, Kubota Y, Takeda M. Molecular genetics of Alzheimer's disease and aging. Methods Find Exp Clin Pharmacol 2005; 27 Suppl A:1-573.

Cacabelos R, Fernández-Novoa L, Pichel V, Lombardi V, Kubota Y, Takeda M. Pharmacogenomic studies with a combination therapy in Alzheimer's disease. In: Cacabelos R, Tanaka T, Takeda M (Eds). Molecular neurobiology of Alzheimer´s disease and related disorders. Basel, Karger, 2004:94-107.

Cacabelos R, Hashimoto R, Takeda M. Pharmacogenomics of antipsychotics efficacy for schizophrenia. Psychiatry Clin Neurosci 2011; 65:3-19.

Cacabelos R, Lombardi V, Fernández-Novoa L et al. A functional genomics approach to the analysis of biological markers in Alzheimer disease. In: Cacabelos R, Tanaka T, Takeda M (Eds). Molecular neurobiology of Alzheimer´s disease and related disorders. Basel, Karger, 2004:236-85.

Cacabelos R, Llovo R, Fraile C, Fernández-Novoa L. Pharmacogenetic aspects of therapy with cholinesterase inhibitors: the role of CYP2D6 in Alzheimer's disease pharmacogenetics. Curr Alzheimer Res 2007; 4:479-500.

Cacabelos R, Martínez-Bouza R. Genomics and pharmacogenomics of schizophrenia. CNS Neurosci Ther 2011; 17:541-65.

Cacabelos R, Martínez-Bouza R. Genomics and pharmacogenomics of dementia. CNS Neurosci Ther 2011; 17:566-76.

Cacabelos R, Rodríguez B, Carrera C et al. APOE-Related frequency of cognitive and noncognitive symptoms in dementia. Methods Find Exp Clin Pharmacol 1996; 18:693-706.

Cacabelos R, Takeda M. Pharmacogenomics, nutrigenomics and future therapeutics in Alzheimer's disease. Drugs Future 2006; 31(Suppl B):5-146.

Caccia S. Biotransformation of post-clozapine antipsychotics: pharmacological implications. Clin Pharmacokinet 2000; 38:393-414.

Caccia S. New antipsychotic agents for schizophrenia: pharmacokinetics and metabolism update. Curr Opin Investig Drugs 2002; 3:1073-80.

Caccia S. Metabolism of the newest antidepressants: comparisons with related predecessors. IDrugs 2004; 7:143-50.

Caccia S. N-dealkylation of arylpiperazine derivatives: disposition and metabolism of the 1-aryl-piperazines formed. Curr Drug Metab 2007; 8:612-22.

Caglayan AO, Dundar M, Tanriverdi F et al. Idiopathic hirsutism: local and peripheral expression of aromatase (CYP19A) and 5α-reductase genes (SRD5A1 and SRD5A2). Fertil Steril 2011; 96:479-82.

Cai J, Zhao Y, Liu Y et al. Directed differentiation of human embryonic stem cells into functional hepatic cells. Hepatology 2007; 45:1229-39.

Cai P, Tsao R, Ruppen ME. In vitro metabolic study of temsirolimus: preparation, isolation, and identification of the metabolites. Drug Metab Dispos 2007; 35:1554-63.

Cai SY, He H, Nguyen T, Mennone A, Boyer JL. Retinoic acid represses CYP7A1 expression in human hepatocytes and HepG2 cells by FXR/RXR-dependent and independent mechanisms. J Lipid Res 2010; 51:2265-74.

Cai T, Dufour JF, Muellhaupt B et al. Viral genotype-specific role of PNPLA3, PPARG, MTTP and IL28B in Hepatitis C virus-associated steatosis. J Hepatol 2011; 55:529-35.

Cai WM, Chen B, Cai MH, Zhang YD. CYP2D6 phenotype determines pharmacokinetic variability of propafenone enantiomers in 16 HAN Chinese subjects. Zhongguo Yao Li Xue Bao 1999; 20:720-4.

Cai WM, Chen B, Zhang WX. Frequency of CYP2D6*10 and *14 alleles and their influence on the metabolic activity of CYP2D6 in a healthy Chinese population. Clin Pharmacol Ther 2007; 81:95-8.

Cai WM, Chen B, Zhou Y, Zhang YD. Fluoxetine impairs the CYP2D6-mediated metabolism of propafenone enantiomers in healthy Chinese volunteers. Clin Pharmacol Ther 1999; 66:516-21.

Cai WM, Nikoloff DM, Pan RM et al. CYP2D6 genetic variation in healthy adults and psychiatric African-American subjects: implications for clinical practice and genetic testing. Pharmacogenomics J 2006; 6:343-50.

Cai X, Wang RW, Edom RW et al. Validation of (-)-N-3-benzyl-phenobarbital as a selective inhibitor of CYP2C19 in human liver microsomes. Drug Metab Dispos 2004; 32:584-6.

Cai Y, Shen XZ, Zhou CH, Wang JY. Abnormal expression of Smurf2 during the process of rat liver fibrosis. Chin J Dig Dis 2006; 7:237-45.

Caillier B, Lépine J, Tojcic J et al. A pharmacogenomics study of the human estrogen glucuronosyltransferase UGT1A3. Pharmacogenet Genomics 2007; 17:481-95.

Cain JW, Hauptschein RS, Stewart JK, Bagci T, Sahagian GG, Jay DG. Identification of CD44 as a surface biomarker for drug resistance by surface proteome signature technology. Mol Cancer Res 2011; 9:637-47.

Cairns W, Smith CA, McLaren AW, Wolf CR. Characterization of the human cytochrome P4502D6 promoter. A potential role for antagonistic interactions between members of the nuclear receptor family. J Biol Chem 1996; 271:25269-76.

Calabresi L, Nilsson P, Pinotti E et al. A novel homozygous mutation in CETP gene as a cause of CETP deficiency in a Caucasian kindred. Atherosclerosis 2009; 205:506-11.

Calabresi L, Pazzucconi F, Ferrara S, Di Paolo A, Tacca MD, Sirtori C. Pharmacokinetic interactions between omeprazole/pantoprazole and clarithromycin in health volunteers. Pharmacol Res 2004; 49:493-9.

Calaf GM, Emenaker NJ, Hei TK. Effect of retinol on radiation- and estrogen-induced neoplastic transformation of human breast epithelial cells. Oncol Rep 2005; 13:1017-27.

Calarge CA, Ellingrod VL, Acion L et al. Variants of the dopamine D2 receptor gene and risperidone-induced hyperprolactinemia in children and adolescents. Pharmacogenet Genomics 2009; 19:373-82.

Calarge CA, Miller del D. Predictors of risperidone and 9-hydroxyrisperidone serum concentration in children and adolescents. J Child Adolesc Psychopharmacol 2011; 21:163-9.

Calayir E, Becker TM, Kratzer A et al. LXR-agonists regulate ApoM expression differentially in liver and intestine. Curr Pharm Biotechnol 2008; 9:516-21.

Calcagno AM, Fostel JM, To KK et al. Single-step doxorubicin-selected cancer cells overexpress the ABCG2 drug transporter through epigenetic changes. Br J Cancer 2008; 98:1515-24.

Caldas C, Hahn SA, da Costa LT et al. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat Genet 1994; 8:27-32.

Caldas YA, Giral H, Cortázar MA et al. Liver X receptor-activating ligands modulate renal and intestinal sodium-phosphate transporters. Kidney Int 2011; 80:535-44.

Caldwell MD, Awad T, Johnson JA et al. CYP4F2 genetic variant alters required warfarin dose. Blood 2008; 111:4106-12.

Caley CF, Cooper CK. Ziprasidone: the fifth atypical antipsychotic. Ann Pharmacother 2002; 36:839-51.

Calhoun ME, Wiederhold KH, Abramowski D et al. Neuron loss in APP transgenic mice. Nature 1998; 395:755-6.

Cali JJ, Hsieh CL, Francke U, Russell DW. Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis. J Biol Chem 1991; 266:7779-83.

Calissano P, Matrone C, Amadoro G. Apoptosis and in vitro Alzheimer disease neuronal models. Commun Integr Biol 2009; 2:163-9.

Calixto LA, de Oliveira AR, Jabor VA, Bonato PS. In vitro characterization of rosiglitazone metabolites and determination of the kinetic parameters employing rat liver microsomal fraction. Eur J Drug Metab Pharmacokinet 2011; 36:159-66.

Callaghan JT, Bergstrom RF, Ptak LR, Beasley CM. Olanzapine. Pharmacokinetic and pharmacodynamic profile. Clin Pharmacokinet 1999; 37:177-93.

Callaghan JT, Cerimele BJ, Kassahun KJ et al. Olanzapine: interaction study with imipramine. J Clin Pharmacol 1997; 37:971-8.

Callahan SM, Wonganan P, Croyle MA. Molecular and macromolecular alterations of recombinant adenoviral vectors do not resolve changes in hepatic drug metabolism during infection. Virol J 2008; 5:111.

Callard GV, Tarrant AM, Novillo A et al. Evolutionary origins of the estrogen signaling system: Insights from amphioxus. J Steroid Biochem Mol Biol 2011. doi:10. 1016/j. jsbmb. 2011. 03. 022.

Callegari E, Malhotra B, Bungay PJ et al. A comprehensive nonclinical evaluation of the CNS penetration potential of antimuscarinic agents for the treatment of overactive bladder. Br J Clin Pharmacol 2011; 72:235-46.

Camargo SM, Singer D, Makrides V et al. Tissue-specific amino acid transporter partners ACE2 and collectrin differentially interact with hartnup mutations. Gastroenterology 2009; 136:872-82.

Camci L, Kilic Z, Dinleyici EC, Muslumanoglu H, Tepeli E, Ucar B. Angiotensin-converting enzyme gene insertion/deletion polymorphism frequency in normotensive children with a positive family history of essential hypertension. J Paediatr Child Health 2009; 45:742-6.

Camenzind RS, Chip S, Gutmann H, Kapfhammer JP, Nitsch C, Bendfeldt K. Preservation of transendothelial glucose transporter 1 and P-glycoprotein transporters in a cortical slice culture model of the blood-brain barrier. Neuroscience 2010; 170:361-71.

Cameron MD, Wen B, Allen KE et al. Cooperative binding of midazolam with testosterone and alpha-naphthoflavone within the CYP3A4 active site: a NMR T1 paramagnetic relaxation study. Biochemistry 2005; 44:14143-51.

Cameron MD, Wen B, Roberts AG, Atkins WM, Campbell AP, Nelson SD. Cooperative binding of acetaminophen and caffeine within the P450 3A4 active site. Chem Res Toxicol 2007; 20:1434-41.

Cameron MD, Wright J, Black CB, Ye N. In vitro prediction and in vivo verification of enantioselective human tofisopam metabolite profiles. Drug Metab Dispos 2007; 35:1894-902.

Camidge DR, Pemberton M, Growcott J et al. A phase I pharmacodynamic study of the effects of the cyclin-dependent kinase-inhibitor AZD5438 on cell cycle markers within the buccal mucosa, plucked scalp hairs and peripheral blood mononucleocytes of healthy male volunteers. Cancer Chemother Pharmacol 2007; 60:479-88.

Camilleri M, Busciglio I, Carlson P et al. Pharmacogenetics of low dose clonidine in irritable bowel syndrome. Neurogastroenterol Motil 2009; 21:399-410.

Campa D, Zienolddiny S, Maggini V, Skaug V, Haugen A, Canzian F. Association of a common polymorphism in the cyclooxygenase 2 gene with risk of non-small cell lung cancer. Carcinogenesis 2004; 25:229-35.

Campalani E, Allen MH, Fairhurst D et al. Apolipoprotein E gene polymorphisms are associated with psoriasis but do not determine disease response to acitretin. Br J Dermatol 2006; 154:345-52.

Campayo M, Viñolas N, Navarro A et al. Single nucleotide polymorphisms in tobacco metabolism and DNA repair genes and prognosis in resected non-small-cell lung cancer. J Surg Res 2011; 167:5-12.

Campbell CM, Edwards RR, Carmona C et al. Polymorphisms in the GTP cyclohydrolase gene (GCH1) are associated with ratings of capsaicin pain. Pain 2009; 141:114-8.

Campbell CY, Fang BF, Guo X et al. Associations between genetic variants in the ACE, AGT, AGTR1 and AGTR2 genes and renal function in the multi-ethnic study of atherosclerosis. Am J Nephrol 2010; 32:156-62.

Campbell DB, Ebert PJ, Skelly T et al. Ethnic stratification of the association of RGS4 variants with antipsychotic treatment response in schizophrenia. Biol Psychiatry 2008; 63:32-41.

Campbell DB, Sutcliffe JS, Ebert PJ et al. A genetic variant that disrupts MET transcription is associated with autism. Proc Natl Acad Sci USA 2006; 103:16834-9.

Campbell DJ, Woodward M, Chalmers JP et al. Soluble vascular cell adhesion molecule 1 and N-terminal pro-B-type natriuretic peptide in predicting ischemic stroke in patients with cerebrovascular disease. Arch Neurol 2006; 63:60-5.

Campbell IG, Russell SE, Choong DY et al. Mutation of the PIK3CA gene in ovarian and breast cancer. Cancer Res 2004; 64:7678-81.

Campbell MC, Tishkoff SA. African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping. Annu Rev Genomics Hum Genet 2008; 9:403-33.

Campbell TA, Palmer MS, Will RG, Gibb WRG, Luther PJ, Collinge J. A prion disease with a novel 96-base pair insertional mutations in the prion protein gene. Neurology 1996; 46:761-6.

Campia U, Cardillo C, Panza JA. Ethnic differences in the vasoconstrictor activity of endogenous endothelin-1 in hypertensive patients. Circulation 2004; 109:3191-5.

Campo G, Miccoli M, Tebaldi M et al. Genetic determinants of on-clopidogrel high platelet reactivity. Platelets 2011; 22:399-407.

Campos SB, Miranda DM, Souza BR et al. Association study of tryptophan hydroxylase 2 gene polymorphisms in bipolar disorder patients with panic disorder comorbidity. Psychiatr Genet 2011; 21:106-11.

Canaparo R, Finnström N, Serpe L et al. Expression of CYP3A isoforms and P-glycoprotein in human stomach, jejunum and ileum. Clin Exp Pharmacol Physiol 2007; 34:1138-44.

Canaparo R, Nordmark A, Finnström N et al. Expression of cytochromes P450 3A and P-glycoprotein in human large intestine in paired tumour and normal samples. Basic Clin Pharmacol Toxicol 2007; 100:240-8.

Candela P, Gosselet F, Saint-Pol J et al. Apical-to-basolateral transport of amyloid-β peptides through blood-brain barrier cells is mediated by the receptor for advanced glycation end-products and is restricted by P-glycoprotein. J Alzheimers Dis 2010; 22:849-59.

Candeliere GA, Glorieux FH, Prud'homme J, St-Arnaud R. Increased expression of the c-fos proto-oncogene in bone from patients with fibrous dysplasia. N Engl J Med 1995; 332:1546-51.

Candide C, Morlière P, Mazière JC et al. In vitro interaction of the photoactive anticancer porphyrin derivative photofrin II with low density lipoprotein, and its delivery to cultured human fibroblasts. FEBS Lett 1986; 207:133-8.

Candiloro IL, Dobrovic A. Detection of MGMT promoter methylation in normal individuals is strongly associated with the T allele of the rs16906252 MGMT promoter single nucleotide polymorphism. Cancer Prev Res 2009; 2:862-7.

Candini C, Schimmel AW, Peter J et al. Identification and characterization of novel loss of function mutations in ATP-binding cassette transporter A1 in patients with low plasma high-density lipoprotein cholesterol. Atherosclerosis 2010; 213:492-8.

Candiotti KA, Yang Z, Rodriguez Y et al. The impact of CYP2D6 genetic polymorphisms on postoperative morphine consumption. Pain Med 2009; 10:799-805.

Candy G, Samani N, Norton G et al. Association analysis of beta2 adrenoceptor polymorphisms with hypertension in a Black African population. J Hypertens 2000; 18:167-72.

Cantarini L, Volpi N, Galeazzi M et al. Colchicine myopathy and neuromyopathy: two cases with different characteristics. J Clin Rheumatol 2010; 16:229-32.

Cantonwine D, Hu H, Téllez-Rojo MM et al. HFE gene variants modify the association between maternal lead burden and infant birthweight: a prospective birth cohort study in Mexico City, Mexico. Environ Health 2010; 9:43.

Cantor KP, Villanueva CM, Silverman DT et al. Polymorphisms in GSTT1, GSTZ1, and CYP2E1, disinfection by-products, and risk of bladder cancer in Spain. Environ Health Perspect 2010; 118:1545-50.

Cantrell MA, Bream-Rouwenhorst HR, Hemerson P, Magera JS Jr. Silodosin for benign prostatic hyperplasia. Ann Pharmacother 2010; 44:302-10.

Canturk P, Caner V, Oruc N et al. The mRNA expression of cytochrome P450 isoforms in human gastric tissue. Hepatogastroenterology 2010; 57:372-6.

Canu B, Fioravanti A, Orlandi P et al. Irinotecan synergistically enhances the antiproliferative and proapoptotic effects of axitinib in vitro and improves its anticancer activity in vivo. Neoplasia 2011; 13:217-29.

Canu N, Possenti R, Ricco AS, Rocchi M, Levi A. Cloning, structural organization analysis, and chromosomal assignment of the human gene for the neurosecretory protein VGF. Genomics 1997; 45:443-6.

Canzian F, McKay JD, Cleveland RJ et al. Genetic variation in the growth hormone synthesis pathway in relation to circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3, and breast cancer risk: results from the European prospective investigation into cancer and nutrition study. Cancer Epidemiol Biomarkers Prev 2005; 14:2316-25.

Cañete JD, Suárez B, Hernández MV et al. Influence of variants of Fc gamma receptors IIA and IIIA on the American College of Rheumatology and European League Against Rheumatism responses to anti-tumour necrosis factor alpha therapy in rheumatoid arthritis. Ann Rheum Dis 2009; 68:1547-52.

Cao A, Galanello R. Beta-thalassemia. Genet Med 2010; 12:61-76.

Cao FF, Chen XD, Wang QS et al. Associations of the genetic polymorphisms in CYP11B2 gene with nonfamilial structural atrial fibrillation. Zhonghua Liu Xing Bing Xue Za Zhi 2009; 30:1069-72.

Cao H, Qiu C, Zhu P et al. The relationship between left ventricular hypervoltage and CYP11B2 (344T/C) polymorphism in Keriyans. J Renin Angiotensin Aldosterone Syst 2011; 12:375-9.

Cao J, Patisaul HB, Petersen SL. Aryl hydrocarbon receptor activation in lactotropes and gonadotropes interferes with estradiol-dependent and -independent preprolactin, glycoprotein alpha and luteinizing hormone beta gene expression. Mol Cell Endocrinol 2011; 333:151-9.

Cao J, Zhang L, Ye Q et al. YQ36: a novel bisindolylmaleimide analogue induces KB/VCR cell death. J Biomed Biotechnol 2009. doi:10. 1155/2009/535072.

Cao JX, Hu J, Ye XM et al. Association between the 5-HTR1B gene polymorphisms and alcohol dependence in a Han Chinese population. Brain Res 2011; 1376:1-9.

Cao W, Cao YJ, Hu ZY et al. Inhibition of 1,3,8-trihydroxy-5-methoxyxanthone on cytochrome P450s. Zhong Nan Da Xue Xue Bao Yi Xue Ban 2006; 31:858-61.

Cao W, Strnatka D, McQueen CA, Hunter RJ, Erickson RP. N-acetyltransferase 2 activity and folate levels. Life Sci 2010; 86:103-6.

Cao X, Gibbs ST, Fang L et al. Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model. Pharm Res 2006; 23:1675-86.

Cao X, Sudhof TC. A transcriptionally active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 2001; 293:115-20.

Cao XL, Yin RX, Wu DF et al. Genetic variant of V825I in the ATP-binding cassette transporter A1 gene and serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Lipids Health Dis 2011; 10:14.

Cao YF, Zhang YY, Li J et al. CYP3A catalyses schizandrin biotransformation in human, minipig and rat liver microsomes. Xenobiotica 2010; 40:38-47.

Capeau J, Magré J, Caron-Debarle M et al. Human lipodystrophies: genetic and acquired diseases of adipose tissue. Endocr Dev 2010; 19:1-20.

Capeau J, Magré J, Lascols O et al. Diseases of adipose tissue: genetic and acquired lipodystrophies. Biochem Soc Trans 2005; 33:1073-7.

Capon F, Di Meglio P, Szaub J et al. Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis. Hum Genet 2007; 122:201-6.

Caporaso N, Gu F, Chatterjee N et al. Genome-wide and candidate gene association study of cigarette smoking behaviors. PLoS One 2009. doi:10. 1371/journal. pone. 0004653.

Capozzo MA, Schillani G, Aguglia E et al. Serotonin transporter 5-HTTLPR polymorphism and response to citalopram in terminally ill cancer patients: report of twenty-one cases. Tumori 2009; 95:479-83.

Caprioli J, Mele C, Mossali C et al. Polymorphisms of EDNRB, ATG, and ACE genes in salt-sensitive hypertension. Can J Physiol Pharmacol 2008; 86:505-10.

Capron A, Mourad M, de Meyer M et al. CYP3A5 and ABCB1 polymorphisms influence tacrolimus concentrations in peripheral blood mononuclear cells after renal transplantation. Pharmacogenomics 2010; 11:703-14.

Caputo M, Zirpoli H, Torino G, Tecce MF. Selective regulation of UGT1A1 and SREBP-1c mRNA expression by docosahexaenoic, eicosapentaenoic, and arachidonic acids. J Cell Physiol 2011; 226:187-93.

Caracciolo B, Bäckman L, Monastero R, Winblad B, Fratiglioni L. The symptom of low mood in the prodromal stage of mild cognitive impairment and dementia: a cohort study of a community dwelling elderly population. J Neurol Neurosurg Psychiatry 2011; 82:788-93.

Caraci F, Crupi R, Drago F, Spina E. Metabolic drug interactions between antidepressants and anticancer drugs: Focus on selective serotonin reuptake inhibitors and Hypericum extract. Curr Drug Metab 2011; 12:570-7.

Caraco Y. Genetic determinants of drug responsiveness and drug interactions. Ther Drug Monit 1998; 20:517-24.

Caraco Y, Lagerstrom PO, Wood AJ. Ethnic and genetic determinants of omeprazole disposition and effect. Clin Pharmacol Ther 1996; 60:157-67.

Caraco Y, Muszkat M, Wood AJ. Phenytoin metabolic ratio: a putative marker of CYP2C9 activity in vivo. Pharmacogenetics 2001; 11:587-96.

Caraco Y, Sheller J, Wood AJ. Pharmacogenetic determination of the effects of codeine and prediction of drug interactions. J Pharmacol Exp Ther 1996; 278:1165-74.

Caraco Y, Sheller J, Wood AJ. Pharmacogenetic determinants of codeine induction by rifampin: the impact on codeine's respiratory, psychomotor and miotic effects. J Pharmacol Exp Ther 1997; 281:330-6.

Caraco Y, Sheller J, Wood AJ. Impact of ethnic origin and quinidine coadministration on codeine's disposition and pharmacodynamic effects. J Pharmacol Exp Ther 1999; 290:413-22.

Caraco Y, Tateishi T, Guengerich FP, Wood AJ. Microsomal codeine N-demethylation: cosegregation with cytochrome P4503A4 activity. Drug Metab Dispos 1996; 24:761-4.

Caraco Y, Wilkinson GR, Wood AJ. Differences between white subjects and Chinese subjects in the in vivo inhibition of cytochrome P450s 2C19, 2D6, and 3A by omeprazole. Clin Pharmacol Ther 1996; 60:396-404.

Carbonell N, Verstuyft C, Massard J et al. CYP2C9*3 loss-of-function allele is associated with acute upper gastrointestinal bleeding related to the use of NSAIDs other than aspirin. Clin Pharmacol Ther 2010; 87:693-8.

Carcaboso AM, Elmeliegy MA, Shen J et al. Tyrosine kinase inhibitor gefitinib enhances topotecan penetration of gliomas. Cancer Res 2010; 70:4499-508.

Carcangiu V, Vacca GM, Mura MC et al. Relationship between MTNR1A melatonin receptor gene polymorphism and seasonal reproduction in different goat breeds. Anim Reprod Sci 2009; 110:71-8.

Cardona F, Guardiola M, Queipo-Ortuño MI, Murri M, Ribalta J, Tinahones FJ. The -1131T>C SNP of the APOA5 gene modulates response to fenofibrate treatment in patients with the metabolic syndrome: a postprandial study. Atherosclerosis 2009; 206:148-52.

Cardona Pera D. Drug-food interactions. Nutr Hosp 1999; 14 Suppl 2:129-40.

Cardoso CC, Pereira AC, Brito-de-Souza VN et al. IFNG +874 T>A single nucleotide polymorphism is associated with leprosy among Brazilians. Hum Genet 2010; 128:481-90.

Carew JA, Pollak ES, High KA, Bauer KA. Severe factor VII deficiency due to a mutation disrupting an Sp1 binding site in the factor VII promoter. Blood 1998; 92:1639-45.

Carew JA, Pollak ES, Lopaciuk S, Bauer KA. A new mutation in the HNF4 binding region of the factor VII promoter in a patient with severe factor VII deficiency. Blood 2000; 96:4370-2.

Carew MW, Leslie EM. Selenium-dependent and -independent transport of arsenic by the human multidrug resistance protein 2 (MRP2/ABCC2): implications for the mutual detoxification of arsenic and selenium. Carcinogenesis 2010; 31:1450-5.

Cariello L, de Cristofaro T, Zanetti L et al. Transglutaminase activity is related to CAG repeat lengh in patients with Huntington's disease. Hum Genet 1996; 98:633-5.

Carletti E, Colletier JP, Dupeux F, Trovaslet M, Masson P, Nachon F. Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation. J Med Chem 2010; 53:4002-8.

Carlini LE, Meropol NJ, Bever J et al. UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan. Clin Cancer Res 2005; 11:1226-36.

Carlson CS, Aldred SF, Lee PK et al. Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels. Am J Hum Genet 2005; 77:64-77.

Carlson RW, Theriault R, Schurman CM et al. Phase II trial of anastrozole plus goserelin in the treatment of hormone receptor-positive, metastatic carcinoma of the breast in premenopausal women. J Clin Oncol 2010; 28:3917-21.

Carlsson LE, Santoso S, Spitzer C, Kessler C, Greinacher A. The alpha2 gene coding sequence T807/A873 of the platelet collagen receptor integrin alpha2beta1 might be a genetic risk factor for the development of stroke in younger patients. Blood 1999; 93:3583-6.

Carmo H, Brulport M, Hermes M et al. Influence of CYP2D6 polymorphism on 3,4-methylenedioxymethamphetamine ('Ecstasy') cytotoxicity. Pharmacogenet Genomics 2006; 16:789-99.

Carmo H, Brulport M, Hermes M et al. CYP2D6 increases toxicity of the designer drug 4-methylthioamphetamine (4-MTA). Toxicology 2007; 229:236-44.

Carmona O, Masuet C, Alía P et al. Apolipoprotein alleles and the response to interferon-β-1b in multiple sclerosis. Eur Neurol 2011; 65:132-7.

Caro AA, Cederbaum AI. Synergistic toxicity of iron and arachidonic acid in HepG2 cells overexpressing CYP2E1. Mol Pharmacol 2001; 60:742-52.

Caro AA, Cederbaum AI. Inhibition of CYP2E1 catalytic activity in vitro by S-adenosyl-L-methionine. Biochem Pharmacol 2005; 69:1081-93.

Caro AA, Thompson S, Tackett J. Increased oxidative stress and cytotoxicity by hydrogen sulfide in HepG2 cells overexpressing cytochrome P450 2E1. Cell Biol Toxicol 2011; 27:439-53.

Caron G, Ermondi G, Testa B. Predicting the oxidative metabolism of statins: an application of the MetaSite algorithm. Pharm Res 2007; 24:480-501.

Caronia D, Martin M, Sastre J et al. A polymorphism in the cytidine deaminase promoter predicts severe capecitabine-induced Hand-Foot syndrome. Clin Cancer Res 2011; 17:2006-13.

Caronia D, Patiño-García A, Milne RL et al. Common variations in ERCC2 are associated with response to cisplatin chemotherapy and clinical outcome in osteosarcoma patients. Pharmacogenomics J 2009; 9:347-53.

Carr B, Norcross R, Fang Y et al. Characterization of the rhesus monkey CYP3A64 enzyme: species comparisons of CYP3A substrate specificity and kinetics using baculovirus-expressed recombinant enzymes. Drug Metab Dispos 2006; 34:1703-12.

Carr BA, Ramakanth S, Dannan GA, Yost GS. Characterization of pulmonary CYP4B2, specific catalyst of methyl oxidation of 3-methylindole. Mol Pharmacol 2003; 63:1137-47.

Carr DF, la Porte CJ, Pirmohamed M, Owen A, Cortes CP. Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort. J Antimicrob Chemother 2010; 65:1889-93.

Carr EJ, Niederer HA, Williams J et al. Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis. BMC Med Genet 2009; 10:121.

Carr LG, Zeng D, Li TK. Failure to find exon 7 polymorphism of the ADH7 gene in Chinese, Japanese, African-Americans, and Caucasians. Alcohol Clin Exp Res 1996; 20:418-9.

Carr LGC, Foroud T, Stewart T, Castelluccio P, Edenberg HJ, Li TK. Influence of ADH1B polymorphism on alcohol use and its subjective effects in a Jewish population. Am J Med Genet 2002; 112:138-43.

Carrasco-Portugal Mdel C, Aguilar-Carrasco JC, Luján M, Reyes-García G, Medina-Santillán R, Flores-Murrieta FJ. Further evidence for interethnic differences in the oral pharmacokinetics of meloxicam. Clin Drug Investig 2005; 25:307-13.

Carrasco-Portugal Mdel C, Luján M, Flores-Murrieta FJ. Evaluation of gender in the oral pharmacokinetics of clindamycin in humans. Biopharm Drug Dispos 2008; 29:427-30.

Carrascosa A, Audí L, Esteban C et al. Growth hormone (GH) dose, but not exon 3-deleted/full-length GH receptor polymorphism genotypes, influences growth response to two-year GH Therapy in Short Small-for-Gestational-Age Children. J Clin Endocrinol Metab 2008; 93:147-53.

Carrasquillo MM, Belbin O, Hunter TA et al. Replication of BIN1 association with Alzheimer's disease and evaluation of genetic interactions. J Alzheimers Dis 2011; 23:1-8.

Carreau S, Bois C, Zanatta L, Silva FR, Bouraima-Lelong H, Delalande C. Estrogen signaling in testicular cells. Life Sci 2011; 89:584-7.

Carregaro F, Carta A, Cordeiro JA, Lobo SM, Silva EH, Leopoldino AM. Polymorphisms IL10-819 and TLR-2 are potentially associated with sepsis in Brazilian patients. Mem Inst Oswaldo Cruz 2010; 105:649-56.

Carrier JS, Turgeon D, Journault K, Hum DW, Belanger A. Isolation and characterization of the human UGT2B7 gene. Biochem Biophys Res Commun 2000; 272:616-21.

Carrillo JA, Dahl ML, Svensson JO, Alm C, Rodríguez I, Bertilsson L. Disposition of fluvoxamine in humans is determined by the polymorphic CYP2D6 and also by the CYP1A2 activity. Clin Pharmacol Ther 1996; 60:183-90.

Carrillo JA, Herráiz AG, Ramos SI, Gervasini G, Vizcaíno S, Benítez J. Role of the smoking-induced cytochrome P450 (CYP)1A2 and polymorphic CYP2D6 in steady-state concentration of olanzapine. J Clin Psychopharmacol 2003; 23:119-27.

Carrillo JA, Ramos SI, Herraiz AG et al. Pharmacokinetic interaction of fluvoxamine and thioridazine in schizophrenic patients. J Clin Psychopharmacol 1999; 19:494-9.

Carrington M, Kissner T, Gerrard B, Ivanov S, O'Brien SJ, Dean M. Novel alleles of the chemokine-receptor gene CCR5. Am J Hum Genet 1997; 61:1261-7.

Carrington M, Nelson GW, Martin MP et al. HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantage. Science 1999; 283:1748-52.

Carrodeguas JA, Rodolosse A, Garza MV et al. The chick embryo appears as a natural model for research in beta-amyloid precursor protein processing. Neuroscience 2005; 134:1285-300.

Carrol ED, Payton A, Payne D et al. The IL1RN promoter rs4251961 correlates with IL-1 receptor antagonist concentrations in human infection and is differentially regulated by GATA-1. J Immunol 2011; 186:2329-35.

Carroll CL, Stoltz P, Schramm CM, Zucker AR. Beta2-adrenergic receptor polymorphisms affect response to treatment in children with severe asthma exacerbations. Chest 2009; 135:1186-92.

Carrozzo R, Bellini C, Lucioli S et al. Peroxisomal acyl-CoA-oxidase deficiency: two new cases. Am J Med Genet A 2008; 146:1676-81.

Carstea ED, Morris JA, Coleman KG et al. Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis. Science 1997; 277:228-31.

Carta C, Pantaleoni F, Bocchinfuso G et al. Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype. Am J Hum Genet 2006; 79:129-35.

Carter AM, Ossei-Gerning N, Wilson IJ, Grant PJ. Association of the platelet Pl(A) polymorphism of glycoprotein IIb/IIIa and the fibrinogen Bbeta 448 polymorphism with myocardial infarction and extent of coronary artery disease. Circulation 1997; 96:1424-31.

Carter CJ. Convergence of genes implicated in Alzheimer's disease on the cerebral cholesterol shuttle: APP, cholesterol, lipoproteins, and atherosclerosis. Neurochem Int 2007; 50:12-38.

Carter NJ, McCormack PL. Duloxetine: a review of its use in the treatment of generalized anxiety disorder. CNS Drugs 2009; 23:523-41.

Cartron G, Dacheux L, Salles G et al. Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcgammaRIIIa gene. Blood 2002; 99:754-8.

Carvajal CA, Stehr CB, González PA et al. A de novo unequal cross-over mutation between CYP11B1 and CYP11B2 genes causes familial hyperaldosteronism type I. J Endocrinol Invest 2011; 34:140-4.

Carvalho RS, Friedrich K, de-Oliveira AC, Suarez-Kurtz G, Paumgartten FJ. Malaria downmodulates mRNA expression and catalytic activities of CYP1A2, 2E1 and 3A11 in mouse liver. Eur J Pharmacol 2009; 616:265-9.

Casabar RC, Das PC, Dekrey GK et al. Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor. Toxicol Appl Pharmacol 2010; 245:335-43.

Casabar RC, Wallace AD, Hodgson E, Rose RL. Metabolism of endosulfan-alpha by human liver microsomes and its utility as a simultaneous in vitro probe for CYP2B6 and CYP3A4. Drug Metab Dispos 2006; 34:1779-85.

Casado M, Vallet VS, Kahn A, Vaulont S. Essential role in vivo of upstream stimulatory factors for a normal dietary response of the fatty acid synthase gene in the liver. J Biol Chem 1999; 274:2009-13.

Casarejos MJ, Solano RM, Menéndez J et al. Differential effects of l-DOPA on monoamine metabolism, cell survival and glutathione production in midbrain neuronal-enriched cultures from parkin knockout and wild-type mice. J Neurochem 2005; 94:1005-14.

Casari G, de Fusco M, Ciarmatori S et al. Spastic paraplegia and OXPHOS impairment caused by mutations in paraplegin, a nuclear-encoded mitochondrial metalloprotease. Cell 1998; 93:973-83.

Casas JP, Bautista LE, Humphries SE, Hingorani AD. Endothelial nitric oxide synthase genotype and ischemic heart disease: meta-analysis of 26 studies involving 23028 subjects. Circulation 2004; 109:1359-65.

Casas JP, Hingorani AD, Bautista LE, Sharma P. Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18000 cases and 58000 controls. Arch Neurol 2004; 61:1652-62.

Cascorbi I. P-glycoprotein: tissue distribution, substrates, and functional consequences of genetic variations. Handb Exp Pharmacol 2011:261-83.

Cascorbi I, Brockmöller J, Bauer S, Reum T, Roots I. NAT2*12A (803A→G) codes for rapid arylamine n-acetylation in humans. Pharmacogenetics 1996; 6:257-9.

Cascorbi I, Drakoulis N, Brockmöller J, Maurer A, Sperling K, Roots I. Arylamine N-acetyltransferase (NAT2) mutations and their allelic linkage in unrelated Caucasian individuals: correlation with phenotypic activity. Am J Hum Genet 1995; 57:581-92.

Cascorbi I, Paul M, Kroemer HK. Pharmacogenomics of heart failure - focus on drug disposition and action. Cardiovasc Res 2004; 64:32-9.

Caselli RJ, Dueck AC, Locke DE et al. Cerebrovascular risk factors and preclinical memory decline in healthy APOE ε4 homozygotes. Neurology 2011; 76:1078-84.

Caselli RJ, Dueck AC, Locke DE et al. Longitudinal modeling of frontal cognition in APOE {varepsilon}4 homozygotes, heterozygotes, and noncarriers. Neurology 2011; 76:1383-8.

Cash HL, Tao L, Yuan JM et al. LINE-1 hypomethylation is associated with bladder cancer risk among nonsmoking Chinese. Int J Cancer 2011. doi:10. 1002/ijc. 26098.

Cashman JR, Zhang J. Human flavin-containing monooxygenases. Annu Rev Pharmacol Toxicol 2006; 46:65-100.

Caslake MJ, Stewart G, Day SP et al. Phenotype-dependent and -independent actions of rosuvastatin on atherogenic lipoprotein subfractions in hyperlipidaemia. Atherosclerosis 2003; 171:245-53.

Casp CB, She JX, McCormack WT. Genetic association of the catalase gene (CAT) with vitiligo susceptibility. Pigment Cell Res 2002; 15:62-6.

Caspi A, McClay J, Moffitt TE et al. Role of genotype in the cycle of violence in maltreated children. Science 2002; 297:851-4.

Cassio D, Macias RI, Grosse B, Marin JJ, Monte MJ. Expression, localization, and inducibility by bile acids of hepatobiliary transporters in the new polarized rat hepatic cell lines, Can 3-1 and Can 10. Cell Tissue Res 2007; 330:447-60.

Castano R, Bossé Y, Endam LM, Filali-Mouhim A, Desrosiers M. c-MET pathway involvement in chronic rhinosinusitis: a genetic association analysis. Otolaryngol Head Neck Surg 2010; 142:665-71.

Castberg I, Helle J, Aamo TO. Prolonged pharmacokinetic drug interaction between terbinafine and amitriptyline. Ther Drug Monit 2005; 27:680-2.

Castberg I, Spigset O. Effects of comedication on the serum levels of aripiprazole: evidence from a routine therapeutic drug monitoring service. Pharmacopsychiatry 2007; 40:107-10.

Castell JV, Donato MT, Gómez-Lechón MJ. Metabolism and bioactivation of toxicants in the lung. The in vitro cellular approach. Exp Toxicol Pathol 2005; 57 Suppl 1:189-204.

Castellano JM, Kim J, Stewart FR et al. Human apoE Isoforms Differentially Regulate Brain Amyloid-{beta} Peptide Clearance. Sci Transl Med 2011; 3:89ra57.

Castellone MD, Teramoto H, Williams BO, Druey KM, Gutkind JS. Prostaglandin E2 promotes colon cancer cell growth through a GS-axin-beta-catenin signaling axis. Science 2005; 310:1504-10.

Castellucci L, Jamieson SE, Miller EN et al. CXCR1 and SLC11A1 polymorphisms affect susceptibility to cutaneous leishmaniasis in Brazil: a case-control and family-based study. BMC Med Genet 2010; 11:10.

Castilla LH, Couch FJ, Erdos MR et al. Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer. Nat Genet 1994; 8:387-91.

Castrioto A, Tambasco N, Rossi A, Calabresi P. Acute dystonia induced by the combination of midodrine and perphenazine. J Neurol 2008; 255:767-8.

Castro J, Ribó M, Puig T, Colomer R, Vilanova M, Benito A. A cytotoxic ribonuclease reduces the expression level of P-glycoprotein in multidrug-resistant cell lines. Invest New Drugs 2011. doi:10. 1007/s10637-011-9636-2.

Castro R, Rivera I, Ravasco P et al. 5,10-Methylenetetrahydrofolate reductase (MTHFR) 677C→T and 1298A→C mutations are associated with DNA hypomethylation. J Med Genet 2004; 41:454-8.

Catalano A, Procopio A. New aspects on the role of lipoxygenases in cancer progression. Histol Histopathol 2005; 20:969-75.

Catalano S, Malivindi R, Giordano C et al. Farnesoid X receptor, through the binding with steroidogenic factor 1-responsive element, inhibits aromatase expression in tumor Leydig cells. J Biol Chem 2010; 285:5581-93.

Catano G, Kulkarni H, He W et al. HIV-1 disease-influencing effects associated with ZNRD1, HCP5 and HLA-C alleles are attributable mainly to either HLA-A10 or HLA-B*57 alleles. PLoS One 2008. doi:10. 1371/journal. pone. 0003636.

Catapano AL. Pitavastatin-pharmacological profile from early phase studies. Atheroscler Suppl 2010; 11:3-7.

Cater MA, McInnes KT, Li QX et al. Intracellular copper deficiency increases amyloid-beta secretion by diverse mechanisms. Biochem J 2008; 412:141-52.

Cattaneo A, Bocchio-Chiavetto L, Zanardini R, Milanesi E, Placentino A, Gennarelli M. Reduced peripheral brain-derived neurotrophic factor mRNA levels are normalized by antidepressant treatment. Int J Neuropsychopharmacol 2010; 13:103-8.

Cattaneo M, Zighetti ML, Lombardi R et al. Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding. Proc Nat Acad Sci USA 2003; 100:1978-83.

Catteau-Jonard S, Dewailly D. Anti-Mullerian hormone and polycystic ovary syndrome. Gynecol Obstet Fertil 2011; 39:514-7.

Cattelotte J, Tournier N, Rizzo-Padoin N, Schinkel AH, Scherrmann JM, Cisternino S. Changes in dipole membrane potential at the mouse blood-brain barrier enhance the transport of 99mTechnetium Sestamibi more than inhibiting Abcb1, Abcc1, or Abcg2. J Neurochem 2009; 108:767-75.

Caulfield M, Lavender P, Farrall M et al. Linkage of the angiotensinogen gene to essential hypertension. New Eng J Med 1994; 330:1629-33.

Cavaco I, Gil JP, Gil-Berglund E, Ribeiro V. CYP3A4 and MDR1 alleles in a Portuguese population. Clin Chem Lab Med 2003; 41:1345-50.

Cavaco I, Reis R, Gil JP, Ribeiro V. CYP3A4*1B and NAT2*14 alleles in a native African population. Clin Chem Lab Med 2003; 41:606-9.

Cavaliere C, Corvigno S, Galgani M, Limite G, Nardone A, Veneziani BM. Combined inhibitory effect of formestane and herceptin on a subpopulation of CD44+/CD24low breast cancer cells. Cancer Sci 2010; 101:1661-9.

Cavallari LH, Limdi NA. Warfarin pharmacogenomics. Curr Opin Mol Ther 2009; 11:243-51.

Cavallari U, Trabetti E, Malerba G et al. Gene sequence variations of the platelet P2Y12 receptor are associated with coronary artery disease. BMC Med Genet 2007; 8:59.

Cavanillas ML, Alcina A, Núñez C et al. Polymorphisms in the IL2, IL2RA and IL2RB genes in multiple sclerosis risk. Eur J Hum Genet 2010; 18:794-9.

Cazali N, Tran A, Treluyer JM et al. Inhibitory effect of stiripentol on carbamazepine and saquinavir metabolism in human. Br J Clin Pharmacol 2003; 56:526-36.

Cecchin E, Agostini M, Pucciarelli S et al. Tumor response is predicted by patient genetic profile in rectal cancer patients treated with neo-adjuvant chemo-radiotherapy. Pharmacogenomics J 2011; 11:214-26.

Cecchin E, Innocenti F, D'Andrea M et al. Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan. J Clin Oncol 2009; 27:2457-65.

Cecil JE, Palmer CN, Fischer B et al. Variants of the peroxisome proliferator-activated receptor gamma- and beta-adrenergic receptor genes are associated with measures of compensatory eating behaviors in young children. Am J Clin Nutr 2007; 86:167-73.

Ceckova M, Vackova Z, Radilova H, Libra A, Buncek M, Staud F. Effect of ABCG2 on cytotoxicity of platinum drugs: interference of EGFP. Toxicol In Vitro 2008; 22:1846-52.

Cederbaum A. Nrf2 and antioxidant defense against CYP2E1 toxicity. Expert Opin Drug Metab Toxicol 2009; 5:1223-44.

Cederbaum AI. Cytochrome P450 2E1-dependent oxidant stress and upregulation of anti-oxidant defense in liver cells. J Gastroenterol Hepatol 2006; 21 Suppl 3:22-5.

Cederbaum AI. Hepatoprotective effects of S-adenosyl-L-methionine against alcohol- and cytochrome P450 2E1-induced liver injury. World J Gastroenterol 2010; 16:1366-76.

Cejas P, López-Gómez M, Aguayo C et al. KRAS mutations in primary colorectal cancer tumors and related metastases: a potential role in prediction of lung metastasis. PLoS One 2009. doi:10. 1371/journal. pone. 0008199.

Celhay O, Yacoub M, Irani J, Dore B, Cussenot O, Fromont G. Expression of estrogen related proteins in hormone refractory prostate cancer: association with tumor progression. J Urol 2010; 184:2172-8.

Celius T, Matthews J. Functional analysis of six human aryl hydrocarbon receptor variants in human breast cancer and mouse hepatoma cell lines. Toxicology 2010; 277:59-65.

Celius T, Roblin S, Harper PA et al. Aryl hydrocarbon receptor-dependent induction of flavin-containing monooxygenase mRNAs in mouse liver. Drug Metab Dispos 2008; 36:2499-505.

Cen J, Qi Y, Tao YF et al. HZ08, a great regulator to reverse multidrug resistance via cycle arrest and apoptosis sensitization in MCF-7/ADM. Eur J Pharmacol 2010; 647:21-30.

Cenarro A, Artieda M, Castillo S et al. A common variant in the ABCA1 gene is associated with a lower risk for premature coronary heart disease in familial hypercholesterolaemia. J Med Genet 2003; 40:163-8.

Cénit MC, Alcina A, Márquez A et al. STAT3 locus in inflammatory bowel disease and multiple sclerosis susceptibility. Genes Immun 2010; 11:264-8.

Ceppa F, Fontan E, Cremades S et al. Role of pharmacogenetics in chemotherapy of colorectal cancers. Rev Med Interne 2007; 28:594-602.

Cerda A, Genvigir FD, Arazi SS et al. Influence of SCARB1 polymorphisms on serum lipids of hypercholesterolemic individuals treated with atorvastatin. Clin Chim Acta 2010; 411:631-7.

Cerf E, Gustot A, Goormaghtigh E, Ruysschaert JM, Raussens V. High ability of apolipoprotein E4 to stabilize amyloid-{beta} peptide oligomers, the pathological entities responsible for Alzheimer's disease. FASEB J 2011; 25:1585-95.

Cermanova J, Fuksa L, Brcakova E et al. Up-regulation of renal Mdr1 and Mrp2 transporters during amiodarone pretreatment in rats. Pharmacol Res 2010; 61:129-35.

Cerne JZ, Novakovic S, Frkovic-Grazio S, Pohar-Perme M, Stegel V, Gersak K. Estrogen metabolism genotypes, use of long-term hormone replacement therapy and risk of postmenopausal breast cancer. Oncol Rep 2011; 26:479-85.

Cerri AP, Arosio B, Viazzoli C, Confalonieri R, Vergani C, Annoni G. The -308 (G/A) single nucleotide polymorphism in the TNF-alpha gene and the risk of major depression in the elderly. Int J Geriatr Psychiatry 2010; 25:219-23.

Cerveny L, Pavek P, Malakova J, Staud F, Fendrich Z. Lack of interactions between breast cancer resistance protein (bcrp/abcg2) and selected antiepileptic agents. Epilepsia 2006; 47:461-8.

Cerveny L, Svecova L, Anzenbacherova E et al. Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways. Drug Metab Dispos 2007; 35:1032-41.

César TB, Manthey JA, Myung K. Minor furanocoumarins and coumarins in grapefruit peel oil as inhibitors of human cytochrome P450 3A4. J Nat Prod 2009; 2:1702-4.

Cesari M, Narkiewicz K, de Toni R et al. Heritability of plasma adiponectin levels and body mass index in twins. J Clin Endocr Metab 2007; 92:3082-8.

Cesari R, Martin ES, Calin GA et al. Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27. Proc Natl Acad Sci USA 2003; 100:5956-61.

Cetinkalp S, Karadeniz M, Erdoğan M et al. Human multidrug resistance-1 gene expression levels in graves-basedow disease. Exp Clin Endocrinol Diabetes 2010; 118:158-60.

Cetta F, Chiappetta G, Melillo RM et al. The ret/ptc1 oncogene is activated in familial adenomatous polyposis-associated thyroid papillary carcinomas. J Clin Endocrinol Metab 1998; 83:1003-6.

Ceyhan ST, Onguru O, Fidan U et al. Comparison of aromatase inhibitor (letrozole) and immunomodulators (infliximab and etanercept) on the regression of endometriotic implants in a rat model. Eur J Obstet Gynecol Reprod Biol 2011; 154:100-4.

Cha J, Ivanov V, Ivanova S, Kalinovsky T, Rath M, Niedzwiecki A. Evolution of angiotensin II-mediated atherosclerosis in ApoE KO mice. Mol Med Report 2010; 3:565-70.

Cha PC, Mushiroda T, Takahashi A et al. Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanese. Hum Mol Genet 2010; 19:4735-44.

Cha PC, Mushiroda T, Zembutsu H et al. Single nucleotide polymorphism in ABCG2 is associated with irinotecan-induced severe myelosuppression. J Hum Genet 2009; 54:572-80.

Cha SH, Kim HT, Jang Y et al. Association of alpha-adducin Gly460Trp polymorphism with coronary artery disease in a Korean population. J Hypertens 2007; 25:2413-20.

Chacko BK, Srivastava A, Johnson MS et al. Mitochondria-targeted ubiquinone (MitoQ) decreases ethanol-dependent micro and macro hepatosteatosis. Hepatology 2011; 54:153-63.

Chae SC, Shim SC, Chung HT. Association of TBX21 polymorphisms in a Korean population with rheumatoid arthritis. Exp Mol Med 2009; 41:33-41.

Chai L, McLaren RP, Byrne A et al. The chemosensitizing activity of inhibitors of glucosylceramide synthase is mediated primarily through modulation of P-gp function. Int J Oncol 2011; 38:701-11.

Chai YG, Oh DY, Chung EK et al. Alcohol and aldehyde dehydrogenase polymorphisms in men with type I and type II alcoholism. Am J Psychiat 2005; 162:1003-5.

Chainuvati S, Nafziger AN, Leeder JS et al. Combined phenotypic assessment of cytochrome p450 1A2, 2C9, 2C19, 2D6, and 3A, N-acetyltransferase-2, and xanthine oxidase activities with the "Cooperstown 5+1 cocktail". Clin Pharmacol Ther 2003; 74:437-47.

Chakrabarti S, Ghanekar Y, Kaur K et al. A polymorphism in the CYP1B1 promoter is functionally associated with primary congenital glaucoma. Hum Mol Genet 2010; 19:4083-90.

Chakraborty PK, Scharner B, Jurasovic J, Messner B, Bernhard D, Thévenod F. Chronic cadmium exposure induces transcriptional activation of the Wnt pathway and upregulation of epithelial-to-mesenchymal transition markers in mouse kidney. Toxicol Lett 2010; 198:69-76.

Chakrapani BP, Kumar S, Subramaniam JR. Development and evaluation of an in vivo assay in Caenorhabditis elegans for screening of compounds for their effect on cytochrome P450 expression. J Biosci 2008; 33:269-77.

Chalasani N, Chowdhury NR, Chowdhury JR, Boyer TD. Kernicterus in an adult who is heterozygous for Crigler-Najjar syndrome and homozygous for Gilbert-type genetic defect. Gastroenterology 1997; 112:2099-103.

Chalkiadis GA, Anderson BJ, Tay M, Bjorksten A, Kelly JJ. Pharmacokinetics of levobupivacaine after caudal epidural administration in infants less than 3 months of age. Br J Anaesth 2005; 95:524-9.

Chamberlin KW, Cottle M, Neville R, Tan J. Oral oxymorphone for pain management. Ann Pharmacother 2007; 41:1144-52.

Chambers SK, Ivins CM, Carcangiu ML. Plasminogen activator inhibitor-1 is an independent poor prognostic factor for survival in advanced stage epithelial ovarian cancer patients. Int J Cancer 1998; 79:449-54.

Chambers SK, Kacinski BM, Ivins CM, Carcangiu ML. Overexpression of epithelial macrophage colony-stimulating factor (CSF-1) and CSF-1 receptor: a poor prognostic factor in epithelial ovarian cancer, contrasted with a protective effect of stromal CSF-1. Clin Cancer Res 1997; 3:999-1007.

Chan AM, Miki T, Meyers KA, Aaronson SA. A human oncogene of the RAS superfamily unmasked by expression cDNA cloning. Proc Natl Acad Sci USA 1994; 91:7558-62.

Chan AT, Tranah GJ, Giovannucci EL, Hunter DJ, Fuchs CS. Genetic variants in the UGT1A6 enzyme, aspirin use, and the risk of colorectal adenoma. J Natl Cancer Inst 2005; 97:457-60.

Chan AT, Zauber AG, Hsu M et al. Cytochrome P450 2C9 variants influence response to celecoxib for prevention of colorectal adenoma. Gastroenterology 2009; 136:2127-36.

Chan CY, New LS, Ho HK, Chan EC. Reversible time-dependent inhibition of cytochrome P450 enzymes by duloxetine and inertness of its thiophene ring towards bioactivation. Toxicol Lett 2011; 206:314-24.

Chan DKY, Lam MKP, Wong R, Hung WT, Wilcken DEL. Strong association between N-acetyltransferase 2 genotype and PD in Hong Kong Chinese. Neurology 2003; 60:1002-5.

Chan E, Hegde A, Chen X. Effect of rutin on warfarin anticoagulation and pharmacokinetics of warfarin enantiomers in rats. J Pharm Pharmacol 2009; 61:451-8.

Chan GN, Bendayan R. Molecular and functional characterization of P-glycoprotein in vitro. Methods Mol Biol 2011; 686:313-36.

Chan GN, Tozammel Hoque M, Cummins CL, Bendayan R. Regulation of P-glycoprotein by orphan nuclear receptors in human brain microvessel endothelial cells. J Neurochem 2011; 118:163-75.

Chan IH, Tang NL, Leung TF et al. Association of prostaglandin-endoperoxide synthase 2 gene polymorphisms with asthma and atopy in Chinese children. Allergy 2007; 62:802-9.

Chan J, Donalson LM, Kushwaha RS, Ferdinandusse S, VandeBerg JF, VandeBerg JL. Differential expression of hepatic genes involved in cholesterol homeostasis in high- and low-responding strains of laboratory opossums. Metabolism 2008; 57:718-24.

Chan JD. Pharmacokinetic drug interactions of vinca alkaloids: summary of case reports. Pharmacotherapy 1998; 18:1304-7.

Chan JL, Oral EA. Clinical classification and treatment of congenital and acquired lipodystrophy. Endocr Pract 2010; 16:310-23.

Chan KY, Ching JC, Xu MS et al. Association of ICAM3 genetic variant with severe acute respiratory syndrome. J Infect Dis 2007; 196:271-80.

Chan LM, Cooper AE, Dudley AL, Ford D, Hirst BH. P-glycoprotein potentiates CYP3A4-mediated drug disappearance during Caco-2 intestinal secretory detoxification. J Drug Target 2004; 12:405-13.

Chan MY, Huang H, Leung LK. 2,3,7,8-Tetrachlorodibenzo-para-dioxin increases aromatase (CYP19) mRNA stability in MCF-7 cells. Mol Cell Endocrinol 2010; 317:8-13.

Chan WH, Liao JW, Chou CP, Chan PK, Wei CF, Ueng TH. Induction of CYP1A1, 2B, 2E1 and 3A in rat liver by organochlorine pesticide dicofol. Toxicol Lett 2009; 190:150-5.

Chan WK, Delucchi AB. Resveratrol, a red wine constituent, is a mechanism-based inactivator of cytochrome P450 3A4. Life Sci 2000; 67:3103-12.

Chan WK, Nguyen LT, Miller VP, Harris RZ. Mechanism-based inactivation of human cytochrome P450 3A4 by grapefruit juice and red wine. Life Sci 1998; 62:135-42.

Chan WP, Lee CK, Kwong YL, Lam CK, Liang R. A novel mutation of Arg306 of factor V gene in Hong Kong Chinese. Blood 1998; 91:1135-9.

Chand AL, Herridge KA, Howard TL, Simpson ER, Clyne CD. Tissue-specific regulation of aromatase promoter II by the orphan nuclear receptor LRH-1 in breast adipose stromal fibroblasts. Steroids 2011; 76:741-4.

Chand AL, Herridge KA, Thompson EW, Clyne CD. The orphan nuclear receptor LRH-1 promotes breast cancer motility and invasion. Endocr Relat Cancer 2010; 17:965-75.

Chanda D, Xie YB, Choi HS. Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation. Nucleic Acids Res 2010; 38:4607-19.

Chandrasekaran K, Swaminathan K, Kumar SM, Chatterjee S, Clemens DL, Dey A. Elevated glutathione level does not protect against chronic alcohol mediated apoptosis in recombinant human hepatoma cell line VL-17A over-expressing alcohol metabolizing enzymes-alcohol dehydrogenase and Cytochrome P450 2E1. Toxicol In Vitro 2011; 25:969-78.

Chang CH, Chen CY, Chiou JY, Peng RY, Peng CH. Astaxanthine secured apoptotic death of PC12 cells induced by beta-amyloid peptide 25-35: its molecular action targets. J Med Food 2010; 13:548-56.

Chang DJ, Chang TK, Yamanishi SS et al. Molecular cloning, genomic characterization and expression of novel human alpha-1A-adrenoceptor isoforms. FEBS Lett 1998; 422:279-83.

Chang EJ, Ha J, Kang SS, Lee ZH, Kim HH. AWP1 binds to tumor necrosis factor receptor-associated factor 2 (TRAF2) and is involved in TRAF2-mediated nuclear factor-kappaB signaling. Int J Biochem Cell Biol 2011; 43:1612-20.

Chang H, Rha SY, Jeung HC et al. Association of the ABCB1 gene polymorphisms 2677G>T/A and 3435C>T with clinical outcomes of paclitaxel monotherapy in metastatic breast cancer patients. Ann Oncol 2009; 20:272-7.

Chang H, Rha SY, Jeung HC et al. Association of the ABCB1 3435C>T polymorphism and treatment outcomes in advanced gastric cancer patients treated with paclitaxel-based chemotherapy. Oncol Rep 2010; 23:271-8.

Chang HC, Chen TL, Chen RM. Cytoskeleton interruption in human hepatoma HepG2 cells induced by ketamine occurs possibly through suppression of calcium mobilization and mitochondrial function. Drug Metab Dispos 2009; 37:24-31.

Chang JH, Kochansky CJ, Shou M. The role of P-glycoprotein in the bioactivation of raloxifene. Drug Metab Dispos 2006; 34:2073-8.

Chang JW, Lee WY, Milstien S, Kang UJ. A site-specific mutation of tyrosine hydroxylase reduces feedback inhibition by dopamine in genetically modified cells grafted in parkinsonian rats. J Neurochem 2002; 83:141-9.

Chang JY, Liu JF, Juang SH, Liu TW, Chen LT. Novel mutation of topoisomerase I in rendering cells resistant to camptothecin. Cancer Res 2002; 62:3716-21.

Chang MH, Yesupriya A, Ned RM, Mueller PW, Dowling NF. Genetic variants associated with fasting blood lipids in the U. S. population: Third National Health and Nutrition Examination Survey. BMC Med Genet 2010; 11:62.

Chang PF, Lin YC, Liu K, Yeh SJ, Ni YH. Risk of hyperbilirubinemia in breast-fed infants. J Pediatr 2011; 159:561-5.

Chang S, Ma T, Miranda RD, Balestra ME, Mahley RW, Huang Y. Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity. Proc Nat Acad Sci USA 2005; 102:18694-99.

Chang SC, Ehresman DJ, Bjork JA et al. Gestational and lactational exposure to potassium perfluorooctanesulfonate (K+PFOS) in rats: toxicokinetics, thyroid hormone status, and related gene expression. Reprod Toxicol 2009; 27:387-99.

Chang SJ, Chen CJ, Tsai FC et al. Associations between gout tophus and polymorphisms 869T/C and -509C/T in transforming growth factor beta1 gene. Rheumatology 2008; 5:617-21.

Chang SY, Chen C, Yang Z, Rodrigues AD. Further assessment of 17alpha-ethinyl estradiol as an inhibitor of different human cytochrome P450 forms in vitro. Drug Metab Dispos 2009; 37:1667-75.

Chang SY, Fancher RM, Zhang H, Gan J. Mechanism-based inhibition of human cytochrome P4503A4 by domperidone. Xenobiotica 2010; 40:138-45.

Chang SY, Li W, Traeger SC et al. Confirmation that cytochrome P450 2C8 (CYP2C8) plays a minor role in (S)-(+)- and (R)-(-)-ibuprofen hydroxylation in vitro. Drug Metab Dispos 2008; 36:2513-22.

Chang TJ, Tsai MH, Jiang YD et al. The Arg16Gly polymorphism of human beta2-adrenoreceptor is associated with type 2 diabetes in Taiwanese people. Clin Endocrinol 2002; 57:685-90.

Chang TK, Chen J, Yang G, Yeung EY. Inhibition of procarcinogen-bioactivating human CYP1A1, CYP1A2 and CYP1B1 enzymes by melatonin. J Pineal Res 2010; 48:55-64.

Chang TK, Yeung RK. Effect of trans-resveratrol on 7-benzyloxy-4-trifluoromethylcoumarin O-dealkylation catalyzed by human recombinant CYP3A4 and CYP3A5. Can J Physiol Pharmacol 2001; 79:220-6.

Chang TK, Yu L, Maurel P, Waxman DJ. Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines. Cancer Res 1997; 57:1946-54.

Chang W, Tu C, Chen TH, Bikle D, Shoback D. The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development. Sci Signal 2008; 1:1.

Chang WL, Chang CS, Chiang PC et al. 2-Phenyl-5-(pyrrolidin-1-yl)-1-(3,4,5-trimethoxybenzyl)-1H-benzimidazole, a benzimidazole derivative, inhibits growth of human prostate cancer cells by affecting tubulin and c-Jun N-terminal kinase. Br J Pharmacol 2010; 160:1677-89.

Chang X, Cui Y, Zong M et al. Identification of proteins with increased expression in rheumatoid arthritis synovial tissues. J Rheumatol 2009; 36:872-80.

Chang XL, Mao XY, Li HH et al. Association of GWAS loci with PD in China. Am J Med Genet B Neuropsychiatr Genet 2011; 156:334-9.

Chang XT, Wang ZH, Du X et al. Effect of polymorphism of human intestinal fatty acid binding protein gene on the therapeutic efficacy of fenofibrate. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2006; 28:230-3.

Chang Y, Fang WB, Lin SN, Moody DE. Stereo-selective metabolism of methadone by human liver microsomes and cDNA-expressed cytochrome P450s: a reconciliation. Basic Clin Pharmacol Toxicol 2011; 108:55-62.

Chang YT, Sharma R, Marsh JL et al. Levodopa-responsive aromatic L-amino acid decarboxylase deficiency. Ann Neurol 2004; 55:435-8.

Chang YT, Sun HS, Fann CS et al. Association of the gamma-aminobutyric acid A receptor gene cluster with alcohol dependence in Taiwanese Han. Mol Psychiatry 2002; 7:828-9.

Chang YY, Chou CH, Chiu CH et al. Preventive effects of taurine on development of hepatic steatosis induced by a high-fat/cholesterol dietary habit. J Agric Food Chem 2011; 59:450-7.

Chang-Claude J, Ambrosone CB, Lilla C et al. Genetic polymorphisms in DNA repair and damage response genes and late normal tissue complications of radiotherapy for breast cancer. Br J Cancer 2009; 100:1680-6.

Chanmahasathien W, Ampasavate C, Greger H, Limtrakul P. Stemona alkaloids, from traditional Thai medicine, increase chemosensitivity via P-glycoprotein-mediated multidrug resistance. Phytomedicine 2011; 18:199-204.

Chanplakorn N, Chanplakorn P, Suzuki T et al. Increased 5α-reductase type 2 expression in human breast carcinoma following aromatase inhibitor therapy: the correlation with decreased tumor cell proliferation. Horm Cancer 2011; 2:73-81.

Chantarangsu S, Cressey TR, Mahasirimongkol S et al. Influence of CYP2B6 polymorphisms on the persistence of plasma nevirapine concentrations following a single intra-partum dose for the prevention of mother to child transmission in HIV-infected Thai women. J Antimicrob Chemother 2009; 64:1265-73.

Chao YC, Young TH, Chang WK, Tang HS, Hsu CT. An investigation of whether polymorphisms of cytochrome P4502E1 are genetic markers of susceptibility to alcoholic end-stage organ damage in a Chinese population. Hepatology 1995; 22:1409-14.

Chapman J, Arlazoroff A, Goldfarb LG et al. Fatal insomnia in a case of familial Creutzfeldt-Jakob disease with the codon 200(lys) mutation. Neurology 1996; 46:758-61.

Chapman J, Korczyn AD, Karussis DM, Michaelson DM. The effects of APOE genotype on age at onset and progression of neurodegenerative diseases. Neurology 2001; 57:1482-5.

Chapman J, Vinokurov S, Achiron A et al. APOE genotype is a major predictor of long-term progression of disability in MS. Neurology 2001; 56:312-6.

Chapman JV, Gouazé-Andersson V, Cabot MC. Expression of P-glycoprotein in HeLa cells confers resistance to ceramide cytotoxicity. Int J Oncol 2010; 37:1591-7.

Chapman JV, Gouazé-Andersson V, Karimi R, Messner MC, Cabot MC. P-glycoprotein antagonists confer synergistic sensitivity to short-chain ceramide in human multidrug-resistant cancer cells. Exp Cell Res 2011; 317:1736-45.

Chapman TM, Goa KL. Cilostazol: a review of its use in intermittent claudication. Am J Cardiovasc Drugs 2003; 3:117-38.

Charasson V, Haaz MC, Robert J. Determination of drug interactions occurring with the metabolic pathways of irinotecan. Drug Metab Dispos 2002; 30:731-3.

Charbit B, Becquemont L, Lepère B, Peytavin G, Funck-Brentano C. Pharmacokinetic and pharmacodynamic interaction between grapefruit juice and halofantrine. Clin Pharmacol Ther 2002; 72:514-23.

Charles KA, Rivory LP, Brown SL, Liddle C, Clarke SJ, Robertson GR. Transcriptional repression of hepatic cytochrome P450 3A4 gene in the presence of cancer. Clin Cancer Res 2006; 12:7492-7.

Charlier TD, Newman AE, Heimovics SA, Po KW, Saldanha CJ, Soma KK. Rapid effects of aggressive interactions on aromatase activity and oestradiol in discrete brain regions of wild male white-crowned sparrows. J Neuroendocrinol 2011; 23:742-53.

Charmandari E, Kino T, Ichijo T et al. A novel point mutation in helix 11 of the ligand-binding domain of the human glucocorticoid receptor gene causing generalized glucocorticoid resistance. J Clin Endocrinol Metab 2007; 92:3986-90.

Charmandari E, Kino T, Ichijo T, Zachman K, Alatsatianos A, Chrousos GP. Functional characterization of the natural human glucocorticoid receptor (hGR) mutants hGRalphaR477H and hGRalphaG679S associated with generalized glucocorticoid resistance. J Clin Endocrinol Metab 2006; 91:1535-43.

Charmandari E, Raji A, Kino T et al. A novel point mutation in the ligand-binding domain (LBD) of the human glucocorticoid receptor (hGR) causing generalized glucocorticoid resistance: the importance of the C terminus of hGR LBD in conferring transactivational activity. J Clin Endocrinol Metab 2005; 90:3696-705.

Chartier-Harlin M-C, Crawford F, Houlden H et al. Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene. Nature 1991; 353:844-6.

Charvet C, Liao WL, Heo GY et al. Isolevuglandins and mitochondrial enzymes in the retina: mass spectrometry detection of post-translational modification of sterol-metabolizing CYP27A1. J Biol Chem 2011; 286:20413-22.

Charvin D, Roze E, Perrin V et al. Haloperidol protects striatal neurons from dysfunction induced by mutated huntingtin in vivo. Neurobiol Dis 2008; 29:22-9.

Chasman DI, Posada D, Subrahmanyan L, Cook NR, Stanton VP Jr, Ridker PM. Pharmacogenetic study of statin therapy and cholesterol reduction. JAMA 2004; 291:2821-7.

Chassaing N, Martin L, Calvas P, Le Bert M, Hovnanian A. Pseudoxanthoma elasticum: a clinical, pathophysiological and genetic update including 11 novel ABCC6 mutations. J Med Genet 2005; 42:881-92.

Chasseraud M, Liabeuf S, Mozar A et al. Tumor necrosis factor-related apoptosis-inducing ligand and vascular calcification. Ther Apher Dial 2011; 15:140-6.

Chaste P, Clement N, Mercati O et al. Identification of pathway-biased and deleterious melatonin receptor mutants in autism spectrum disorders and in the general population. PLoS One 2010. doi:10. 1371/journal. pone. 0011495.

Chatterjee P, Franklin MR. Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components. Drug Metab Dispos 2003; 31:1391-7.

Chatterjee S, Dhar S, Sengupta B et al. Polymorphisms of CYP1A1, GSTM1 and GSTT1 loci as the genetic predispositions of oral cancers and other oral pathologies: tobacco and alcohol as risk modifiers. Indian J Clin Biochem 2010; 25:260-72.

Chatterjee S, Lyle N, Mandal A, Kundu S. GSTT1 and GSTM1 gene deletions are not associated with hepatotoxicity caused by antitubercular drugs. J Clin Pharm Ther 2010; 35:465-70.

Chatuphonprasert W, Kondo S, Jarukamjorn K, Kawasaki Y, Sakuma T, Nemoto N. Potent modification of inducible CYP1A1 expression by flavonoids. Biol Pharm Bull 2010; 33:1698-703.

Chatzikyriakidou A, Georgiou I, Voulgari PV, Papadopoulos CG, Tzavaras T, Drosos AA. Transcription regulatory polymorphism -43T>C in the 5'-flanking region of SLC19A1 gene could affect rheumatoid arthritis patient response to methotrexate therapy. Rheumatol Int 2007; 11:1057-61.

Chatzikyriakidou A, Vakalis KV, Kolaitis N et al. Distinct association of SLC19A1 polymorphism -43T>C with red cell folate levels and of MTHFR polymorphism 677C>T with plasma folate levels. Clin Biochem 2008; 3:174-76.

Chaudhry AS, Kochhar R, Kohli KK. Importance of CYP2C19 genetic polymorphism in the eradication of Helicobacter pylori in north Indians. Indian J Med Res 2009; 130:437-43.

Chaudhry AS, Urban TJ, Lamba JK et al. CYP2C9*1B promoter polymorphisms, in linkage with CYP2C19*2, affect phenytoin autoinduction of clearance and maintenance dose. J Pharmacol Exp Ther 2010; 332:599-611.

Chauhan PS, Ihsan R, Yadav DS et al. Association of glutathione S-transferase, EPHX, and p53 codon 72 gene polymorphisms with adult acute myeloid leukemia. DNA Cell Biol 2011; 30:39-46.

Chaung WW, Jacob A, Ji Y, Wang P. Suppression of PGC-1 alpha by ethanol: implications of its role in alcohol induced liver injury. Int J Clin Exp Med 2008; 1:161-70.

Chauret N, Yergey JA, Brideau C et al. In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663). Bioorg Med Chem Lett 2001; 11:1059-62.

Chavarria-Soley G, Sticht H, Aklillu E et al. Mutations in CYP1B1 cause primary congenital glaucoma by reduction of either activity or abundance of the enzyme. Hum Mutat 2008; 29:1147-53.

Chave KJ, Ryan TJ, Chmura SE, Galivan J. Identification of single nucleotide polymorphisms in the human gamma-glutamyl hydrolase gene and characterization of promoter polymorphisms. Gene 2003; 319:167-75.

Chaves FJ, Corella D, Sorli JV, Marin-Garcia P, Guillen M, Redon J. Polymorphisms of the renin-angiotensin system influence height in normotensive women in a Spanish population. J Clin Endocr Metab 2004; 89:2301-5.

Chavez C, Gogos A, Hill R et al. Differential effect of amphetamine on c-fos expression in female aromatase knockout (ArKO) mice compared to wildtype controls. Psychoneuroendocrinology 2011; 36:761-8.

Checkoway H, Franklin GM, Costa-Mallen P et al. A genetic polymorphism of MAO-B modifies the association of cigarette smoking and Parkinson's disease. Neurology 1998; 50:1458-61.

Cheer SM, Goa KL. Fluoxetine: a review of its therapeutic potential in the treatment of depression associated with physical illness. Drugs 2001; 61:81-110.

Chefson A, Auclair K. CYP3A4 activity in the presence of organic cosolvents, ionic liquids, or water-immiscible organic solvents. Chembiochem 2007; 8:1189-97.

Chefson A, Zhao J, Auclair K. Sugar-mediated lyoprotection of purified human CYP3A4 and CYP2D6. J Biotechnol 2007; 130:436-40.

Chen AA, Marsit CJ, Christensen BC et al. Genetic variation in the vitamin C transporter, SLC23A2, modifies the risk of HPV16-associated head and neck cancer. Carcinogenesis 2009; 30:977-81.

Chen AC, Manz N, Tang Y et al. Single-nucleotide polymorphisms in corticotropin releasing hormone receptor 1 gene (CRHR1) are associated with quantitative trait of event-related potential and alcohol dependence. Alcohol Clin Exp Res 2010; 34:988-96.

Chen AY, Lee AJ, Jiang XR, Zhu BT. Chemical synthesis of six novel 17beta-estradiol and estrone dimers and study of their formation catalyzed by human cytochrome P450 isoforms. J Med Chem 2007; 50:5372-81.

Chen B, Bronson RT, Klaman LD et al. Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis. Nat Genet 2000; 24:296-9.

Chen B, Cai WM. Influence of CYP2D6*10B genotype on pharmacokinetics of propafenone enantiomers in Chinese subjects. Acta Pharmacol Sin 2003; 24:1277-80.

Chen B, Hu Y, Jin T et al. The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers. Sci Total Environ 2007; 381:38-46.

Chen B, Mi S, Wright B, Connon CJ. Investigation of K14/K5 as a stem cell marker in the limbal region of the bovine cornea. PLoS One 2010. doi:10. 1371/journal. pone. 0013192.

Chen B, Nie S, Luo S, Zhang W, Xiao C. Association of the human CYP11B2 gene and essential hypertension in southwest Han Chinese population: a haplotype-based case-control study. Clin Exp Hypertens 2011; 33:106-12.

Chen B, Nie S, Yue Z, Shou W, Xiao C. Haplotype-based case-control study of the human CYP11B2 gene and essential hypertension in Yi and Hani minorities of China. Biochem Genet 2011; 49:122-37.

Chen B, Qiu LX, Li Y et al. The CYP1B1 Leu432Val polymorphism contributes to lung cancer risk: evidence from 6501 subjects. Lung Cancer 2010; 70:247-52.

Chen B, Yin L, Cheng J et al. Effect of D, L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol and tetrandrine on the reversion of multidrug resistance in K562/A02 cells. Hematology 2011; 16:24-30.

Chen B, Zhang W, Fang J et al. Influence of the MDR1 haplotype and CYP3A5 genotypes on cyclosporine blood level in Chinese renal transplant recipients. Xenobiotica 2009; 39:931-8.

Chen BA, Mao PP, Cheng J et al. Reversal of multidrug resistance by magnetic Fe3O4 nanoparticle copolymerizating daunorubicin and MDR1 shRNA expression vector in leukemia cells. Int J Nanomedicine 2010; 5:437-44.

Chen BA, Shan XY, Chen J, Xia GH, Xu WL, Schmit M. Effects of imatinib and 5-bromotetrandrine on the reversal of multidrug resistance of the K562/A02 cell line. Chin J Cancer 2010; 29:591-5.

Chen BA, Wang F, Cheng J et al. Effect of hypoxia inducible factor1-α inhibitor on reversal of multidrug resistance of K562/A02 cell line. Zhonghua Xue Ye Xue Za Zhi 2010; 31:389-93.

Chen BL, Chen Y, Tu JH et al. Clopidogrel inhibits CYP2C19-dependent hydroxylation of omeprazole related to CYP2C19 genetic polymorphisms. J Clin Pharmacol 2009; 49:574-81.

Chen C, Chen Y, Pontillo J et al. Potent and orally bioavailable zwitterion GnRH antagonists with low CYP3A4 inhibitory activity. Bioorg Med Chem Lett 2008; 18:3301-5.

Chen C, Han YH, Yang Z, Rodrigues AD. Effect of interferon-α2b on the expression of various drug-metabolizing enzymes and transporters in co-cultures of freshly prepared human primary hepatocytes. Xenobiotica 2011; 41:476-85.

Chen C, Hanson E, Watson JW, Lee JS. P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists. Drug Metab Dispos 2003; 31:312-8.

Chen C, Li G, Liao W et al. Selective inhibitors of CYP2J2 related to terfenadine exhibit strong activity against human cancers in vitro and in vivo. J Pharmacol Exp Ther 2009; 329:908-18.

Chen C, Mireles RJ, Campbell SD et al. Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1. Drug Metab Dispos 2005; 33:537-46.

Chen C, Shen HL, Yang J, Chen QY, Xu WL. Preventing chemoresistance of human breast cancer cell line, MCF-7 with celecoxib. J Cancer Res Clin Oncol 2011; 137:9-17.

Chen C, Thakker DR. The fallacy of using adrenochrome reaction for measurement of reactive oxygen species formed during cytochrome p450-mediated metabolism of xenobiotics. J Pharmacol Exp Ther 2002; 300:417-20.

Chen C, Wei X, Rao X et al. Cytochrome P450 2J2 is highly expressed in hematologic malignant diseases and promotes tumor cell growth. J Pharmacol Exp Ther 2011; 336:344-55.

Chen C, Westenbroek RE, Xu X et al. Mice lacking sodium channel beta-1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture. J Neurosci 2004; 24:4030-42.

Chen C, Wu D, Guo Z et al. Discovery of sodium R-(+)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (elagolix), a potent and orally available nonpeptide antagonist of the human gonadotropin-releasing hormone receptor. J Med Chem 2008; 51:7478-85.

Chen C, Zhao W, Lu Y et al. High-throughput detection of highly benzimidazole-resistant allele E198A with mismatch primers in allele-specific real-time polymerase chain reaction. Pest Manag Sci 2009; 65:413-9.

Chen CC, Lu RB, Chen YC et al. Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism. Am J Hum Genet 1999; 65:795-807.

Chen CJ, Hsu LI, Wang CH et al. Biomarkers of exposure, effect, and susceptibility of arsenic-induced health hazards in Taiwan. Toxicol Appl Pharmacol 2005; 206:198-206.

Chen CL, Liu Q, Pui CH et al. Higher frequency of glutathione S-transferase deletions in black children with acute lymphoblastic leukemia. Blood 1997; 89:1701-7.

Chen CP, Lin SP, Chern SR et al. A de novo 7. 9 Mb deletion in 22q13. 2→qter in a boy with autistic features, epilepsy, developmental delay, atopic dermatitis and abnormal immunological findings. Eur J Med Genet 2010; 53:329-32.

Chen CS, Jounaidi Y, Waxman DJ. Enantioselective metabolism and cytotoxicity of R-ifosfamide and S-ifosfamide by tumor cell-expressed cytochromes P450. Drug Metab Dispos 2005; 33:1261-7.

Chen CS, Ouyang P, Yeh YC et al. Apolipoprotein E polymorphism and behavioral and psychological symptoms of dementia in patients with Alzheimer disease. Alzheimer Dis Assoc Disord 2011. doi:10. 1097/WAD. 0b013e31821f5787.

Chen CW, Cheng HH. A rice bran oil diet increases LDL-receptor and HMG-CoA reductase mRNA expressions and insulin sensitivity in rats with streptozotocin/nicotinamide-induced type 2 diabetes. J Nutr 2006; 136:1472-6.

Chen CY, Shyue SK, Ching LC et al. Wogonin promotes cholesterol efflux by increasing protein phosphatase 2B-dependent dephosphorylation at ATP-binding cassette transporter-A1 in macrophages. J Nutr Biochem 2011; 22:1015-21.

Chen D, Reierstad S, Fang F, Bulun SE. JunD and JunB integrate prostaglandin E2 activation of breast cancer-associated proximal aromatase promoters. Mol Endocrinol 2011; 25:767-75.

Chen D, Tian T, Wang H et al. Association of human aryl hydrocarbon receptor gene polymorphisms with risk of lung cancer among cigarette smokers in a Chinese population. Pharmacogenet Genomics 2009; 19:25-34.

Chen DY, Chih HM, Lan JL, Chang HY, Chen WW, Chiang EP. Blood lipid profiles and peripheral blood mononuclear cell cholesterol metabolism gene expression in patients with and without methotrexate treatment. BMC Med 2011; 9:4.

Chen F, Ritter JK, Wang MG, McBride OW, Lubet RA, Owens IS. Characterization of a cloned human dihydrotestosterone/androstanediol UDP-glucuronosyltransferase and its comparison to other steroid isoforms. Biochemistry 1993; 32:10648-57.

Chen G, Paka L, Kako Y, Singhal P, Duan W, Pillarisetti S. A protective role for kidney apolipoprotein E: regulation of mesangial cell proliferation and matrix expansion. J Biol Chem 2001; 276:49142-7.

Chen G, Wang P, Zhao G et al. Cytochrome P450 epoxygenase CYP2J2 attenuates nephropathy in streptozotocin-induced diabetic mice. Prostaglandins Other Lipid Mediat 2011. doi:10. 1016/j. prostaglandins. 2011. 06. 009.

Chen H, Bi W, Cao B et al. A novel podophyllotoxin derivative (YB-1EPN) induces apoptosis and down-regulates express of P-glycoprotein in multidrug resistance cell line KBV200. Eur J Pharmacol 2010; 627:69-74.

Chen H, Chen W, Gan LS, Mutlib AE. Metabolism of (S)-5,6-difluoro-4-cyclopropylethynyl-4-trifluoromethyl-3, 4-dihydro-2(1H)-quinazolinone, a non-nucleoside reverse transcriptase inhibitor, in human liver microsomes. Metabolic activation and enzyme kinetics. Drug Metab Dispos 2003; 31:122-32.

Chen H, Hernandez W, Shriver MD, Ahaghotu CA, Kittles RA. ICAM gene cluster SNPs and prostate cancer risk in African Americans. Hum Genet 2006; 120:69-76.

Chen H, Howald WN, Juchau MR. Biosynthesis of all-trans-retinoic acid from all-trans-retinol: catalysis of all-trans-retinol oxidation by human P-450 cytochromes. Drug Metab Dispos 2000; 28:315-22.

Chen H, Huang Q, Dong J, Zhai DZ, Wang AD, Lan Q. Overexpression of CDC2/CyclinB1 in gliomas, and CDC2 depletion inhibits proliferation of human glioma cells in vitro and in vivo. BMC Cancer 2008; 8:29.

Chen H, Sandler DP, Taylor JA et al. Increased risk for myelodysplastic syndromes in individuals with glutathione transferase theta 1 (GSTT1) gene defect. Lancet 1996; 347:295-7.

Chen H, Wang L, Beretov J, Hao J, Xiao W, Li Y. Co-expression of CD147/EMMPRIN with monocarboxylate transporters and multiple drug resistance proteins is associated with epithelial ovarian cancer progression. Clin Exp Metastasis 2010; 27:557-69.

Chen H, Zientek M, Jalaie M, Zhang Y, Bigge C, Mutlib A. Characterization of cytochrome P450-mediated bioactivation of a compound containing the chemical scaffold, 4,5-dihydropyrazole-1-carboxylic acid-(4-chlorophenyl amide), to a chemically reactive p-chlorophenyl isocyanate intermediate in human liver microsomes. Chem Res Toxicol 2009; 22:1603-12.

Chen HC, Sytwu HK, Chang JL et al. Hypoxia enhances the stemness markers of cochlear stem/progenitor cells and expands sphere formation through activation of hypoxia-inducible factor-1alpha. Hear Res 2011; 275:43-52.

Chen HR, Yang HC, Hsieh DJ, Liu Z, Tsai KJ. Zebrafish sod1 and sp1 expression are modulated by the copper ATPase gene atp7a in response to intracellular copper status. Chem Biol Interact 2011; 189:192-7.

Chen J, Cai SP, Yu W et al. Sequence analysis of MYOC and CYP1B1 in a Chinese pedigree of primary open-angle glaucoma. Mol Vis 2011; 17:1431-5.

Chen J, Hong CJ, Chiu HJ et al. Apoliprotein E genotype and schizophrenia. Biol Psychiatry 1999; 39:141-3.

Chen J, Huang XF. The effects of diets enriched in beta-glucans on blood lipoprotein concentrations. J Clin Lipidol 2009; 3:154-8.

Chen J, Lu L, Feng Y et al. PKD2 mediates multi-drug resistance in breast cancer cells through modulation of P-glycoprotein expression. Cancer Lett 2011; 300:48-56.

Chen J, Sun J, Ma Q et al. CYP2B6 polymorphism and nonnucleoside reverse transcriptase inhibitor plasma concentrations in Chinese HIV-infected patients. Ther Drug Monit 2010; 32:573-8.

Chen J, Tran C, Xiao L et al. Co-induction of CYP3A12 and 3A26 in dog liver slices by xenobiotics: species difference between human and dog CYP3A induction. Drug Metab Lett 2009; 3:61-6.

Chen J, Yang XX, Huang M et al. Small interfering RNA-mediated silencing of cytochrome P450 3A4 gene. Drug Metab Dispos 2006; 34:1650-7.

Chen J, Zhao H, Yang Y, Liu B, Ni J, Wang W. Lipid-lowering and antioxidant activities of Jiang-Zhi-Ning in Traditional Chinese Medicine. J Ethnopharmacol 2011; 134:919-30.

Chen JT, Chen RM. Mechanisms of ketamine-involved regulation of cytochrome P450 gene expression. Expert Opin Drug Metab Toxicol 2010; 6:273-81.

Chen K, Wang R, Wen SY, Li J, Wang SQ. Relationship of P450 2C9 genetic polymorphisms in Chinese and the pharmacokinetics of tolbutamide. J Clin Pharm Ther 2005; 30:241-9.

Chen KG, Valencia JC, Gillet JP, Hearing VJ, Gottesman MM. Involvement of ABC transporters in melanogenesis and the development of multidrug resistance of melanoma. Pigment Cell Melanoma Res 2009; 22:740-9.

Chen KH, Lin BR, Chien CT, Ho CH. Emblica officinalis Gaertn. Attentuates N-Nitrosodiethylamine-induced apoptosis, autophagy, and inflammation in rat livers. J Med Food 2011; 14:746-55.

Chen KX, Vibulbhan B, Liu T et al. The role of P-glycoprotein in the pharmacokinetics and tissue distribution of a hepatitis C virus protease inhibitor. Drug Metab Lett 2009; 3:290-5.

Chen L, Li Y, Zhao Q, Peng H, Hou T. ADME evaluation in drug discovery. 10. Predictions of P-glycoprotein inhibitors using recursive partitioning and naive Bayesian classification techniques. Mol Pharm 2011; 8:889-900.

Chen L, Meyers D, Javorsky G et al. Arg389Gly-beta1-adrenergic receptors determine improvement in left ventricular systolic function in nonischemic cardiomyopathy patients with heart failure after chronic treatment with carvedilol. Pharmacogenet Genomics 2007; 17:941-9.

Chen L, Qin S, Xie J et al. Genetic polymorphism analysis of CYP2C19 in Chinese Han populations from different geographic areas of mainland China. Pharmacogenomics 2008; 9:691-702.

Chen L, Yoshino G, Maeda E, Zeng S. Effect of microsomal triglyceride transfer protein gene polymorphism in the promoter region on dyslipidemia in type 2 diabetic subjects. Chin Med J 2003; 116:215-7.

Chen LM, Liang YJ, Zhang X et al. Reversal of P-gp-mediated multidrug resistance by bromotetrandrine in vivo is associated with enhanced accumulation of chemotherapeutical drug in tumor tissue. Anticancer Res 2009; 29:4597-604.

Chen ML, Tsai SH, Ip SP, Ko KM, Che CT. Long-term treatment with a "Yang-invigorating" Chinese herbal formula, Wu-Zi-Yan-Zong-Wan, reduces mortality and liver oxidative damage in chronic alcohol-intoxicated rats. Rejuvenation Res 2010; 13:459-67.

Chen PL, Yeh KT, Tsai YY et al. XRCC1, but not APE1 and hOGG1 gene polymorphisms is a risk factor for pterygium. Mol Vis 2010; 16:991-6.

Chen Q, Gruber H, Pakenham C, Ratnayake WM, Scoggan KA. Dietary phytosterols and phytostanols alter the expression of sterol-regulatory genes in SHRSP and WKY inbred rats. Ann Nutr Metab 2009; 55:341-50.

Chen Q, Reis SE, Kammerer C et al. Association of anti-oxidized LDL and candidate genes with severity of coronary stenosis in the Women's Ischemia Syndrome Evaluation study. J Lipid Res 2011; 52:801-7.

Chen Q, Wu J, Yu Y. Establishment of transgenic cell line CHL-3A4 and its metabolic activation. Zhonghua Yu Fang Yi Xue Za Zhi 1998; 32:281-4.

Chen Q, Zhou J, Jiang C, Chen J. Reversal of P-glycoprotein-mediated multidrug resistance in SGC7901/VCR cells by PPARgamma activation by troglitazone. J Huazhong Univ Sci Technolog Med Sci 2010; 30:326-31.

Chen QJ, Lu L, Jin C et al. Insertion/insertion genotype of α(2B)-adrenergic receptor gene polymorphism is associated with silent myocardial ischemia in patients with type 2 diabetes mellitus. Clin Biochem 2010; 43:1201-4.

Chen S, Ferrone F, Wetzel R. Hungtington's disease age-of-onset linked to polyglutamine aggregation nucleation. Proc Nat Acad Sci USA 2002; 99:11884-9.

Chen S, Huo X, Lin Y et al. Association of MDR1 and ERCC1 polymorphisms with response and toxicity to cisplatin-based chemotherapy in non-small-cell lung cancer patients. Int J Hyg Environ Health 2010; 213:140-5.

Chen S, Li X. Transposable elements are enriched within or in close proximity to xenobiotic-metabolizing cytochrome P450 genes. BMC Evol Biol 2007; 7:46.

Chen S, Tsybouleva N, Ballantyne CM, Gotto AM Jr, Marian AJ. Effects of PPARalpha, gamma and delta haplotypes on plasma levels of lipids, severity and progression of coronary atherosclerosis and response to statin therapy in the lipoprotein coronary atherosclerosis study. Pharmacogenetics 2004; 14:61-71.

Chen S, Wang K, Wan YJ. Retinoids activate RXR/CAR-mediated pathway and induce CYP3A. Biochem Pharmacol 2010; 9:270-6.

Chen S, Ye J, Kijima I, Evans D. The HDAC inhibitor LBH589 (panobinostat) is an inhibitory modulator of aromatase gene expression. Proc Natl Acad Sci USA 2010; 107:11032-7.

Chen SC, Slavin MA, Sorrell TC. Echinocandin antifungal drugs in fungal infections: a comparison. Drugs 2011; 71:11-41.

Chen SF, Shen YC, Chen CH. Effects of the DRD3 Ser9Gly polymorphism on aripiprazole efficacy in schizophrenic patients as modified by clinical factors. Prog Neuropsychopharmacol Biol Psychiatry 2009; 33:470-4.

Chen SF, Shen YC, Chen CH. HTR2A A-1438G/T102C polymorphisms predict negative symptoms performance upon aripiprazole treatment in schizophrenic patients. Psychopharmacology 2009; 205:285-92.

Chen SG, Xiao J, Liu XH et al. Ibrolipim increases ABCA1/G1 expression by the LXRα signaling pathway in THP-1 macrophage-derived foam cells. Acta Pharmacol Sin 2010; 31:1343-9.

Chen SH, Chou FF, Ko JY. The use of simvastatin with aromasin in an ovariectomized rat model: effects on the skeletal system. Chang Gung Med J 2010; 33:509-14.

Chen SP, Chiu SC, Wu CC et al. The association of methylation in the promoter of APC and MGMT and the prognosis of Taiwanese CRC patients. Genet Test Mol Biomarkers 2009; 13:67-71.

Chen SP, Wu CC, Lin SZ et al. Prognostic significance of interaction between somatic APC mutations and 5-fluorouracil adjuvant chemotherapy in Taiwanese colorectal cancer subjects. Am J Clin Oncol 2009; 32:122-6.

Chen W, Stambolian D, Edwards AO et al. Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci USA 2010; 107:7401-6.

Chen WY, Chang WL, Tsai YC, Cheng HC, Lu CC, Sheu BS. Double-dosed pantoprazole accelerates the sustained symptomatic response in overweight and obese patients with reflux esophagitis in Los Angeles grades A and B. Am J Gastroenterol 2010; 105:1046-52.

Chen X, Chen Y, Wang L et al. Confirmation and further mapping of the GLC3C locus in primary congenital glaucoma. Front Biosci 2011; 17:2052-9.

Chen X, Jiang R, Geng Z. Cold stress in broiler: global gene expression analyses suggest a major role of CYP genes in cold responses. Mol Biol Rep 2011. doi:10. 1007/s11033-011-0754-x.

Chen X, Sun CK, Han GZ et al. Protective effect of tea polyphenols against paracetamol-induced hepatotoxicity in mice is significantly correlated with cytochrome P450 suppression. World J Gastroenterol 2009; 15:1829-35.

Chen X, Wang H, Zhou G et al. Molecular population genetics of human CYP3A locus: signatures of positive selection and implications for evolutionary environmental medicine. Environ Health Perspect 2009; 117:1541-8.

Chen X, Wang X, Hossain S et al. Haplotypes spanning SPEC2, PDZ-GEF2 and ACSL6 genes are associated with schizophrenia. Hum Mol Genet 2006; 15:3329-42.

Chen X, Zhang M, Liu LX. The overexpression of multidrug resistance-associated proteins and gankyrin contribute to arsenic trioxide resistance in liver and gastric cancer cells. Oncol Rep 2009; 22:73-80.

Chen X, Zhao Y, Guo Z, Zhou L, Okoro EU, Yang H. Transcriptional regulation of ATP-binding cassette transporter A1 expression by a novel signaling pathway. J Biol Chem 2011; 286:8917-23.

Chen XC, Huang SP, Wang XY. Effect of astrocytes with different degrees of proliferation on multidrug resistance gene expression in rats with epilepsy. Zhongguo Dang Dai Er Ke Za Zhi 2010; 12:908-11.

Chen XC, Xu MT, Zhou W, Han CL, Chen WQ. A meta-analysis of relationship between beta-fibrinogen gene -148C/T polymorphism and susceptibility to cerebral infarction in Han Chinese. Chin Med J 2007; 120:1198-202.

Chen XH, Li XQ, Chen Y, Feng YM. Risk of aggressive breast cancer in women of Han nationality carrying TGFB1 rs1982073 C allele and FGFR2 rs1219648 G allele in North China. Breast Cancer Res Treat 2011; 125:575-82.

Chen XP, Tan ZR, Huang SL, Huang Z, Ou-Yang DS, Zhou HH. Isozyme-specific induction of low-dose aspirin on cytochrome P450 in healthy subjects. Clin Pharmacol Ther 2003; 73:264-71.

Chen XW, Serag ES, Sneed KB, Zhou SF. Herbal bioactivation, molecular targets and the toxicity relevance. Chem Biol Interact 2011; 192:161-76.

Chen Y, Bai Y, Yuan J et al. Association of polymorphisms in AhR, CYP1A1, GSTM1, and GSTT1 genes with levels of DNA damage in peripheral blood lymphocytes among coke-oven workers. Cancer Epidemiol Biomarkers Prev 2006; 15:1703-7.

Chen Y, Chen C, Shi S et al. Endometriotic implants regress in rat models treated with puerarin by decreasing estradiol level. Reprod Sci 2011; 18:886-91.

Chen Y, Goldstein JA. The transcriptional regulation of the human CYP2C genes. Curr Drug Metab 2009; 10:567-78.

Chen Y, Huang C, Zhou T, Zhang S, Chen G. Biochanin A induction of sulfotransferases in rats. J Biochem Mol Toxicol 2010; 24:102-14.

Chen Y, Jia L, Wei C, Wang F, Lv H, Jia J. Association between polymorphisms in the apolipoprotein D gene and sporadic Alzheimer's disease. Brain Res 2008; 1233:196-202.

Chen Y, Kang Z, Yan J et al. Liu wei di huang wan, a well-known traditional Chinese medicine, induces CYP1A2 while suppressing CYP2A6 and N-acetyltransferase 2 activities in man. J Ethnopharmacol 2010; 132:213-8.

Chen Y, Li G, Yin S et al. Genetic polymorphisms involved in toxicant-metabolizing enzymes and the risk of chronic benzene poisoning in Chinese occupationally exposed populations. Xenobiotica 2007; 37:103-12.

Chen Y, Liu HF, Liu L, Nguyen K, Jones EB, Fretland AJ. The in vitro metabolism of bupropion revisited: concentration dependent involvement of cytochrome P450 2C19. Xenobiotica 2010; 40:536-46.

Chen Y, Liu L, Laille E, Kumar G, Surapaneni S. In vitro assessment of cytochrome P450 inhibition and induction potential of azacitidine. Cancer Chemother Pharmacol 2010; 65:995-1000.

Chen Y, Liu WH, Chen BL et al. Plant polyphenol curcumin significantly affects CYP1A2 and CYP2A6 activity in healthy, male Chinese volunteers. Ann Pharmacother 2010; 44:1038-45.

Chen Y, Pawlikowska L, Yao JS et al. Interleukin-6 involvement in brain arteriovenous malformations. Ann Neurol 2006; 59:72-80.

Chen Y, Tang Y, Chen S, Nie D. Regulation of drug resistance by human pregnane X receptor in breast cancer. Cancer Biol Ther 2009; 8:1265-72.

Chen Y, Tang Y, Wang MT, Zeng S, Nie D. Human pregnane X receptor and resistance to chemotherapy in prostate cancer. Cancer Res 2007; 67:10361-7.

Chen Y, Tu JH, He YJ et al. Effect of sodium tanshinone II A sulfonate on the activity of CYP1A2 in healthy volunteers. Xenobiotica 2009; 39:508-13.

Chen Y, Xiao CQ, He YJ et al. Genistein alters caffeine exposure in healthy female volunteers. Eur J Clin Pharmacol 2011; 67:347-53.

Chen Y, Xiao P, Ou-Yang DS et al. Simultaneous action of the flavonoid quercetin on cytochrome P450 (CYP) 1A2, CYP2A6, N-acetyltransferase and xanthine oxidase activity in healthy volunteers. Clin Exp Pharmacol Physiol 2009; 36:828-33.

Chen YC, Kraft P, Bretsky P et al. Sequence variants of estrogen receptor beta and risk of prostate cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium. Cancer Epidemiol Biomarkers Prev 2007; 16:1973-81.

Chen YK, Chen SQ, Li X, Zeng S. Quantitative regioselectivity of glucuronidation of quercetin by recombinant UDP-glucuronosyltransferases 1A9 and 1A3 using enzymatic kinetic parameters. Xenobiotica 2005; 35:943-54.

Chen YL, Cheng TS, Lung FW. Prolactin levels in olanzapine treatment correlate with positive symptoms of schizophrenia: Results from an open-label, flexible-dose study. Prim Care Companion J Clin Psychiatry 2009; 11:16-20.

Chen YL, Tseng HS, Kuo WH, Yang SF, Chen DR, Tsai HT. Glutathione S-Transferase P1 (GSTP1) gene polymorphism increases age-related susceptibility to hepatocellular carcinoma. BMC Med Genet 2010; 11:46.

Chen YW, Lin GJ, Chuang YP et al. Triptolide circumvents drug-resistant effect and enhances 5-fluorouracil antitumor effect on KB cells. Anticancer Drugs 2010; 21:502-13.

Chen YX, Cabana B, Kivel N, Pieniaszek H, Gilman S, Michaelis A. Lack of effect of rifalazil on ethinyl estradiol pharmacokinetics in healthy postmenopausal women. Int J Clin Pharmacol Ther 2007; 45:418-22.

Chen Z, Dunning LA, Anderson KE, Holtzman JL, Zheng W. Within-person variability of urinary 6beta-hydroxycortisol to urinaryl ratios in Caucasian women. Steroids 2004; 69:67-70.

Chen Z, Li Z, Niu X et al. The effect of CYP1A1 polymorphisms on the risk of lung cancer: a global meta-analysis based on 71 case-control studies. Mutagenesis 2011; 26:437-46.

Chen Z, Simmons MS, Perry RT, Wiener HW, Harrell LE, Go RC. Genetic association of neurotrophic tyrosine kinase receptor type 2 (NTRK2) With Alzheimer's disease. Am J Med Genet B Neuropsychiatr Genet 2008; 147:363-9.

Chen ZH, Zhang H, Savarese TM. Gene deletion chemoselectivity: codeletion of the genes for p16(INK4), methylthioadenosine phosphorylase, and the alpha- and beta-interferons in human pancreatic cell carcinoma lines and its implications for chemotherapy. Cancer Res 1996; 56:1083-90.

Chen ZR, Somogyi AA, Reynolds G, Bochner F. Disposition and metabolism of codeine after single and chronic doses in one poor and seven extensive metabolisers. Br J Clin Pharmacol 1991; 31:381-90.

Chen ZS, Lee K, Walther S et al. Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. Cancer Res 2002; 62:3144-50.

Chenel M, Bouzom F, Aarons L, Ogungbenro K. Drug-drug interaction predictions with PBPK models and optimal multiresponse sampling time designs: application to midazolam and a phase I compound. Part 1: comparison of uniresponse and multiresponse designs using PopDes. J Pharmacokinet Pharmacodyn 2008; 35:635-59.

Chenel M, Bouzom F, Cazade F, Ogungbenro K, Aarons L, Mentré F. Drug-drug interaction predictions with PBPK models and optimal multiresponse sampling time designs: application to midazolam and a phase I compound. Part 2: clinical trial results. J Pharmacokinet Pharmacodyn 2008; 35:661-81.

Cheng CH, Leung AY, Chen CF. The effects of two different Ganoderma species (Lingzhi) on gene expression in human monocytic THP-1 cells. Nutr Cancer 2010; 62:648-58.

Cheng J, Ma X, Krausz KW, Idle JR, Gonzalez FJ. Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity. Drug Metab Dispos 2009; 37:1611-21.

Cheng J, Meziani MJ, Sun YP, Cheng SH. Poly(ethylene glycol)-conjugated multi-walled carbon nanotubes as an efficient drug carrier for overcoming multidrug resistance. Toxicol Appl Pharmacol 2011; 250:184-93.

Cheng J, Wan DF, Gu JR et al. Establishment of a yeast system that stably expresses human cytochrome P450 reductase: application for the study of drug metabolism of cytochrome P450s in vitro. Protein Expr Purif 2006; 47:467-76.

Cheng J, Wang JQ, Chen BA et al. MDR reversal activity of bromotetrandrine in vitro and in vivo. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2009; 17:1183-91.

Cheng J, Wang T, Chen BA et al. Effect of desferioxamine on K562/A02 cell line and its mechanism. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2011; 19:337-41.

Cheng JW. Bosentan. Heart Dis 2003; 5:161-9.

Cheng LC, Su KH, Kou YR et al. α-Lipoic acid ameliorates foam cell formation via liver X receptor α-dependent upregulation of ATP-binding cassette transporters A1 and G1. Free Radic Biol Med 2011; 50:47-54.

Cheng N, Wauthier E, Reid LM. Mature human hepatocytes from ex vivo differentiation of alginate-encapsulated hepatoblasts. Tissue Eng 2008; 14:1-7.

Cheng Q, Cheng C, Crews KR et al. Epigenetic regulation of human gamma-glutamyl hydrolase activity in acute lymphoblastic leukemia cells. Am J Hum Genet 2006; 79:264-74.

Cheng Q, Sohl CD, Guengerich FP. High-throughput fluorescence assay of cytochrome P450 3A4. Nat Protoc 2009; 4:1258-61.

Cheng Q, Wu B, Kager L et al. A substrate specific functional polymorphism of human gamma-glutamyl hydrolase alters catalytic activity and methotrexate polyglutamate accumulation in acute lymphoblastic leukaemia cells. Pharmacogenetics 2004; 14:557-67.

Cheng X, Taleb S, Wang J et al. Inhibition of IL-17A in atherosclerosis. Atherosclerosis 2011; 215:471-4.

Cheng X, Xu G. A systemic review of the relationship between aldosterone synthase - 344 C/T polymorphism and hypertension in Han. Clin Exp Hypertens 2010; 32:301-7.

Cheng XD, Lu WG, Ye F, Wan XY, Xie X. The association of XRCC1 gene single nucleotide polymorphisms with response to neoadjuvant chemotherapy in locally advanced cervical carcinoma. J Exp Clin Cancer Res 2009; 28:91.

Cheng XW, Song H, Sasaki T et al. Angiotensin type 1 receptor blocker reduces intimal neovascularization and plaque growth in apolipoprotein e-deficient mice. Hypertension 2011; 57:981-9.

Cheng Y, Austin SC, Rocca B et al. Role of prostacyclin in the cardiovascular response to thromboxane A2. Science 2002; 296:539-41.

Cheng Y, Liu G, Pan Q, Guo S, Yang X. Elevated expression of liver X receptor alpha (LXRα) in myocardium of streptozotocin-induced diabetic rats. Inflammation 2010. doi:10. 1007/s10753-010-9281-5.

Cheng Z, Zhang J, Liu H, Li Y, Zhao Y, Yang E. Central nervous system penetration for small molecule therapeutic agents does not increase in multiple sclerosis- and Alzheimer's disease-related animal models despite reported blood-brain barrier disruption. Drug Metab Dispos 2010; 38:1355-61.

Cheng Z, Zhou H, Luther M, Yin JJ, Yu LL. Effects of wheat antioxidants on oxygen diffusion-concentration products in liposomes and mRNA levels of HMG-CoA reductase and cholesterol 7alpha-hydroxylase in primary rat hepatocytes. J Agric Food Chem 2008; 56:5033-42.

Cheng ZN, Shu Y, Liu ZQ, Wang LS, Ou-Yang DS, Zhou HH. Role of cytochrome P450 in estradiol metabolism in vitro. Acta Pharmacol Sin 2001; 22:148-54.

Cheng ZN, Zhou HH. Contribution of genetic variations in estradiol biosynthesis and metabolism enzymes to osteoporosis. Acta Pharmacol Sin 2000; 21:587-90.

Chenhsu RY, Loong CC, Chou MH, Lin MF, Yang WC. Renal allograft dysfunction associated with rifampin-tacrolimus interaction. Ann Pharmacother 2000; 34:27-31.

Chenn A, Walsh CA. Cranking it up a Notch. Science 1999; 286:689-90.

Cheok MH, Yang W, Pui CH et al. Treatment-specific changes in gene expression discriminate in vivo drug response in human leukemia cells. Nat Genet 2003; 34:85-90.

Cheon KA, Cho DY, Koo MS, Song DH, Namkoong K. Association between homozygosity of a G allele of the alpha-2a-adrenergic receptor gene and methylphenidate response in Korean children and adolescents with attention-deficit/hyperactivity disorder. Biol Psychiatry 2009; 65:564-70.

Cheong JY, Cho SW, Choi JY et al. RANTES, MCP-1, CCR2, CCR5, CXCR1 and CXCR4 gene polymorphisms are not associated with the outcome of hepatitis B virus infection: results from a large scale single ethnic population. J Korean Med Sci 2007; 22:529-35.

Cherezov V, Rosenbaum DM, Hanson MA et al. High-resolution crystal structure of an engineered human beta-2-adrenergic G protein-coupled receptor. Science 2007; 318:1258-65.

Cherner M, Bousman C, Everall I et al. Cytochrome P450-2D6 extensive metabolizers are more vulnerable to methamphetamine-associated neurocognitive impairment: preliminary findings. J Int Neuropsychol Soc 2010; 16:890-901.

Cherstniakova SA, Bi D, Fuller DR, Mojsiak JZ, Collins JM, Cantilena LR. Metabolism of vanoxerine,1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine, by human cytochrome P450 enzymes. Drug Metab Dispos 2001; 29:1216-20.

Cheshire WP, Tsuboi Y, Wszolek ZK. Physiologic assessment of automatic dysfunction in pallidopontonigral degeneration with N279K mutation in the tau gene on chromosome 17. Auton Neurosci 2002; 102:71-7.

Chesné C, Guyomard C, Guillouzo A, Schmid J, Ludwig E, Sauter T. Metabolism of Meloxicam in human liver involves cytochromes P4502C9 and 3A4. Xenobiotica 1998; 28:1-13.

Chetty M, d'Esposito F, Zhang WV et al. In vitro and in vivo evaluation of the inhibition potential of risperidone toward clozapine biotransformation. Br J Clin Pharmacol 2009; 68:574-9.

Chetty M, Murray M. CYP-mediated clozapine interactions: how predictable are they? Curr Drug Metab 2007; 8:307-13.

Cheung C, Gonzalez FJ. Humanized mouse lines and their application for prediction of human drug metabolism and toxicological risk assessment. J Pharmacol Exp Ther 2008; 327:288-99.

Cheung C, Loy S, Li GX, Liu AB, Yang CS. Rapid induction of colon carcinogenesis in CYP1A-humanized mice by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate. Carcinogenesis 2011; 32:233-9.

Cheung C, Yu AM, Chen CS et al. Growth hormone determines sexual dimorphism of hepatic cytochrome P450 3A4 expression in transgenic mice. J Pharmacol Exp Ther 2006; 316:1328-34.

Cheung ST, Cheung PF, Cheng CK, Wong NC, Fan ST. Granulin-epithelin precursor and ATP-dependent binding cassette (ABC)B5 regulate liver cancer cell chemoresistance. Gastroenterology 2011; 140:344-55.

Chew SC, Singh O, Chen X et al. The effects of CYP3A4, CYP3A5, ABCB1, ABCC2, ABCG2 and SLCO1B3 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of docetaxel in nasopharyngeal carcinoma patients. Cancer Chemother Pharmacol 2011, 67:1471-8.

Chew SC, Singh O, Chen X et al. The effects of CYP3A4, CYP3A5, ABCB1, ABCC2, ABCG2 and SLCO1B3 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of docetaxel in nasopharyngeal carcinoma patients. Cancer Chemother Pharmacol 2011; 67:1471-8.

Chew WM, Xu MJ, Cordova CA, Chow HH. Quantification of a cytochrome P450 3A4 substrate, buspirone, in human plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2006; 844:235-9.

Chhun S, Verstuyft C, Rizzo-Padoin N et al. Gefitinib-phenytoin interaction is not correlated with the C-erythromycin breath test in healthy male volunteers. Br J Clin Pharmacol 2009; 68:226-37.

Chi AC, Appleton K, Henriod JB et al. Differential induction of CYP1A1 and CYP1B1 by benzo[a]pyrene in oral squamous cell carcinoma cell lines and by tobacco smoking in oral mucosa. Oral Oncol 2009; 45:980-5.

Chianella C, Gragnaniello D, Maisano Delser P et al. BCHE and CYP2D6 genetic variation in Alzheimer's disease patients treated with cholinesterase inhibitors. Eur J Clin Pharmacol 2011; 67:1147-57.

Chiang CP, Wu CW, Lee SP et al. Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human pancreas: implications for pathogenesis of alcohol-induced pancreatic injury. Alcohol Clin Exp Res 2009; 33:1059-68.

Chiang HC, Wang CY, Lee HL, Tsou TC. Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation-a mammalian cell-based mutagenesis approach. Toxicol Appl Pharmacol 2011; 253:145-52.

Chiang JY. Bile acids: regulation of synthesis. J Lipid Res 2009; 50:1955-66.

Chiba K, Morimoto K. Genetic marker of statin-induced rhabdomyolysis. Yakugaku Zasshi 2011; 131:247-53.

Chiba M, Hensleigh M, Nishime JA, Balani SK, Lin JH. Role of cytochrome P450 3A4 in human metabolism of MK-639, a potent human immunodeficiency virus protease inhibitor. Drug Metab Dispos 1996; 24:307-14.

Chiba M, Jin L, Neway W et al. P450 interaction with HIV protease inhibitors: relationship between metabolic stability, inhibitory potency, and P450 binding spectra. Drug Metab Dispos 2001; 29:1-3.

Chiba M, Nishime JA, Lin JH. Potent and selective inactivation of human liver microsomal cytochrome P-450 isoforms by L-754,394, an investigational human immune deficiency virus protease inhibitor. J Pharmacol Exp Ther 1995; 275:1527-34.

Chiba M, Nishime JA, Neway W, Lin Y, Lin JH. Comparative in vitro metabolism of indinavir in primates-a unique stereoselective hydroxylation in monkey. Xenobiotica 2000; 30:117-29.

Chiba M, Tang C, Neway WE et al. P450 interaction with farnesyl-protein transferase inhibitors metabolic stability, inhibitory potency, and P450 binding spectra in human liver microsomes. Biochem Pharmacol 2001; 62:773-6.

Chiba M, Xu X, Nishime JA, Balani SK, Lin JH. Hepatic microsomal metabolism of montelukast, a potent leukotriene D4 receptor antagonist, in humans. Drug Metab Dispos 1997; 25:1022-31.

Chiba-Falek O, Nichols M, Suchindran S et al. Impact of gene variants on sex-specific regulation of human Scavenger receptor class B type 1 (SR-BI) expression in liver and association with lipid levels in a population-based study. BMC Med Genet 2010; 11:9.

Chico LK, Behanna H, Hu W, Zhong G, Roy SM, Watterson DM. Molecular properties and CYP2D6 substrates: central nervous system therapeutics case study and pattern analysis of a substrate database. Drug Metab Dispos 2009; 37:2204-11.

Chida D, Hashimoto O, Kuwahara M et al. Increased fat:carbohydrate oxidation ratio in Il1ra (-/-) mice on a high-fat diet is associated with increased sympathetic tone. Diabetologia 2008; 51:1698-706.

Chida M, Yokoi T, Nemoto N, Inaba M, Kinoshita M, Kamataki T. A new variant CYP2D6 allele (CYP2D6*21) with a single base insertion in exon 5 in a Japanese population associated with a poor metabolizer phenotype. Pharmacogenetics 1999; 9:287-93.

Chieli E, Romiti N, Rodeiro I, Garrido G. In vitro modulation of ABCB1/P-glycoprotein expression by polyphenols from Mangifera indica. Chem Biol Interact 2010; 186:287-94.

Chien CC, Yen BL, Lee FK et al. In vitro differentiation of human placenta-derived multipotent cells into hepatocyte-like cells. Stem Cells 2006; 24:1759-68.

Chien CF, Wu YT, Lee WC, Lin LC, Tsai TH. Herb-drug interaction of Andrographis paniculata extract and andrographolide on the pharmacokinetics of theophylline in rats. Chem Biol Interact 2010; 184:458-65.

Chien KL, Lin YL, Wen HC et al. Common sequence variant in lipoprotein lipase gene conferring triglyceride response to fibrate treatment. Pharmacogenomics 2009; 10:267-76.

Chihara T, Shimpo K, Kaneko T, Beppu H, Tomatsu A, Sonoda S. Inhibitory effects of high temperature- and pressure-treated garlic on formation of 1,2-dimethylhydrazine-induced mucin-depleted foci and O(6)-methylguanine DNA adducts in the rat colorectum. Asian Pac J Cancer Prev 2009; 10:827-31.

Chijimatsu T, Tatsuguchi I, Abe K, Oda H, Mochizuki S. A freshwater clam (Corbicula fluminea) extract improves cholesterol metabolism in rats fed on a high-cholesterol diet. Biosci Biotechnol Biochem 2008; 72:2566-71.

Chikazawa N, Tanaka H, Tasaka T et al. Inhibition of Wnt signaling pathway decreases chemotherapy-resistant side-population colon cancer cells. Anticancer Res 2010; 30:2041-8.

Childs E, Hohoff C, Deckert J, Xu K, Badner J, de Wit H. Association between ADORA2A and DRD2 polymorphisms and caffeine-induced anxiety. Neuropsychopharmacology 2008; 33:2791-800.

Chillón M, Casals T, Mercier B et al. Mutations in the cystic fibrosis gene in patients with congenital absence of the vas deferens. N Engl J Med 1995; 332:1475-80.

Chimento A, Sirianni R, Zolea F et al. Nandrolone and stanozolol induce Leydig cell tumor proliferation through an estrogen-dependent mechanism involving IGF-I system. J Cell Physiol 2011. doi:10. 1002/jcp. 22936.

Chin J, Hong JY, Lee J et al. Selective peroxisome proliferator-activated receptor Δ isosteric selenium agonists as potent anti-atherogenic agents in vivo. Bioorg Med Chem Lett 2010; 20:7239-42.

Chinetti-Gbaguidi G, Baron M, Bouhlel MA et al. Human atherosclerotic plaque alternative macrophages display low cholesterol handling but high phagocytosis because of distinct activities of the PPARγ and LXRα pathways. Circ Res 2011; 108:985-95.

Chiney MS, Schwarzenberg SJ, Johnson LA. Altered xanthine oxidase and N-acetyltransferase activity in obese children. Br J Clin Pharmacol 2011; 72:109-15.

Chinta SJ, Pai HV, Upadhya SC, Boyd MR, Ravindranath V. Constitutive expression and localization of the major drug metabolizing enzyme, cytochrome P4502D in human brain. Brain Res Mol Brain Res 2002; 103:49-61.

Chiodini BD, Specchia C, Gori F et al. Adiponectin gene polymorphisms and their effect on the risk of myocardial infarction and type 2 diabetes: an association study in an Italian population. Ther Adv Cardiovasc Dis 2010; 4:223-30.

Chiras T, Papadakis ED, Katopodi A et al. Platelet GP IIIA polymorphism HPA-1 (PLA1/2) is associated with hypertension as the primary cause for end-stage renal disease in hemodialysis patients from Greece. In Vivo 2009; 23:177-81.

Chirgwin J, Sun Z, Smith I et al. The advantage of letrozole over tamoxifen in the BIG 1-98 trial is consistent in younger postmenopausal women and in those with chemotherapy-induced menopause. Breast Cancer Res Treat 2011. doi:10. 1007/s10549-011-1741-6.

Chiron C. Stiripentol. Expert Opin Investig Drugs 2005; 14:905-11.

Chiron C. Stiripentol. Neurotherapeutics 2007; 4:123-5.

Chisaki I, Kobayashi M, Itagaki S, Hirano T, Iseki K. Liver X receptor regulates expression of MRP2 but not that of MDR1 and BCRP in the liver. Biochim Biophys Acta 2009; 1788:2396-403.

Chishti MA, Yang DS, Janus C et al. Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695. J Biol Chem 2001; 276:21562-70.

Chistiakov DA, Savost'anov KV, Turakulov RI. Screening of SNPs at 18 positional candidate genes, located within the GD-1 locus on chromosome 14q23-q32, for susceptibility to Graves' disease: a TDT study. Mol Genet Metab 2004; 83:264-70.

Chiu HJ, Wang YC, Liou JH et al. Serotonin 6 receptor polymorphism in schizophrenia: frequency, age at onset and cognitive function. Neuropsychobiology 2001; 43:113-6.

Chiu KW, Nakano T, Hu TH et al. Influence of CYP2C19 genotypes on graft pathological findings and postoperative liver function in recipients after living-donor liver transplantation. Ann Transplant 2010; 15:38-43.

Chiu KW, Tai WC, Nakano T et al. Donor graft does not affect the P450 2C19 genotype expressed in peripheral blood in recipients of living donor liver transplantation. Clin Transplant 2010; 24:830-4.

Chiu LY, Ko JL, Lee YJ, Yang TY, Tee YT, Sheu GT. L-type calcium channel blockers reverse docetaxel and vincristine-induced multidrug resistance independent of ABCB1 expression in human lung cancer cell lines. Toxicol Lett 2010; 192:408-18.

Cho CG, Lee SK, Nam SY et al. Association of the GSTP1 and NQO1 polymorphisms and head and neck squamous cell carcinoma risk. J Korean Med Sci 2006; 21:1075-9.

Cho H, Choi MK, Cho DY et al. Effect of CYP2C19 genetic polymorphism on pharmacokinetics and pharmacodynamics of a new proton pump inhibitor, ilaprazole. J Clin Pharmacol 2011. doi:10. 1177/0091270011408611.

Cho HJ, Park YS, Kang WK, Kim JW, Lee SY. Thymidylate synthase (TYMS) and dihydropyrimidine dehydrogenase (DPYD) polymorphisms in the Korean population for prediction of 5-fluorouracil-associated toxicity. Ther Drug Monit 2007; 2:190-6.

Cho HY, Lee YB. Pharmacokinetics and bioequivalence evaluation of risperidone in healthy male subjects with different CYP2D6 genotypes. Arch Pharm Res 2006; 29:525-33.

Cho HY, Yoo HD, Lee YB. Influence of ABCB1 genetic polymorphisms on the pharmacokinetics of levosulpiride in healthy subjects. Neuroscience 2010; 169:378-87.

Cho HY, Yoon H, Park GK, Lee YB. Pharmacokinetics and bioequivalence of two formulations of rebamipide 100-mg tablets: a randomized, single-dose, two-period, two-sequence crossover study in healthy Korean male volunteers. Clin Ther 2009; 31:2712-21.

Cho IH, Yoo HJ, Park M, Lee YS, Kim SA. Family-based association study of 5-HTTLPR and the 5-HT2A receptor gene polymorphisms with autism spectrum disorder in Korean trios. Brain Res 2007; 1139:34-41.

Cho KH, Lee SM. Altered activity of cytochrome P450 in alcoholic fatty liver exposed to ischemia/reperfusion. Arch Pharm Res 2007; 30:50-7.

Cho SC, Kim JW, Kim BN et al. Association between the alpha-2C-adrenergic receptor gene and attention deficit hyperactivity disorder in a Korean sample. Neurosci Lett 2008; 446:108-11.

Cho SH, Oh SY, Bahn JW et al. Association between bronchodilating response to short-acting beta-agonist and non-synonymous single-nucleotide polymorphisms of beta-adrenoceptor gene. Clin Exp Allergy 2005; 35:1162-7.

Cho TM, Rose RL, Hodgson E. In vitro metabolism of naphthalene by human liver microsomal cytochrome P450 enzymes. Drug Metab Dispos 2006; 34:176-83.

Cho TM, Rose RL, Hodgson E. The effect of chlorpyrifos-oxon and other xenobiotics on the human cytochrome P450-dependent metabolism of naphthalene and deet. Drug Metabol Drug Interact 2007; 22:235-62.

Choi BS, Alberti DB, Schelman WR et al. The maximum tolerated dose and biologic effects of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) in combination with irinotecan for patients with refractory solid tumors. Cancer Chemother Pharmacol 2010; 66:973-80.

Choi CI, Kim MJ, Chung EK et al. CYP2C9*3 and *13 alleles significantly affect the pharmacokinetics of irbesartan in healthy Korean subjects. Eur J Clin Pharmacol 2011. doi:10. 1007/s00228-011-1098-0.

Choi CI, Kim MJ, Jang CG, Park YS, Bae JW, Lee SY. Effects of the CYP2C9*1/*13 genotype on the pharmacokinetics of lornoxicam. Basic Clin Pharmacol Toxicol 2011. doi:10. 1111/j. 1742-7843. 2011. 00751. x.

Choi DH, Chang KS, Hong SP, Choi JS, Han HK. Effect of atorvastatin on the intravenous and oral pharmacokinetics of verapamil in rats. Biopharm Drug Dispos 2008; 29:45-50.

Choi DH, Chung JH, Choi JS. Pharmacokinetic interaction between oral lovastatin and verapamil in healthy subjects: role of P-glycoprotein inhibition by lovastatin. Eur J Clin Pharmacol 2010; 66:285-90.

Choi DH, Li C, Choi JS. Effects of simvastatin on the pharmacokinetics of verapamil and its main metabolite, norverapamil, in rats. Eur J Drug Metab Pharmacokinet 2009; 34:163-8.

Choi DH, Li C, Choi JS. Effects of myricetin, an antioxidant, on the pharmacokinetics of losartan and its active metabolite, EXP-3174, in rats: possible role of cytochrome P450 3A4, cytochrome P450 2C9 and P-glycoprotein inhibition by myricetin. J Pharm Pharmacol 2010; 62:908-14.

Choi DH, Shin WG, Choi JS. Drug interaction between oral atorvastatin and verapamil in healthy subjects: effects of atorvastatin on the pharmacokinetics of verapamil and norverapamil. Eur J Clin Pharmacol 2008; 64:445-9.

Choi EM, Lee MG, Lee SH, Choi KW, Choi SH. Association of ABCB1 polymorphisms with the efficacy of ondansetron for postoperative nausea and vomiting. Anaesthesia 2010; 65:996-1000.

Choi H, Shin DW, Kim W, Doh SJ, Lee SH, Noh M. Asian dust storm particles induce a broad toxicological transcriptional program in human epidermal keratinocytes. Toxicol Lett 2011; 200:92-9.

Choi HK, Zhu Y, Mount DB. Genetics of gout. Curr Opin Rheumatol 2010; 22:144-51.

Choi I, Kim SY, Kim H et al. Classification models for CYP450 3A4 inhibitors and non-inhibitors. Eur J Med Chem 2009; 44:2354-60.

Choi JH, Lee YJ, Jang SB, Lee JE, Kim KH, Park K. Influence of the CYP3A5 and MDR1 genetic polymorphisms on the pharmacokinetics of tacrolimus in healthy Korean subjects. Br J Clin Pharmacol 2007; 64:185-91.

Choi JS, Boralevi F, Brissaud O et al. Paroxysmal extreme pain disorder: a molecular lesion of peripheral neurons. Nat Rev Neurol 2011; 7:51-5.

Choi JS, Burm JP. Effect of pioglitazone on the pharmacokinetics of verapamil and its major metabolite, norverapamil, in rats. Arch Pharm Res 2008; 31:1200-4.

Choi JS, Burm JP. Effects of oral epigallocatechin gallate on the pharmacokinetics of nicardipine in rats. Arch Pharm Res 2009; 32:1721-5.

Choi JS, Choi BC, Kang KW. Effect of resveratrol on the pharmacokinetics of oral and intravenous nicardipine in rats: possible role of P-glycoprotein inhibition by resveratrol. Pharmazie 2009; 64:49-52.

Choi JS, Han HK. The effect of quercetin on the pharmacokinetics of verapamil and its major metabolite, norverapamil, in rabbits. J Pharm Pharmacol 2004; 56:1537-42.

Choi JS, Han HK. Pharmacokinetic interaction between diltiazem and morin, a flavonoid, in rats. Pharmacol Res 2005; 52:386-91.

Choi JS, Kang KW. Enhanced tamoxifen bioavailability after oral administration of tamoxifen in rats pretreated with naringin. Arch Pharm Res 2008; 31:1631-6.

Choi JS, Kang NS, Min YK, Kim SH. Euphorbiasteroid reverses P-glycoprotein-mediated multi-drug resistance in human sarcoma cell line MES-SA/Dx5. Phytother Res 2010; 24:1042-6.

Choi JS, Lee WJ, Baik SH et al. Array CGH reveals genomic aberrations in human emphysema. Lung 2009; 187:165-72.

Choi JS, Li X. The effect of verapamil on the pharmacokinetics of paclitaxel in rats. Eur J Pharm Sci 2005; 24:95-100.

Choi JY, Abel J, Neuhaus T et al. Role of alcohol and genetic polymorphisms of CYP2E1 and ALDH2 in breast cancer development. Pharmacogenetics 2003; 13:67-72.

Choi JY, Lee KM, Park SK et al. Genetic polymorphisms of SULT1A1 and SULT1E1 and the risk and survival of breast cancer. Cancer Epidemiol Biomarkers Prev 2005; 14:1090-5.

Choi KH, Chen C-J, Kriegler M, Roninson IB. An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene. Cell 1988; 53:519-29.

Choi MH, Skipper PL, Wishnok JS, Tannenbaum SR. Characterization of testosterone 11 beta-hydroxylation catalyzed by human liver microsomal cytochromes P450. Drug Metab Dispos 2005; 33:714-8.

Choi MJ, Kang RH, Ham BJ, Jeong HY, Lee MS. Serotonin receptor 2A gene polymorphism (-1438A/G) and short-term treatment response to citalopram. Neuropsychobiology 2005; 52:155-62.

Choi MJ, Lee HJ, Lee HJ et al. Association between major depressive disorder and the -1438A/G polymorphism of the serotonin 2A receptor gene. Neuropsychobiology 2004; 49:38-41.

Choi MK, Kim H, Han YH, Song IS, Shim CK. Involvement of Mrp2/MRP2 in the species different excretion route of benzylpenicillin between rat and human. Xenobiotica 2009; 39:171-81.

Choi SJ, Ji HY, Lee HY, Lee DH, Lim H, Lee HS. In vitro metabolism of a new H(+)/K(+) ATPase inhibitor DBM-819 in liver microsomes using HPLC and electrospray mass spectrometry. Biomed Chromatogr 2001; 15:503-6.

Choi SJ, Shin SC, Choi JS. Effects of myricetin on the bioavailability of doxorubicin for oral drug delivery in rats: Possible role of CYP3A4 and P-glycoprotein inhibition by myricetin. Arch Pharm Res 2011; 34:309-15.

Choi SY, Fischer L, Yang K, Chung H, Jeong H. Isoform-specific regulation of cytochrome P450 expression and activity by estradiol in female rats. Biochem Pharmacol 2011; 81:777-82.

Choi YH, Lee YS, Lee MG, Kim TK, Lee BY. Pharmacokinetics of mirodenafil, a new erectogenic, and its metabolite, SK3541, in rats: involvement of CYP1A1/2, 2B1/2, 2D subfamily, and 3A1/2 for the metabolism of both mirodenafil and SK3541. J Pharm Pharm Sci 2010; 13:93-106.

Choi YH, Suh JH, Lee JH, Cho IH, Lee MG. Effects of tesmilifene, a substrate of CYP3A and an inhibitor of P-glycoprotein, on the pharmacokinetics of intravenous and oral docetaxel in rats. J Pharm Pharmacol 2010; 62:1084-8.

Chompret A, Kannengiesser C, Barrois M et al. PDGFRA germline mutation in a family with multiple cases of gastrointestinal stromal tumor. Gastroenterology 2004; 126:318-21.

Chong E, Ensom MH. Pharmacogenetics of the proton pump inhibitors: a systematic review. Pharmacotherapy 2003; 23:460-71.

Chong S, Almqvist E, Telenius H et al. Contribution of DNA sequence and CAG size to mutation frequencies of intermediate alleles for Huntington disease: evidence from single sperm analyses. Hum Molec Genet 1997; 6:301-9.

Chonlahan J, Halloran MA, Hammonds A. Leflunomide and warfarin interaction: case report and review of the literature. Pharmacotherapy 2006; 26:868-71.

Chopra V, Metzler M, Rasper D et al. HIP12 is a non-proapoptotic member of a gene family including HIP1, an interacting protein with huntingtin. Mammalian Genome 2000; 11:1006-15.

Chou IC, Lin HC, Wang CH et al. Polymorphisms of interleukin 1 gene IL1RN are associated with Tourette syndrome. Pediatr Neurol 2010; 42:320-4.

Chou M, Bertrand J, Segeral O et al. Population pharmacokinetic-pharmacogenetic study of nevirapine in HIV-infected Cambodian patients. Antimicrob Agents Chemother 2010; 54:4432-9.

Chou YC, Chung YT, Liu TY et al. The oxidative metabolism of dimemorfan by human cytochrome P450 enzymes. J Pharm Sci 2010; 99:1063-77.

Chouchane S, Snow ET. In vitro effect of arsenical compounds on glutathione-related enzymes. Chem Res Toxicol 2001; 14:517-22.

Choudhary C, Schwäble J, Brandts C et al. AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations. Blood 2005; 106:265-73.

Choudhary D, Jansson I, Schenkman JB. CYP1B1, a developmental gene with a potential role in glaucoma therapy. Xenobiotica 2009; 39:606-15.

Choudhary S, Xiao T, Vergara LA et al. Role of aldehyde dehydrogenase isozymes in the defense of rat lens and human lens epithelial cells against oxidative stress. Invest Ophthalmol Vis Sci 2005; 46:259-67.

Choudhry S, Ung N, Avila PC et al. Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma. Am J Respir Crit Care Med 2005; 171:563-70.

Choudhuri S, Valerio LG Jr. Usefulness of studies on the molecular mechanism of action of herbals/botanicals: The case of St. John's wort. J Biochem Mol Toxicol 2005; 19:1-11.

Chougnet A, Grinkova Y, Ricard D, Sligar S, Woggon WD. Fluorescent probes for rapid screening of potential drug-drug interactions at the CYP3A4 level. ChemMedChem 2007; 2:717-24.

Chouinard G, Lefko-Singh K, Teboul E. Metabolism of anxiolytics and hypnotics: benzodiazepines, buspirone, zoplicone, and zolpidem. Cell Mol Neurobiol 1999; 19:533-52.

Choura M, Frikha F, Kharrat N, Aifa S, Rebaï A. Investigating the function of three non-synonymous SNPs in EGFR gene: structural modelling and association with breast cancer. Protein J 2010; 29:50-4.

Chourasia D, Achyut BR, Tripathi S, Mittal B, Mittal RD, Ghoshal UC. Genotypic and functional roles of IL-1B and IL-1RN on the risk of gastroesophageal reflux disease: the presence of IL-1B-511*T/IL-1RN*1 (T1) haplotype may protect against the disease. Am J Gastroenterol 2009; 104:2704-13.

Chow EC, Maeng HJ, Liu S, Khan AA, Groothuis GM, Pang KS. 1alpha,25-Dihydroxyvitamin D(3) triggered vitamin D receptor and farnesoid X receptor-like effects in rat intestine and liver in vivo. Biopharm Drug Dispos 2009; 30:457-75.

Chow EC, Sondervan M, Jin C, Groothuis GM, Pang KS. Comparative effects of doxercalciferol (1α-hydroxyvitamin D(2)) versus calcitriol (1α,25-dihydroxyvitamin D(3)) on the expression of transporters and enzymes in the rat in vivo. J Pharm Sci 2010; 100:1594-604.

Chow HH, Garland LL, Hsu CH et al. Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study. Cancer Prev Res 2010; 3:1168-75.

Chow HH, Hakim IA, Vining DR et al. Effects of repeated green tea catechin administration on human cytochrome P450 activity. Cancer Epidemiol Biomarkers Prev 2006; 15:2473-6.

Chow JD, Jones ME, Prelle K, Simpson ER, Boon WC. A selective estrogen receptor {alpha} agonist ameliorates hepatic steatosis in the male aromatase knockout mouse. J Endocrinol 2011; 210:323-34.

Chow JD, Price JT, Bills MM, Simpson ER, Boon WC. A doxycycline-inducible, tissue-specific aromatase-expressing transgenic mouse. Transgenic Res 2011. doi:10. 1007/s11248-011-9525-7.

Chow LW, Yip AY, Chu WP, Loo WT, Toi M. Bone metabolism and quality-of-life of postmenopausal women with invasive breast cancer receiving neoadjuvant hormonal therapy: sub-analyses from celecoxib anti-aromatase neoadjuvant (CAAN) trial. J Steroid Biochem Mol Biol 2011; 125:112-9.

Chow MS, White CM, Lau CP, Fan C, Tang MO. Evaluation of CYP2D6 oxidation of dextromethorphan and propafenone in a Chinese population with atrial fibrillation. J Clin Pharmacol 2001; 41:92-6.

Chow T, Imaoka S, Hiroi T, Funae Y. Developmental changes in the catalytic activity and expression of CYP2D isoforms in the rat liver. Drug Metab Dispos 1999; 27:188-92.

Chow TW, Pollock BG, Milgram NW. Potential cognitive enhancing and disease modification effects of SSRIs for Alzheimer's disease. Neuropsychiatr Dis Treat 2007; 3:627-36.

Chowbay B, Cumaraswamy S, Cheung YB, Zhou Q, Lee EJ. Genetic polymorphisms in MDR1 and CYP3A4 genes in Asians and the influence of MDR1 haplotypes on cyclosporin disposition in heart transplant recipients. Pharmacogenetics 2003; 13:89-95.

Chowbay B, Zhou S, Lee EJ. An interethnic comparison of polymorphisms of the genes encoding drug-metabolizing enzymes and drug transporters: experience in Singapore. Drug Metab Rev 2005; 37:327-78.

Chowdari KV, Northup A, Pless L et al. DNA pooling: a comprehensive, multi-stage association analysis of ACSL6 and SIRT5 polymorphisms in schizophrenia. Genes Brain Behav 2007; 6:229-39.

Chowdhury J, Kagiala GV, Pushpakom S et al. Microfluidic platform for single nucleotide polymorphism genotyping of the thiopurine S-methyltransferase gene to evaluate risk for adverse drug events. J Mol Diagnostics 2007; 4:521-9.

Chowdhury S, Pickering L, Ellis P. Controversies in the use of adjuvant trastuzumab (Herceptin). J Br Menopause Soc 2006; 12:172-4.

Christakos S, Ajibade DV, Dhawan P, Fechner AJ, Mady LJ. Vitamin D: metabolism. Endocrinol Metab Clin North Am 2010; 39:243-53.

Christen U, Hintermann E, Holdener M, von Herrath MG. Viral triggers for autoimmunity: Is the 'glass of molecular mimicry' half full or half empty? J Autoimmun 2010; 34:38-44.

Christen U, Holdener M, Hintermann E. Animal models for autoimmune hepatitis. Autoimmun Rev 2007; 6:306-11.

Christensen B, Arbour L, Tran P et al. Genetic polymorphisms in methylenetetrahydrofolate reductase and methionine synthase, folate levels in red blood cells, and risk of neural tube defects. Am J Med Genet 1999; 84:151-7.

Christensen H, Asberg A, Holmboe AB, Berg KJ. Coadministration of grapefruit juice increases systemic exposure of diltiazem in healthy volunteers. Eur J Clin Pharmacol 2002; 58:515-20.

Christensen H, Mathiesen L, Postvoll LW, Winther B, Molden E. Different enzyme kinetics of midazolam in recombinant CYP3A4 microsomes from human and insect sources. Drug Metab Pharmacokinet 2009; 24:261-8.

Christensen M, Andersson K, Dalén P et al. The Karolinska cocktail for phenotyping of five human cytochrome P450 enzymes. Clin Pharmacol Ther 2003; 73:517-28.

Christensen M, Tybring G, Mihara K et al. Low daily 10-mg and 20-mg doses of fluvoxamine inhibit the metabolism of both caffeine (cytochrome P4501A2) and omeprazole (cytochrome P4502C19). Clin Pharmacol Ther 2002; 71:141-52.

Christiansen A, Backensfeld T, Denner K, Weitschies W. Effects of non-ionic surfactants on cytochrome P450-mediated metabolism in vitro. Eur J Pharm Biopharm 2011; 78:166-72.

Christopher LJ, Hong H, Vakkalagadda BJ et al. Metabolism and disposition of [14C]BMS-690514, an ErbB/vascular endothelial growth factor receptor inhibitor, after oral administration to humans. Drug Metab Dispos 2010; 38:2049-59.

Christopoulos S, Bourdeau I, Lacroix A. Clinical and subclinical ACTH-independent macronodular adrenal hyperplasia and aberrant hormone receptors. Horm Res 2005; 64:119-31.

Chrousos GP, Renquist D, Brandon D et al. Glucocorticoid hormone resistance during primate evolution: receptor-mediated mechanisms. Proc Nat Acad Sci USA 1982; 79:2036-40.

Chroust K, Jowett T, Farid-Wajidi MF et al. Activation or detoxification of mutagenic and carcinogenic compounds in transgenic Drosophila expressing human glutathione S-transferase. IMutat Res 2001; 498:169-79.

Chrzanowska M, Kurzawski M, Drozdzik M, Mazik M, Oko A, Czekalski S. Thiopurine S-methyltransferase phenotype-genotype correlation in hemodialyzed patients. Pharmacological reports 2007; 6:973-78.

Chu CC, Pan KL, Yao HT, Hsu JT. Development of a whole-cell screening system for evaluation of the human CYP1A2-mediated metabolism. Biotechnol Bioeng 2011; 108:2932-40.

Chu J, Dolnick BJ. Natural antisense (rTS-alpha) RNA induces site-specific cleavage of thymidylate synthase mRNA. Biochim Biophys Acta 2002; 1587:183-93.

Chu J, Praticò D. 5-lipoxygenase as an endogenous modulator of amyloid β formation in vivo. Ann Neurol 2011; 69:34-46.

Chu LW, Zhu Y, Yu K et al. Correlation between circadian gene variants and serum levels of sex steroids and insulin-like growth factor-I. Cancer Epidemiol Biomarkers Prev 2008; 17:3268-73.

Chu PH, Huang TY, Williams J, Stafford DW. Purified vitamin K epoxide reductase alone is sufficient for conversion of vitamin K epoxide to vitamin K and vitamin K to vitamin KH(2). Proc Nat Acad Sci USA 2007; 103:19308-13.

Chu W, Fyles A, Sellers EM et al. Association between CYP3A4 genotype and risk of endometrial cancer following tamoxifen use. Carcinogenesis 2007; 28:2139-42

Chu X, Dong Y, Shen M et al. Polymorphisms in the ADRB2 gene and Graves disease: a case-control study and a meta-analysis of available evidence. BMC Med Genet 2009; 10:26.

Chu XY, Strauss JR, Mariano MA et al. Characterization of mice lacking the multidrug resistance protein MRP2 (ABCC2). J Pharmacol Exp Ther 2006; 317:579-89.

Chua SC Jr, Liu SM, Li Q et al. Transgenic complementation of leptin receptor deficiency. II. Increased leptin receptor transgene dose effects on obesity/diabetes and fertility/lactation in lepr-db/db mice. Am J Physiol Endocrinol Metab 2004; 286:384-92.

Chuah B, Goh BC, Lee SC et al. Comparison of the pharmacokinetics and pharmacodynamics of S-1 between Caucasian and East Asian patients. Cancer Sci 2011; 102:478-83.

Chugh R, Wagner T, Griffith KA et al. Assessment of ifosfamide pharmacokinetics, toxicity, and relation to CYP3A4 activity as measured by the erythromycin breath test in patients with sarcoma. Cancer 2007; 109:2315-22.

Chui D-H, Tanahashi H, Ozawa K et al. Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation. Nat Med 1999; 5:560-564.

Chun J, Kent UM, Moss RM, Sayre LM, Hollenberg PF. Mechanism-based inactivation of cytochromes P450 2B1 and P450 2B6 by 2-phenyl-2-(1-piperidinyl)propane. Drug Metab Dispos 2000; 28:905-11.

Chun YJ, Lee S, Yang SA, Park S, Kim MY. Modulation of CYP3A4 expression by ceramide in human colon carcinoma HT-29 cells. Biochem Biophys Res Commun 2002; 298:687-92.

Chun YJ, Oh YK, Kim BJ et al. Potent inhibition of human cytochrome P450 1B1 by tetramethoxystilbene. Toxicol Lett 2009; 189:84-9.

Chun YJ, Park S, Yang SA. Activation of Fas receptor modulates cytochrome P450 3A4 expression in human colon carcinoma cells. Toxicol Lett 2003; 146:75-81.

Chung CJ, Hsueh YM, Bai CH et al. Polymorphisms in arsenic metabolism genes, urinary arsenic methylation profile and cancer. Cancer Causes Control 2009; 20:1653-61.

Chung CJ, Pu YS, Su CT, Huang CY, Hsueh YM. Gene polymorphisms of glutathione S-transferase omega 1 and 2, urinary arsenic methylation profile and urothelial carcinoma. Sci Total Environ 2011; 409:465-70.

Chung CM, Wang RY, Chen JW et al. A genome-wide association study identifies new loci for ACE activity: potential implications for response to ACE inhibitor. Pharmacogenomics J 2010; 10:537-44.

Chung HH, Kim MK, Kim JW et al. XRCC1 R399Q polymorphism is associated with response to platinum-based neoadjuvant chemotherapy in bulky cervical cancer. Gynecol Oncol 2006; 103:1031-7.

Chung HJ, Kang HE, Yang KH, Kim SY, Lee MG. Ipriflavone pharmacokinetics in mutant Nagase analbuminemic rats. Biopharm Drug Dispos 2009; 30:294-304.

Chung HW, Seo JS, Hur SE et al. Association of interleukin-6 promoter variant with bone mineral density in pre-menopausal women. J Hum Genet 2003; 48:243-8.

Chung JW, Yang SH, Choi JS. Effects of lovastatin on the pharmacokinetics of nicardipine in rats. Biopharm Drug Dispos 2010; 31:436-41.

Chung JY, Cho JY, Lim HS et al. Effects of pregnane X receptor (NR1I2) and CYP2B6 genetic polymorphisms on the induction of bupropion hydroxylation by rifampin. Drug Metab Dispos 2011; 39:92-7.

Chung JY, Cho JY, Yu KS et al. Effect of the UGT2B15 genotype on the pharmacokinetics, pharmacodynamics, and drug interactions of intravenous lorazepam in healthy volunteers. Clin Pharmacol Ther 2005; 77:486-94.

Chung JY, Jang SB, Lee YJ, Park MS, Park K. Effect of CYP2B6 genotype on the pharmacokinetics of sibutramine and active metabolites in healthy subjects. J Clin Pharmacol 2011; 51:53-9.

Chung MJ, Park KW, Kim KH et al. Asian plantain (Plantago asiatica) essential oils suppress 3-hydroxy-3-methyl-glutaryl-co-enzyme A reductase expression in vitro and in vivo and show hypocholesterolaemic properties in mice. Br J Nutr 2008; 99:67-75.

Chung MJ, Sung NJ, Park CS et al. Antioxidative and hypocholesterolemic activities of water-soluble puerarin glycosides in HepG2 cells and in C57 BL/6J mice. Eur J Pharmacol 2008; 578:159-70.

Chung SJ, Armasu SM, Biernacka JM et al. Common variants in PARK loci and related genes and Parkinson's disease. Mov Disord 2011; 26:280-8.

Chung SJ, Armasu SM, Biernacka JM et al. Variants in estrogen-related genes and risk of Parkinson's disease. Mov Disord 2011; 26:1234-42.

Chung WH, Hung SI, Hong HS et al. Medical genetics: a marker for Stevens-Johnson syndrome. Nature 2004; 428:486.

Chung WK, Deng L, Carroll JS et al. Polymorphism in the angiotensin II type 1 receptor (AGTR1) is associated with age at diagnosis in pulmonary arterial hypertension. J Heart Lung Transplant 2009; 28:373-9.

Chutinet A, Suwanwela NC, Snabboon T, Chaisinanunkul N, Furie KL, Phanthumchinda K. Association between genetic polymorphisms and sites of cervicocerebral artery atherosclerosis. J Stroke Cerebrovasc Dis 2011. doi:10. 1016/j. jstrokecerebrovasdis. 2010. 10. 002.

Chuu CP, Chen RY, Barkinge JL, Ciaccio MF, Jones RB. Systems-level analysis of ErbB4 signaling in breast cancer: a laboratory to clinical perspective. Mol Cancer Res 2008; 6:885-91.

Chyka PA, Erdman AR, Christianson G et al. Salicylate poisoning: an evidence-based consensus guideline for out-of-hospital management. Clin Toxicol 2007; 45:95-131.

Cianfriglia M, Mallano A, Ascione A, Dupuis ML. Multidrug transporter proteins and cellular factors involved in free and mAb linked calicheamicin-gamma1 (gentuzumab ozogamicin, GO) resistance and in the selection of GO resistant variants of the HL60 AML cell line. Int J Oncol 2010; 36:1513-20.

Ciccacci C, Borgiani P, Ceffa S et al. Nevirapine-induced hepatotoxicity and pharmacogenetics: a retrospective study in a population from Mozambique. Pharmacogenomics 2010; 11:23-31.

Ciccacci C, Falconi M, Paolillo N et al. Characterization of a novel CYP2C9 gene mutation and structural bioinformatic protein analysis in a warfarin hypersensitive patient. Pharmacogenet Genomics 2011; 21:344-6.

Ciccone PE, Ramabadran K, Jessen LM. Potential interactions of methylphenidate and atomoxetine with dextromethorphan. J Am Pharm Assoc 2006; 46:472-8.

Cicoira M, Rossi A, Bonapace S et al. Effects of ACE gene insertion/deletion polymorphism on response to spironolactone in patients with chronic heart failure. Am J Med 2004; 116:657-61.

Cichoz-Lach H, Celiński K, Wojcierowski J, Słomka M, Lis E. Genetic polymorphism of alcohol-metabolizing enzyme and alcohol dependence in Polish men. Braz J Med Biol Res 2010; 43:257-61.

Cichoz-Lach H, Partycka J, Nesina I, Celinski K, Słomka M, Wojcierowski J. Genetic polymorphism of alcohol dehydrogenase 3 in alcohol liver cirrhosis and in alcohol chronic pancreatitis. Alcohol Alcohol 2006; 41:14-7.

Cichoz-Lach H, Partycka J, Nesina I, Celinski K, Slomka M, Wojcierowski J. Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphism in alcohol liver cirrhosis and alcohol chronic pancreatitis among Polish individuals. Scand J Gastroenterol 2007; 42:493-8.

Ciervo CA, Shi J. Pharmacokinetics of telithromycin: application to dosing in the treatment of community-acquired respiratory tract infections. Curr Med Res Opin 2005; 21:1641-50.

Cigana C, Nicolis E, Pasetto M, Assael BM, Melotti P. Effects of azithromycin on the expression of ATP binding cassette transporters in epithelial cells from the airways of cystic fibrosis patients. J Chemother 2007; 19:643-9.

Cimino L, Boiardi L, Aldigeri R et al. G/R 241 polymorphism of intercellular adhesion molecule 1 (ICAM-1) is associated with Fuchs uveitis. Invest Ophthalmol Vis Sci 2010; 51:4447-50.

Cinar C, Yazici C, Ergünsu S et al. Genetic diagnosis in infertile men with numerical and constitutional sperm abnormalities. Genet Test 2008; 12:195-202.

Cindric M, Cipak A, Serly J et al. Reversal of multidrug resistance in murine lymphoma cells by amphiphilic dihydropyridine antioxidant derivative. Anticancer Res 2010; 30:4063-9.

Ciolino HP, Dai Z, Nair V. Retinol inhibits aromatase activity and expression in vitro. J Nutr Biochem 2011; 22:522-6.

Ciolino HP, Daschner PJ, Wang TT, Yeh GC. Effect of curcumin on the aryl hydrocarbon receptor and cytochrome P450 1A1 in MCF-7 human breast carcinoma cells. Biochem Pharmacol 1998; 56:197-206.

Ciotti M, Chen F, Rubaltelli FF, Owens IS. Coding defect and a TATA box mutation at the bilirubin UDP-glucuronosyltransferase gene cause Crigler-Najjar type I disease. Biochim Biophys Acta 1998; 1407:40-50.

Ciotti M, Marrone A, Potter C, Owens IS. Genetic polymorphism in the human UGT1A6 (planar phenol) UDP-glucuronosyltransferase: pharmacological implications. Pharmacogenetics 1997; 7:485-95.

Ciotti M, Obaray R, Martín MG, Owens IS. Genetic defects at the UGT1 locus associated with Crigler-Najjar type I disease, including a prenatal diagnosis. Am J Med Genet 1997; 68:173-8.

Ciotti M, Werlin SL, Owens IS. Delayed response to phenobarbital treatment of a Crigler-Najjar type II patient with partially inactivating missense mutations in the bilirubin UDP-glucuronosyltransferase gene. J Pediatr Gastroenterol Nutr 1999; 28:210-3.

Ciotti M, Yeatman MT, Sokol RJ, Owens IS. Altered coding for a strictly conserved di-glycine in the major bilirubin UDP-glucuronosyltransferase of a Crigler-Najjar type I patient. J Biol Chem 1995; 270:3284-91.

Cipollone F, Fazia ML, Iezzi A et al. Association between prostaglandin E receptor subtype EP4 overexpression and unstable phenotype in atherosclerotic plaques in human. Arterioscler Thromb Vasc Biol 2005; 25:1925-31.

Cipollone F, Toniato E, Martinotti S et al. A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke. JAMA 2004; 291:2221-8.

Cirrito JR, Disabato BM, Restivo JL et al. Serotonin signaling is associated with lower amyloid-{beta} levels and plaques in transgenic mice and humans. Proc Natl Acad Sci USA 2011; 108:14968-73.

Citrome L. Iloperidone: chemistry, pharmacodynamics, pharmacokinetics and metabolism, clinical efficacy, safety and tolerability, regulatory affairs, and an opinion. Expert Opin Drug Metab Toxicol 2010; 6:1551-64.

Citron M. Beta-secretase inhibition for the treatment of Alzheimer's disease- promise and challenge. Trends Pharmacol Sci 2004; 25:92-7.

Citron M, Westaway D, Xia W et al. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat Med 1997; 3:67-72.

Ciuclan L, Ehnert S, Ilkavets I et al. TGF-beta enhances alcohol dependent hepatocyte damage via down-regulation of alcohol dehydrogenase I. J Hepatol 2010; 52:407-16.

Ciusani E, Zullino DF, Eap CB, Brawand-Amey M, Brocard M, Baumann P. Combination therapy with venlafaxine and carbamazepine in depressive patients not responding to venlafaxine: pharmacokinetic and clinical aspects. J Psychopharmacol 2004; 18:559-66.

Cizmarikova M, Wagnerova M, Schonova L et al. MDR1 (C3435T) polymorphism: relation to the risk of breast cancer and therapeutic outcome. Pharmacogenomics J 2010; 10:62-9.

Claessens AJ, Risler LJ, Eyal S, Shen DD, Easterling TR, Hebert MF. CYP2D6 mediates 4-hydroxylation of clonidine in vitro: implication for pregnancy-induced changes in clonidine clearance. Drug Metab Dispos 2010; 38:1393-6.

Clappers N, van Oijen MG, Sundaresan S et al. The C50T polymorphism of the cyclooxygenase-1 gene and the risk of thrombotic events during low-dose therapy with acetyl salicylic acid. Thromb Haemost 2008; 100:70-5.

Clària J, Romano M. Pharmacological intervention of cyclooxygenase-2 and 5-lipoxygenase pathways. Impact on inflammation and cancer. Curr Pharm Des 2005; 11:3431-47.

Clark D, Morgan A, Hananeia L, Coulter D, Olds R. Drug metabolism genotypes and their association with adverse drug reactions in selected populations: a pilot study of methodology. Pharmacoepidemiol Drug Saf 2000; 9:393-400.

Clark DA, Mata I, Kerwin RW, Munro J, Arranz MJ. No association between ADRA2A polymorphisms and schizophrenia. Am J Med Genet B Neuropsychiatr Genet 2007; 144:341-3.

Clark JJ, Cools J, Curley DP et al. Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518. Blood 2004; 104:2867-72.

Clark LN, Poorkaj P, Wszolek Z et al. Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17. Proc Nat Acad Sci USA 1998; 95:13103-7.

Clark MS, Neumaier JF. The 5-HT1B receptor: behavioral implications. Psychopharmacol Bull 2001; 35:170-85.

Clark TG, Fry AE, Auburn S et al. Allelic heterogeneity of G6PD deficiency in West Africa and severe malaria susceptibility. Eur J Hum Genet 2009; 17:1080-5.

Clark VJ, Metheny N, Dean M, Peterson RJ. Statistical estimation and pedigree analysis of CCR2-CCR5 haplotypes. Hum Genet 2001; 108:484-93.

Clarke G, Collins R, Leavitt B et al. A one-hit model of cell death in inherited neuronal degenerations. Nature 2000; 406:195-9.

Clarke JA, Cutler M, Gong I, Schwarz UI, Freeman D, Dasgupta M. Cytochrome P450 2D6 phenotyping in an elderly population with dementia and response to galantamine in dementia: a pilot study. Am J Geriatr Pharmacother 2011; 9:224-33.

Clarke MW, Burnett JR, Croft KD. Vitamin E in human health and disease. Crit Rev Clin Lab Sci 2008; 45:417-50.

Clarke MW, Burnett JR, Wu JH et al. Vitamin E supplementation and hepatic drug metabolism in humans. J Cardiovasc Pharmacol 2009; 54:491-6.

Clarke SJ, Rivory LP. Clinical pharmacokinetics of docetaxel. Clin Pharmacokinet 1999; 36:99-114.

Clarke TA, Waskell LA. The metabolism of clopidogrel is catalyzed by human cytochrome P450 3A and is inhibited by atorvastatin. Drug Metab Dispos 2003; 31:53-9.

Clarke TK, Dempster E, Docherty SJ et al. Multiple polymorphisms in genes of the adrenergic stress system confer vulnerability to alcohol abuse. Addict Biol 2010. doi:10. 1111/j. 1369-1600. 2010. 00263. x.

Clay PG, Adams MM. Pseudo-Parkinson disease secondary to ritonavir-buspirone interaction. Ann Pharmacother 2003; 37:202-5.

Clayton PT. Clinical consequences of defects in peroxisomal beta-oxidation. Biochem Soc Trans 2001; 29:298-305.

Cleary SP, Cotterchio M, Shi E, Gallinger S, Harper P. Cigarette smoking, genetic variants in carcinogen-metabolizing enzymes, and colorectal cancer risk. Am J Epidemiol 2010; 172:1000-14.

Cleary SP, Kim H, Croitoru ME et al. Missense polymorphisms in the adenomatous polyposis coli gene and colorectal cancer risk. Dis Colon Rectum 2008; 51:1467-73.

Clement K, Boutin P, Froguel P. Genetics of obesity. Am J Pharmacogenomics 2002; 2:177-87.

Clément K, Vaisse C, Lahlou N et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998; 392:398-401.

Clemente-Postigo M, Queipo-Ortuño M, Valdivielso P, Tinahones FJ, Cardona F. Effect of apolipoprotein C3 and apolipoprotein A1 polymorphisms on postprandial response to a fat overload in metabolic syndrome patients. Clin Biochem 2010; 43:1300-4.

Clerc RG, Stauffer A, Weibel F et al. Mechanisms underlying off-target effects of the cholesteryl ester transfer protein inhibitor torcetrapib involve L-type calcium channels. J Hypertens 2010; 28:1676-86.

Clerici C, Castellani D, Asciutti S et al. 3alpha-6alpha-Dihydroxy-7alpha-fluoro-5beta-cholanoate (UPF-680), physicochemical and physiological properties of a new fluorinated bile acid that prevents 17alpha-ethynyl-estradiol-induced cholestasis in rats. Toxicol Appl Pharmacol 2006; 214:199-208.

Cleveland RJ, Gammon MD, Long CM et al. Common genetic variations in the LEP and LEPR genes, obesity and breast cancer incidence and survival. Breast Cancer Res Treat 2010; 120:745-52.

Clinard F, Sgro C, Bardou M et al. Association between concomitant use of several systemic NSAIDs and an excess risk of adverse drug reaction. A case/non-case study from the French Pharmacovigilance system database. Eur J Clin Pharmacol 2004; 60:279-83.

Clodfelter JE, B Gentry M, Drotschmann K. MSH2 missense mutations alter cisplatin cytotoxicity and promote cisplatin-induced genome instability. Nucleic Acids Res 2005; 33:3323-30.

Close SL. Clopidogrel pharmacogenetics: metabolism and drug interactions. Drug Metabol Drug Interact 2011; 26:45-51.

Clot F, Grabli D, Cazeneuve C et al. Exhaustive analysis of BH4 and dopamine biosynthesis genes in patients with Dopa-responsive dystonia. Brain 2009; 132:1753-63.

Clouthier DE, Comerford SA, Hammer RE. Hepatic fibrosis, glomerulosclerosis, and lipodystrophy-like PEPCK-TGF-beta-1 transgenic mice. J Clin Invest 1997; 100:2697-2713.

Coate L, Cuffe S, Horgan A, Hung RJ, Christiani D, Liu G. Germline genetic variation, cancer outcome, and pharmacogenetics. J Clin Oncol 2010; 28:4029-37.

Cobaugh DJ, Erdman AR, Booze LL et al. Atypical antipsychotic medication poisoning: an evidence-based consensus guideline for out-of-hospital management. Clin Toxicol 2007; 45:918-42.

Cobb SA, Wider C, Ross OA et al. GCH1 in early-onset Parkinson's disease. Mov Disord 2009; 24:2070-5.

Cobos-Trigueros N, Ateka O, Pitart C, Vila J. Macrolides and ketolides. Enferm Infecc Microbiol Clin 2009; 27:412-8.

Coburger C, Lage H, Molnár J, Langner A, Hilgeroth A. Multidrug resistance reversal properties and cytotoxic evaluation of representatives of a novel class of HIV-1 protease inhibitors. J Pharm Pharmacol 2010; 62:1704-10.

Coburger C, Wollmann J, Krug M et al. Novel structure-activity relationships and selectivity profiling of cage dimeric 1,4-dihydropyridines as multidrug resistance (MDR) modulators. Bioorg Med Chem 2010; 18:4983-90.

Cocco G, Chu DC, Pandolfi S. Colchicine in clinical medicine. A guide for internists. Eur J Intern Med 2010; 21:503-8.

Cockcroft JR, Gazis AG, Cross DJ et al. Beta(2)-adrenoceptor polymorphism determines vascular reactivity in humans. Hypertension 2000; 36:371-5.

Cocks G, Wilde JI, Graham SJ et al. The thiazolidinedione pioglitazone increases cholesterol biosynthetic gene expression in primary cortical neurons by a PPARgamma-independent mechanism. J Alzheimers Dis 2010; 19:631-46.

Cockshott ID. Bicalutamide: clinical pharmacokinetics and metabolism. Clin Pharmacokinet 2004; 43:855-78.

Cochrane WA, Payne WW, Simpkiss MJ, Woolf LI. Familial hypoglycemia precipitated by amino acids. J Clin Invest 1956; 35:411-2.

Code EL, Crespi CL, Penman BW, Gonzalez FJ, Chang TK, Waxman DJ. Human cytochrome P4502B6: interindividual hepatic expression, substrate specificity, and role in procarcinogen activation. Drug Metab Dispos 1997; 25:985-93.

Coecke S, Bogni A, Langezaal I, Worth A, Hartung T, Monshouwer M. The use of genetically engineered cells for assessing CYP2D6-related polymorphic effects. Toxicol In Vitro 2001; 15:553-6.

Coen D, Zadro R, Honović L, Banfić L, Stavljenić Rukavina A. Prevalence and association of the factor V Leiden and prothrombin G20210A in healthy subjects and patients with venous thromboembolism. Croat Med J 2001; 42:488-92.

Coenen MJ, Toonen EJ, Scheffer H, Radstake TR, Barrera P, Franke B. Pharmacogenetics of anti-TNF treatment in patients with rheumatoid arthritis. Pharmacogenomics 2007; 8:761-73.

Cofán F, Gutiérrez R, Beardo P, Campistol JM, Oppenheimer F, Alcover J. Interaction between sildenafil and calcineurin inhibitors in renal transplant recipients with erectile dysfunction. Nefrologia 2002; 22:470-6.

Coffey GL, Botts SR, de Leon J. High vulnerability to acute dystonic reactions: a case of antipsychotic exposure and uncontrolled seizure activity. Prog Neuropsychopharmacol Biol Psychiatry 2005; 29:770-4.

Coffman BL, Tephly TR, Irshaid YM et al. Characterization and primary sequence of a human hepatic microsomal estriol UDP-glucuronosyltransferase. Arch Biochem Biophys 1990; 281:170-5.

Cohen BM, Lipinski JF. In vivo potencies of antipsychotic drugs in blocking alpha 1 noradrenergic and dopamine D2 receptors: implications for drug mechanisms of action. Life Sci 1986; 39:2571-80.

Cohen FE, Prusiner SB. Structural studies of prion proteins. In: Prusiner SB (Ed). Prion biology and diseases. Cold Spring Harbor Laboratory Press, New York, 1999:191-228.

Cohen H, Neumann L, Glazer Y, Ebstein RP, Buskila D. The relationship between a common catechol-O-methyltransferase (COMT) polymorphism val(158) met and fibromyalgia. Clin Exp Rheumatol 2009; 27(5 Suppl 56):51-6.

Cohen IL, Liu X, Schutz C et al. Association of autism severity with a monoamine oxidase A functional polymorphism. Clin Genet 2003; 64:190-7.

Cohen JC, Kiss RS, Pertsemlidis A, Marcel YL, McPherson R, Hobbs HH. Multiple rare alleles contribute to low plasma levels of HDL cholesterol. Science 2004; 305:869-72.

Cohen JI, Roychowdhury S, McMullen MR, Stavitsky AB, Nagy LE. Complement and alcoholic liver disease: role of C1q in the pathogenesis of ethanol-induced liver injury in mice. Gastroenterology 2010; 139:664-74.

Cohen JS, Benton AS, Nwachukwu F, Ozedirne T, Teach SJ, Freishtat RJ. P-glycoprotein transporter expression on a549 respiratory epithelial cells is positively correlated with intracellular dexamethasone levels. J Investig Med 2010; 58:991-4.

Cohen K, Grant A, Dandara C et al. Effect of rifampicin-based antitubercular therapy and the cytochrome P450 2B6 516G>T polymorphism on efavirenz concentrations in adults in South Africa. Antivir Ther 2009; 14:687-95.

Cohen LH, van Leeuwen RE, van Thiel GC, van Pelt JF, Yap SH. Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos 2000; 21:353-64.

Cohen MH, Williams GA, Sridhara R et al. United States Food and Drug Administration Drug Approval summary: Gefitinib (ZD1839; Iressa) tablets. Clin Cancer Res 2004; 10:1212-8.

Cohen RE, Wade J. Aromatase mRNA in the brain of adult green anole lizards: effects of sex and season. J Neuroendocrinol 2011; 23:254-60.

Cohn RD, van Erp C, Habashi JP et al. Angiotensin II type 1 receptor blockade attenuates TGF-beta-induced failure of muscle regeneration in multiple myopathic states. Nat Med 2007; 13:204-10.

Coindre JM. Molecular biology of soft-tissue sarcomas. Bull Cancer 2010; 97:1337-45.

Cojocaru V, Balali-Mood K, Sansom MS, Wade RC. Structure and dynamics of the membrane-bound cytochrome P450 2C9. PLoS Comput Biol 2011. doi:10. 1371/journal. pcbi. 1002152.

Colabufo NA, Berardi F, Perrone MG et al. Substrates, inhibitors and activators of P-glycoprotein: candidates for radiolabeling and imaging perspectives. Curr Top Med Chem 2010; 10:1703-14.

Colabufo NA, Contino M, Berardi F et al. A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents. Toxicol In Vitro 2011; 25:222-30.

Colabufo NA, Contino M, Niso M, Berardi F, Leopoldo M, Perrone R. EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives. Front Biosci 2011; 16:1811-23.

Colamonici OR, Domanski P, Platanias LC, Diaz MO. Correlation between interferon (IFN) alpha resistance and deletion of the IFN alpha/beta genes in acute leukemia cell lines suggests selection against the IFN system. Blood 1992; 80:744-9.

Colburn DE, Giles FJ, Oladovich D, Smith JA. In vitro evaluation of cytochrome P450-mediated drug interactions between cytarabine, idarubicin, itraconazole and caspofungin. Hematology 2004; 9:217-21.

Cole LK, Dolinsky VW, Dyck JR, Vance DE. Impaired phosphatidylcholine biosynthesis reduces atherosclerosis and prevents lipotoxic cardiac dysfunction in ApoE-/- Mice. Circ Res 2011; 108:686-94.

Cole SL, Vassar R. BACE1 structure and function in health and Alzheimer's disease. Curr Alzheimer Res 2008; 5:100-20.

Cole SPC, Bhardwaj G, Gerlach JH et al. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 1992; 258:1650-4.

Cole TB, Jansen K, Park S, Li WF, Furlong CE, Costa LG. The toxicity of mixtures of specific organophosphate compounds is modulated by paraoxonase 1 status. Adv Exp Med Biol 2010; 660:47-60.

Colella S, Nardo T, Mallery D et al. Alterations in the CSB gene in three Italian patients with the severe form of Cockayne syndrome (CS) but without clinical photosensitivity. Hum Mol Genet 1999; 8:935-41.

Coleman MD, Smith SN, Kelly DE, Kelly SL, Seydel JK. Studies on the toxicity of analogues of dapsone in-vitro using rat, human and heterologously expressed metabolizing systems. J Pharm Pharmacol 1996; 48:945-50.

Coleman S, Linderman R, Hodgson E, Rose RL. Comparative metabolism of chloroacetamide herbicides and selected metabolites in human and rat liver microsomes. Environ Health Perspect 2000; 108:1151-7.

Coleman T, Ellis SW, Martin IJ, Lennard MS, Tucker GT. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is N-demethylated by cytochromes P450 2D6, 1A2 and 3A4-implications for susceptibility to Parkinson's disease. J Pharmacol Exp Ther 1996; 277:685-90.

Coles BF, Morel F, Rauch C et al. Effect of polymorphism in the human glutathione S-transferase A1 promoter on hepatic GSTA1 and GSTA2 expression. Pharmacogenetics 2001; 11:663-9.

Coletta DK, Sriwijitkamol A, Wajcberg E et al. Pioglitazone stimulates AMP-activated protein kinase signalling and increases the expression of genes involved in adiponectin signalling, mitochondrial function and fat oxidation in human skeletal muscle in vivo: a randomised trial. Diabetologia 2009; 52:723-32.

Coley HM. Overcoming multidrug resistance in cancer: clinical studies of p-glycoprotein inhibitors. Methods Mol Biol 2010; 596:341-58.

Colin EM, Uitterlinden AG, Meurs JBJ et al. Interaction between vitamin D receptor genotype and estrogen receptor alpha genotype influences vertebral fracture risk. J Clin Endocr Metab 2003; 88:3777-84.

Colombo S, Buclin T, Cavassini M et al. Population pharmacokinetics of atazanavir in patients with human immunodeficiency virus infection. Antimicrob Agents Chemother 2006; 50:3801-8.

Colombo S, Buclin T, Décosterd LA et al. Orosomucoid (alpha1-acid glycoprotein) plasma concentration and genetic variants: effects on human immunodeficiency virus protease inhibitor clearance and cellular accumulation. Clin Pharmacol Ther 2006; 80:307-18.

Colombo S, Rauch A, Rotger M et al. The HCP5 single-nucleotide polymorphism: a simple screening tool for prediction of hypersensitivity reaction to abacavir. J Infect Dis 2008; 198:864-7.

Colombo S, Soranzo N, Rotger M et al. Swiss HIV Cohort Study. Influence of ABCB1, ABCC1, ABCC2, and ABCG2 haplotypes on the cellular exposure of nelfinavir in vivo. Pharmacogenet Genomics 2005; 15:599-608.

Colomer V, Engelender S, Sharp A et al. Huntingtin-associated protein 1 (HAP) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domains. Hum Molec Genet 1997; 6:1519-25.

Colson NJ, Lea RA, Quinlan S, Griffiths LR. No role for estrogen receptor 1 gene intron 1 Pvu II and exon 4 C325G polymorphisms in migraine susceptibility. BMC Med Genet 2006; 7:12.

Colton CA, Needham LK, Brown C et al. APOE genotype-specific differences in human and mouse macrophage nitric oxide production. J Neuroimmunol 2004; 147:62-7.

Coll E, Campos B, González-Núñez D, Botey A, Poch E. Association between the A1166C polymorphism of the angiotensin II receptor type 1 and progression of chronic renal insufficiency. J Nephrol 2003; 16:357-64.

Coller JK. Oxidative metabolism of tamoxifen to Z-4-hydroxy-tamoxifen by cytochrome P450 isoforms: an appraisal of in vitro studies. Clin Exp Pharmacol Physiol 2003; 30:845-8.

Coller JK, Barratt DT, Dahlen K, Loennechen MH, Somogyi AA. ABCB1 genetic variability and methadone dosage requirements in opioid-dependent individuals. Clin Pharmacol Ther 2006; 80:682-90.

Coller JK, Christrup LL, Somogyi AA. Role of active metabolites in the use of opioids. Eur J Clin Pharmacol 2009; 65:121-39.

Coller JK, Joergensen C, Foster DJ et al. Lack of influence of CYP2D6 genotype on the clearance of (R)-, (S)- and racemic-methadone. Int J Clin Pharmacol Ther 2007; 45:410-7.

Coller JK, Krebsfaenger N, Klein K et al. The influence of CYP2B6, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z-4-hydroxy-tamoxifen in human liver. Br J Clin Pharmacol 2002; 54:157-67.

Coller JK, Krebsfaenger N, Klein K et al. Large interindividual variability in the in vitro formation of tamoxifen metabolites related to the development of genotoxicity. Br J Clin Pharmacol 2004; 57:105-11.

Coller JK, Somogyi AA, Bochner F. Flunitrazepam oxidative metabolism in human liver microsomes: involvement of CYP2C19 and CYP3A4. Xenobiotica 1999; 29:973-86.

Coller JK, Somogyi AA, Bochner F. Comparison of (S)-mephenytoin and proguanil oxidation in vitro: contribution of several CYP isoforms. Br J Clin Pharmacol 1999; 48:158-67.

Colli ML, Gross JL, Canani LH. Mutation H63D in the HFE gene confers risk for the development of type 2 diabetes mellitus but not for chronic complications. J Diabetes Complications 2011; 25:25-30.

Collinge J. Human prion diseases and bovine spongiform encephalopathy (BSE) Hum Molec Genet 1997; 6:1699-705.

Collinge J. Variant Creutzfeldt-Jakob disease. Lancet 1999; 354:317-23.

Collinge J, Palmer MS, Dryden AJ. Genetic predisposition to iatrogenic Creutzfeldt-Jakob disease. Lancet 1991; 337:1441-2.

Collinge J, Sidle KCL, Heads J, Ironside J, Hill AF. Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD. Nature 1996; 383:685-90.

Collins SJ, Groudine MT. Rearrangement and amplification of c-abl sequences in the human chronic myelogenous leukemia cell line K-562. Proc Natl Acad Sci USA 1983; 80:4813-7.

Collnot EM, Baldes C, Schaefer UF, Edgar KJ, Wempe MF, Lehr CM. Vitamin E TPGS P-glycoprotein inhibition mechanism: influence on conformational flexibility, intracellular ATP levels, and role of time and site of access. Mol Pharm 2010; 7:642-51.

Comasco E, Sylvén SM, Papadopoulos FC, Sundström-Poromaa I, Oreland L, Skalkidou A. Postpartum depression symptoms: a case-control study on monoaminergic functional polymorphisms and environmental stressors. Psychiatr Genet 2011; 21:19-28.

Combarros O, Infante J, Llorca J, Peña N, Fernández-Viadero C, Berciano J. The chemokine receptor CCR5-Delta32 gene mutation is not protective against Alzheimer's disease. Neurosci Lett 2004; 366:312-4.

Combarros O, van Duijn CM, Hammond N et al. Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease. J Neuroinflammation 2009; 6:22.

Combrinck M, Gilbert JD, Byard RW. Pseudoxanthoma elasticum and sudden death. J Forensic Sci 2011; 56:418-22.

Combs TP, Wagner JA, Berger J et al. Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: a potential mechanism of insulin sensitization. Endocrinology 2002; 143:998-1007.

Comen E, Davids M, Kirchhoff T, Hudis C, Offit K, Robson M. Relative contributions of BRCA1 and BRCA2 mutations to "triple-negative" breast cancer in Ashkenazi Women. Breast Cancer Res Treat 2011; 129:185-90.

Comincini S, Foti MG, Tranulis MA et al. Genomic organization, comparative analysis, and genetic polymorphisms of the bovine and ovine prion Doppel genes (PNRD). Mammalian Genome 2001; 12:729-33.

Comings DE, Gade-Andavolu R, Gonzalez N, Blake H, Wu S, MacMurray JP. Additive effect of three noradrenergic genes (ADRA2a, ADRA2C, DBH) on attention-deficit hyperactivity disorder and learning disabilities in Tourette syndrome subjects. Clin Genet 1999; 55:160-72.

Comley LH, Fuller HR, Wishart TM et al. ApoE isoform-specific regulation of regeneration in the peripheral nervous system. Hum Mol Genet 2011; 20:2406-21.

Compton MT, Miller AH. Priapism associated with conventional and atypical antipsychotic medications: a review. J Clin Psychiatry 2001; 62:362-6.

Comuzzie AG, Funahashi T, Sonnenberg G et al. The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome. J Clin Endocr Metab 2001; 86:4321-5.

Conard J, Horellou MH, van Dreden P et al. Homozygous protein C deficiency with late onset and recurrent coumarin-induced skin necrosis. Lancet 1992; 339:743-4.

Conen D, Glynn RJ, Buring JE, Ridker PM, Zee RY. Association of renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms with blood pressure progression and incident hypertension: prospective cohort study. J Hypertens 2008; 26:1780-6.

Conen D, Glynn RJ, Buring JE, Ridker PM, Zee RY. Renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms are not associated with the risk of incident type 2 diabetes mellitus: a prospective cohort study. J Intern Med 2008; 263:376-85.

Conesa-Zamora P, Santaclara V, Gadea-Niñoles E, Ortiz-Reina S, Perez-Guillermo M. Association of polymorphism in FcGR3A gene and progression of low-grade precursor lesions of cervical carcinoma. Hum Immunol 2010; 71:314-7.

Congiu M, Mashford ML, Slavin JL, Desmond PV. Coordinate regulation of metabolic enzymes and transporters by nuclear transcription factors in human liver disease. J Gastroenterol Hepatol 2009; 24:1038-44.

Connell JW, Gibb GM, Betts JC et al. Effects of FTDP-17 mutations on the in vitro phosphorylation of tau by glycogen synthase kinase 3-beta identified by mass spectrometry demonstrate certain mutations exert long-range conformational changes. FEBS 2001; 493:40-4.

Connelly SJ, Mukaetova-Ladinska EB, Abdul-All Z et al. Synaptic changes in frontotemporal lobar degeneration: correlation with MAPT haplotype and APOE genotype. Neuropathol Appl Neurobiol 2011; 37:366-80.

Conner TS, Jensen KP, Tennen H, Furneaux HM, Kranzler HR, Covault J. Functional polymorphisms in the serotonin 1B receptor gene (HTR1B) predict self-reported anger and hostility among young men. Am J Med Genet B Neuropsychiatr Genet 2010; 153:67-78.

Connor H. Serotonin syndrome after single doses of co-amoxiclav during treatment with venlafaxine. J R Soc Med 2003; 96:233-4.

Connor JR, Lee SY. HFE mutations and Alzheimer's disease. J Alzheimers Dis 2006; 10:267-76.

Connors SL, Crowell DE, Eberhart CG et al. beta2-adrenergic receptor activation and genetic polymorphisms in autism: data from dizygotic twins. J Child Neurol 2005; 20:876-84.

Conrad C, Andreadis A, Trajanowski JQ et al. Genetic evidence for the involvement of tau in progressive supranuclear palsy. Ann Neurol 1997; 41:277-81.

Conrad C, Vianna C, Freeman M, Davies P. A polymorphic gene nested within an intron of the tau gene: implications for Alzheimer's disease. Proc Nat Acad Sci USA 2002; 99:7751-6.

Conrad DJ, Stenbit AE, Zettner EM, Wick I, Eckhardt C, Hardiman G. Frequency of mitochondrial 12S ribosomal RNA variants in an adult cystic fibrosis population. Pharmacogenet Genomics 2008; 18:1095-102.

Conrad S, Kauffmann HM, Ito K et al. Identification of human multidrug resistance protein 1 (MRP1) mutations and characterization of a G671V substitution. J Hum Genet 2001; 46:656-63.

Conrad S, Kauffmann HM, Ito K et al. A naturally occurring mutation in MRP1 results in a selective decrease in organic anion transport and in increased doxorubicin resistance. Pharmacogenetics 2002; 12:321-30.

Conroy MC, Randinitis EJ, Turner JL. Pharmacology, pharmacokinetics, and therapeutic use of meclofenamate sodium. Clin J Pain 1991; 7 Suppl 1:44-8.

Contardo-Jara V, Lorenz C, Pflugmacher S, Nützmann G, Kloas W, Wiegand C. Molecular effects and bioaccumulation of levonorgestrel in the non-target organism Dreissena polymorpha. Environ Pollut 2011; 159:38-44.

Contardo-Jara V, Pflugmacher S, Nützmann G, Kloas W, Wiegand C. The beta-receptor blocker metoprolol alters detoxification processes in the non-target organism Dreissena polymorpha. Environ Pollut 2010; 158:2059-66.

Contin M, Sangiorgi S, Riva R, Parmeggiani A, Albani F, Baruzzi A. Evidence of polymorphic CYP2C19 involvement in the human metabolism of N-desmethylclobazam. Ther Drug Monit 2002; 24:737-41.

Contopoulos-Ioannidis DG, Manoli EN, Ioannidis JPA. Meta-analysis of the association of beta-2-adrenergic receptor polymorphisms with asthma phenotypes. J Allergy Clin Immun 2005; 115:963-72.

Contractor A, Swanson G, Heinemann SF. Kainate receptors are involved in short- and long-term plasticity at mossy fiber synapses in the hippocampus. Neuron 2001; 29:209-16.

Contreras AV, Monge-Cazares T, Alfaro-Ruiz L et al. Resequencing, haplotype construction and identification of novel variants of CYP2D6 in Mexican mestizos. Pharmacogenomics 2011; 12:745-56.

Conus P, Bondolfi G, Eap CB, Macciardi F, Baumann P. Pharmacokinetic fluvoxamine-clomipramine interaction with favorable therapeutic consequences in therapy-resistant depressive patient. Pharmacopsychiatry 1996; 29:108-10.

Conway S, Mowat ES, Drew JE, Barrett P, Delagrange P, Morgan PJ. Serine residues 110 and 114 are required for agonist binding but not antagonist binding to the melatonin MT(1) receptor. Biochem Biophys Res Commun 2001; 282:1229-36.

Cook CS, Berry LM, Kim DH, Burton EG, Hribar JD, Zhang L. Involvement of CYP3A in the metabolism of eplerenone in humans and dogs: differential metabolism by CYP3A4 and CYP3A5. Drug Metab Dispos 2002; 30:1344-51.

Cook EH Jr, Scherer SW. Copy-number variations associated with neuropsychiatric conditions. Nature 2008; 455:919-23.

Cook JR, Semple RK. Hypoadiponectinemia-cause or consequence of human "insulin resistance"? J Clin Endocrinol Metab 2010; 95:1544-54.

Cooke GS, Aucan C, Walley AJ et al. Association of Fcgamma receptor IIa (CD32) polymorphism with severe malaria in West Africa. Am J Trop Med Hyg 2003; 69:565-8.

Cooke GS, Hill AV. Genetics of susceptibility to human infectious disease. Nat Rev Genet 2001; 2:967-77.

Cooke KR, Ferrara JL. A protective gene for graft-versus-host disease. N Engl J Med 2003; 349:2183-4.

Cools J, DeAngelo DJ, Gotlib J et al. A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med 2003; 348:1201-14.

Cooper A, Daly E, Foy C et al. Proteome-based identification of plasma proteins associated with hippocampal metabolism in early Alzheimer's disease. J Neurol 2008; 255:1712-20.

Cooper BW, Cho TM, Thompson PM, Wallace AD. Phthalate induction of CYP3A4 is dependent on glucocorticoid regulation of PXR expression. Toxicol Sci 2008; 103:268-77.

Cooper DA, Heera J, Goodrich J et al. Maraviroc versus efavirenz, both in combination with zidovudine-lamivudine, for the treatment of antiretroviral-naive subjects with CCR5-tropic HIV-1 infection. J Infect Dis 2010; 201:803-13.

Cooper GM, Johnson JA, Langaee TY et al. A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose. Blood 2008; 112:1022-7.

Cooper HL, Groves JT. Molecular probes of the mechanism of cytochrome P450. Oxygen traps a substrate radical intermediate. Arch Biochem Biophys 2011; 507:111-8.

Cooper JD, Smyth DJ, Walker NM et al. Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes. Diabetes 2011; 60:1624-31.

Cooper KJ, Martin PD, Dane AL, Warwick MJ, Raza A, Schneck DW. The effect of erythromycin on the pharmacokinetics of rosuvastatin. Eur J Clin Pharmacol 2003; 59:51-6.

Cooper KJ, Martin PD, Dane AL, Warwick MJ, Schneck DW, Cantarini MV. Effect of itraconazole on the pharmacokinetics of rosuvastatin. Clin Pharmacol Ther 2003; 73:322-9.

Cooper WO, Hernandez-Diaz S, Arbogast PG et al. Major congenital malformations after first-trimester exposure to ACE inhibitors. New Eng J Med 2006; 354:2443-51.

Cooper-Kazaz R, van der Deure WM, Medici M et al. Preliminary evidence that a functional polymorphism in type 1 deiodinase is associated with enhanced potentiation of the antidepressant effect of sertraline by triiodothyronine. J Affect Disord 2009; 116:113-6.

Copin B, Brezin AP, Valtot F, Dascotte JC, Bechetoille A, Garchon HJ. Apolipoprotein E-promoter single-nucleotide polymorphisms affect the phenotype of primary open-angle glaucoma and demonstrate interaction with the myocilin gene. Am J Hum Genet 2002; 70:1575-81.

Coppedè F. One-carbon metabolism and Alzheimer's disease: focus on epigenetics. Curr Genomics 2010; 11:246-60.

Coppedè F, Migheli F, Lo Gerfo A et al. Association study between XRCC1 gene polymorphisms and sporadic amyotrophic lateral sclerosis. Amyotroph Lateral Scler 2010; 11:122-4.

Corbalán MS, Marti A, Forga L, Martínez-González MA, Martínez JA. The 27Glu polymorphism of the beta-2-adrenergic receptor gene interacts with physical activity influencing obesity risk among female subjects. Clin Genet 2002; 6:305-7.

Corbera J, Vaño D, Martínez D et al. A medicinal-chemistry-guided approach to selective and druglike sigma 1 ligands. ChemMedChem 2006; 1:140-54.

Corbett AH, Lim ML, Kashuba AD. Kaletra (lopinavir/ritonavir). Ann Pharmacother 2002; 36:1193-203.

Corbin AS, La Rosée P, Stoffregen EP, Druker BJ, Deininger MW. Several Bcr-Abl kinase domain mutants associated with imatinib mesylate resistance remain sensitive to imatinib. Blood 2003; 101:4611-4.

Corbo RM, Scacchi R. Apolipoprotein E (APOE) allele distribution in the world: is APOE*4 a 'thrifty' allele? Ann Hum Genet 1999; 63:301-10.

Corbo RM, Scacchi R, Cresta M. Differential reproductive efficiency associated with common apolipoprotein e alleles in postreproductive-aged subjects. Fertil Steril 2004; 81:104-7.

Corbo RM, Ulizzi L, Positano L, Scacchi R. Association of CYP19 and ESR1 pleiotropic genes with human longevity. J Gerontol A Biol Sci Med Sci 2011; 66:51-5.

Corboz MR, Rivelli MA, McCormick KD et al. Pharmacological characterization of a novel {alpha}2C-adrenoceptor agonist N-[3,4-dihydro-4-(1H-imidazol-4-ylmethyl)-2H-1, 4-benzoxazin-6-yl]-N-ethyl-N'-methylurea (Compound A). J Pharmacol Exp Ther 2011; 337:256-66.

Corchero J, Granvil CP, Akiyama TE et al. The CYP2D6 humanized mouse: effect of the human CYP2D6 transgene and HNF4alpha on the disposition of debrisoquine in the mouse. Mol Pharmacol 2001; 60:1260-7.

Corchero J, Pimprale S, Kimura S, Gonzalez FJ. Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation. Pharmacogenetics 2001; 11:1-6.

Cordell B. b-Amyloid formation as a potential therapeutic target for Alzheimer's disease. Annu Rev Pharmacol Toxicol 1994; 34:69-89.

Corder EH, Robertson K, Lannfelt L et al. HIV-infected subjects with the E4 allele for APOE have excess dementia and peripheral neuropathy. Nat Med 1998; 4:1182-4.

Corder EH, Saunders AM, Risch NJ et al. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat Genet 1994; 7:180-4.

Corder EH, Saunders AM, Strittmatter WJ et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993; 261:921-3.

Cordts EB, Christofolini DM, dos Santos AA, Bianco B, Barbosa CP. Genetic aspects of premature ovarian failure: a literature review. Arch Gynecol Obstet 2011; 283:635-43.

Corella D, Arregui M, Coltell O et al. Association of the LCT-13910C>T polymorphism with obesity and its modulation by dairy products in a Mediterranean population. Obesity 2011; 19:1707-14.

Corella D, Guillén M, Portolés O et al. Gender specific associations of the Trp64Arg mutation in the beta3-adrenergic receptor gene with obesity-related phenotypes in a Mediterranean population: interaction with a common lipoprotein lipase gene variation. J Intern Med 2001; 250:348-60.

Corleto VD, Pagnini C, Margagnoni G et al. IL-1beta-511 and IL-1RN*2 polymorphisms in inflammatory bowel disease: An Italian population study and meta-analysis of European studies. Dig Liver Dis 2010; 42:179-84.

Cornelis MC, Bae SC, Kim I, El-Sohemy A. CYP1A2 genotype and rheumatoid arthritis in Koreans. Rheumatol Int 2010; 30:1349-54.

Cornelis MC, El-Sohemy A, Campos H. Genetic polymorphism of the adenosine A2A receptor is associated with habitual caffeine consumption. Am J Clin Nutr 2007; 86:240-4.

Cornelis MC, Monda KL, Yu K et al. Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. PLoS Genet 2011. doi:10. 1371/journal. pgen. 1002033.

Cornelissen JJ, Sonneveld P, Schoester M et al. MDR-1 expression and response to vincristine, doxorubicin, and dexamethasone chemotherapy in multiple myeloma refractory to alkylating agents. J Clin Oncol 1994; 12:115-9.

Corneveaux JJ, Myers AJ, Allen AN et al. Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. Hum Mol Genet 2010; 19:3295-301.

Cornu JN, Merlet B, Cussenot O et al. Genetic susceptibility to urinary incontinence: implication of polymorphisms of androgen and oestrogen pathways. World J Urol 2011; 29:239-42.

Corominas R, Sobrido MJ, Ribasés M et al. Association study of the serotoninergic system in migraine in the Spanish population. Am J Med Genet B Neuropsychiatr Genet 2010; 153:177-84.

Corona C, Pensalfini A, Frazzini V, Sensi SL. New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc. Cell Death Dis 2011. doi:10. 1038/cddis. 2011. 57.

Corona G, Razzoli E, Forti G, Maggi M. The use of phosphodiesterase 5 inhibitors with concomitant medications. J Endocrinol Invest 2008; 31:799-808.

Corpechot C, Ping C, Wendum D, Matsuda F, Barbu V, Poupon R. Identification of a novel 974C→G nonsense mutation of the MRP2/ABCC2 gene in a patient with Dubin-Johnson syndrome and analysis of the effects of rifampicin and ursodeoxycholic acid on serum bilirubin and bile acids. Am J Gastroenterol 2006; 101:2427-32.

Correale P, Marra M, Remondo C et al. Cytotoxic drugs up-regulate epidermal growth factor receptor (EGFR) expression in colon cancer cells and enhance their susceptibility to EGFR-targeted antibody-dependent cell-mediated-cytotoxicity (ADCC). Eur J Cancer 2010; 46:1703-11.

Correia AP, Pinto JP, Dias V, Mascarenhas C, Almeida S, Porto G. CAT53 and HFE alleles in Alzheimer's disease: a putative protective role of the C282Y HFE mutation. Neurosci Lett 2009; 457:129-32.

Correia CT, Almeida JP, Santos PE et al. Pharmacogenetics of risperidone therapy in autism: association analysis of eight candidate genes with drug efficacy and adverse drug reactions. Pharmacogenomics J 2010; 10:418-30.

Correia MA, Sadeghi S, Mundo-Paredes E. Cytochrome P450 ubiquitination: branding for the proteolytic slaughter? Annu Rev Pharmacol Toxicol 2005; 45:439-64.

Corrigan CJ, Brown PH, Barnes NC, Tsai JJ, Frew AJ, Kay AB. Glucocorticoid resistance in chronic asthma. Peripheral blood T lymphocyte activation and comparison of the T lymphocyte inhibitory effects of glucocorticoids and cyclosporin A. Am Rev Respir Dis 1991; 144:1026-32.

Corso A, Lorenzi A, Terulla V et al. Modification of thrombomodulin plasma levels in refractory myeloma patients during treatment with thalidomide and dexamethasone. Ann Hematol 2004; 83:588-91.

Corso C, Parry EM. The application of comparative genomic hybridization and fluorescence in situ hybridization to the characterization of genotoxicity screening tester strains AHH-1 and MCL-5. Mutagenesis 1999; 14:417-26.

Cortes J, Jabbour E, Kantarjian H, et al. Dynamics of BCR-ABL kinase domain mutations in chronic myeloid leukemia after sequential treatment with multiple tyrosine kinase inhibitors. Blood 2007; 110:4005-11.

Cortés VA, Curtis DE, Sukumaran S et al. Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy. Cell Metab 2009; 9:165-76.

Cortes-Dericks L, Carboni GL, Schmid RA, Karoubi G. Putative cancer stem cells in malignant pleural mesothelioma show resistance to cisplatin and pemetrexed. Int J Oncol 2010; 37:437-44.

Cortez MA, Scrideli CA, Yunes JA et al. mRNA expression profile of multidrug resistance genes in childhood acute lymphoblastic leukemia. Low expression levels associated with a higher risk of toxic death. Pediatr Blood Cancer 2009; 53:996-1004.

Corti N, Heck A, Rentsch K et al. Effect of ritonavir on the pharmacokinetics of the benzimidazoles albendazole and mebendazole: an interaction study in healthy volunteers. Eur J Clin Pharmacol 2009; 65:999-1006.

Cortina H, Vidal J, Vallcanera A, Alberto C, Muro D, Dominguez F. Humero-spinal dysostosis. Pediatr Radiol 1979; 8:188-90.

Corvol H, Burchard EG. Pharmacogenetic response to albuterol among asthmatics. Pharmacogenomics 2008; 9:505-10.

Corvol H, de Giacomo A, Eng C et al. Genetic ancestry modifies pharmacogenetic gene-gene interaction for asthma. Pharmacogenet Genomics 2009; 19:489-96.

Corzo L, Fernández-Novoa L, Zas R et al. Apolipoprotein E genotype-related serum apolipoprotein E and lipid levels in Alzheimer's disease. Ann Psychiatry 1999; 7:99-107.

Corzo L, Fernández-Novoa L, Zas R et al. Influence of the APOE genotype on serum ApoE levels in Alzheimer´s disease patients. In: Fisher A, Hanin I, Yoshida M (Eds). Progress in Alzheimer´s and Parkinson´s diseases. Plenum Press, New York, 1998:765-71.

Corzo L, Zas R, Rodríguez S, Fernández-Novoa L, Cacabelos R. Decreased levels of serum nitric oxide in different forms of dementia. Neurosci Lett 2007; 420:263-7.

Costa E, Vieira E, Martins M et al. Analysis of the UDP-glucuronosyltransferase gene in Portuguese patients with a clinical diagnosis of Gilbert and Crigler-Najjar syndromes. Blood Cells Mol Dis 2006; 36:91-7.

Costacou T, Ferrell RE, Orchard TJ. Haptoglobin genotype: a determinant of cardiovascular complication risk in type 1 diabetes. Diabetes 2008; 57:1702-6.

Costa-Mallen P, Costa LG, Smith-Weller T et al. Genetic polymorphism of dopamine D2 receptors in Parkinson's disease and interactions with cigarette smoking and MAO-B intron 13 polymorphism. J Neurol Neurosurg Psychiatry 2000; 69:535-7.

Costas J, Carrera N, Domínguez E et al. A common haplotype of DRD3 affected by recent positive selection is associated with protection from schizophrenia. Hum Genet 2009; 124:607-13.

Costea I, Mack DR, Israel D et al. Genes involved in the metabolism of poly-unsaturated fatty-acids (PUFA) and risk for Crohn's disease in children & young adults. PLoS One 2010. doi:10. 1371/journal. pone. 0015672.

Costea I, Moghrabi A, Krajinovic M. The influence of cyclin D1 (CCND1) 870A>G polymorphism and CCND1-thymidylate synthase (TS) gene-gene interaction on the outcome of childhood acute lymphoblastic leukaemia. Pharmacogenetics 2003; 13:577-80.

Costrop LM, Vanakker OO, van Laer L et al. Novel deletions causing pseudoxanthoma elasticum underscore the genomic instability of the ABCC6 region. J Hum Genet 2010; 55:112-7.

Côté CS, Kor C, Cohen J, Auclair K. Composition and biological activity of traditional and commercial kava extracts. Biochem Biophys Res Commun 2004; 322:147-52.

Cote ML, Chen W, Smith DW et al. Meta- and pooled analysis of GSTP1 polymorphism and lung cancer: a HuGE-GSEC review. Am J Epidemiol 2009; 169:802-14.

Coto E, Tavira B. Pharmacogenetics of calcineurin inhibitors in renal transplantation. Transplantation 2009; 88(3 Suppl):62-7.

Cotroneo MS, Haag JD, Zan Y et al. Characterizing a rat Brca2 knockout model. Oncogene 2007; 26:1626-35.

Cotte S, von Ahsen N, Kruse N et al. ABC-transporter gene-polymorphisms are potential pharmacogenetic markers for mitoxantrone response in multiple sclerosis. Brain 2009; 132:2517-30.

Coughtrie MWH, Gilissen RA, Shek B et al. Phenol sulphotransferase SULT1A1 polymorphism: molecular diagnosis and allele frequencies in Caucasian and African populations. Biochem J 1999; 337:45-9.

Couillard CM, Légaré B, Bernier A, Dionne Z. Embryonic exposure to environmentally relevant concentrations of PCB126 affect prey capture ability of Fundulus heteroclitus larvae. Mar Environ Res 2011; 71:257-65.

Coulam CB, Jeyendran RS, Fishel LA, Roussev R. Multiple thrombophilic gene mutations rather than specific gene mutations are risk factors for recurrent miscarriage. Am J Reprod Immunol 2006; 55:360-8.

Coulombe N, Lefebvre A, Lehoux JG. Characterization of the hamster CYP11B2 gene encoding adrenal cytochrome P450 aldosterone synthase. DNA Cell Biol 1997; 16:993-1002.

Coulouarn C, Factor VM, Thorgeirsson SS. Transforming growth factor-beta gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer. Hepatology 2008; 6:2059-67.

Coultas L, Bouillet P, Stanley EG, Brodnicki TC, Adams JM, Strasser A. Proapoptotic BH3-only Bcl-2 family member Blk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death. Mol Cell Biol 2004; 24:1570-81.

Coulter-Mackie MB, Lian Q. Consequences of missense mutations for dimerization and turnover of alanine:glyoxylate aminotransferase: study of a spectrum of mutations. Mol Genet Metab 2006; 89:349-59.

Coulter-Mackie MB, White CT, Hurley RM, Chew BH, Lange D Primary hyperoxaluria type 1. In: Pagon RA, Bird TC, Dolan CR, Stephens K (Eds). GeneReviews. University of Washington, Seattle, 1993-2003. Available from: http://www. ncbi. nlm. nih. gov/books/NBK1283/

Coumoul X, Diry M, Barouki R. PXR-dependent induction of human CYP3A4 gene expression by organochlorine pesticides. Biochem Pharmacol 2002; 64:1513-9.

Couroucli XI, Liang YH, Jiang W et al. Prenatal administration of the cytochrome P4501A inducer, Β-naphthoflavone (BNF), attenuates hyperoxic lung injury in newborn mice: Implications for bronchopulmonary dysplasia (BPD) in premature infants. Toxicol Appl Pharmacol 2011; 256:83-94.

Court MH, Duan SX, von Moltke LL et al. Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms. J Pharmacol Exp Ther 2001; 299:998-1006.

Court MH, Hao Q, Krishnaswamy S et al. UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver. J Pharmacol Exp Ther 2004; 310:656-65.

Cousein E, Barthélémy C, Poullain S et al. P-glycoprotein and cytochrome P450 3A4 involvement in risperidone transport using an in vitro Caco-2/TC7 model and an in vivo model. Prog Neuropsychopharmacol Biol Psychiatry 2007; 31:878-86.

Coustou V, Deleu C, Saupe S, Begueret J. The protein product of the het-s heterokaryon incompatibility gene of the fungus Podospora anserina behaves as a prion analog. Proc Natl Acad Sci USA 1997; 94:9773-8.

Coutts RT, Su P, Baker GB. Involvement of CYP2D6, CYP3A4, and other cytochrome P-450 isozymes in N-dealkylation reactions. J Pharmacol Toxicol Methods 1994; 31:177-86.

Cowpland C, Su GM, Murray M, Puddey IB, Croft KD. Effect of alcohol on cytochrome p450 arachidonic acid metabolism and blood pressure in rats and its modulation by red wine polyphenolics. Clin Exp Pharmacol Physiol 2006; 33:183-8.

Cox A, Dunning AM, Garcia-Closas M et al. A common coding variant in CASP8 is associated with breast cancer risk. Nat Genet 2007; 39:352-8.

Cox CD, Garbaccio RM. Discovery of allosteric inhibitors of kinesin spindle protein (KSP) for the treatment of taxane-refractory cancer: MK-0731 and analogs. Anticancer Agents Med Chem 2010; 10:697-712.

Cox DG, Pontes C, Guino E et al. Polymorphisms in prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) and risk of colorectal cancer. Br J Cancer 2004; 91:339-43.

Cox JJ, Reimann F, Nicholas AK et al. An SCN9A channelopathy causes congenital inability to experience pain. Nature 2006; 444:894-8.

Cox JJ, Sheynin J, Shorer Z et al. Congenital insensitivity to pain: novel SCN9A missense and in-frame deletion mutations. Hum Mutat 2010; 31:1670-86.

Cox MC, Low J, Lee J et al. Influence of garlic (Allium sativum) on the pharmacokinetics of docetaxel. Clin Cancer Res 2006; 12:4636-40.

Cox SE, Doherty C, Atkinson SH et al. Haplotype association between haptoglobin (Hp2) and Hp promoter SNP (A-61C) may explain previous controversy of haptoglobin and malaria protection. PLoS One 2007. doi:10. 1371/journal. pone. 0000362.

Coy DJ, Wooton-Kee CR, Yan B et al. ABCG5/ABCG8-independent biliary cholesterol excretion in lactating rats. Am J Physiol Gastrointest Liver Physiol 2010; 299:228-35.

Cozier GE, Leese MP, Lloyd MD et al. Structures of human carbonic anhydrase II/inhibitor complexes reveal a second binding site for steroidal and nonsteroidal inhibitors. Biochemistry 2010; 49:3464-76.

Cozza A, Melissari E, Iacopetti P et al. SNPs in neurotrophin system genes and Alzheimer's disease in an Italian population. J Alzheimers Dis 2008; 15:61-70.

Crabb DW, Matsumoto M, Chang D, You M. Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology. Proc Nutr Soc 2004; 63:49-63.

Crabbe P, Bogaert V, de Bacquer D, Goemaere S, Zmierczak H, Kaufman JM. Part of the interindividual variation in serum testosterone levels in healthy men reflects differences in androgen sensitivity and feedback set point: contribution of the androgen receptor polyglutamine tract polymorphism. J Clin Endocrinol Metab 2007; 92:3604-10.

Craig TJ, Shimomura K, Holl RW, Flanagan SE, Ellard S, Ashcroft FM. An in-frame deletion in Kir6. 2 (KCNJ11) causing neonatal diabetes reveals a site of interaction between Kir6. 2 and SUR1. J Clin Endocrinol Metab 2009; 94:2551-7.

Craig ZR, Leslie TC, Hatfield KP, Gupta RK, Flaws JA. Mono-hydroxy methoxychlor alters levels of key sex steroids and steroidogenic enzymes in cultured mouse antral follicles. Toxicol Appl Pharmacol 2010; 249:107-13.

Cravchik A, Sibley DR, Gejman PV. Functional analysis of the human D2 dopamine receptor missense variants. J Biol Chem 1996; 271:26013-7.

Crawford FC, Vanderploeg RD, Freeman MJ et al. APOE genotype influences acquisition and recall following traumatic brain injury. Neurology 2002; 58:1115-8.

Crean S, Ward A, Mercaldi CJ et al. Apolipoprotein E ε4 prevalence in Alzheimer's disease patients varies across global populations: a systematic literature review and meta-analysis. Dement Geriatr Cogn Disord 2011; 31:20-30.

Crecelius EA. Changes in the chemical speciation of arsenic following ingestion by man. Environ Health Perspect 1977; 19:147-50.

Cresci S, Jones PG, Sucharov CC et al. Interaction between PPARA genotype and beta-blocker treatment influences clinical outcomes following acute coronary syndromes. Pharmacogenomics 2008; 9:1403-17.

Crespi CL, Fox L, Stocker P, Hu M, Steimel DT. Analysis of drug transport and metabolism in cell monolayer systems that have been modified by cytochrome P4503A4 cDNA-expression. Eur J Pharm Sci 2000; 12:63-8.

Crespi CL, Langenbach R, Penman BW. Human cell lines, derived from AHH-1 TK+/- human lymphoblasts, genetically engineered for expression of cytochromes P450. Toxicology 1993; 82:89-104.

Crespi CL, Miller VP. The R144C change in the CYP2C9*2 allele alters interaction of the cytochrome P450 with NADPH: cytochrome P450 oxidoreductase. Pharmacogenetics 1997; 7:203-10.

Crespi CL, Penman BW, Hu M. Development of Caco-2 cells expressing high levels of cDNA-derived cytochrome P4503A4. Pharm Res 1996; 13:1635-41.

Crespi CL, Penman BW, Steimel DT, Gelboin HV, Gonzalez FJ. The development of a human cell line stably expressing human CYP3A4: role in the metabolic activation of aflatoxin B1 and comparison to CYP1A2 and CYP2A3. Carcinogenesis 1991; 12:355-9.

Crespi CL, Penman BW. Use of cDNA-expressed human cytochrome P450 enzymes to study potential drug-drug interactions. Adv Pharmacol 1997; 43:171-88.

Crespo K, Chauvet C, Blain M, Ménard A, Roy J, Deng AY. Normotension in Lewis and Dahl salt-resistant rats is governed by different genes. J Hypertens 2011; 29:460-5.

Crespo M, Mir M, Marin M, Hurtado S et al. De novo kidney transplant recipients need higher doses of Advagraf compared with Prograf to get therapeutic levels. Transplant Proc 2009; 41:2115-7.

Cresteil T. Onset of xenobiotic metabolism in children: toxicological implications. Food Addit Contam 1998; 15 Suppl:45-51.

Cresteil T, Monsarrat B, Dubois J, Sonnier M, Alvinerie P, Gueritte F. Regioselective metabolism of taxoids by human CYP3A4 and 2C8: structure-activity relationship. Drug Metab Dispos 2002; 30:438-45.

Crettol S, Besson J, Croquette-Krokar M et al. Association of dopamine and opioid receptor genetic polymorphisms with response to methadone maintenance treatment. Prog Neuropsychopharmacol Biol Psychiatry 2008; 32:1722-7.

Crettol S, Déglon JJ, Besson J et al. ABCB1 and cytochrome P450 genotypes and phenotypes: influence on methadone plasma levels and response to treatment. Clin Pharmacol Ther 2006; 80:668-81.

Crettol S, Venetz JP, Fontana M, Aubert JD, Pascual M, Eap CB. CYP3A7, CYP3A5, CYP3A4, and ABCB1 genetic polymorphisms, cyclosporine concentration, and dose requirement in transplant recipients. Ther Drug Monit 2008; 30:689-99.

Crew KD, Gammon MD, Terry MB et al. Polymorphisms in nucleotide excision repair genes, polycyclic aromatic hydrocarbon-DNA adducts, and breast cancer risk. Cancer Epidemiol Biomarkers Prev 2007; 16:2033-41.

Crewe HK, Ellis SW, Lennard MS, Tucker GT. Variable contribution of cytochromes P450 2D6, 2C9 and 3A4 to the 4-hydroxylation of tamoxifen by human liver microsomes. Biochem Pharmacol 1997; 53:171-8.

Crewe HK, Notley LM, Wunsch RM, Lennard MS, Gillam EM. Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen. Drug Metab Dispos 2002; 30:869-74.

Cribb A, Nuss C, Wang R. Antipeptide antibodies against overlapping sequences differentially inhibit human CYP2D6. Drug Metab Dispos 1995; 23:671-5.

Cripe LD, Uno H, Paietta EM et al. Zosuquidar, a novel modulator of P-glycoprotein, does not improve the outcome of older patients with newly diagnosed acute myeloid leukemia: a randomized, placebo-controlled trial of the Eastern Cooperative Oncology Group 3999. Blood 2010; 116:4077-85.

Criscitiello C, Fumagalli D, Saini KS, Loi S. Tamoxifen in early-stage estrogen receptor-positive breast cancer: overview of clinical use and molecular biomarkers for patient selection. Onco Targets Ther 2010; 4:1-11.

Cristalli G, Cacciari B, Dal Ben D et al. Highlights on the development of A(2A) adenosine receptor agonists and antagonists. ChemMedChem 2007; 2:260-81.

Cristalli G, Müller CE, Volpini R. Recent developments in adenosine A2A receptor ligands. Handb Exp Pharmacol 2009; 5:59-98.

Criswell LA, Lum RF, Turner KN et al. The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept. Arthritis Rheum 2004; 50:2750-6.

Crivello A, Giacalone A, Vaglica M et al. Regulatory cytokine gene polymorphisms and risk of colorectal carcinoma. Ann N Y Acad Sci 2006; 1089:98-103.

Crivori P, Zamora I, Speed B, Orrenius C, Poggesi I. Model based on GRID-derived descriptors for estimating CYP3A4 enzyme stability of potential drug candidates. J Comput Aided Mol Des 2004; 18:155-66.

Croarkin PE, Emslie GJ, Mayes TL. Neuroleptic malignant syndrome associated with atypical antipsychotics in pediatric patients: a review of published cases. J Clin Psychiatry 2008; 69:1157-65.

Crobu F, Palumbo L, Franco E et al. Role of TGF-beta1 haplotypes in the occurrence of myocardial infarction in young Italian patients. BMC Med Genet 2008; 9:13.

Crocenzi FA, Sánchez Pozzi EJ, Pellegrino JM et al. Beneficial effects of silymarin on estrogen-induced cholestasis in the rat: a study in vivo and in isolated hepatocyte couplets. Hepatology 2001; 34:329-39.

Crocq MA, Mant R, Asherson P et al. Association between schizophrenia and homozygosity at the dopamine D3 receptor gene. J Med Genet 1992; 29:858-60.

Croera C, Ferrario D, Gribaldo L. In vitro toxicity of naphthalene, 1-naphthol, 2-naphthol and 1,4-naphthoquinone on human CFU-GM from female and male cord blood donors. Toxicol In Vitro 2008; 22:1555-61.

Croes EA, Alizadeh BZ, Bertoli-Avella AM et al. Polymorphisms in the prion gene and in the doppel gene increase susceptibility for Creutzfeldt-Jakob disease. Europ J Hum Genet 2004; 12:389-94.

Croes EA, Dermaut B, Houwing-Duistermaat JJ et al. Early cognitive decline is associated with prion protein codon 129 polymorphism. Ann Neurol 2003; 54:275-6.

Crook T, Vousden KH. Properties of p53 mutations detected in primary and secondary cervical cancers suggest mechanisms of metastasis and involvement of environmental carcinogens. EMBO J 1992; 11:3935-40.

Crooke PS, Justenhoven C, Brauch H; GENICA Consortium. Estrogen metabolism and exposure in a genotypic-phenotypic model for breast cancer risk prediction. Cancer Epidemiol Biomarkers Prev 2011; 20:1502-15.

Croom EL, Stevens JC, Hines RN, Wallace AD, Hodgson E. Human hepatic CYP2B6 developmental expression: the impact of age and genotype. Biochem Pharmacol 2009; 78:184-90.

Croom EL, Wallace AD, Hodgson E. Human variation in CYP-specific chlorpyrifos metabolism. Toxicology 2010; 276:184-91.

Crosier MD, Peter I, Booth SL, Bennett G, Dawson-Hughes B, Ordovas JM. Association of sequence variations in vitamin K epoxide reductase and gamma-glutamyl carboxylase genes with biochemical measures of vitamin K status. J Nutr Sci Vitaminol 2009; 55:112-9.

Crosignani A, del Puppo M, Longo M et al. Changes in classic and alternative pathways of bile acid synthesis in chronic liver disease. Clin Chim Acta 2007; 382:82-8.

Crotti L, Taravelli E, Girardengo G, Schwartz PJ. Congenital Short QT Syndrome. Indian Pacing Electrophysiol J 2010; 10:86-95.

Crouthamel MH, Wu D, Yang Z, Ho RJ. A novel MDR1 G1199T variant alters drug resistance and efflux transport activity of P-glycoprotein in recombinant Hek cells. J Pharm Sci 2006; 95:2767-77.

Crouthamel MH, Wu D, Yang Z, Ho RJ. A novel MDR1 GT1292-3TG (Cys431Leu) genetic variation and its effect on P-glycoprotein biologic functions. AAPS J 2010; 12:548-55.

Crowley E, McDevitt CA, Callaghan R. Generating inhibitors of P-glycoprotein: where to, now? Methods Mol Biol 2010; 596:405-32.

Crowley SD, Gurley SB, Herrera MJ et al. Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proc Nat Acad Sci USA 2006; 103:17985-90.

Croxtall JD, McKeage K. Fulvestrant: a review of its use in the management of hormone receptor-positive metastatic breast cancer in postmenopausal women. Drugs 2011; 71:363-80.

Cruchaga C, Graff C, Chiang HH et al. Association of TMEM106B gene polymorphism with age at onset in granulin mutation carriers and plasma granulin protein levels. Arch Neurol 2011; 68:581-6.

Cruts M, Backhovens H, Martin JJ, van Broeckhoven C. Genetic analysis of the cellular oncogene fos in patients with chromosome 14 encoded Alzheimer's disease. Neurosci Lett 1994; 174:97-100.

Cruts M, Backhovens H, Theuns J et al. Genetic and physical characterization of the early-onset Alzheimer's disease AD3 locus on chromosome 14q24. 3. Hum Mol Genet 1995; 4:1355-64.

Cruts M, Dermaut B, Koster MN et al. The alpha-2-macroglobulin gene in AD: a population-based study and meta-analysis. Neurology 2000; 55:678-84.

Cruz TD, Valdes AM, Santiago A et al. DPB1 alleles are associated with type 1 diabetes susceptibility in multiple ethnic groups. Diabetes 2004; 53:2158-63.

Cruz-Robles D, Chávez-González JP, Cavazos-Quero MM, Pérez-Méndez O, Reyes PA, Vargas-Alarcón G. Association between IL-1B and IL-1RN gene polymorphisms and Chagas' disease development susceptibility. Immunol Invest 2009; 38:231-9.

Csáki KF. Synthetic surfactant food additives can cause intestinal barrier dysfunction. Med Hypotheses 2011; 76:676-81.

Csanaky IL, Lu H, Zhang Y, Ogura K, Choudhuri S, Klaassen CD. Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice. Hepatology 2011; 53:272-81.

Cuchel M, Bloedon LT, Szapary PO et al. Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia. New Eng J Med 2007; 356:148-56.

Cuchel M, Rader DJ. Reply to Hegele Familial hypercholesterolemia. New Eng J Med 2007; 356:1779-80.

Cuda C, Badawi A, Karmali M, El-Sohemy A. Polymorphisms in Toll-like receptor 4 are associated with factors of the metabolic syndrome and modify the association between dietary saturated fat and fasting high-density lipoprotein cholesterol. Metabolism 2011; 60:1131-5.

Cudaback E, Li X, Montine KS, Montine TJ, Keene CD. Apolipoprotein E isoform-dependent microglia migration. FASEB J 2011; 25:2082-91.

Cuendet M, Pezzuto JM. The role of cyclooxygenase and lipoxygenase in cancer chemoprevention. Drug Metabol Drug Interact 2000; 17:109-57.

Cuesta de Juan S, Monte MJ, Macias RI, Wauthier V, Calderon PB, Marin JJ. Ontogenic development-associated changes in the expression of genes involved in rat bile acid homeostasis. J Lipid Res 2007; 48:1362-70.

Cui H, Okuhira K, Ohoka N et al. Tributyltin chloride induces ABCA1 expression and apolipoprotein A-I-mediated cellular cholesterol efflux by activating LXRalpha/RXR. Biochem Pharmacol 2011; 81:819-24.

Cui J, Eitzman DT, Westrick RJ et al. Spontaneous thrombosis in mice carrying the factor V Leiden mutation. Blood 2000; 96:4222-6.

Cui J, Melista E, Chazaro I et al. Sequence variation of bradykinin receptors B1 and B2 and association with hypertension. J Hypertens 2005; 23:55-62.

Cui X, Thomas A, Gerlach V, White RE, Morrison RA, Cheng KC. Application and interpretation of hPXR screening data: Validation of reporter signal requirements for prediction of clinically relevant CYP3A4 inducers. Biochem Pharmacol 2008; 76:680-9.

Cui XR, Saito R, Kubo T, Kon D, Hirano Y, Saito S. Preparations of anthraquinone and naphthoquinone derivatives and their cytotoxic effects. Chem Pharm Bull 2011; 59:302-14.

Cuisset T, Frere C, Quilici J et al. Role of the T744C polymorphism of the P2Y12 gene on platelet response to a 600-mg loading dose of clopidogrel in 597 patients with non-ST-segment elevation acute coronary syndrome. Thromb Res 2007; 120:893-9.

Cummins CL, Jacobsen W, Benet LZ. Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4. J Pharmacol Exp Ther 2002; 300:1036-45.

Cummins CL, Jacobsen W, Christians U, Benet LZ. CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam. J Pharmacol Exp Ther 2004; 308:143-55.

Cummins CL, Mangravite LM, Benet LZ. Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1, and MRP2) in CYP3A4-transfected Caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate. Pharm Res 2001; 18:1102-9.

Cummins TD, Hawi Z, Hocking J et al. Dopamine transporter genotype predicts behavioural and neural measures of response inhibition. Mol Psychiatry 2011. doi:10. 1038/mp. 2011. 104.

Curley CR, Monsuur AJ, Wapenaar MC, Rioux JD, Wijmenga C. A functional candidate screen for coeliac disease genes. Eur J Hum Genet 2006; 14:1215-22.

Curran CP, Nebert DW, Genter MB et al. In utero and lactational exposure to PCBs in mice: adult offspring show altered learning and memory depending on Cyp1a2 and Ahr genotypes. Environ Health Perspect 2011; 119:1286-93.

Curran T, Morgan JI. Fos: an immediate-early transcription factor in neurons. J Neurobiol 1995; 26:403-12.

Curry SC, Watts DJ, Katz KD, Bikin D, Bukaveckas BL. The effect of single-dose tramadol on oxycodone clearance. J Emerg Med 2007; 33:407-11.

Curry-McCoy TV, Osna NA, Nanji AA, Donohue TM Jr. Chronic ethanol consumption results in atypical liver injury in copper/zinc superoxide dismutase deficient mice. Alcohol Clin Exp Res 2010; 34:251-61.

Cury NM, Russo A, Galbiatti AL et al. Polymorphisms of the CYP1A1 and CYP2E1 genes in head and neck squamous cell carcinoma risk. Mol Biol Rep 2011. doi:10. 1007/s11033-011-0831-1.

Cusatis G, Gregorc V, Li J et al. Pharmacogenetics of ABCG2 and adverse reactions to gefitinib. J Natl Cancer Inst 2006; 98:1739-42.

Cusi D, Barlassina C, Azzani T et al. Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension. Lancet 1997; 349:1353-7.

Cusimano MD, Rewilak D, Stuss DT, Barrera-Martinez JC, Salehi F, Freedman M. Normal-pressure hydrocephalus: is there a genetic predisposition? Can J Neurol Sci 2011; 38:274-81.

Cussigh A, Falleti E, Fabris C et al. Interleukin 6 promoter polymorphisms influence the outcome of chronic hepatitis C. Immunogenetics 2011; 63:33-41.

Cust AE, Harland M, Makalic E et al. Melanoma risk for CDKN2A mutation carriers who are relatives of population-based case carriers in Australia and the UK. J Med Genet 2011; 48:266-72.

Custódio AC, Almeida LO, Pinto GR et al. GSTP1 Ile105Val polymorphism in astrocytomas and glioblastomas. Genet Mol Res 2010; 9:2328-34.

Cutler MJ, Urquhart BL, Velenosi TJ et al. In vitro and in vivo assessment of renal drug transporters in the disposition of mesna and dimesna. J Clin Pharmacol 2011. doi:10. 1177/0091270011400414.

Cvelbar M, Hocevar M, Vidmar G, Teugels E. BRCA1/2 status and clinicopathologic characteristics of patients with double primary breast and ovarian cancer. Neoplasma 2011; 58:198-204.

Cvetkovic RS, Goa KL. Lopinavir/ritonavir: a review of its use in the management of HIV infection. Drugs 2003; 63:769-802.

Cygnar KD, Zhao H. Phosphodiesterase 1C is dispensable for rapid response termination of olfactory sensory neurons. Nat Neurosci 2009; 12:454-62.

Cymbron T, Raposo M, Kazachkova N et al. Cross-sectional study of risk factors for atherosclerosis in the Azorean population. Ann Hum Biol 2011; 38:354-9.

Czerski PM, Rybakowski F, Kapelski P et al. Association of tumor necrosis factor -308G/A promoter polymorphism with schizophrenia and bipolar affective disorder in a Polish Population. Neuropsychobiology 2008; 57:88-94.

Czerwinski M, McLemore TL, Gelboin HV, Gonzalez FJ. Quantification of CYP2B7, CYP4B1, and CYPOR messenger RNAs in normal human lung and lung tumors. Cancer Res 1994; 54:1085-91.

Czerwinski M, McLemore TL, Philpot RM et al. Metabolic activation of 4-ipomeanol by complementary DNA-expressed human cytochromes P-450: evidence for species-specific metabolism. Cancer Res 1991; 51:4636-8.

Cziraky MJ, Willey VJ, McKenney JM et al. Statin safety: an assessment using an administrative claims database. Am J Cardiol 2006; 97:61-68.

Czirr E, Weggen S. Gamma-secretase modulation with Abeta42-lowering nonsteroidal anti-inflammatory drugs and derived compounds. Neurodegener Dis 2006; 3:298-304.

da Costa KA, Kozyreva OG, Song J, Galanko JA, Fischer LM, Zeisel SH. Common genetic polymorphisms affect the human requirement for the nutrient choline. FASEB J 2006; 20:1336-44.

da Rocha MD, Viegas FP, Campos HC et al. The role of natural products in the discovery of new drug candidates for the treatment of neurodegenerative disorders II: Alzheimer's disease. CNS Neurol Disord Drug Targets 2011; 10:251-70.

Daali Y, Ancrenaz V, Bosilkovska M, Dayer P, Desmeules J. Ritonavir inhibits the two main prasugrel bioactivation pathways in vitro: a potential drug-drug interaction in HIV patients. Metabolism 2011; 60:1584-9.

Dabora SL, Roberts P, Nieto A et al. Association between a high-expressing interferon-gamma allele and a lower frequency of kidney angiomyolipomas in TSC2 patients. Am J Hum Genet 2002; 71:750-8.

Dabrowski MJ, Schrag ML, Wienkers LC, Atkins WM. Pyrene. pyrene complexes at the active site of cytochrome P450 3A4: evidence for a multiple substrate binding site. J Am Chem Soc 2002; 124:11866-7.

Dadashzadeh S, Javadian B, Sadeghian S. The effect of gender on the pharmacokinetics of verapamil and norverapamil in human. Biopharm Drug Dispos 2006; 27:329-34.

Dadkhah A, Allameh A, Khalafi H, Ashrafihelan J. Inhibitory effects of dietary caraway essential oils on 1,2-dimethylhydrazine-induced colon carcinogenesis is mediated by liver xenobiotic metabolizing enzymes. Nutr Cancer 2011; 63:46-54.

Dagle JM, Fisher TJ, Haynes SE et al. Cytochrome P450 (CYP2D6) genotype is associated with elevated systolic blood pressure in preterm infants after discharge from the neonatal intensive care unit. J Pediatr 2011; 159:104-9.

Dahabreh I, Terasawa T, Castaldi P, Trikalinos TA. CYP2D6 testing to predict response to tamoxifen in women with breast cancer. Pharmacogenomic. PLoS Curr 2010. doi:10. 1371/currents. RRN1176.

Dahan A, Amidon GL. Grapefruit juice and its constituents augment colchicine intestinal absorption: potential hazardous interaction and the role of p-glycoprotein. Pharm Res 2009; 26:883-92.

Dahan A, Amidon GL. Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting. Am J Physiol Gastrointest Liver Physiol 2009; 297:371-7.

Dahan A, Amidon GL. MRP2 mediated drug-drug interaction: indomethacin increases sulfasalazine absorption in the small intestine, potentially decreasing its colonic targeting. Int J Pharm 2010; 386:216-20.

Daher W, Pelinski L, Klieber S et al. In vitro metabolism of ferroquine (SSR97193) in animal and human hepatic models and antimalarial activity of major metabolites on Plasmodium falciparum. Drug Metab Dispos 2006; 34:667-82.

Dahiyat M, Cumming A, Harrington C et al. Association between Alzheimer's disease and the NOS3 gene. Ann Neurol 1999; 46:664-7.

Dahl ML. Cytochrome p450 phenotyping/genotyping in patients receiving antipsychotics: useful aid to prescribing? Clin Pharmacokinet 2002; 41:453-70.

Dahl ML, Iselius L, Alm C et al. Polymorphic 2-hydroxylation of desipramine. A population and family study. Eur J Clin Pharmacol 1993; 44:445-50.

Dahl ML, Johansson I, Bertilsson L, Ingelman-Sundberg M, Sjöqvist F. Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis. J Pharmacol Exp Ther 1995; 274:516-20.

Dahl ML, Sjöqvist F. Pharmacogenetic methods as a complement to therapeutic monitoring of antidepressants and neuroleptics. Ther Drug Monit 2000; 22:114-7.

Dahl N, Pigg M, Ristoff E et al. Missense mutations in the human glutathione synthetase gene result in severe metabolic acidosis, 5-oxoprolinuria, hemolytic anemia and neurological dysfunction. Hum Mol Genet 1997; 6:1147-52.

Dahlman I, Vaxillaire M, Nilsson M et al. Estrogen receptor alpha gene variants associate with type 2 diabetes and fasting plasma glucose. Pharmacogenet Genomics 2008; 18:967-75.

Dai CL, Liang YJ, Chen LM et al. Sensitization of ABCB1 overexpressing cells to chemotherapeutic agents by FG020326 via binding to ABCB1 and inhibiting its function. Biochem Pharmacol 2009; 78:355-64.

Dai CL, Liang YJ, Wang YS et al. Sensitization of ABCG2-overexpressing cells to conventional chemotherapeutic agent by sunitinib was associated with inhibiting the function of ABCG2. Cancer Lett 2009; 279:74-83.

Dai CL, Xiong HY, Tang LF et al. Tetrandrine achieved plasma concentrations capable of reversing MDR in vitro and had no apparent effect on doxorubicin pharmacokinetics in mice. Cancer Chemother Pharmacol 2007; 60:741-50.

Dai D, Tang J, Rose R et al. Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos. J Pharmacol Exp Ther 2001; 299:825-31.

Dai D, Zeldin DC, Blaisdell JA et al. Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid. Pharmacogenetics 2001; 11:597-607.

Dai GD, Cui LB, Song L et al. Metabolism of terephthalic acid and its effects on CYP4B1 induction. Biomed Environ Sci 2006; 19:8-14.

Dai J, Zhang F, Zheng J. Retrorsine, but not monocrotaline, is a mechanism-based inactivator of P450 3A4. Chem Biol Interact 2010; 183:49-56.

Dai Y, Grant S. Cyclin-dependent kinase inhibitors. Curr Opin Pharmacol 2003; 3:362-70.

Dai Y, Hebert MF, Isoherranen N et al. Effect of CYP3A5 polymorphism on tacrolimus metabolic clearance in vitro. Drug Metab Dispos 2006; 34:836-47.

Dai Y, Iwanaga K, Lin YS et al. In vitro metabolism of cyclosporine A by human kidney CYP3A5. Biochem Pharmacol 2004; 68:1889-902.

Dai Y, Wang Q, Zhang X et al. Molecular docking and QSAR study on steroidal compounds as aromatase inhibitors. Eur J Med Chem 2010; 45:5612-20.

Dai Z, Papp AC, Wang D, Hampel H, Sadee W. Genotyping panel for assessing response to cancer chemotherapy. BMC Med Genomics 2008; 1:24.

Daigo S, Takahashi Y, Fujieda M et al. A novel mutant allele of the CYP2A6 gene (CYP2A6*11) found in a cancer patient who showed poor metabolic phenotype towards tegafur. Pharmacogenetics 2002; 12:299-306.

Daily EB, Aquilante CL. Cytochrome P450 2C8 pharmacogenetics: a review of clinical studies. Pharmacogenomics 2009; 10:1489-510.

Dajani R, Hood AM, Coughtrie MW. A single amino acid, glu146, governs the substrate specificity of a human dopamine sulfotransferase, SULT1A3. Mol Pharmacol 1998; 54:942-8.

Dal Forno G, Carson KA, Brookmeyer R, Troncoso J, Kawas CH, Brandt J. APOE genotype and survival in men and women with Alzheimer's disease. Neurology 2002; 58:1045-50.

Dalén P, Dahl ML, Bernal Ruiz ML, Nordin J, Bertilsson L. 10-Hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes. Clin Pharmacol Ther 1998; 63:444-52.

Dalén P, Dahl ML, Roh HK et al. Disposition of debrisoquine and nortriptyline in Korean subjects in relation to CYP2D6 genotypes, and comparison with Caucasians. Br J Clin Pharmacol 2003; 55:630-4.

Daley D, Lemire M, Akhabir L et al. Analyses of associations with asthma in four asthma population samples from Canada and Australia. Hum Genet 2009; 125:445-59.

Daley D, Lewis S, Platzer P et al. Identification of susceptibility genes for cancer in a genome-wide scan: results from the colon neoplasia sibling study. Am J Hum Genet 2008; 82:723-36.

Daly AK. Pharmacogenetics of the cytochromes P450. Curr Top Med Chem 2004; 4:1733-44.

Daly AK. Significance of the minor cytochrome P450 3A isoforms. Clin Pharmacokinet 2006; 45:13-31.

Daly AK. Drug-induced liver injury: past, present and future. Pharmacogenomics 2010; 11:607-11.

Daly AK, Aithal GP. Genetic regulation of warfarin metabolism and response. Semin Vasc Med 2003; 3:231-8.

Daly AK, Aithal GP, Leathart JB, Swainsbury RA, Dang TS, Day CP. Genetic susceptibility to diclofenac-induced hepatotoxicity: contribution of UGT2B7, CYP2C8, and ABCC2 genotypes. Gastroenterology 2007; 132:272-81.

Daly AK, Day CP, Donaldson PT. Polymorphisms in immunoregulatory genes: towards individualized immunosuppressive therapy? Am J Pharmacogenomics 2002; 2:13-23.

Daly AK, Donaldson PT, Bhatnagar P et al. HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. Nat Genet 2009; 41:816-9.

Daly AK, Fairbrother KS, Andreassen OA, London SJ, Idle JR, Steen VM. Characterization and PCR-based detection of two different hybrid CYP2D7P/CYP2D6 alleles associated with the poor metabolizer phenotype. Pharmacogenetics 1996; 6:319-28.

Daly AK, Leathart JB, London SJ, Idle JR. An inactive cytochrome P450 CYP2D6 allele containing a deletion and a base substitution. Hum Genet 1995; 95:337-41.

Daly AK, Salh BS, Bilton D et al. Deficient nifedipine oxidation: a rare inherited trait associated with cystic fibrosis kindreds. Pharmacogenetics 1992; 2:19-24.

Dalley JW, Fryer TD, Brichard L et al. Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement. Science 2007; 315:1267-70.

Dallongeville J, Cottel D, Montaye M, Codron V, Amouyel P, Helbecque N. Impact of APOA5/A4/C3 genetic polymorphisms on lipid variables and cardiovascular disease risk in French men. Int J Cardiol 2006; 106:152-6.

Dallongeville J, Helbecque N, Cottel D, Amouyel P, Meirhaeghe A. The Gly16-Arg16 and Gln27-Glu27 polymorphisms of beta-2-adrenergic receptor are associated with metabolic syndrome in men. J Clin Endocr Metab 2003; 88:4862-6.

Dally H, Bartsch H, Jäger B et al. Genotype relationships in the CYP3A locus in Caucasians. Cancer Lett 2004; 207:95-9.

Dally H, Edler L, Jäger B et al. The CYP3A4*1B allele increases risk for small cell lung cancer: effect of gender and smoking dose. Pharmacogenetics 2003; 13:607-18.

Dam V, Morgan BT, Mazanek P, Hogarty MD. Mutations in PIK3CA are infrequent in neuroblastoma. BMC Cancer 2006; 6:177.

Damani SB, Topol EJ. Emerging genomic applications in coronary artery disease. JACC Cardiovasc Interv 2011; 4:473-82.

D'Ambrosio RL, D'Andrea G, Cappucci F et al. Polymorphisms in factor II and factor VII genes modulate oral anticoagulation with warfarin. Haematologica 2004; 89:1510-6.

Damiani D, Tiribelli M, Michelutti A et al. Fludarabine-based induction therapy does not overcome the negative effect of ABCG2 (BCRP) over-expression in adult acute myeloid leukemia patients. Leuk Res 2010; 34:942-5.

Damkier P, Brøsen K. Quinidine as a probe for CYP3A4 activity: intrasubject variability and lack of correlation with probe-based assays for CYP1A2, CYP2C9, CYP2C19, and CYP2D6. Clin Pharmacol Ther 2000; 68:199-209.

Damkier P, Hansen LL, Brosen K. Effect of diclofenac, disulfiram, itraconazole, grapefruit juice and erythromycin on the pharmacokinetics of quinidine. Br J Clin Pharmacol 1999; 48:829-38.

Damkier P, Hansen LL, Brøsen K. Rifampicin treatment greatly increases the apparent oral clearance of quinidine. Pharmacol Toxicol 1999; 85:257-62.

Damle BD, Uderman H, Biswas P, Crownover P, Lin C, Glue P. Influence of CYP2C19 polymorphism on the pharmacokinetics of nelfinavir and its active metabolite. Br J Clin Pharmacol 2009; 68:682-9.

Damme B, Darmer D, Pankow D. Induction of hepatic cytochrome P4502E1 in rats by acetylsalicylic acid or sodium salicylate. Toxicology 1996; 106:99-103.

Damnjanovic T, Milicevic R, Novkovic T et al. Association between the methylenetetrahydrofolate reductase polymorphisms and risk of acute lymphoblastic leukemia in Serbian children. J Pediatr Hematol Oncol 2010; 32:148-50.

Damy T, Pousset F, Caplain H, Hulot JS, Lechat P. Pharmacokinetic and pharmacodynamic interactions between metoprolol and dronedarone in extensive and poor CYP2D6 metabolizers healthy subjects. Fundam Clin Pharmacol 2004; 18:113-23.

Dan H, Wu J, Peng M et al. Hypolipidemic effects of Alismatis rhizome on lipid profile in mice fed high-fat diet. Saudi Med J 2011; 32:701-7.

Dandara C, Masimirembwa CM, Magimba A et al. Genetic polymorphism of CYP2D6 and CYP2C19 in east- and southern African populations including psychiatric patients. Eur J Clin Pharmacol 2001; 57:11-7.

D'Andrea G, Brisdelli F, Bozzi A. AZT: an old drug with new perspectives. Curr Clin Pharmacol 2008; 3:20-37.

Danenberg HD, Grad E, Swaminathan RV et al. Neointimal formation is reduced after arterial injury in human crp transgenic mice. Atherosclerosis 2008; 201:85-91.

Danesi R, Pasqualetti G, Giovannetti E et al. Pharmacogenomics in non-small-cell lung cancer chemotherapy. Adv Drug Deliv Rev 2009; 61:408-17.

Danesi R, Pasqualetti G, Giovannetti E, del Tacca M. The role of pharmacogenetics in adjuvant treatment of non-small cell lung cancer. J Thorac Oncol 2007; 2:27-30.

Dang DT, Chen F, Kohli M, Rago C, Cummins JM, Dang LH. Glutathione S-transferase pi1 promotes tumorigenicity in HCT116 human colon cancer cells. Cancer Res 2005; 65:9485-94.

Daniel F, Loriot MA, Seksik P et al. Multidrug resistance gene-1 polymorphisms and resistance to cyclosporine A in patients with steroid resistant ulcerative colitis. Inflamm Bowel Dis 2007; 13:19-23.

Daniel W. Metabolism of psychotropic drugs: pharmacological and clinical relevance. Pol J Pharmacol 1995; 47:367-79.

Daniel WA, Haduch A, Wójcikowski J. Inhibition of rat liver CYP2D in vitro and after 1-day and long-term exposure to neuroleptics in vivo-possible involvement of different mechanisms. Eur Neuropsychopharmacol 2005; 15:103-10.

Daniele A, Cammarata R, Pasanisi F et al. Molecular analysis of the adiponectin gene in severely obese patients from southern Italy. Ann Nutr Metab 2008; 53:155-61.

Danks RA, Dorevitch M, Cummins JT, Byrne E. Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS): adolescent onset with severe cerebral edema. Aust N Z J Med 1988; 18:69-72.

Dannenberg LO, Edenberg HJ. Epigenetics of gene expression in human hepatoma cells: expression profiling the response to inhibition of DNA methylation and histone deacetylation. BMC Genomics 2006; 7:181.

Danpure CJ. Molecular aetiology of primary hyperoxaluria type 1. Nephron Exp Nephrol 2004; 98:39-44.

Danpure CJ, Birdsey GM, Rumsby G, Lumb MJ, Purdue PE, Allsop J. Molecular characterization and clinical use of a polymorphic tandem repeat in an intron of the human alanine:glyoxylate aminotransferase gene. Hum Genet 1994; 94:55-64.

Dansky HM, Barlow CB, Lominska C et al. Adhesion of monocytes to arterial endothelium and initiation of atherosclerosis are critically dependent on vascular cell adhesion molecule-1 gene dosage. Arterioscler Thromb Vasc Biol 2001; 21:1662-7.

Dao TT, Kailasam MT, Parmer RJ et al. Expression of altered alpha2-adrenergic phenotypic traits in normotensive humans at genetic risk of hereditary (essential) hypertension. J Hypertens 1998; 16:779-92.

Daood M, Tsai C, Ahdab-Barmada M, Watchko JF. ABC transporter (P-gp/ABCB1, MRP1/ABCC1, BCRP/ABCG2) expression in the developing human CNS. Neuropediatrics 2008; 39:211-8.

Dapkunas J, Sazonovas A, Japertas P. Probabilistic prediction of the human CYP3A4 and CYP2D6 metabolism sites. Chem Biodivers 2009; 6:2101-6.

Darabi H, Czene K, Wedrén S et al. Genetic variation in the androgen estrogen conversion pathway in relation to breast cancer prognosticators. Breast Cancer Res Treat 2011; 127:503-9.

Darabi M, Ani M, Panjehpour M, Rabbani M, Movahedian A, Zarean E. Effect of estrogen receptor β A1730G polymorphism on ABCA1 gene expression response to postmenopausal hormone replacement therapy. Genet Test Mol Biomarkers 2011; 15:11-5.

Darabi M, Rabbani M, Ani M, Zarean E, Panjehpour M, Movahedian A. Increased leukocyte ABCA1 gene expression in post-menopausal women on hormone replacement therapy. Gynecol Endocrinol 2011; 27:701-5.

Darazy M, Balbaa M, Mugharbil A, Saeed H, Sidani H, Abdel-Razzak Z. CYP1A1, CYP2E1, and GSTM1 gene polymorphisms and susceptibility to colorectal and gastric cancer Among Lebanese. Genet Test Mol Biomarkers 2011; 15:423-9.

Darbar D, Kannankeril PJ, Donahue BS et al. Cardiac sodium channel (SCN5A) variants associated with atrial fibrillation. Circulation 2008; 15:1927-35.

Darbari DS, Minniti CP, Rana S, van den Anker J. Pharmacogenetics of morphine: Potential implications in sickle cell disease. Am J Hematol 2008; 83:233-6.

Darby JK, Pasta DJ, Wilson MG, Herbert J. Long-term therapeutic drug monitoring of risperidone and olanzapine identifies altered steady-state pharmacokinetics: a clinical, two-group, naturalistic study. Clin Drug Investig 2008; 28:553-64.

Darby RA, Callaghan R, McMahon RM. P-glycoprotein inhibition; the past, the present and the future. Curr Drug Metab 2011; 12:722-31.

Darendeliler F, Fournet JC, Baş F et al. ABCC8 (SUR1) and KCNJ11 (KIR6. 2) mutations in persistent hyperinsulinemic hypoglycemia of infancy and evaluation of different therapeutic measures. J Pediatr Endocrinol Metab 2002; 15:993-1000.

Darling TN, Skarulis MC, Steinberg SM, Marx SJ, Spiegel AM, Turner M. Multiple facial angiofibromas and collagenomas in patients with multiple endocrine neoplasia type 1. Arch Derm 1997; 133:853-7.

Darnell JE Jr, Henriksen MA, Lerner L, Zhang X. STAT3-dependent enhanceosome assembly and disassembly: synergy with GR for full transcriptional increase of the alpha 2-macroglobulin gene. Genes Dev 2003; 17:2564-77.

Darnell M, Karlsson JE, Owen A et al. Investigation of the involvement of P-glycoprotein and multidrug resistance-associated protein 2 in the efflux of ximelagatran and its metabolites by using short hairpin RNA knockdown in Caco-2 cells. Drug Metab Dispos 2010; 38:491-7.

Darrah R, McKone E, O'Connor C et al. EDNRA variants associate with smooth muscle mRNA levels, cell proliferation rates, and cystic fibrosis pulmonary disease severity. Physiol Genomics 2010; 41:71-7.

Darreh-Shori T, Soininen H. Effects of cholinesterase inhibitors on the activities and protein levels of cholinesterases in the cerebrospinal fluid of patients with Alzheimer's disease: a review of recent clinical studies. Curr Alzheimer Res 2010; 7:67-73.

D'Arrigo C, Migliardi G, Santoro V et al. Effect of fluvoxamine on plasma risperidone concentrations in patients with schizophrenia. Pharmacol Res 2005; 52:497-501.

Darsigny M, Babeu JP, Dupuis AA et al. Loss of hepatocyte-nuclear-factor-4alpha affects colonic ion transport and causes chronic inflammation resembling inflammatory bowel disease in mice. PLoS One 2009. doi:10. 1371/journal. pone. 0007609.

Darwish M, Kirby M, Robertson P Jr, Hellriegel ET. Interaction profile of armodafinil with medications metabolized by cytochrome P450 enzymes 1A2, 3A4 and 2C19 in healthy subjects. Clin Pharmacokinet 2008; 47:61-74.

Darwish WS, Ikenaka Y, Eldaly EA et al. Cytochrome P450 1A-dependent activities in deer, cattle and horses. J Vet Med Sci 2010; 72:561-6.

Darwish WS, Kawai Y, Ikenaka Y, Yamamoto H, Muroya T, Ishizuka M. Identification and phylogenetic analysis of novel cytochrome P450 1A genes from ungulate species. J Vet Med Sci 2010; 72:1237-41.

Das A, Xi L, Kukreja RC. Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling. J Biol Chem 2005; 280:12944-55.

Das A, Zhao J, Schatz GC, Sligar SG, van Duyne RP. Screening of type I and II drug binding to human cytochrome P450-3A4 in nanodiscs by localized surface plasmon resonance spectroscopy. Anal Chem 2009; 81:3754-9.

Das BC, Madhukumar AV, Anguiano J et al. Synthesis of novel ketoconazole derivatives as inhibitors of the human Pregnane X Receptor (PXR; NR1I2; also termed SXR, PAR). Bioorg Med Chem Lett 2008; 18:3974-7.

Das I, Craig C, Funahashi Y et al. Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function. J Biol Chem 2004; 279:30771-80.

Das J, Ghosh J, Manna P, Sil PC. Acetaminophen induced acute liver failure via oxidative stress and JNK activation: protective role of taurine by the suppression of cytochrome P450 2E1. Free Radic Res 2010; 44:340-55.

Das PC, Cao Y, Cherrington N, Hodgson E, Rose RL. Fipronil induces CYP isoforms and cytotoxicity in human hepatocytes. Chem Biol Interact 2006; 164:200-14.

Das PC, Cao Y, Roset RL, Cherrington N, Hodgson E. Enzyme induction and cytotoxicity in human hepatocytes by chlorpyrifos and N,N-diethyl-m-toluamide (DEET). Drug Metabol Drug Interact 2008; 23:237-60.

Das PC, Streit TM, Cao Y et al. Pyrethroids: cytotoxicity and induction of CYP isoforms in human hepatocytes. Drug Metabol Drug Interact 2008; 23:211-36.

Das S, Levinson B, Vulpe C, Whitney S, Gitschier J, Packman S. Similar splicing mutations of the Menkes/mottled copper-transporting ATPase gene in occipital horn syndrome and the blotchy mouse. Am J Hum Genet 1995; 56:570-6.

Das S, Makino S, Melman YF et al. Mutation in the S3 segment of KCNQ1 results in familial lone atrial fibrillation. Heart Rhythm 2009; 6:1146-53.

Dasbiswas A, Shinde S, Dasbiswas D. S-metoprolol: the 2008 clinical review. J Indian Med Assoc 2008; 106:259-62.

Datta SK, Kumar V, Ahmed RS, Tripathi AK, Kalra OP, Banerjee BD. Effect of GSTM1 and GSTT1 double deletions in the development of oxidative stress in diabetic nephropathy patients. Indian J Biochem Biophys 2010; 47:100-3.

Datta SR, McQuillin A, Puri V et al. Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22. 3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophrenia. Behav Brain Funct 2007; 3:50.

Davaalkham J, Hayashida T, Tsuchiya K, Gatanaga H, Nyamkhuu D, Oka S. Allele and genotype frequencies of cytochrome P450 2B6 gene in a Mongolian population. Drug Metab Dispos 2009; 37:1991-3.

Dávalos A, Fernández-Hernando C, Cerrato F et al. Red grape juice polyphenols alter cholesterol homeostasis and increase LDL-receptor activity in human cells in vitro. J Nutr 2006; 136:1766-73.

Davar R, Oskouian H, Ahmadi S, Firouzabadi RD. GnRH antagonist/letrozole versus microdose GnRH agonist flare protocol in poor responders undergoing in vitro fertilization. Taiwan J Obstet Gynecol 2010; 49:297-301.

Davare MA, Avdonin V, Hall DD et al. A beta-2 adrenergic receptor signaling complex assembled with the Ca2+ channel Ca(V)1. 2. Science 2001; 293:98-101.

David JP, Mehic D, Bakiri L et al. Essential role of RSK2 in c-Fos-dependent osteosarcoma development. J Clin Invest 2005; 115:664-72.

David SP, Johnstone EC, Murphy MF et al. Genetic variation in the serotonin pathway and smoking cessation with nicotine replacement therapy: new data from the Patch in Practice trial and pooled analyses. Drug Alcohol Depend 2008; 98:77-85.

Davidson MH. Treatment of the elderly with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors: focus on drug interactions. J Cardiovasc Pharmacol Ther 2001; 6:219-29.

Davidson MH. Therapies targeting exogenous cholesterol uptake: new insights and controversies. Curr Atheroscler Rep 2011; 13:95-100.

Davidson SI, Liu Y, Danoy PA et al. Association of STAT3 and TNFRSF1A with ankylosing spondylitis in Han Chinese. Ann Rheum Dis 2011; 70:289-92.

Davidzon G, Mancuso M, Ferraris S et al. POLG mutations and Alpers syndrome. Ann Neurol 2005; 57:921-3.

Davies A, Jordanides NE, Giannoudis A et al. Nilotinib concentration in cell lines and primary CD34(+) chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters. Leukemia 2009; 23:1999-2006.

Davies BJ, Coller JK, James HM, Somogyi AA, Horowitz JD, Sallustio BC. The influence of CYP2D6 genotype on trough plasma perhexiline and cis-OH-perhexiline concentrations following a standard loading regimen in patients with myocardial ischaemia. Br J Clin Pharmacol 2006; 61:321-5.

Davies BJ, Coller JK, Somogyi AA, Milne RW, Sallustio BC. CYP2B6, CYP2D6, and CYP3A4 catalyze the primary oxidative metabolism of perhexiline enantiomers by human liver microsomes. Drug Metab Dispos 2007; 35:128-38.

Davies BJ, Herbert MK, Coller JK, Somogyi AA, Milne RW, Sallustio BC. Steady-state pharmacokinetics of the enantiomers of perhexiline in CYP2D6 poor and extensive metabolizers administered Rac-perhexiline. Br J Clin Pharmacol 2008; 65:347-54.

Davies GF, Juurlink BH, Harkness TA. Troglitazone reverses the multiple drug resistance phenotype in cancer cells. Drug Des Devel Ther 2009; 3:79-88.

Davies M, Heikkilä T, McConkey GA, Fishwick CW, Parsons MR, Johnson AP. Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases. J Med Chem 2009; 52:2683-93.

Davies MA, Setola V, Strachan RT et al. Pharmacologic analysis of non-synonymous coding h5-HT2A SNPs reveals alterations in atypical antipsychotic and agonist efficacies. Pharmacogenomics J 2006; 6:42-51.

Davies MF, Tsui JY, Flannery JA, Li X, DeLorey TM, Hoffman BB. Augmentation of the noradrenergic system in alpha-2 adrenergic receptor deficient mice: anatomical changes associated with enhanced fear memory. Brain Res 2003; 986:157-65.

Davies NM, Windmeijer F, Martin RM et al. Use of genotype frequencies in medicated groups to investigate prescribing practice: APOE and statins as a proof of principle. Clin Chem 2011; 57:502-10.

Davies P, Fontaine SN, Moualla D, Wang X, Wright JA, Brown DR. Amyloidogenic metal-binding proteins: new investigative pathways. Biochem Soc Trans 2008; 36:1299-303.

Davies SJ, Eayrs S, Pratt P, Lennard MS. Potential for drug interactions involving cytochromes P450 2D6 and 3A4 on general adult psychiatric and functional elderly psychiatric wards. Br J Clin Pharmacol 2004; 57:464-72.

Davies SJ, Lennard MS, Ghahramani P, Pratt P, Robertson A, Potokar J. PRN prescribing in psychiatric inpatients: potential for pharmacokinetic drug interactions. J Psychopharmacol 2007; 21:153-60.

Davies SJ, Westin AA, Castberg I et al. Characterisation of zuclopenthixol metabolism by in vitro and therapeutic drug monitoring studies. Acta Psychiatr Scand 2010; 122:444-53.

Davis BR, Arnett DK, Boerwinkle E et al. Antihypertensive therapy, the alpha-adducin polymorphism, and cardiovascular disease in high-risk hypertensive persons: the genetics of hypertension-associated treatment study. Pharmacogenomics J 2007; 7:112-22.

Davis HR Jr, Lowe RS, Neff DR. Effects of ezetimibe on atherosclerosis in preclinical models. Atherosclerosis 2011; 215:266-78.

Davis JD, Podolanczuk A, Donahue JE et al. Thyroid hormone levels in the prefrontal cortex of post-mortem brains of Alzheimer's disease patients. Curr Aging Sci 2008; 1:175-81.

Davis MP. Buprenorphine in cancer pain. Support Care Cancer 2005; 13:878-87.

Davis MP. Does trazodone have a role in palliating symptoms? Support Care Cancer 2007; 15:221-4.

Davis-Dao CA, Tuazon ED, Sokol RZ, Cortessis VK. Male infertility and variation in CAG repeat length in the androgen receptor gene: a meta-analysis. J Clin Endocrinol Metab 2007; 92:4319-26.

Davit-Spraul A, Gonzales E, Baussan C, Jacquemin E. The spectrum of liver diseases related to ABCB4 gene mutations: pathophysiology and clinical aspects. Semin Liver Dis 2010; 30:134-46.

Davydov DR, Baas BJ, Sligar SG, Halpert JR. Allosteric mechanisms in cytochrome P450 3A4 studied by high-pressure spectroscopy: pivotal role of substrate-induced changes in the accessibility and degree of hydration of the heme pocket. Biochemistry 2007; 46:7852-64.

Davydov DR, Davydova NY, Tsalkova TN, Halpert JR. Effect of glutathione on homo- and heterotropic cooperativity in cytochrome P450 3A4. Arch Biochem Biophys 2008; 471:134-45.

Davydov DR, Fernando H, Baas BJ, Sligar SG, Halpert JR. Kinetics of dithionite-dependent reduction of cytochrome P450 3A4: heterogeneity of the enzyme caused by its oligomerization. Biochemistry 2005; 44:13902-13.

Davydov DR, Halpert JR, Renaud JP, Hui Bon Hoa G. Conformational heterogeneity of cytochrome P450 3A4 revealed by high pressure spectroscopy. Biochem Biophys Res Commun 2003; 312:121-30.

Davydov DR, Sineva EV, Sistla S et al. Electron transfer in the complex of membrane-bound human cytochrome P450 3A4 with the flavin domain of P450BM-3: The effect of oligomerization of the heme protein and intermittent modulation of the spin equilibrium. Biochim Biophys Acta 2009; 1797:378-90.

Daw EW, Payami H, Nemens EJ et al. The number of trait loci in late-onset Alzheimer disease. Am J Hum Genet 2000; 66:196-204.

Dawson HN, Ferreira A, Eyster MV, Ghoshal N, Binder LI, Vitek MP. Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice. J Cell Sci 2001; 114:1179-87.

Dawson PA, Haywood J, Craddock AL et al. Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice. J Biol Chem 2003; 278:33920-7.

Dayangac-Erden D, Karaduman A, Erdem-Yurter H. Polymorphisms of vitamin D receptor gene in Turkish familial psoriasis patients. Arch Dermatol Res 2007; 299:487-91.

Dayer P, Desmeules J, Collart L. Pharmacology of tramadol. Drugs 1997; 53 Suppl 2:18-24.

Dayer P, Desmeules J, Striberni R. In vitro forecasting of drugs that may interfere with codeine bioactivation. Eur J Drug Metab Pharmacokinet 1992; 17:115-20.

de Almagro MC, Selga E, Thibaut R, Porte C, Noé V, Ciudad CJ. UDP-glucuronosyltransferase 1A6 overexpression in breast cancer cells resistant to methotrexate. Biochem Pharmacol 2011; 81:60-70.

de Beer MC, Ji A, Jahangiri A et al. ATP binding cassette G1-dependent cholesterol efflux during inflammation. J Lipid Res 2011; 52:345-53.

de Berardinis V, Moulis C, Maurice M et al. Human microsomal epoxide hydrolase is the target of germander-induced autoantibodies on the surface of human hepatocytes. Mol Pharmacol 2000; 58:542-51.

de Bie P, Muller P, Wijmenga C, Klomp LW. Molecular pathogenesis of Wilson and Menkes disease: correlation of mutations with molecular defects and disease phenotypes. J Med Genet 2007; 44:673-88.

de Bodinat C, Guardiola-Lemaitre B, Mocaër E, Renard P, Muñoz C, Millan MJ. Agomelatine, the first melatonergic antidepressant: discovery, characterization and development. Nat Rev Drug Discov 2010; 9:628-42.

de Boer OJ, van der Meer JJ, Teeling P et al. Differential expression of interleukin-17 family cytokines in intact and complicated human atherosclerotic plaques. J Pathol 2010; 220:499-508.

de Boussac H, Ratajewski M, Sachrajda I et al. The ERK1/2-hepatocyte nuclear factor 4alpha axis regulates human ABCC6 gene expression in hepatocytes. J Biol Chem 2010; 285:22800-8.

de Braekeleer E, Douet-Guilbert N, Morel F et al. Philadelphia chromosome-positive acute lymphoblastic leukemia: a cytogenetic study of 33 patients diagnosed between 1981 and 2008. Anticancer Res 2010; 30:569-73.

de Bruijn P, Kehrer DF, Verweij J, Sparreboom A. Liquid chromatographic determination of ketoconazole, a potent inhibitor of CYP3A4-mediated metabolism. J Chromatogr B Biomed Sci Appl 2001; 753:395-400.

de Bruin ML, van Puijenbroek EP, Bracke M, Hoes AW, Leufkens HG. Pharmacogenetics of drug-induced arrhythmias: a feasibility study using spontaneous adverse drug reactions reporting data. Pharmacoepidemiol Drug Saf 2006; 15:99-105.

de Bruyne S, Wyffels L, Boos TL et al. In vivo evaluation of [123I]-4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(4-iodobenzyl)piperidine, an iodinated SPECT tracer for imaging the P-gp transporter. Nucl Med Biol 2010; 37:469-77.

de Buyzere M. Selective genetic advantages for users of thiazide diuretics. Is there a case for the 460Trp variant of alpha-adducin? J Hypertens 2009; 27:24-7.

de Castro WV, Mertens-Talcott S, Rubner A, Butterweck V, Derendorf H. Variation of flavonoids and furanocoumarins in grapefruit juices: a potential source of variability in grapefruit juice-drug interaction studies. J Agric Food Chem 2006; 54:249-55.

de Castro-Orós I, Pampín S, Cofán M et al. Promoter variant -204A > C of the cholesterol 7α-hydroxylase gene: association with response to plant sterols in humans and increased transcriptional activity in transfected HepG2 cells. Clin Nutr 2011; 30:239-46.

de Caterina R, Zampolli A. From asthma to atherosclerosis-5-lipoxygenase, leukotrienes, and inflammation. New Eng J Med 2004; 350:4-7.

de Cid R, Fonseca F, Gratacòs M et al. BDNF variability in opioid addicts and response to methadone treatment: preliminary findings. Genes Brain Behav 2008; 7:515-22.

de Clerck F, Somers Y, Mannaert E, Greenspan A, Eerdekens M. In vitro effects of risperidone and 9-hydroxy-risperidone on human platelet function, plasma coagulation, and fibrinolysis. Clin Ther 2004; 26:1261-73.

de Craemer D, van den Branden C, Pauwels M, Vamecq J. Peroxisome-proliferating effects of fenoprofen in mice. Lipids 1998; 33:539-43.

de Denus S, Zakrzewski M, Barhdadi A et al. Association between renal function and CYP3A5 genotype in heart transplant recipients treated with calcineurin inhibitors. J Heart Lung Transplant 2011; 30:326-31.

de Denus S, Zakrzewski-Jakubiak M, Dubé MP et al. Effects of AGTR1 A1166C gene polymorphism in patients with heart failure treated with candesartan. Ann Pharmacother 2008; 42:925-32.

de Dios A, Shih C, López de Uralde B et al. Design of potent and selective 2-aminobenzimidazole-based p38alpha MAP kinase inhibitors with excellent in vivo efficacy. J Med Chem 2005; 48:2270-3.

de Felice FG, Ferreira ST. Novel neuroprotective, neuritogenic and anti-amyloidogenic properties of 2,4-dinitrophenol: the gentle face of Janus. IUBMB Life 2006; 58:185-91.

de Felice FG, Houzel JC, Garcia-Abreu J et al. Inhibition of Alzheimer's disease beta-amyloid aggregation, neurotoxicity, and in vivo deposition by nitrophenols: implications for Alzheimer's therapy. FASEB J 2001; 15:1297-9.

de Franchis R, Buoninconti A, Mandato C et al. The C677T mutation of the 5,10-methylenetetrahydrofolate reductase gene is a moderate risk factor for spina bifida in Italy. J Med Genet 1998; 35:1009-13.

de Gasperi R, Gama Sosa MA, Wen PH, Li J, Perez GM, Curran T, Elder GA. Cortical development in the presenilin-1 null mutant mouse fails after splitting of the preplate and is not due to a failure of reelin-dependent signaling. Dev Dyn 2008; 237:2405-14.

de George BR Jr, Koch WJ. Beta blocker specificity: a building block toward personalized medicine. J Clin Invest 2007; 117:86-9.

de Gregorio L, Manenti G, Incarbone M et al. Prognostic value of loss of heterozygosity and KRAS2 mutations in lung adenocarcinoma. Int J Cancer 1998; 79:269-72.

de Groene EM, Hassing IG, Blom MJ, Seinen W, Fink-Gremmels J, Horbach GJ. Development of human cytochrome P450-expressing cell lines: application in mutagenicity testing of ochratoxin A. Cancer Res 1996; 56:299-304.

de Groene EM, Nijmeijer SM, Horbach GJ, Witkamp RF. Tiamulin inhibits human CYP3A4 activity in an NIH/3T3 cell line stably expressing CYP3A4 cDNA. Biochem Pharmacol 1995; 50:771-3.

de Groene EM, Seinen W, Horbach GJ. A NIH/3T3 cell line stably expressing human cytochrome P450-3A4 used in combination with a lacZ' shuttle vector to study mutagenicity. Eur J Pharmacol 1995; 293:47-53.

de Groote P, Ennezat PV, Mouquet F. Bisoprolol in the treatment of chronic heart failure. Vasc Health Risk Manag 2007; 3:431-9.

de Groote P, Helbecque N, Lamblin N et al. Beta-adrenergic receptor blockade and the angiotensin-converting enzyme deletion polymorphism in patients with chronic heart failure. Eur J Heart Fail 2004; 6:17-21.

de Groote P, Helbecque N, Lamblin N et al. Association between beta-1 and beta-2 adrenergic receptor gene polymorphisms and the response to beta-blockade in patients with stable congestive heart failure. Pharmacogenet Genomics 2005; 15:137-42.

de Haas EC, Zwart N, Meijer C et al. Variation in bleomycin hydrolase gene is associated with reduced survival after chemotherapy for testicular germ cell cancer. J Clin Oncol 2008; 26:1817-23.

de Iudicibus S, de Pellegrin A, Stocco G, Bartoli F, Bussani R, Decorti G. ABCB1 gene polymorphisms and expression of P-glycoprotein and long-term prognosis in colorectal cancer. Anticancer Res 2008; 28:3921-8.

de Jager PL, Jia X, Wang J et al. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet 2009; 41:776-82.

de Jager R, Cheverton P, Tamanoi K et al. DX-8951f: summary of phase I clinical trials. Ann N Y Acad Sci 2000; 922:260-73.

de Jong FA, de Jonge MJ, Verweij J, Mathijssen RH. Role of pharmacogenetics in irinotecan therapy. Cancer Lett 2006; 234:90-106.

de Jong FA, Marsh S, Mathijssen RH et al. ABCG2 pharmacogenetics: ethnic differences in allele frequency and assessment of influence on irinotecan disposition. Clin Cancer Res 2004; 10:5889-94.

de Jong FA, Scott-Horton TJ, Kroetz DL et al. Irinotecan-induced diarrhea: functional significance of the polymorphic ABCC2 transporter protein. Clin Pharmacol Ther 2007; 81:42-9.

de Jonghe C, Esselens C, Kumar-Singh S et al. Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect A-beta secretion and APP C-terminal fragment stability. Hum Mol Genet 2001; 10:1665-71.

de Jonghe C, Zehr C, Yager D et al. Flemish and Dutch mutations in amyloid beta precursor protein have different effects on amyloid beta secretion. Neurobiol Dis 1998; 5:281-6.

de Kauwe AL, Chen Z, Anderson RP et al. Resistance to celiac disease in humanized HLA-DR3-DQ2-transgenic mice expressing specific anti-gliadin CD4+ T cells. J Immunol 2009; 182:7440-50.

de Klein A, van Kessel AG, Grosveld G et al. A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia. Nature 1982; 300:765-7.

de Klerk OL, Willemsen AT, Bosker FJ et al. Regional increase in P-glycoprotein function in the blood-brain barrier of patients with chronic schizophrenia: a PET study with [(11)C]verapamil as a probe for P-glycoprotein function. Psychiatry Res 2010; 183:151-6.

de Krom M, Staal WG, Ophoff RA et al. A common variant in DRD3 receptor is associated with autism spectrum disorder. Biol Psychiatry 2009; 65:625-30.

de la Monte SM, Tong M. Mechanisms of nitrosamine-mediated neurodegeneration: potential relevance to sporadic Alzheimer's disease. J Alzheimers Dis 2009; 17:817-25.

de la Torre R, Farré M, Roset PN et al. Human pharmacology of MDMA: pharmacokinetics, metabolism, and disposition. Ther Drug Monit 2004; 26:137-44.

de Leener A, Montanelli L, van Durme J et al. Presence and absence of follicle-stimulating hormone receptor mutations provide some insights into spontaneous ovarian hyperstimulation syndrome physiopathology. J Clin Endocrinol Metab 2006; 91:555-62.

de León DD, Stanley CA. Permanent neonatal diabetes mellitus. In: Pagon RA, Bird TC, Dolan CR, Stephens K (Eds). GeneReviews. University of Washington, Seattle, 1993-2008. Available from: http://www. ncbi. nlm. nih. gov/books/NBK1447/

de Leon J. Pharmacogenomics: the promise of personalized medicine for CNS disorders. Neuropsychopharmacology 2009; 34:159-72.

de Leon J, Armstrong SC, Cozza KL. The dosing of atypical antipsychotics. Psychosomatics 2005; 46:262-73.

de Leon J, Armstrong SC, Cozza KL. Clinical guidelines for psychiatrists for the use of pharmacogenetic testing for CYP450 2D6 and CYP450 2C19. Psychosomatics 2006; 47:75-85.

de Leon J, Correa JC, Ruaño G, Windemuth A, Arranz MJ, Díaz FJ. Exploring genetic variations that may be associated with the direct effects of some antipsychotics on lipid levels. Schizophr Res 2008; 98:40-6.

de Leon J, Diaz FJ, Wedlund P, Josiassen RC, Cooper TB, Simpson GM. Haloperidol half-life after chronic dosing. J Clin Psychopharmacol 2004; 24:656-60.

de Leon J, Nikoloff DM. Paradoxical excitation on diphenhydramine may be associated with being a CYP2D6 ultrarapid metabolizer: three case reports. CNS Spectr 2008; 13:133-5.

de Leon J, Susce MT, Johnson M et al. DNA microarray technology in the clinical environment: the AmpliChip CYP450 test for CYP2D6 and CYP2C19 genotyping. CNS Spectr 2009; 14:19-34.

de Leon J, Susce MT, Murray-Carmichael E. The AmpliChip CYP450 genotyping test: Integrating a new clinical tool. Mol Diagn Ther 2006; 10:135-51.

de Leon J, Susce MT, Pan RM, Fairchild M, Koch WH, Wedlund PJ. The CYP2D6 poor metabolizer phenotype may be associated with risperidone adverse drug reactions and discontinuation. J Clin Psychiatry 2005; 66:15-27.

de Leon J, Susce MT, Pan RM, Koch WH, Wedlund PJ. Polymorphic variations in GSTM1, GSTT1, PgP, CYP2D6, CYP3A5, and dopamine D2 and D3 receptors and their association with tardive dyskinesia in severe mental illness. J Clin Psychopharmacol 2005; 25:448-56.

de Leon J, Wynn G, Sandson NB. The pharmacokinetics of paliperidone versus risperidone. Psychosomatics 2010; 51:80-8.

de Lima EL, da Silva VC, da Silva HD et al. MTR polymorphic variant A2756G and retinoblastoma risk in Brazilian children. Pediatr Blood Cancer 2010; 54:904-8.

de Luca V, Muglia P, Vincent JB, Lanktree M, Jain U, Kennedy JL. Adrenergic alpha 2C receptor genomic organization: association study in adult ADHD. Am J Med Genet B Neuropsychiatr Genet 2004; 127:65-7.

de Luca V, Müller DJ, Hwang R et al. HTR2C haplotypes and antipsychotics-induced weight gain: X-linked multimarker analysis. Hum Psychopharmacol 2007; 22:463-7.

de Luis DA, González Sagrado M, Aller R, Izaola O, Conde R. Influence of Trp64Arg polymorphism of beta 3-adrenoreceptor gene on insulin resistance, adipocytokines and weight loss secondary to two hypocaloric diets. Ann Nutr Metab 2009; 54:104-10.

de Luis DA, Sagrado MG, Aller R, Izaola O, Conde R. Influence of ALA54THR polymorphism of fatty acid-binding protein 2 on obesity and cardiovascular risk factors. Horm Metab Res 2007; 39:830-4.

de Luis DA, Sagrado MG, Aller R, Izaola O, Conde R, Romero E. Ala54Thr Polymorphism of Fatty Acid Binding Protein 2, Role on Insulin Resistance and Cardiovascular Risk Factors in Presurgical Morbid Obesity Patients. Obes Surg 2010; 19:1691-6.

de Maat MP, Jukema JW, Ye S et al. Effect of the stromelysin-1 promoter on efficacy of pravastatin in coronary atherosclerosis and restenosis. Am J Cardiol 1999; 83:852-6.

de Maat MP, Kastelein JJ, Jukema JW et al. -455G/A polymorphism of the beta-fibrinogen gene is associated with the progression of coronary atherosclerosis in symptomatic men: proposed role for an acute-phase reaction pattern of fibrinogen. Arterioscler Thromb Vasc Biol 1998; 18:265-71.

de Mattia E, Toffoli G. C677T and A1298C MTHFR polymorphisms, a challenge for antifolate and fluoropyrimidine-based therapy personalisation. Eur J Cancer 2009; 45:1333-51.

de Meirleir L, Seneca S, Lissens W, Schoentjes E, Desprechins B. Bilateral striatal necrosis with a novel point mutation in the mitochondrial ATPase 6 gene. Pediat Neurol 1995; 13:242-6.

de Mey C, Althaus M, Ezan E, Retzow A. Erythromycin increases plasma concentrations of alpha-dihydroergocryptine in humans. Clin Pharmacol Ther 2001; 70:142-8.

de Morais SM, Wilkinson GR, Blaisdell J, Meyer UA, Nakamura K, Goldstein JA. Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese. Mol Pharmacol 1994; 46:594-8.

de Morais SM, Wilkinson GR, Blaisdell J, Nakamura K, Meyer UA, Goldstein JA. The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans. J Biol Chem 1994; 269:15419-22.

de Palma G, Dick FD, Calzetti S et al. A case-control study of Parkinson's disease and tobacco use: gene-tobacco interactions. Mov Disord 2010; 25:912-9.

de Paz B, Alperi-López M, Ballina-García FJ et al. Interleukin 10 and tumor necrosis factor-alpha genotypes in rheumatoid arthritis-association with clinical response to glucocorticoids. J Rheumatol 2010; 37:503-11.

de Placido S, Carlomagno C, de Laurentiis M, Bianco AR. c-erbB2 expression predicts tamoxifen efficacy in breast cancer patients. Breast Cancer Res Treat 1998; 52:55-64.

de Pontual L, Pelet A, Trochet D et al. Mutations of the RET gene in isolated and syndromic Hirschsprung's disease in human disclose major and modifier alleles at a single locus. J Med Genet 2006; 43:419-23.

de Raedt T, Cools J, Debiec-Rychter M et al. Intestinal neurofibromatosis is a subtype of familial GIST and results from a dominant activating mutation in PDGFRA. Gastroenterology 2006; 131:1907-12.

de Rooij K, Dorsman J, Smoor M, den Dunnen J, van Ommen G. Subnuclear localization of the Huntington's disease gene product in cell lines by immunofluorescence and biochemical subcellular fractionation. Hum Molec Genet 1996; 5:1093-9.

de Silva R, Ironside JW, McCardle L et al. Neuropathological phenotype and 'prion protein' genotype correlation in sporadic Creutzfeldt-Jakob disease. Neurosci Lett 1994; 179:50-2.

de Strooper B, Saftig P, Craessaerts K et al. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature 1998; 391:387-90.

de Velde F, Alffenaar JW, Wessels AM, Greijdanus B, Uges DR. Simultaneous determination of clarithromycin, rifampicin and their main metabolites in human plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2009; 877:1771-7.

de Vos A, van der Weide J, Loovers HM. Association between CYP2C19*17 and metabolism of amitriptyline, citalopram and clomipramine in Dutch hospitalized patients. Pharmacogenomics J 2011; 11:359-67.

de Vries E, Koene HR, Vossen JM et al. Identification of an unusual Fc gamma receptor IIIa (CD16) on natural killer cells in a patient with recurrent infections. Blood 1996; 88:3022-7.

de Vries HS, te Morsche RH, van Oijen MG, Nagtegaal ID, Peters WH, de Jong DJ. The functional -765G→C polymorphism of the COX-2 gene may reduce the risk of developing crohn's disease. PLoS One 2010. doi:10. 1371/journal. pone. 0015011.

de Vries NA, Buckle T, Zhao J, Beijnen JH, Schellens JH, van Tellingen O. Restricted brain penetration of the tyrosine kinase inhibitor erlotinib due to the drug transporters P-gp and BCRP. Invest New Drugs 2010. doi:10. 1007/s10637-010-9569-1.

de Waard MC, van der Pluijm I, Zuiderveen Borgesius N et al. Age-related motor neuron degeneration in DNA repair-deficient Ercc1 mice. Acta Neuropathol 2010; 120:461-75.

de Waart DR, Häusler S, Vlaming ML et al. Hepatic transport mechanisms of cholyl-L-lysyl-fluorescein. J Pharmacol Exp Ther 2010; 334:78-86.

de Waart DR, Vlaming ML, Kunne C, Schinkel AH, Oude Elferink RP. Complex pharmacokinetic behavior of ezetimibe depends on abcc2, abcc3, and abcg2. Drug Metab Dispos 2009; 37:1698-702.

de Wet H, Fotinou C, Amad N, Dreger M, Ashcroft FM. The ATPase activities of sulfonylurea receptor 2A and sulfonylurea receptor 2B are influenced by the C-terminal 42 amino acids. FEBS J 2010; 277:2654-62.

de Wildt SN, Berns MJ, van den Anker JN. 13C-erythromycin breath test as a noninvasive measure of CYP3A activity in newborn infants: a pilot study. Ther Drug Monit 2007; 29:225-30.

de Wildt SN, Kearns GL, Hop WC et al. Pharmacokinetics and metabolism of intravenous midazolam in preterm infants. Clin Pharmacol Ther 2001; 70:525-31.

de Wildt SN, Kearns GL, Hop WC, Murry DJ, Abdel-Rahman SM, van den Anker JN. Pharmacokinetics and metabolism of oral midazolam in preterm infants. Br J Clin Pharmacol 2002; 53:390-2.

de Wildt SN, Kearns GL, Leeder JS, van den Anker JN. Cytochrome P450 3A: ontogeny and drug disposition. Clin Pharmacokinet 1999; 37:485-505.

de Wildt SN, Kearns GL, Murry DJ, Koren G, van den Anker JN. Ontogeny of midazolam glucuronidation in preterm infants. Eur J Clin Pharmacol 2010; 66:165-70.

Deakin S, Leviev I, Guernier S, James RW. Simvastatin modulates expression of the PON1 gene and increases serum paraoxonase: a role for sterol regulatory element-binding protein-2. Arterioscler Thromb Vasc Biol 2003; 23:2083-9.

Dean B, Laws SM, Hone E et al. Increased levels of apolipoprotein E in the frontal cortex of subjects with schizophrenia. Biol Psychiatry 2003; 54:616-22.

Dean B, Soulby A, Evin GM, Scarr E. Levels of [(3)H]pirenzepine binding in Brodmann's area 6 from subjects with schizophrenia is not associated with changes in the transcription factor SP1 or BACE1. Schizophr Res 2008; 106:229-36.

Dean BJ, Chang S, Silva Elipe MV et al. Metabolism of MK-0524, a prostaglandin D2 receptor 1 antagonist, in microsomes and hepatocytes from preclinical species and humans. Drug Metab Dispos 2007; 35:283-92.

Dean M, Carrington M, Winkler C et al. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study. Science 1996; 273:1856-62.

DeArmond SJ, Ironside JW. Neuropathology of prion disease. In: Prusiner SB (Ed). Prion biology and diseases. Cold Spring Harbor Laboratory Press, New York, 1999:585-652.

Deary IJ, Whiteman MC, Pattie A et al. Cognitive change and the APOE epsilon-4 allele. Nature 2002; 418:932.

Deb GK, Dey SR, Bang JI et al. 9-cis retinoic acid improves developmental competence and embryo quality during in vitro maturation of bovine oocytes through the inhibition of oocyte tumor necrosis factor-{alpha} gene expression. J Anim Sci 2011; 89:2759-67.

Deb S, Bandiera SM. Regulation of cytochrome P450 1B1 expression by luteinizing hormone in mouse MA-10 and rat R2C Leydig cells: role of protein kinase A. Biol Reprod 2011; 85:89-96.

Debelenko LV, Brambilla E, Agarwal SK et al. Identification of MEN1 gene mutations in sporadic carcinoid tumors of the lung. Hum Molec Genet 1997; 6:2285-90.

Debruyne D, Coquerel A. Pharmacokinetics of antifungal agents in onychomycoses. Clin Pharmacokinet 2001; 40:441-72.

Decano JL, Viereck JC, McKee AC, Hamilton JA, Ruiz-Opazo N, Herrera VL. Early-life sodium exposure unmasks susceptibility to stroke in hyperlipidemic, hypertensive heterozygous Tg25 rats transgenic for human cholesteryl ester transfer protein. Circulation 2009; 119:1501-9.

Decker CJ, Laitinen LM, Bridson GW, Raybuck SA, Tung RD, Chaturvedi PR. Metabolism of amprenavir in liver microsomes: role of CYP3A4 inhibition for drug interactions. J Pharm Sci 1998; 87:803-7.

Declerck E, de Loof H, de Meyer GR. Statins under fire: justified or not? J Pharm Belg 2009:119-30.

Declèves X, Jacob A, Yousif S, Shawahna R, Potin S, Scherrmann JM. Interplay of drug metabolizing CYP450 enzymes and ABC transporters in the blood-brain barrier. Curr Drug Metab 2011; 12:732-41.

Decottignies A, Goffeau A. Complete inventory of the yeast ABC proteins. Nat Genet 1997; 15:137-45.

Deeb SS, Fajas L, Nemoto M et al. A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet 1998; 20:284-7.

Deeken JF, Cormier T, Price DK et al. A pharmacogenetic study of docetaxel and thalidomide in patients with castration-resistant prostate cancer using the DMET genotyping platform. Pharmacogenomics J 2010; 10:191-9.

Deeken JF, Robey RW, Shukla S et al. Identification of compounds that correlate with ABCG2 transporter function in the National Cancer Institute Anticancer Drug Screen. Mol Pharmacol 2009; 76:946-56.

Deelen J, Beekman M, Uh HW et al. Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited. Aging Cell 2011; 10:686-98.

Deeni YY, Paine MJ, Ayrton AD, Clarke SE, Chenery R, Wolf CR. Expression, purification, and biochemical characterization of a human cytochrome P450 CYP2D6-NADPH cytochrome P450 reductase fusion protein. Arch Biochem Biophys 2001; 396:16-24.

Degerli N, Yilmaz E, Bardakci F. The delta32 allele distribution of the CCR5 gene and its relationship with certain cancers in a Turkish population. Clin Biochem 2005; 38:248-52.

Degnan AP, Chaturvedula PV, Conway CM et al. Discovery of (R)-4-(8-fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide (BMS-694153): a potent antagonist of the human calcitonin gene-related peptide receptor for migraine with rapid and efficient intranasal exposure. J Med Chem 2008; 51:4858-61.

Degousee N, Fazel S, Angoulvant D et al. Microsomal prostaglandin E2 synthase-1 deletion leads to adverse left ventricular remodeling after myocardial infarction. Circulation 2008; 117:1701-10.

Dehal SS, Kupfer D. Cytochrome P-450 3A and 2D6 catalyze ortho hydroxylation of 4-hydroxytamoxifen and 3-hydroxytamoxifen (droloxifene) yielding tamoxifen catechol: involvement of catechols in covalent binding to hepatic proteins. Drug Metab Dispos 1999; 27:681-8.

Dehning S, Müller N, Matz J et al. A genetic variant of HTR2C may play a role in the manifestation of Tourette syndrome. Psychiatr Genet 2010; 20:35-8.

Deierborg T, Wieloch T, Diano S, Warden CH, Horvath TL, Mattiasson G. Overexpression of UCP2 protects thalamic neurons following global ischemia in the mouse. J Cereb Blood Flow Metab 2008; 28:1186-95.

Dejeux E, Rønneberg JA, Solvang H et al. DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response. Mol Cancer 2010; 9:68.

Deka M, Bose M, Baruah B et al. Role of CYP2E1 gene polymorphisms association with hepatitis risk in Northeast India. World J Gastroenterol 2010; 16:4800-8.

DeKeyser JG, Stagliano MC, Auerbach SS, Prabhu KS, Jones AD, Omiecinski CJ. Di(2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant CAR2. Mol Pharmacol 2009; 75:1005-13.

del Bo R, Comi GP, Giorda R et al. The 129 codon polymorphism of the prion protein gene influences earlier cognitive performance in Down syndrome subjects. J Neurol 2003; 250:688-92.

del Bo R, Scarlato M, Ghezzi S et al. Vascular endothelial growth factor gene variability is associated with increased risk for AD. Ann Neurol 2005; 57:373-80.

del Mastro L, Levaggi A, Giraudi S, Pronzato P. Luteinising hormone releasing hormone agonists (LH-RHa) in premenopausal early breast cancer patients: current role and future perspectives. Cancer Treat Rev 2011; 37:208-11.

Delacourte A, Sergeant N, Champain D et al. Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer's disease. Neurology 2002; 59:398-407.

Delaloy C, Hadchouel J, Imbert-Teboul M, Clemessy M, Houot AM, Jeunemaitre X. Cardiovascular expression of the mouse WNK1 gene during development and adulthood revealed by a BAC reporter assay. Am J Pathol 2006; 169:105-18.

Delanghe JR, Langlois MR, de Buyzere ML, Torck MA. Vitamin C deficiency and scurvy are not only a dietary problem but are codetermined by the haptoglobin polymorphism. Clin Chem 2007; 53:1397-400.

Delhanty JD, Cooke HM. Increased chromosome breakage by N-methyl-N1-nitro-N-nitrosoguanidine in patients with adenomatous polyposis coli. Cancer Genet Cytogenet 1989; 42:263-71.

D'Elia P, de Matteis F, Dragoni S, Shah A, Sgaragli G, Valoti M. DP7, a novel dihydropyridine multidrug resistance reverter, shows only weak inhibitory activity on human CYP3A enzyme(s). Eur J Pharmacol 2009; 614:7-13.

Delić D, Dkhil M, Al-Quraishy S, Wunderlich F. Hepatic miRNA expression reprogrammed by Plasmodium chabaudi malaria. Parasitol Res 2011; 108:1111-21.

Delić D, Ellinger-Ziegelbauer H, Vohr HW, Dkhil M, Al-Quraishy S, Wunderlich F. Testosterone response of hepatic gene expression in female mice having acquired testosterone-unresponsive immunity to Plasmodium chabaudi malaria. Steroids 2011; 76:1204-12.

Delisle MB, Murrell JR, Richardson R et al. A mutation at codon 279 (N279K) in exon 10 of the tau gene causes a tauopathy with dementia and supranuclear palsy. Acta Neuropath 1999; 98:62-77.

DeLoia JA, Zamboni WC, Jones JM, Strychor S, Kelley JL, Gallion HH. Expression and activity of taxane-metabolizing enzymes in ovarian tumors. Gynecol Oncol 2008; 108:355-60.

Delou JM, Capella MA, Gattass CR. Betulinic acid does not modulate the activity of P-gp/ABCB1 or MRP1/ABCC1 in a non-tumoral renal cell line: Possible utility in multidrug resistance cancer chemotherapy. Mol Med Report 2009; 2:271-5.

Delozier TC, Kissling GE, Coulter SJ et al. Detection of human CYP2C8, CYP2C9, and CYP2J2 in cardiovascular tissues. Drug Metab Dispos 2007; 35:682-8.

DeLozier TC, Lee SC, Coulter SJ, Goh BC, Goldstein JA. Functional characterization of novel allelic variants of CYP2C9 recently discovered in southeast Asians. J Pharmacol Exp Ther 2005; 315:1085-90.

Delvaeye M, Noris M, de Vriese A et al. Thrombomodulin mutations in atypical hemolytic-uremic syndrome. N Engl J Med 2009; 361:345-57.

Dellapasqua S, Colleoni M. Letrozole. Expert Opin Drug Metab Toxicol 2010; 6:251-9.

Dellinger RW, Chen G, Blevins-Primeau AS, Krzeminski J, Amin S, Lazarus P. Glucuronidation of PhIP and N-OH-PhIP by UDP-glucuronosyltransferase 1A10. Carcinogenesis 2007; 28:2412-8.

Dellinger RW, Fang JL, Chen G, Weinberg R, Lazarus P. Importance of UDP-glucuronosyltransferase 1A10 (UGT1A10) in the detoxification of polycyclic aromatic hydrocarbons: decreased glucuronidative activity of the UGT1A10139Lys isoform. Drug Metab Dispos 2006; 34:943-9.

Demaria M, Giorgi C, Lebiedzinska M et al. A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction. Aging 2010; 2:823-42.

DeMattos RB, Cirrito JR, Parsadanian M et al. ApoE and clusterin cooperatively suppress A-beta levels and deposition: evidence that ApoE regulates extracellular A-beta metabolism in vivo. Neuron 2004; 41:193-202.

DeMichele A, Aplenc R, Botbyl J et al. Drug-metabolizing enzyme polymorphisms predict clinical outcome in a node-positive breast cancer cohort. J Clin Oncol 2005; 23:5552-9. Erratum in: J Clin Oncol 2007; 25:5675-7. Retraction in: J Clin Oncol 2006; 24:3315.

Demichele-Sweet MA, Lopez OL, Sweet RA. Psychosis in Alzheimer's disease in the national Alzheimer's disease coordinating center uniform data set: clinical correlates and association with apolipoprotein E. Int J Alzheimers Dis 2011. doi:10. 4061/2011/926597.

Demokan S, Suoglu Y, Gözeler M, Demir D, Dalay N. N-acetyltransferase 1 and 2 gene sequence variants and risk of head and neck cancer. Mol Biol Rep 2010; 37:3217-26.

D'empaire I, Guico-Pabia CJ, Preskorn SH. Antidepressant treatment and altered CYP2D6 activity: Are pharmacokinetic variations clinically relevant? J Psychiatr Pract 2011; 17:330-9.

Demura M, Demura Y, Ameshima S et al. Changes in aromatase (CYP19) gene promoter usage in non-small cell lung cancer. Lung Cancer 2011; 73:289-93.

Demura M, Wang F, Yoneda T et al. Multiple noncoding exons 1 of nuclear receptors NR4A family (nerve growth factor-induced clone B, Nur-related factor 1 and neuron-derived orphan receptor 1) and NR5A1 (steroidogenic factor 1) in human cardiovascular and adrenal tissues. J Hypertens 2011; 29:1185-95.

den Broeder MJ, van der Linde H, Brouwer JR, Oostra BA, Willemsen R, Ketting RF. Generation and characterization of FMR1 knockout zebrafish. PLoS One 2009. doi:10. 1371/journal. pone. 0007910.

Den Dunen JT, Antonarakis SE. Mutation nomenclature extensions and suggestions to describe complex mutations: a discussion. Hum Mutat 2000; 15:7-12.

den Hartog JE, Lyons JM, Ouburg S et al. TLR4 in Chlamydia trachomatis infections: knockout mice, STD patients and women with tubal factor subfertility. Drugs Today 2009; 45 Suppl B:75-82.

den Uyl D, van der Horst-Bruinsma IE, van Agtmael M. Progression of HIV to AIDS: a protective role for HLA-B27? AIDS Rev 2004; 6:89-96.

Deng CN, Shen LH, Tang CS. Effect of spironolactone on L-arginine/iNOS/NO pathway of aortic adventitia in spontaneously hypertensive rats. Zhonghua Yi Xue Za Zhi 2010; 90:424-6.

Deng CX, Wang RH. Roles of BRCA1 in DNA damage repair: a link between development and cancer. Hum Molec Genet 2003; 12:113-23.

Deng G, Zhou G, Zhai Y et al. Association of estrogen receptor alpha polymorphisms with susceptibility to chronic hepatitis B virus infection. Hepatology 2004; 40:318-26.

Deng GH, Zhou X, Pang ZY, Liu SM, Xie Y. Study on mitochondrial function of ND1 gene with 3316 G→A mutation in human diabetes. Zhonghua Yi Xue Za Zhi 2009; 89:2822-6.

Deng HB, Jiang CQ, Tomlinson B et al. A polymorphism in transforming growth factor-β1 is associated with carotid plaques and increased carotid intima-media thickness in older Chinese men: The Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort. Atherosclerosis 2011; 214:391-6.

Deng LJ, Wang F, Li HD. Effect of gemfibrozil on the pharmacokinetics of pioglitazone. Eur J Clin Pharmacol 2005; 61:831-6.

Deng Q, Li ZP, Huang CM et al. Effect and mechanism of DNMT inhibitor on the reversal of multidrug resistance in human colon cancer cell line sw620/L-OHP. Sichuan Da Xue Xue Bao Yi Xue Ban 2010; 41:975-9.

Deng R, Yang D, Radke A, Yang J, Yan B. The hypolipidemic agent guggulsterone regulates the expression of human bile salt export pump: dominance of transactivation over farsenoid X receptor-mediated antagonism. J Pharmacol Exp Ther 2007; 320:1153-62.

Deng S, Zhu G, Liu F et al. CYP4F2 gene V433M polymorphism is associated with ischemic stroke in the male Northern Chinese Han population. Prog Neuropsychopharmacol Biol Psychiatry 2010; 34:664-8.

Deng Y, Edin ML, Theken KN et al. Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice. FASEB J 2011; 25:703-13.

Deng Y, Newman B, Dunne MP, Silburn PA, Mellick GD. Further evidence that interactions between CYP2D6 and pesticide exposure increase risk for Parkinson's disease. Ann Neurol 2004; 55:897.

Deng Y, Newman B, Dunne MP, Silburn PA, Mellick GD. Case-only study of interactions between genetic polymorphisms of GSTM1, P1, T1 and Z1 and smoking in Parkinson's disease. Neurosci Lett 2004; 366:326-31.

Denisov IG, Baas BJ, Grinkova YV, Sligar SG. Cooperativity in cytochrome P450 3A4: linkages in substrate binding, spin state, uncoupling, and product formation. J Biol Chem 2007; 282:7066-76.

Denisov IG, Grinkova YV, Baas BJ, Sligar SG. The ferrous-dioxygen intermediate in human cytochrome P450 3A4. Substrate dependence of formation and decay kinetics. J Biol Chem 2006; 281:23313-8.

Denisov IG, Grinkova YV, McLean MA, Sligar SG. The one-electron autoxidation of human cytochrome P450 3A4. J Biol Chem 2007; 282:26865-73.

Deniz M, Bayazit YA, Celenk F et al. Significance of serotonin transporter gene polymorphism in tinnitus. Otol Neurotol 2010; 31:19-24.

Denk GU, Aslanidis C, Schmitz G, Parhofer KG, Pusl T. Association of HDL deficiency with a novel mutation in the ABCA1 gene. Exp Clin Endocrinol Diabetes 2011; 119:53-5.

Denlinger CS, Blanchard R, Xu L et al. Pharmacokinetic analysis of irinotecan plus bevacizumab in patients with advanced solid tumors. Cancer Chemother Pharmacol 2009; 65:97-105.

Dennison JB, Jones DR, Renbarger JL, Hall SD. Effect of CYP3A5 expression on vincristine metabolism with human liver microsomes. J Pharmacol Exp Ther 2007; 321:553-63.

Dennison JB, Kulanthaivel P, Barbuch RJ, Renbarger JL, Ehlhardt WJ, Hall SD. Selective metabolism of vincristine in vitro by CYP3A5. Drug Metab Dispos 2006; 34:1317-27.

Dennison JB, Mohutsky MA, Barbuch RJ, Wrighton SA, Hall SD. Apparent high CYP3A5 expression is required for significant metabolism of vincristine by human cryopreserved hepatocytes. J Pharmacol Exp Ther 2008; 327:248-57.

Dentice M, Marsili A, Ambrosio R et al. The FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration. J Clin Invest 2010; 120:4021-30.

Denucci SM, Tong M, Longato L et al. Rat strain differences in susceptibility to alcohol-induced chronic liver injury and hepatic insulin resistance. Gastroenterol Res Pract 2010. doi:10. 1155/2010/312790.

Denys D, van Nieuwerburgh F, Deforce D, Westenberg HG. Association between serotonergic candidate genes and specific phenotypes of obsessive compulsive disorder. J Affect Disord 2006; 91:39-44.

Denzel MS, Hebbard LW, Shostak G, Shapiro L, Cardiff RD, Ranscht B. Adiponectin deficiency limits tumor vascularization in the MMTV-PyV-mT mouse model of mammary cancer. Clin Cancer Res 2009; 15:3256-64.

Deo AK, Bandiera SM. Identification of human hepatic cytochrome p450 enzymes involved in the biotransformation of cholic and chenodeoxycholic acid. Drug Metab Dispos 2008; 36:1983-91.

Deo AK, Bandiera SM. 3-ketocholanoic acid is the major in vitro human hepatic microsomal metabolite of lithocholic acid. Drug Metab Dispos 2009; 37:1938-47.

Deonna T, Arczynska W, Torrado A. Congenital failure of automatic ventilation (Ondine's curse). J Pediat 1974; 84:710-4.

Depondt C, Godard P, Espel RS, Da Cruz AL, Lienard P, Pandolfo M. A candidate gene study of antiepileptic drug tolerability and efficacy identifies an association of CYP2C9 variants with phenytoin toxicity. Eur J Neurol 2011; 18:1159-64.

Dere E, Zlomuzica A, Viggiano D et al. Episodic-like and procedural memory impairments in histamine H1 Receptor knockout mice coincide with changes in acetylcholine esterase activity in the hippocampus and dopamine turnover in the cerebellum. Neuroscience 2008; 157:532-41.

Deremer DL, Ustun C, Natarajan K. Nilotinib: a second-generation tyrosine kinase inhibitor for the treatment of chronic myelogenous leukemia. Clin Ther 2008; 30:1956-75.

Dergunov AD. Local/bulk determinants of conformational stability of exchangeable apolipoproteins. Biochim Biophys Acta 2011; 1814:1169-77.

Dergunov AD. Apolipoprotein E genotype as a most significant predictor of lipid response at lipid-lowering therapy: Mechanistic and clinical studies. Biomed Pharmacother 2011. doi:10. 1016/j. biopha. 2011. 04. 003.

Derks M, Fowler S, Kuhlmann O. A single-center, open-label, one-sequence study of dalcetrapib coadministered with ketoconazole, and an in vitro study of the S-methyl metabolite of dalcetrapib. Clin Ther 2009; 31:586-99.

Derks M, Fowler S, Kuhlmann O. In vitro and in vivo assessment of the effect of dalcetrapib on a panel of CYP substrates. Curr Med Res Opin 2009; 25:891-902.

Dermaut B, Croes EA, Rademakers R et al. PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease. Ann Neurol 2003; 53:409-12.

Dermaut B, Kumar-Singh S, Engelborghs S et al. A novel presenilin 1 mutation associated with Pick's disease but not beta-amyloid plaques. Ann Neurol 2004; 55:617-26.

Deroussent A, Ré M, Hoellinger H, Cresteil T. Metabolism of sanguinarine in human and in rat: characterization of oxidative metabolites produced by human CYP1A1 and CYP1A2 and rat liver microsomes using liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal 2010; 52:391-7.

Dervieux T, Furst D, Lein DO et al. Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis. Arthritis Rheum 2004; 50:2766-74.

Dervieux T, Furst D, Lein DO et al. Pharmacogenetic and metabolite measurements are associated with clinical status in patients with rheumatoid arthritis treated with methotrexate: results of a multicentred cross sectional observational study. Ann Rheum Dis 2005; 64:1180-5.

Dervieux T, Kremer J, Lein DO et al. Contribution of common polymorphisms in reduced folate carrier and gamma-glutamylhydrolase to methotrexate polyglutamate levels in patients with rheumatoid arthritis. Pharmacogenetics 2004; 14:733-9.

Desai AA, Innocenti F, Janisch L et al. A phase I trial of pharmacokinetic modulation of carboxyamidotriazole (CAI) with ketoconazole in patients with advanced cancer. Cancer Chemother Pharmacol 2004; 54:377-84.

Desai M, Tanus-Santos JE, Li L et al. Pharmacokinetics and QT interval pharmacodynamics of oral haloperidol in poor and extensive metabolizers of CYP2D6. Pharmacogenomics J 2003; 3:105-13.

Desai PB, Duan J, Sridhar R, Damle BD. Reversal of doxorubicin resistance in multidrug resistant melanoma cells in vitro and in vivo by dipyridamole. Methods Find Exp Clin Pharmacol 1997; 19:231-9.

Desai PB, Duan JZ, Zhu YW, Kouzi S. Human liver microsomal metabolism of paclitaxel and drug interactions. Eur J Drug Metab Pharmacokinet 1998; 23:417-24.

Desai PB, Nallani SC, Sane RS et al. Induction of cytochrome P450 3A4 in primary human hepatocytes and activation of the human pregnane X receptor by tamoxifen and 4-hydroxytamoxifen. Drug Metab Dispos 2002; 30:608-12.

Desai R, Ruesch D, Forman SA. Gamma-amino butyric acid type A receptor mutations at beta2N265 alter etomidate efficacy while preserving basal and agonist-dependent activity. Anesthesiology 2009; 111:774-84.

Deslys JP, Jaegly A, d'Aignaux JH, Mouthon F, de Villemeur TB, Dormont D. Genotype at codon 129 and susceptibility to Creutzfeldt-Jakob disease. Lancet 1998; 351:1251.

Desmeules J, Gascon MP, Dayer P, Magistris M. Impact of environmental and genetic factors on codeine analgesia. Eur J Clin Pharmacol 1991; 41:23-6.

Desrivières S, Lourdusamy A, Müller C et al. Glucocorticoid receptor (NR3C1) gene polymorphisms and onset of alcohol abuse in adolescents. Addict Biol 2011; 16:510-3.

Desta Z, Kerbusch T, Flockhart DA. Effect of clarithromycin on the pharmacokinetics and pharmacodynamics of pimozide in healthy poor and extensive metabolizers of cytochrome P450 2D6 (CYP2D6). Clin Pharmacol Ther 1999; 65:10-20.

Desta Z, Kerbusch T, Soukhova N, Richard E, Ko JW, Flockhart DA. Identification and characterization of human cytochrome P450 isoforms interacting with pimozide. J Pharmacol Exp Ther 1998; 285:428-37.

Desta Z, Soukhova N, Mahal SK, Flockhart DA. Interaction of cisapride with the human cytochrome P450 system: metabolism and inhibition studies. Drug Metab Dispos 2000; 28:789-800.

Desta Z, Soukhova N, Morocho AM, Flockhart DA. Stereoselective metabolism of cisapride and enantiomer-enantiomer interaction in human cytochrome P450 enzymes: major role of CYP3A. J Pharmacol Exp Ther 2001; 298:508-20.

Desta Z, Ward BA, Soukhova NV, Flockhart DA. Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther 2004; 310:1062-75.

Desta Z, Wu GM, Morocho AM, Flockhart DA. The gastroprokinetic and antiemetic drug metoclopramide is a substrate and inhibitor of cytochrome P450 2D6. Drug Metab Dispos 2002; 30:336-43.

Desta Z, Zhao X, Shin JG, Flockhart DA. Clinical significance of the cytochrome P450 2C19 genetic polymorphism. Clin Pharmacokinet 2002; 41:913-58.

Desuzinges-Mandon E, Arnaud O, Martinez L, Huché F, di Pietro A, Falson P. ABCG2 transports and transfers heme to albumin through its large extracellular loop. J Biol Chem 2010; 285:33123-33.

Dettling M, Sachse C, Brockmöller J et al. Long-term therapeutic drug monitoring of clozapine and metabolites in psychiatric in- and outpatients. Psychopharmacology 2000; 152:80-6.

Dettling M, Sachse C, Müller-Oerlinghausen B et al. Clozapine-induced agranulocytosis and hereditary polymorphisms of clozapine metabolizing enzymes: no association with myeloperoxidase and cytochrome P4502D6. Pharmacopsychiatry 2000; 33:218-20.

Deuchar GA, McLean D, Hadoke PW et al. 11β-hydroxysteroid dehydrogenase type 2 deficiency accelerates atherogenesis and causes proinflammatory changes in the endothelium in apoe-/- mice. Endocrinology 2011; 152:236-46.

Deupree JD, Smith SD, Kratochvil CJ et al. Possible involvement of alpha-2A adrenergic receptors in attention deficit hyperactivity disorder: radioligand binding and polymorphism studies. Am J Med Genet B Neuropsychiatr Genet 2006; 141:877-84.

Deuschle M, Schredl M, Schilling C et al. Association between a serotonin transporter length polymorphism and primary insomnia. Sleep 2010; 33:343-7.

DeVane CL, Donovan JL, Liston HL et al. Comparative CYP3A4 inhibitory effects of venlafaxine, fluoxetine, sertraline, and nefazodone in healthy volunteers. J Clin Psychopharmacol 2004; 24:4-10.

DeVane CL, Gill HS. Clinical pharmacokinetics of fluvoxamine: applications to dosage regimen design. J Clin Psychiatry 1997; 58 Suppl 5:7-14.

DeVane CL, Markowitz JS, Carson SW et al. Single-dose pharmacokinetics of methylphenidate in CYP2D6 extensive and poor metabolizers. J Clin Psychopharmacol 2000; 20:347-9.

DeVane CL, Nemeroff CB. Clinical pharmacokinetics of quetiapine: an atypical antipsychotic. Clin Pharmacokinet 2001; 40:509-22.

Devedjian JC, Pujol A, Cayla C et al. Transgenic mice overexpressing alpha2A-adrenoceptors in pancreatic beta-cells show altered regulation of glucose homeostasis. Diabetologia 2000; 43:899-906.

Devlin AH, McIlroy M, McKeen HD et al. Cytochrome P450 1B1 expression in rat esophageal tumorigenesis promoted by gastric and duodenal reflux. Mol Carcinog 2009; 48:110-7.

Devlin AH, Thompson P, Robson T, McKeown SR. Cytochrome P450 1B1 mRNA untranslated regions interact to inhibit protein translation. Mol Carcinog 2010; 49:190-9.

Devold HM, Molden E, Skurtveit S, Furu K. Co-medication of statins and CYP3A4 inhibitors before and after introduction of new reimbursement policy. Br J Clin Pharmacol 2009; 67:234-41.

Devonshire HW, Kong I, Cooper M, Sloan TP, Idle JR, Smith RL. The contribution of genetically determined oxidation status to inter-individual variation in phenacetin disposition. Brit J Clin Pharm 1983; 16:157-66.

DeVos L, Chanson A, Liu Z et al. Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine, and DNA uracil concentrations. Am J Clin Nutr 2008; 88:1149-58.

Devys D, Biancalana V, Rousseau F, Boué J, Mandel JL, Oberlé I. Analysis of full fragile X mutations in fetal tissues and monozygotic twins indicate that abnormal methylation and somatic heterogeneity are established early in development. Am J Med Genet 1992; 43:208-16.

Dewar AL, Cambareri AC, Zannettino AC et al. Macrophage colony-stimulating factor receptor c-fms is a novel target of imatinib. Blood 2005; 105:3127-32.

Dewar JC, Wilkinson J, Wheatley A et al. The glutamine 27 beta-2-adrenoceptor polymorphism is associated with elevated IgE levels in asthmatic families. J Allergy Clin Immun 1997; 100:261-5.

Dey A, Kumar SM. Cytochrome P450 2E1 and hyperglycemia-induced liver injury. Cell Biol Toxicol 2011; 27:285-310.

Dhaenens CM, Burnouf S, Simonin C et al. A genetic variation in the ADORA2A gene modifies age at onset in Huntington's disease. Neurobiol Dis 2009; 35:474-6.

Dhaini HR, Thomas DG, Giordano TJ et al. Cytochrome P450 CYP3A4/5 expression as a biomarker of outcome in osteosarcoma. J Clin Oncol 2003; 21:2481-5.

Dhar M, Sepkovic DW, Hirani V, Magnusson RP, Lasker JM. Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11. J Lipid Res 2008; 49:612-24.

Dhikav V, Anand K. Potential predictors of hippocampal atrophy in Alzheimer's disease. Drugs Aging 2011; 28:1-11.

Dhillon VS, Thomas P, Iarmarcovai G, Kirsch-Volders M, Bonassi S, Fenech M. Genetic polymorphisms of genes involved in DNA repair and metabolism influence micronucleus frequencies in human peripheral blood lymphocytes. Mutagenesis 2011; 26:33-42.

Dhiman N, Haralambieva IH, Kennedy RB et al. SNP/haplotype associations in cytokine and cytokine receptor genes and immunity to rubella vaccine. Immunogenetics 2010; 62:197-210.

Dhiman N, Ovsyannikova IG, Cunningham JM et al. Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes. J Infect Dis 2007; 195:21-9.

Dhiman N, Ovsyannikova IG, Vierkant RA et al. Associations between SNPs in toll-like receptors and related intracellular signaling molecules and immune responses to measles vaccine: preliminary results. Vaccine 2008; 26:1731-6.

Dhiman N, Ovsyannikova IG, Vierkant RA, Pankratz VS, Jacobson RM, Poland GA. Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population. Tissue Antigens 2008; 72:211-20.

Dhir RN, Dworakowski W, Thangavel C, Shapiro BH. Sexually dimorphic regulation of hepatic isoforms of human cytochrome p450 by growth hormone. J Pharmacol Exp Ther 2006; 316:87-94.

Dhitavat S, Ortiz D, Rogers E, Rivera E, Shea TB. Folate, vitamin E, and acetyl-L-carnitine provide synergistic protection against oxidative stress resulting from exposure of human neuroblastoma cells to amyloid-beta. Brain Res 2005; 1061:114-7.

Di Bartolomeo S, Luly P, Spinedi A. P-glycoprotein is not a key target for the chemosensitizing effect of 1-phenyl-2-decanoylamino-3-morpholino-1-propanol in HepG2 cells exposed to doxorubicin. Drug Metab Lett 2010; 4:39-44.

Di Consiglio E, Meneguz A, Testai E. Organophosphorothionate pesticides inhibit the bioactivation of imipramine by human hepatic cytochrome P450s. Toxicol Appl Pharmacol 2005; 205:237-46.

Di Fede G, Catania M, Morbin M et al. A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis. Science 2009; 323:1473-7.

Di Fiore F, Blanchard F, Charbonnier F et al. Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy. Br J Cancer 2007; 96:1166-9.

Di Fiore F, Michel P. Prognostic role of KRAS mutation in colorectal cancer. Bull Cancer 2009; 96 Suppl:23-30.

Di Iulio J, Fayet A, Arab-Alameddine M et al. In vivo analysis of efavirenz metabolism in individuals with impaired CYP2A6 function. Pharmacogenet Genomics 2009; 19:300-9.

Di L, Kerns EH, Li SQ, Carter GT. Comparison of cytochrome P450 inhibition assays for drug discovery using human liver microsomes with LC-MS, rhCYP450 isozymes with fluorescence, and double cocktail with LC-MS. Int J Pharm 2007; 335:1-11.

Di Marco A, Marcucci I, Verdirame M et al. Development and validation of a high-throughput radiometric CYP3A4/5 inhibition assay using tritiated testosterone. Drug Metab Dispos 2005; 33:349-58.

Di Nardo G, Fantuzzi A, Sideri A et al. Wild-type CYP102A1 as a biocatalyst: turnover of drugs usually metabolised by human liver enzymes. J Biol Inorg Chem 2007; 12:313-23.

Di Natale M, Perri M, Kawarai T et al. Absence of association between Alzheimer disease and the regulatory region polymorphism on the PS2 gene in an Italian population. Neurosci Lett 2003; 343:210-2.

Di Paolo A, Bocci G, Danesi R, del Tacca M. Clinical pharmacokinetics of irinotecan-based chemotherapy in colorectal cancer patients. Curr Clin Pharmacol 2006; 1:311-23.

Di Pasquale P, Cannizzaro S, Paterna S. Does angiotensin-converting enzyme gene polymorphism affect blood pressure? Findings after 6 years of follow-up in healthy subjects. Eur J Heart Fail 2004; 6:11-6.

Di YM, Chow VD, Yang LP, Zhou SF. Structure, function, regulation and polymorphism of human cytochrome P450 2A6. Curr Drug Metab 2009; 10:754-80.

Di YM, Li CG, Xue CC, Zhou SF. Clinical drugs that interact with St. John's wort and implication in drug development. Curr Pharm Des 2008; 14:1723-42.

Diamanti AP, Rosado M, Germano V et al. Reversion of resistance to immunosuppressive agents in three patients with psoriatic arthritis by cyclosporine A: modulation of P-glycoprotein function. Clin Immunol 2011; 138:9-13.

Diao L, Li N, Brayman TG, Hotz KJ, Lai Y. Regulation of MRP2/ABCC2 and BSEP/ABCB11 expression in sandwich cultured human and rat hepatocytes exposed to inflammatory cytokines TNF-{alpha}, IL-6, and IL-1{beta}. J Biol Chem 2010; 285:31185-92.

Dias V, Ribeiro V. The expression of the solute carriers NTCP and OCT-1 is regulated by cholesterol in HepG2 cells. Fundam Clin Pharmacol 2007; 21:445-50.

Diaz DS, Kozar MP, Smith KS et al. Role of specific cytochrome P450 isoforms in the conversion of phenoxypropoxybiguanide analogs in human liver microsomes to potent antimalarial dihydrotriazines. Drug Metab Dispos 2008; 36:380-5.

Díaz FJ, Meary A, Arranz MJ, Ruaño G, Windemuth A, de León J. Acetyl-coenzyme A carboxylase alpha gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels. Schizophr Res 2009; 115:136-40.

Diaz GJ, Murcia HW, Cepeda SM. Bioactivation of aflatoxin B1 by turkey liver microsomes: responsible cytochrome P450 enzymes. Br Poult Sci 2010; 51:828-37.

Diaz GJ, Murcia HW, Cepeda SM. Cytochrome P450 enzymes involved in the metabolism of aflatoxin B1 in chickens and quail. Poult Sci 2010; 89:2461-9.

Diaz GJ, Squires EJ. Metabolism of 3-methylindole by porcine liver microsomes: responsible cytochrome P450 enzymes. Toxicol Sci 2000; 55:284-92.

Diaz J, Vizuete ML, Traiffort E, Arrang JM, Ruat M, Schwartz JC. Localization of the histamine H2 receptor and gene transcripts in rat stomach: back to parietal cells. Biochem Biophys Res Commun 1994; 198:1195-202.

Diaz Z, Mann KK, Marcoux S et al. A novel arsenical has antitumor activity toward As2O3-resistant and MRP1/ABCC1-overexpressing cell lines. Leukemia 2008; 22:1853-63.

Díaz-Cruz ES, Sugimoto Y, Gallicano GI, Brueggemeier RW, Furth PA. Comparison of increased Aromatase versus ER{alpha} in the generation of mammary hyperplasia and cancer. Cancer Res 2011; 71:5477-87.

Dick FD, de Palma G, Ahmadi A et al. Gene-environment interactions in parkinsonism and Parkinson's disease: the Geoparkinson study. Occup Environ Med 2007; 64:673-80.

Dickens MJ, Cornil CA, Balthazart J. Acute stress differentially affects aromatase activity in specific brain nuclei of adult male and female quail. Endocrinology 2011; 152:4242-51.

Dickerson TJ, Janda KD. Glycation of the amyloid beta-protein by a nicotine metabolite: a fortuitous chemical dynamic between smoking and Alzheimer's disease. Proc Natl Acad Sci USA 2003; 100:8182-7.

Dickmann LJ, Patel SK, Rock DA, Wienkers LC, Slatter JG. Effects of interleukin-6 (IL-6) and an anti-IL-6 monoclonal antibody on drug-metabolizing enzymes in human hepatocyte culture. Drug Metab Dispos 2011; 39:1415-22.

Dickmann LJ, Rettie AE, Kneller MB et al. Identification and functional characterization of a new CYP2C9 variant (CYP2C9*5) expressed among African Americans. Mol Pharmacol 2001; 60:382-7.

Dickmann LJ, Tay S, Senn TD et al. Changes in maternal liver Cyp2c and Cyp2d expression and activity during rat pregnancy. Biochem Pharmacol 2008; 75:1677-87.

Dickson MA, Schwartz GK. Development of cell-cycle inhibitors for cancer therapy. Curr Oncol 2009; 16:36-43.

Diczfalusy U, Kanebratt KP, Bredberg E, Andersson TB, Böttiger Y, Bertilsson L. 4beta-hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half-life of elimination after induction with rifampicin. Br J Clin Pharmacol 2009; 67:38-43.

Diczfalusy U, Miura J, Roh HK et al. 4Beta-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians. Pharmacogenet Genomics 2008; 18:201-8.

Diczfalusy U, Olofsson KE, Carlsson AM et al. Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide. J Lipid Res 2009; 50:2258-64.

Dichgans M, Freilinger T, Eckstein G et al. Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine. Lancet 2005; 366:371-7.

Dideberg V, Louis E, Farnir F et al. Lymphotoxin alpha gene in Crohn's disease patients: absence of implication in the response to infliximab in a large cohort study. Pharmacogenet Genomics 2006; 16:369-73.

Diedrich A, Bock HC, König F et al. Expression of glutathione S-transferase T1 (GSTT1) in human brain tumours. Histol Histopathol 2006; 21:1199-207.

Diefenbach K, Jaeger K, Wollny A, Penzel T, Fietze I, Roots I. Effect of tolterodine on sleep structure modulated by CYP2D6 genotype. Sleep Med 2008; 9:579-82.

Dierks A, Lichtenauer UD, Sackmann S et al. Identification of adrenal genes regulated in a potassium-dependent manner. J Mol Endocrinol 2010; 45:193-206.

Dierks EA, Stams KR, Lim HK, Cornelius G, Zhang H, Ball SE. A method for the simultaneous evaluation of the activities of seven major human drug-metabolizing cytochrome P450s using an in vitro cocktail of probe substrates and fast gradient liquid chromatography tandem mass spectrometry. Drug Metab Dispos 2001; 29:23-9.

Dieterle W, Mann J. Pharmacokinetic interaction between ketoconazole and SPP301 in healthy volunteers. Int J Clin Pharmacol Ther 2006; 44:326-30.

Dietrich C, Kaina B. The aryl hydrocarbon receptor (AhR) in the regulation of cell-cell contact and tumor growth. Carcinogenesis 2010; 31:1319-28.

Dietrich CG, Ottenhoff R, de Waart DR, Oude Elferink RP. Role of MRP2 and GSH in intrahepatic cycling of toxins. Toxicology 2001; 167:73-81.

Dieudé P, Osorio J, Petit-Teixeira E et al. A TNFR1 genotype with a protective role in familial rheumatoid arthritis. Arthritis Rheum 2004; 50:413-9.

Dieudonné AS, Lambrechts D, Claes B et al. Prevalent breast cancer patients with a homozygous mutant status for CYP2D6*4: response and biomarkers in tamoxifen users. Breast Cancer Res Treat 2009; 118:531-8.

DiFligia M, Sapp E, Chase K et al. Aggregation of huntingtin in neuronal intracellular inclusions and dystrophic neurites in brain. Science 1997; 277:1990-3.

DiGeorge AM, Auerbach VH. Leucine-induced hypoglycemia: a review and speculations. Am J Med Sci 1960; 240:792-801.

Digoxin: serious drug interactions. Prescrire Int 2010; 19:68-70.

Dijkstra A, Howard TD, Vonk JM et al. Estrogen receptor 1 polymorphisms are associated with airway hyperresponsiveness and lung function decline, particularly in female subjects with asthma. J Allergy Clin Immunol 2006; 117:604-11.

Dijkstra A, Koppelman GH, Vonk JM, Bruinenberg M, Schouten JP, Postma DS. Pharmacogenomics and outcome of asthma: no clinical application for long-term steroid effects by CRHR1 polymorphisms. J Allergy Clin Immunol 2008; 121:1510-3.

Dijstelbloem HM, Bijl M, Fijnheer R et al. Fcgamma receptor polymorphisms in systemic lupus erythematosus: association with disease and in vivo clearance of immune complexes. Arthritis Rheum 2000; 43:2793-800.

Dikopoulos N, Schmid RM, Bachem M et al. Bile synthesis in rat models of inflammatory bowel diseases. Eur J Clin Invest 2007; 37:222-30.

Dilger K, Cascorbi I, Grünhage F, Hohenester S, Sauerbruch T, Beuers U. Multidrug resistance 1 genotype and disposition of budesonide in early primary biliary cirrhosis. Liver Int 2006; 26:285-90.

Dilger K, Greiner B, Fromm MF, Hofmann U, Kroemer HK, Eichelbaum M. Consequences of rifampicin treatment on propafenone disposition in extensive and poor metabolizers of CYP2D6. Pharmacogenetics 1999; 9:551-9.

Dilger K, Hofmann U, Klotz U. Enzyme induction in the elderly: effect of rifampin on the pharmacokinetics and pharmacodynamics of propafenone. Clin Pharmacol Ther 2000; 67:512-20.

Dilger K, Meisel P, Hofmann U, Eichelbaum M. Disposition of propafenone in a poor metabolizer of CYP2D6 with Gilbert's syndrome. Ther Drug Monit 2000; 22:366-8.

Dilger K, Schwab M, Fromm MF. Identification of budesonide and prednisone as substrates of the intestinal drug efflux pump P-glycoprotein. Inflamm Bowel Dis 2004; 10:578-83.

Dilmaghanian S, Gerber JG, Filler SG, Sánchez A, Gal J. Enantioselectivity of inhibition of cytochrome P450 3A4 (CYP3A4) by ketoconazole: Testosterone and methadone as substrates. Chirality 2004; 16:79-85.

Dimaraki EV, Jaffe CA. Troglitazone induces CYP3A4 activity leading to falsely abnormal dexamethasone suppression test. J Clin Endocrinol Metab 2003; 88:3113-6.

DiMauro S, Gurgel-Giannetti J. The expanding phenotype of mitochondrial myopathy. Curr Opin Neurol 2005; 18:538-42.

Dimitroulakos J, Lorimer IA, Goss G. Strategies to enhance epidermal growth factor inhibition: targeting the mevalonate pathway. Clin Cancer Res 2006; 12:4426-31.

Din OS, Dodwell D, Winter MC, Mori S, Coleman RE. Current opinion of aromatase inhibitor-induced Arthralgia in breast cancer in the UK. Clin Oncol 2011. doi:10. 1016/j. clon. 2011. 06. 007.

Dinamarca MC, Cerpa W, Garrido J, Hancke JL, Inestrosa NC. Hyperforin prevents beta-amyloid neurotoxicity and spatial memory impairments by disaggregation of Alzheimer's amyloid-beta-deposits. Mol Psychiatry 2006; 11:1032-48.

Ding D, Xu L, Menon M, Reddy GP, Barrack ER. Effect of GGC (glycine) repeat length polymorphism in the human androgen receptor on androgen action. Prostate 2005; 62:133-9.

Ding FX, Shen HC, Wilsie LC et al. Discovery of pyrazolyl propionyl cyclohexenamide derivatives as full agonists for the high affinity niacin receptor GPR109A. Bioorg Med Chem Lett 2010; 20:3372-5.

Ding H, Cui G, Zhang L et al. Association of common variants of CYP4A11 and CYP4F2 with stroke in the Han Chinese population. Pharmacogenet Genomics 2010; 20:187-94.

Ding L, Getz G, Wheeler DA et al. Somatic mutations affect key pathways in lung adenocarcinoma. Nature 2008; 455:1069-75.

Ding PR, Tiwari AK, Ohnuma S et al. The phosphodiesterase-5 inhibitor vardenafil is a potent inhibitor of ABCB1/P-glycoprotein transporter. PLoS One 2011. doi:10. 1371/journal. pone. 0019329.

Ding PY, Hu OY, Pool PE, Liao W. Does Chinese ethnicity affect the pharmacokinetics and pharmacodynamics of angiotensin-converting enzyme inhibitors? J Hum Hypertens 2000; 14:163-70.

Ding S, Yao D, Burchell B, Wolf CR, Friedberg T. High levels of recombinant CYP3A4 expression in Chinese hamster ovary cells are modulated by coexpressed human P450 reductase and hemin supplementation. Arch Biochem Biophys 1997; 348:403-10.

Ding X, Kaminsky LS. Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts. Annu Rev Pharmacol Toxicol 2003; 43:149-73.

Ding X, Lichti K, Staudinger JL. The mycoestrogen zearalenone induces CYP3A through activation of the pregnane X receptor. Toxicol Sci 2006; 91:448-55.

Dingemanse J, Schaarschmidt D, van Giersbergen PL. Investigation of the mutual pharmacokinetic interactions between bosentan, a dual endothelin receptor antagonist, and simvastatin. Clin Pharmacokinet 2003; 42:293-301.

Dingemanse J, van Giersbergen PL. Influence of severe renal dysfunction on the pharmacokinetics and metabolism of bosentan, a dual endothelin receptor antagonist. Int J Clin Pharmacol Ther 2002; 40:310-6.

Dingemanse J, van Giersbergen PL. Clinical pharmacology of bosentan, a dual endothelin receptor antagonist. Clin Pharmacokinet 2004; 43:1089-115.

Diniz BS, Talib LL, Joaquim HP, de Paula VR, Gattaz WF, Forlenza OV. Platelet GSK3B activity in patients with late-life depression: Marker of depressive episode severity and cognitive impairment? World J Biol Psychiatry 2011; 12:216-22.

Dionne IJ, Garant MJ, Nolan AA et al. Association between obesity and a polymorphism in the beta(1)-adrenoceptor gene (Gly389Arg ADRB1) in Caucasian women. Int J Obes Relat Metab Disord 2002; 26:633-9.

Diotel N, do Rego JL, Anglade I et al. Activity and expression of steroidogenic enzymes in the brain of adult zebrafish. Eur J Neurosci 2011; 34:45-56.

Diotel N, Vaillant C, Gueguen MM et al. Cxcr4 and Cxcl12 expression in radial glial cells of the brain of adult zebrafish. J Comp Neurol 2010; 518:4855-76.

Dirks NL, Huth B, Yates CR, Meibohm B. Pharmacokinetics of immunosuppressants: a perspective on ethnic differences. Int J Clin Pharmacol Ther 2004; 42:701-18.

Dishy V, Landau R, Sofowora GG et al. Beta-2-adrenoceptor Thr164Ile polymorphism is associated with markedly decreased vasodilator and increased vasoconstrictor sensitivity in vivo. Pharmacogenetics 2004; 14:517-22.

Dishy V, Sofowora GG, Xie HG et al. The effect of common polymorphisms of the beta2-adrenergic receptor on agonist-mediated vascular desensitization. N Engl J Med 2001; 345:1030-5.

Dispenzieri A, Gertz MA, Lacy MQ et al. Flavopiridol in patients with relapsed or refractory multiple myeloma: a phase 2 trial with clinical and pharmacodynamic end-points. Haematologica 2006; 91:390-3.

Distlerath LM, Reilly PE, Martin MV, Davis GG, Wilkinson GR, Guengerich FP. Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin O-deethylation, two prototypes for genetic polymorphism in oxidative drug metabolism. J Biol Chem 1985; 260:9057-67.

Dittrich C, Zandvliet AS, Gneist M, Huitema AD, King AA, Wanders J. A phase I and pharmacokinetic study of indisulam in combination with carboplatin. Br J Cancer 2007; 96:559-66.

DiTusa L, Luzier AB. Potential interaction between troglitazone and atorvastatin. J Clin Pharm Ther 2000; 25:279-82.

Dixit V, Hariparsad N, Desai P, Unadkat JD. In vitro LC-MS cocktail assays to simultaneously determine human cytochrome P450 activities. Biopharm Drug Dispos 2007; 28:257-62.

Dixit V, Hariparsad N, Li F, Desai P, Thummel KE, Unadkat JD. Cytochrome P450 enzymes and transporters induced by anti-human immunodeficiency virus protease inhibitors in human hepatocytes: implications for predicting clinical drug interactions. Drug Metab Dispos 2007; 35:1853-9.

Dixon CM, Colthup PV, Serabjit-Singh CJ et al. Multiple forms of cytochrome P450 are involved in the metabolism of ondansetron in humans. Drug Metab Dispos 1995; 23:1225-30.

Dixon DL, Williams VG. Interaction between gemfibrozil and warfarin: case report and review of the literature. Pharmacotherapy 2009; 29:744-8.

Dixon MB, Lien YH. Tolvaptan and its potential in the treatment of hyponatremia. Ther Clin Risk Manag 2008; 4:1149-55.

Djaffar Jureidini I, Chamseddine N, Keleshian S, Naoufal R, Zahed L, Hakime N. Prevalence of CYP2C19 polymorphisms in the Lebanese population. Mol Biol Rep 2011; 38:5449-52.

Djaffar-Jureidini I, Chamseddine N, Keleshian S, Naoufal R, Zahed L, Hakime N. Pharmacogenetics of coumarin dosing: Prevalence of CYP2C9 and VKORC1 polymorphisms in the Lebanese population. Genet Test Mol Biomarkers 2011; 15:827-30.

Djilali-Saiah I, Schmitz J, Harfouch-Hammoud E, Mougenot JF, Bach JF, Caillat-Zucman S. CTLA-4 gene polymorphism is associated with predisposition to coeliac disease. Gut 1998; 43:187-9.

Djordjevic N, Carrillo JA, Gervasini G, Jankovic S, Aklillu E. In vivo evaluation of CYP2A6 and xanthine oxidase enzyme activities in the Serbian population. Eur J Clin Pharmacol 2010; 66:571-8.

Djousse L, Knowlton B, Hayden M et al. Interaction of normal and expanded CAG repeat sizes influences age at onset of Huntington disease. Am J Med Genet 2003; 119:279-82.

Djuv A, Nilsen OG. Aloe vera juice: IC(50) and dual mechanistic inhibition of CYP3A4 and CYP2D6. Phytother Res 2011. doi:10. 1002/ptr. 3564.

Dlugos AM, Hamidovic A, Hodgkinson C et al. OPRM1 gene variants modulate amphetamine-induced euphoria in humans. Genes Brain Behav 2011; 10:199-209.

Dlugos AM, Hamidovic A, Palmer AA, de Wit H. Further evidence of association between amphetamine response and SLC6A2 gene variants. Psychopharmacology 2009; 206:501-11.

Dluhy RG. Pheochromocytoma-death of an axiom. New Eng J Med 2002; 346:1486-8.

Dmitrzak-Weglarz M, Rybakowski JK, Suwalska A et al. Association studies of the BDNF and the NTRK2 gene polymorphisms with prophylactic lithium response in bipolar patients. Pharmacogenomics 2008; 9:1595-603.

Do Carmo EC, Fernandes T, Koike D et al. Anabolic steroid associated to physical training induces deleterious cardiac effects. Med Sci Sports Exerc 2011; 43:1836-48.

Do Carmo S, Fournier D, Mounier C, Rassart E. Human apolipoprotein D overexpression in transgenic mice induces insulin resistance and alters lipid metabolism. Am J Physiol Endocrinol Metab 2009; 296:802-11.

Dobesh PP. Pharmacokinetics and pharmacodynamics of prasugrel, a thienopyridine P2Y12 inhibitor. Pharmacotherapy 2009; 29:1089-102.

Dobrinas M, Cornuz J, Oneda B, Kohler Serra M, Puhl M, Eap CB. Impact of smoking, smoking cessation, and genetic polymorphisms on CYP1A2 activity and inducibility. Clin Pharmacol Ther 2011; 90:117-25.

Dobrzycka B, Terlikowski SJ, Kowalczuk O, Niklińska W, Chyczewski L, Kulikowski M. Mutations in the KRAS gene in ovarian tumors. Folia Histochem Cytobiol 2009; 47:221-4.

Dočolomanský P, Boháčová V, Barančík M, Breier A. Why the xanthine derivatives are used to study of P-glycoprotein-mediated multidrug resistance in L1210/VCR line cells. Gen Physiol Biophys 2010; 29:215-21.

Dodart JC, Marr RA, Koistinaho M et al. Gene delivery of human apolipoprotein E alters brain amyloid-beta burden in a mouse model of Alzheimer's disease. Proc Nat Acad Sci USA 2005; 102:1211-6.

Dodd S, Boulton DW, Burrows GD, DeVane CL, Norman TR. In vitro metabolism of mirtazapine enantiomers by human cytochrome P450 enzymes. Hum Psychopharmacol 2001; 16:541-4.

Dodds-Ashley E. Management of drug and food interactions with azole antifungal agents in transplant recipients. Pharmacotherapy 2010; 30:842-54.

Dodhia VR, Fantuzzi A, Gilardi G. Engineering human cytochrome P450 enzymes into catalytically self-sufficient chimeras using molecular Lego. J Biol Inorg Chem 2006; 11:903-16.

Doehmer J. V79 Chinese hamster cells genetically engineered for cytochrome P450 and their use in mutagenicity and metabolism studies. Toxicology 1993; 82:105-18.

Doehmer J, Schmalix WA, Greim H. Genetically engineered in vitro systems for biotransformation studies. Methods Find Exp Clin Pharmacol 1994; 16:513-8.

Doehmer J, Tewes B, Klein KU, Gritzko K, Muschick H, Mengs U. Assessment of drug-drug interaction for silymarin. Toxicol In Vitro 2008; 22:610-7.

Doehmer J, Weiss G, McGregor GP, Appel K. Assessment of a dry extract from milk thistle (Silybum marianum) for interference with human liver cytochrome-P450 activities. Toxicol In Vitro 2011; 25:21-7.

Doehring A, Antoniades C, Channon KM, Tegeder I, Lötsch J. Clinical genetics of functionally mild non-coding GTP cyclohydrolase 1 (GCH1) polymorphisms modulating pain and cardiovascular risk. Mutat Res 2008; 659:195-201.

Dogan I, Onen HI, Yurdakul AS et al. Polymorphisms in the vitamin D receptor gene and risk of lung cancer. Med Sci Monit 2009; 15:232-42.

Doggen CJ, Cats VM, Bertina RM, Rosendaal FR. Interaction of coagulation defects and cardiovascular risk factors: increased risk of myocardial infarction associated with factor V Leiden or prothrombin 20210A. Circulation 1998; 97:1037-41.

Doggen CJ, Kunz G, Rosendaal FR et al. A mutation in the thrombomodulin gene, 127G to A coding for Ala25Thr, and the risk of myocardial infarction in men. Thromb Haemost 1998; 80:743-8.

Doherty E, Pakarinen P, Tiitinen A et al. A Novel mutation in the FSH receptor inhibiting signal transduction and causing primary ovarian failure. J Clin Endocrinol Metab 2002; 87:1151-5.

Dohmen K, Baraona E, Ishibashi H et al. Ethnic differences in gastric sigma-alcohol dehydrogenase activity and ethanol first-pass metabolism. Alcohol Clin Exp Res 1996; 20:1569-76.

Dohse M, Scharenberg C, Shukla S et al. Comparison of ATP-binding cassette transporter interactions with the tyrosine kinase inhibitors imatinib, nilotinib, and dasatinib. Drug Metab Dispos 2010; 38:1371-80.

Doh-ura K, Tamura K, Karube Y, Naito M, Tsuruo T, Kataoka Y. Chelating compound, chrysoidine, is more effective in both antiprion activity and brain endothelial permeability than quinacrine. Cell Mol Neurobiol 2007; 27:303-16.

Doh-ura K, Tateishi J, Sasaki H, Kitamoto T, Sakaki Y. Pro-to-leu change at position 102 of prion protein is the most common but not the sole mutation related to Gerstmann-Straussler syndrome. Biochem Biophys Res Commun 1989; 163:974-9.

Doi AM, Patterson PE, Gallagher EP. Variability in aflatoxin B(1)-macromolecular binding and relationship to biotransformation enzyme expression in human prenatal and adult liver. Toxicol Appl Pharmacol 2002; 181:48-59.

Doi H, Horie T. Salicylic acid-induced hepatotoxicity triggered by oxidative stress. Chem Biol Interact 2010; 183:363-8.

Doiron J, Soultan AH, Richard R et al. Synthesis and structure-activity relationship of 1- and 2-substituted-1,2,3-triazole letrozole-based analogues as aromatase inhibitors. Eur J Med Chem 2011; 46:4010-24.

Doki K, Homma M, Kuga K et al. Effect of CYP2D6 genotype on flecainide pharmacokinetics in Japanese patients with supraventricular tachyarrhythmia. Eur J Clin Pharmacol 2006; 62:919-26.

Doki K, Homma M, Kuga K et al. Gender-associated differences in pharmacokinetics and anti-arrhythmic effects of flecainide in Japanese patients with supraventricular tachyarrhythmia. Eur J Clin Pharmacol 2007; 63:951-7.

Doki K, Homma M, Kuga K, Aonuma K, Kohda Y. Effects of CYP2D6 genotypes on age-related change of flecainide metabolism: involvement of CYP1A2-mediated metabolism. Br J Clin Pharmacol 2009; 68:89-96.

Dolder C, Nelson M, Stump A. Pharmacological and clinical profile of newer antidepressants: implications for the treatment of elderly patients. Drugs Aging 2010; 27:625-40.

Dolder CR, Nelson M, Snider M. Agomelatine treatment of major depressive disorder. Ann Pharmacother 2008; 42:1822-31.

Doligalska M, Jóźwicka K, Kiersnowska M, Mroczek A, Pączkowski C, Janiszowska W. Triterpenoid saponins affect the function of P-glycoprotein and reduce the survival of the free-living stages of Heligmosomoides bakeri. Vet Parasitol 2011; 179:144-51.

Dolphin CT, Beckett DJ, Janmohamed A et al. The flavin-containing monooxygenase 2 gene (FMO2) of humans, but not of other primates, encodes a truncated, nonfunctional protein. J Biol Chem 1998; 273:30599-607.

Dolphin CT, Janmohamed A, Smith RL, Shephard EA, Phillips IR. Missense mutation in flavin-containing mono-oxygenase 3 gene, FMO3, underlies fish-odour syndrome. Nat Genet 1997; 17:491-4.

Dolzan V, Plesnicar BK, Serretti A et al. Polymorphisms in dopamine receptor DRD1 and DRD2 genes and psychopathological and extrapyramidal symptoms in patients on long-term antipsychotic treatment. Am J Med Genet B Neuropsychiatr Genet 2007; 144:809-15.

Dollery CT. Beyond genomics. Clin Pharmacol Ther 2007; 82:366-70.

Dolley G, Bertrais S, Frochot V et al. Promoter adiponectin polymorphisms and waist/hip ratio variation in a prospective French adults study. Int J Obes 2008; 32:669-75.

Domanski TL, Finta C, Halpert JR, Zaphiropoulos PG. cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450. Mol Pharmacol 2001; 59:386-92.

Domanski TL, He YA, Khan KK, Roussel F, Wang Q, Halpert JR. Phenylalanine and tryptophan scanning mutagenesis of CYP3A4 substrate recognition site residues and effect on substrate oxidation and cooperativity. Biochemistry 2001; 40:10150-60.

Dombrovski AY, Mulsant BH, Ferrell RE et al. Serotonin transporter triallelic genotype and response to citalopram and risperidone in dementia with behavioral symptoms. Int Clin Psychopharmacol 2010; 25:37-45.

Domingo P, Muñiz-Diaz E, Baraldès MA et al. Associations between Fc gamma receptor IIA polymorphisms and the risk and prognosis of meningococcal disease. Am J Med 2002; 112:19-25.

Domingues-Montanari S, Hernandez-Guillamon M, Fernandez-Cadenas I et al. ACE variants and risk of intracerebral hemorrhage recurrence in amyloid angiopathy. Neurobiol Aging 2011; 32:551.

Do-Monte FH, Allensworth M, Carobrez AP. Impairment of contextual conditioned fear extinction after microinjection of alpha-1-adrenergic blocker prazosin into the medial prefrontal cortex. Behav Brain Res 2010; 211:89-95.

Domschke K, Dannlowski U, Hohoff C et al. Neuropeptide Y (NPY) gene: Impact on emotional processing and treatment response in anxious depression. Eur Neuropsychopharmacol 2010; 20:301-9.

Domschke K, Dannlowski U, Ohrmann P et al. Cannabinoid receptor 1 (CNR1) gene: impact on antidepressant treatment response and emotion processing in major depression. Eur Neuropsychopharmacol 2008; 18:751-9.

Donahue TR, Hines OJ. CXCR2 and RET single nucleotide polymorphisms in pancreatic cancer. World J Surg 2009; 33:710-5.

Donato MT, Gómez-Lechón MJ, Jover R, Nakamura T, Castell JV. Human hepatocyte growth factor down-regulates the expression of cytochrome P450 isozymes in human hepatocytes in primary culture. J Pharmacol Exp Ther 1998; 284:760-7.

Donato MT, Jiménez N, Serralta A, Mir J, Castell JV, Gómez-Lechón MJ. Effects of steatosis on drug-metabolizing capability of primary human hepatocytes. Toxicol In Vitro 2007; 21:271-6.

Donato MT, Lahoz A, Jiménez N et al. Potential impact of steatosis on cytochrome P450 enzymes of human hepatocytes isolated from fatty liver grafts. Drug Metab Dispos 2006; 34:1556-62.

Doney AS, Lee S, Leese GP, Morris AD, Palmer CN. Increased cardiovascular morbidity and mortality in type 2 diabetes is associated with the glutathione S transferase theta-null genotype: a Go-DARTS study. Circulation 2005; 111:2927-34.

Dong C, Wong ML, Licinio J. Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans. Mol Psychiatry 2009; 14:1105-18.

Dong H, Haining RL, Thummel KE, Rettie AE, Nelson SD. Involvement of human cytochrome P450 2D6 in the bioactivation of acetaminophen. Drug Metab Dispos 2000; 28:1397-400.

Dong HJ, Miao KR, Qiao C et al. Polymorphisms and haplotypes in multidrug resistance 1 gene are not associated with chronic lymphocytic leukemia susceptibility and prognostic parameters of chronic lymphocytic leukemia in Chinese population. Leuk Lymphoma 2011; 52:1003-9.

Dong HY, Shao JW, Chen JF, Wang T, Lin FP, Guo YH. Transcriptional regulation of cytochrome P450 3A4 by four kinds of traditional Chinese medicines. Zhongguo Zhong Yao Za Zhi 2008; 33:1014-7, 1089.

Dong J, Dai J, Zhang M, Hu Z, Shen H. Potentially functional COX-2-1195G>A polymorphism increases the risk of digestive system cancers: a meta-analysis. J Gastroenterol Hepatol 2010; 25:1042-50.

Dong JT. Prevalent mutations in prostate cancer. J Cell Biochem 2006; 97:433-47.

Dong L, Luo R, Tong Y, Cai X, Mao M, Yu D. Lack of association between ABCB1 gene polymorphisms and pharmacoresistant epilepsy: an analysis in a western Chinese pediatric population. Brain Res 2011; 1391:114-24.

Dong PP, Fang ZZ, Zhang YY et al. Substrate-dependent modulation of the catalytic activity of CYP3A by erlotinib. Acta Pharmacol Sin 2011; 32:399-407.

Dong S, Guo AL, Chen ZH et al. RRM1 single nucleotide polymorphism -37C→A correlates with progression-free survival in NSCLC patients after gemcitabine-based chemotherapy. J Hematol Oncol 2010; 3:10.

Dong S, Li C, Wu P, Tsien JZ, Hu Y. Environment enrichment rescues the neurodegenerative phenotypes in presenilins-deficient mice. Eur J Neurosci 2007; 26:101-12.

Dong X, Javle M, Hess KR, Shroff R, Abbruzzese JL, Li D. Insulin-like growth factor axis gene polymorphisms and clinical outcomes in pancreatic cancer. Gastroenterology 2010; 139:464-73.

Dong X, Mumper RJ. Nanomedicinal strategies to treat multidrug-resistant tumors: current progress. Nanomedicine 2010; 5:597-615.

Dong X, Wu J, Liang P, Li J, Yuan L, Liu X. Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer: a meta-analysis. Arch Med Res 2010; 41:125-33.

Dong X, Zhao H, Ma X, Wang S. Reduction in bile acid pool causes delayed liver regeneration accompanied by down-regulated expression of FXR and c-Jun mRNA in rats. J Huazhong Univ Sci Technolog Med Sci 2010; 30:55-60.

Dong Z, Guo W, Zhou R et al. Polymorphisms of the DNA repair gene XPA and XPC and its correlation with gastric cardiac adenocarcinoma in a high incidence population in North China. J Clin Gastroenterol 2008; 42:910-5.

Donkin JJ, Stukas S, Hirsch-Reinshagen V et al. ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice. J Biol Chem 2010; 285:34144-54.

Donlon TA, Harris P, Neve RL. Localization of microtubule-associated protein tau (MTBT1) to chromosome 17q21. Cytogenet Cell Genet 1987; 46:607.

Dönmez Y, Gündüz U. Reversal of multidrug resistance by small interfering RNA (siRNA) in doxorubicin-resistant MCF-7 breast cancer cells. Biomed Pharmacother 2011; 65:85-9.

Donnelly JG. Pharmacogenetics in cancer chemotherapy: balancing toxicity and response. Ther Drug Monit 2004; 26:231-5.

Donnelly LA, Doney AS, Dannfald J et al. A paucimorphic variant in the HMG-CoA reductase gene is associated with lipid-lowering response to statin treatment in diabetes: a GoDARTS study. Pharmacogenet Genomics 2008; 18:1021-6.

Donnelly LA, Palmer CNA, Whitley AL et al. Apolipoprotein E genotypes are associated with lipid-lowering responses to statin treatment in diabetes: a Go-DARTS study. Pharmacogenetics Genomics 2008; 18:279-87.

Donner H, Braun J, Seidl C et al. Codon 17 polymorphism of the cytotoxic T lymphocyte antigen 4 gene in Hashimoto's thyroiditis and Addison's disease. J Clin Endocrinol Metab 1997; 82:4130-2.

Donner H, Rau H, Braun J, Herwig J, Usadel KH, Badenhoop K. Highly polymorphic promoter regions of HLA DQA1 and DQB1 genes do not help to further define disease susceptibility in insulin-dependent diabetes mellitus. Tissue Antigens 1997; 50:642-5.

Donovan JL, Chavin KD, Devane CL et al. Green tea (Camellia sinensis) extract does not alter cytochrome p450 3A4 or 2D6 activity in healthy volunteers. Drug Metab Dispos 2004; 32:906-8.

Donovan JL, DeVane CL, Chavin KD et al. Multiple night-time doses of valerian (Valeriana officinalis) had minimal effects on CYP3A4 activity and no effect on CYP2D6 activity in healthy volunteers. Drug Metab Dispos 2004; 32:1333-6.

Donovan JL, DeVane CL, Chavin KD, Taylor RM, Markowitz JS. Siberian ginseng (Eleutheroccus senticosus) effects on CYP2D6 and CYP3A4 activity in normal volunteers. Drug Metab Dispos 2003; 31:519-22.

Donovan JL, DeVane CL, Lewis JG et al. Effects of St John's wort (Hypericum perforatum L. ) extract on plasma androgen concentrations in healthy men and women: a pilot study. Phytother Res 2005; 19:901-6.

Dooley TP, Huang Z. Genomic organization and DNA sequences of two human phenol sulfotransferase genes (STP1 and STP2) on the short arm of chromosome 16. Biochem Biophys Res Commun 1996; 228:134-40.

Doolin MT, Barbaux S, McDonnell M, Hoess K, Whitehead AS, Mitchell LE. Maternal genetic effects, exerted by genes involved in homocysteine remethylation, influence the risk of spina bifida. Am J Hum Genet 2002; 71:1222-6.

Doostdar H, Burke MD, Mayer RT. Bioflavonoids: selective substrates and inhibitors for cytochrome P450 CYP1A and CYP1B1. Toxicology 2000; 144:31-8.

Dorababu M, Nishimura A, Prabha T et al. Effect of cyclosporine on drug transport and pharmacokinetics of nifedipine. Biomed Pharmacother 2009; 63:697-702.

Dorado P, Berecz R, Norberto MJ, Yasar U, Dahl ML, Llerena A. CYP2C9 genotypes and diclofenac metabolism in Spanish healthy volunteers. Eur J Clin Pharmacol 2003; 59:221-5.

Dorado P, Cavaco I, Cáceres MC, Piedade R, Ribeiro V, Llerena A. Relationship between CYP2C8 genotypes and diclofenac 5-hydroxylation in healthy Spanish volunteers. Eur J Clin Pharmacol 2008; 64:967-70.

Dorado P, Peñas-Lledó EM, de la Rubia A, Llerena A. Relevance of CYP2D6 -1584C>G polymorphism for thioridazine:mesoridazine plasma concentration ratio in psychiatric patients. Pharmacogenomics 2009; 10:1083-9.

Dorado P, Sosa-Macias MG, Peñas-Lledó EM et al. CYP2C9 allele frequency differences between populations of Mexican-Mestizo, Mexican-Tepehuano, and Spaniards. Pharmacogenomics J 2011; 11:108-12.

Dorajoo R, Pereira BP, Yu Z et al. Role of multi-drug resistance-associated protein-1 transporter in statin-induced myopathy. Life Sci 2008; 82:823-30.

Dorak MT, Burnett AK, Worwood M. Hemochromatosis gene in leukemia and lymphoma. Leuk Lymphoma 2002; 43:467-77.

Dorak MT, Burnett AK, Worwood M. HFE gene mutations in susceptibility to childhood leukemia: HuGE review. Genet Med 2005; 7:159-68.

Dorfman R, Sandford A, Taylor C et al. Complex two-gene modulation of lung disease severity in children with cystic fibrosis. J Clin Invest 2008; 118:1040-9.

Doria A, Warram JH, Krolewski AS. Genetic predisposition to diabetic nephropathy: evidence for a role of the angiotensin I-converting enzyme gene. Diabetes 1994; 43:690-5.

Dorian P. Clinical pharmacology of dronedarone: implications for the therapy of atrial fibrillation. J Cardiovasc Pharmacol Ther 2010; 15(4 Suppl):15-8.

Döring F, Rimbach G, Lodge JK. In silico search for single nucleotide polymorphisms in genes important in vitamin E homeostasis. IUBMB Life 2004; 56:615-20.

Dorn C, Bataille F, Gaebele E, Heilmann J, Hellerbrand C. Xanthohumol feeding does not impair organ function and homoeostasis in mice. Food Chem Toxicol 2010; 48:1890-7.

Dorn GW 2nd, Liggett SB. Pharmacogenomics of beta-adrenergic receptors and their accessory signaling proteins in heart failure. Clin Transl Sci 2008; 1:255-62.

Dorn GW 2nd. GRK mythology: G-protein receptor kinases in cardiovascular disease. J Mol Med 2009; 87:455-63.

Dornbrook-Lavender KA, Joy MS, Denu-Ciocca CJ, Chin H, Hogan SL, Pieper JA. Effects of atorvastatin on low-density lipoprotein cholesterol phenotype and C-reactive protein levels in patients undergoing long-term dialysis. Pharmacotherapy 2005; 25:335-44.

Dornbrook-Lavender KA, Pieper JA. Genetic polymorphisms in emerging cardiovascular risk factors and response to statin therapy. Cardiovasc Drugs Ther 2003; 17:75-82.

Dorne JL. Impact of inter-individual differences in drug metabolism and pharmacokinetics on safety evaluation. Fundam Clin Pharmacol 2004; 18:609-20.

Dorne JL, Walton K, Renwick AG. Human variability in CYP3A4 metabolism and CYP3A4-related uncertainty factors for risk assessment. Food Chem Toxicol 2003; 41:201-24.

Dorne JL, Walton K, Renwick AG. Human variability in xenobiotic metabolism and pathway-related uncertainty factors for chemical risk assessment: a review. Food Chem Toxicol 2005; 43:203-16.

Dorne JL, Walton K, Slob W, Renwick AG. Human variability in polymorphic CYP2D6 metabolism: is the kinetic default uncertainty factor adequate? Food Chem Toxicol 2002; 40:1633-56.

Dörner B, Kuntner C, Bankstahl JP et al. Synthesis and small-animal positron emission tomography evaluation of [11C]-elacridar as a radiotracer to assess the distribution of P-glycoprotein at the blood-brain barrier. J Med Chem 2009; 52:6073-82.

Dörner B, Kuntner C, Bankstahl JP et al. Radiosynthesis and in vivo evaluation of 1-[(18)F]fluoroelacridar as a positron emission tomography tracer for P-glycoprotein and breast cancer resistance protein. Bioorg Med Chem 2011; 19:2190-8.

Dornetshuber R, Heffeter P, Sulyok M et al. Interactions between ABC-transport proteins and the secondary Fusarium metabolites enniatin and beauvericin. Mol Nutr Food Res 2009; 53:904-20.

Doroshyenko O, Fuhr U. Clinical pharmacokinetics and pharmacodynamics of solifenacin. Clin Pharmacokinet 2009; 48:281-302.

Dorr RT, Alberts DS. Modulation of experimental doxorubicin skin toxicity by beta-adrenergic compounds. Cancer Res 1981; 41:2428-32.

Dos Santos C, Essioux L, Teinturier C et al. A common polymorphism of the growth hormone receptor is associated with increased responsiveness to growth hormone. Nat Genet 2004; 36:720-4.

Doshi U, Li AP. Luciferin IPA-based higher throughput human hepatocyte screening assays for CYP3A4 inhibition and induction. J Biomol Screen 2011; 16:903-9.

Dostalek M, Court MH, Hazarika S, Akhlaghi F. Diabetes mellitus reduces qctivity of human UDP-Glucuronosyltransferase 2B7 in liver and kidney leading to decreased formation of mycophenolic acid acyl-glucuronide metabolite. Drug Metab Dispos 2011; 39:448-55.

Dou J, Jiang C, Wang J et al. Using ABCG2-molecule-expressing side population cells to identify cancer stem-like cells in a human ovarian cell line. Cell Biol Int 2011; 35:227-34.

Doupis J, Veves A. DPP4 inhibitors: a new approach in diabetes treatment. Adv Ther 2008; 25:627-43.

Douvaras P, Antonatos DG, Kekou K et al. Association of VEGF gene polymorphisms with the development of heart failure in patients after myocardial infarction. Cardiology 2009; 114:11-8.

Dowless MS, Barbee JL, Borchert KM, Bocchinfuso WP, Houck KA. Cyclic AMP-independent activation of CYP3A4 gene expression by forskolin. Eur J Pharmacol 2005; 512:9-13.

Downs JR, Clearfield M, Tyroler HA et al. Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TEXCAPS): additional perspectives on tolerability of long-term treatment with lovastatin. Am J Cardiol 2001; 87:1074-9.

Dracopoli NC, Fountain JW. CDKN2 mutations in melanoma. Cancer Surv 1996; 26:115-32.

Drăgan CA, Peters FT, Bour P et al. Convenient gram-scale metabolite synthesis by engineered fission yeast strains expressing functional human P450 systems. Appl Biochem Biotechnol 2011; 163:965-80.

Dragic T, Litwin V, Allaway GP et al. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature 1996; 381:667-73.

Dragin N, Shi Z, Madan R et al. Phenotype of the Cyp1a1/1a2/1b1-/- triple-knockout mouse. Mol Pharmacol 2008; 73:1844-56.

Drago A, Alboni S, Nicoletta B, de Ronchi D, Serretti A. HTR1B as a risk profile maker in psychiatric disorders: a review through motivation and memory. Eur J Clin Pharmacol 2010; 66:5-27.

Drago A, de Ronchi D, Serretti A. Pharmacogenetics of antidepressant response: an update. Hum Genomics 2009; 3:257-74.

Drago A, Ronchi DD, Serretti A. 5-HT1A gene variants and psychiatric disorders: a review of current literature and selection of SNPs for future studies. Int J Neuropsychopharmacol 2008; 11:701-21.

Drago A, Ronchi DD, Serretti A. Pharmacogenetics of antidepressant response: an update. Hum Genomics 2009; 3:257-74.

Drago A, Serretti A. Focus on HTR2C: A possible suggestion for genetic studies of complex disorders. Am J Med Genet B Neuropsychiatr Genet 2009; 150:601-37.

Dragoni S, Bellik L, Frosini M et al. l-Deprenyl metabolism by the cytochrome P450 system in monkey (Cercopithecus aethiops) liver microsomes. Xenobiotica 2003; 33:181-95.

Draheim V, Reichel A, Weitschies W, Moenning U. N-glycosylation of ABC transporters is associated with functional activity in sandwich-cultured rat hepatocytes. Eur J Pharm Sci 2010; 41:201-9.

Drahushuk AT, McGarrigle BP, Larsen KE, Stegeman JJ, Olson JR. Detection of CYP1A1 protein in human liver and induction by TCDD in precision-cut liver slices incubated in dynamic organ culture. Carcinogenesis 1998; 19:1361-8.

Drakenberg K, Nikoshkov A, Horváth MC et al. Mu opioid receptor A118G polymorphism in association with striatal opioid neuropeptide gene expression in heroin abusers. Proc Natl Acad Sci USA 2006; 103:7883-8.

Draper DW, Madenspacher JH, Dixon D, King DH, Remaley AT, Fessler MB. ATP-binding cassette transporter G1 deficiency dysregulates host defense in the lung. Am J Respir Crit Care Med 2010; 182:404-12.

Drazen JM, Yandava CN, Dube L et al. Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment. Nat Genet 1999; 22:168-70.

Dreiseitel A, Oosterhuis B, Vukman KV et al. Berry anthocyanins and anthocyanidins exhibit distinct affinities for the efflux transporters BCRP and MDR1. Br J Pharmacol 2009; 158:1942-50.

Dreiseitel A, Schreier P, Oehme A, Locher S, Hajak G, Sand PG. Anthocyanins and their metabolites are weak inhibitors of cytochrome P450 3A4. Mol Nutr Food Res 2008; 52:1428-33.

Drenth JP, Waxman SG. Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disorders. J Clin Invest 2007; 117:3603-9.

Dresser GK, Bailey DG. A basic conceptual and practical overview of interactions with highly prescribed drugs. Can J Clin Pharmacol 2002; 9:191-8.

Dresser GK, Bailey DG. The effects of fruit juices on drug disposition: a new model for drug interactions. Eur J Clin Invest 2003; 33 Suppl 2:10-6.

Dresser GK, Spence JD, Bailey DG. Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition. Clin Pharmacokinet 2000; 38:41-57.

Dresser GK, Wacher V, Wong S, Wong HT, Bailey DG. Evaluation of peppermint oil and ascorbyl palmitate as inhibitors of cytochrome P4503A4 activity in vitro and in vivo. Clin Pharmacol Ther 2002; 72:247-55.

Drewe E, Huggins ML, Morgan AG, Cassidy MJ, Powell RJ. Treatment of renal amyloidosis with etanercept in tumour necrosis factor receptor-associated periodic syndrome. Rheumatology 2004; 43:1405-8.

Drigo I, Piscianz E, Valencic E et al. Selective resistance to different glucocorticoids in severe autoimmune disorders. Clin Immunol 2010; 134:313-9.

Dring MM, Goulding CA, Trimble VI et al. The pregnane X receptor locus is associated with susceptibility to inflammatory bowel disease. Gastroenterology 2006; 130:341-8.

Driver KE, Song H, Lesueur F et al. Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population. Carcinogenesis 2008; 29:333-41.

Drocourt L, Ourlin JC, Pascussi JM, Maurel P, Vilarem MJ. Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes. J Biol Chem 2002; 277:25125-32.

Drocourt L, Pascussi JM, Assenat E, Fabre JM, Maurel P, Vilarem MJ. Calcium channel modulators of the dihydropyridine family are human pregnane X receptor activators and inducers of CYP3A, CYP2B, and CYP2C in human hepatocytes. Drug Metab Dispos 2001; 29:1325-31.

Drögemöller BI, Wright GE, Niehaus DJ et al. Characterization of the genetic profile of CYP2C19 in two South African populations. Pharmacogenomics 2010; 11:1095-103.

Drolet B, Rousseau G, Daleau P, Cardinal R, Simard C, Turgeon J. Pimozide (Orap) prolongs cardiac repolarization by blocking the rapid component of the delayed rectifier potassium current in native cardiac myocytes. J Cardiovasc Pharmacol Ther 2001; 6:255-60.

Drolet B, Yang T, Daleau P, Roden DM, Turgeon J. Risperidone prolongs cardiac repolarization by blocking the rapid component of the delayed rectifier potassium current. J Cardiovasc Pharmacol 2003; 41:934-7.

Drover VAB, Wong NCW, Agellon LB. A distinct thyroid hormone response element mediates repression of the human cholesterol 7-alpha-hydroxylase (CYP7A1) gene promoter. Mol Endocr 2002; 16:14-23.

Droździk M, Białecka M, Myśliwiec K, Honczarenko K, Stankiewicz J, Sych Z. Polymorphism in the P-glycoprotein drug transporter MDR1 gene: a possible link between environmental and genetic factors in Parkinson's disease. Pharmacogenetics 2003; 13:259-63.

Drozdzik M, Rudas T, Pawlik A, Gornik W, Kurzawski M, Herczynska M. Reduced folate carrier-1 80G>A polymorphism affects methotrexate treatment outcome in rheumatoid arthritis. Pharmacogenomics J 2007; 7:404-7.

Drumm ML, Konstan MW, Schluchter MD et al. Genetic modifiers of lung disease in cystic fibrosis. N Engl J Med 2005; 353:1443-53.

D'Souza DL, Dimmitt DC, Robbins DK, Nezamis J, Simms L, Koch KM. Effect of alosetron on the pharmacokinetics of fluoxetine. J Clin Pharmacol 2001; 41:455-8.

D'Souza DL, Levasseur LM, Nezamis J, Robbins DK, Simms L, Koch KM. Effect of alosetron on the pharmacokinetics of alprazolam. J Clin Pharmacol 2001; 41:452-4.

Du J, Xing Q, Xu L et al. Systematic screening for polymorphisms in the CYP3A4 gene in the Chinese population. Pharmacogenomics 2006; 7:831-41.

Du J, Xu Y, Duan S et al. A case-control association study between the CYP3A4 and CYP3A5 genes and schizophrenia in the Chinese Han population. Prog Neuropsychopharmacol Biol Psychiatry 2009; 33:1200-4.

Du J, Zhang A, Wang L et al. Relationship between response to risperidone, plasma concentrations of risperidone and CYP3A4 polymorphisms in schizophrenia patients. J Psychopharmacol 2010; 24:1115-20.

Du L, Li M. Modeling the Interactions Between alpha(1)-Adrenergic Receptors and Their Antagonists. Curr Comput Aided Drug Des 2010; 6:165-78.

Du L, Neis MM, Ladd PA, Keeney DS. Differentiation-specific factors modulate epidermal CYP1-4 gene expression in human skin in response to retinoic acid and classic aryl hydrocarbon receptor ligands. J Pharmacol Exp Ther 2006; 319:1162-71.

du Plooy M, Viljoen M, Rheeders M. Evidence for time-dependent interactions between ritonavir and lopinavir/ritonavir plasma levels following P-glycoprotein inhibition in Sprague-Dawley rats. Biol Pharm Bull 2011; 34:66-70.

Du Preez J, Matolweni LO, Greenberg J, Mntla P, Adeyemo AA, Mayosi BM. The alpha 2C Del322-325 adrenergic receptor polymorphism is not associated with heart failure due to idiopathic dilated cardiomyopathy in black Africans. Cardiovasc J Afr 2008; 19:15-6.

DU SS, Yao KT. Expression of ATP-binding cassette transporter genes in nasopharyngeal carcinoma. Nan Fang Yi Ke Da Xue Xue Bao 2008; 28:449-52.

Du Z, Qin R, Wei C et al. Pancreatic cancer cells resistant to chemoradiotherapy rich in "stem-cell-like" tumor cells. Dig Dis Sci 2011; 56:741-50.

Duan J, Martinez M, Sanders AR et al. DTNBP1 (Dystrobrevin binding protein 1) and schizophrenia: ssociation evidence in the 3' end of the gene. Hum Hered 2007; 64:97-106.

Duan W, Guo Z, Jiang H et al. Paroxetine retards disease onset and progression in Huntingtin mutant mice. Ann Neurol 2004; 55:590-4.

Duan W, Sun B, Li TW, Tan BJ, Lee MK, Teo TS. Cloning and characterization of AWP1, a novel protein that associates with serine/threonine kinase PRK1 in vivo. Gene 2000; 256:113-21.

Duan Z, Choy E, Jimeno JM, Cuevas Cdel M, Mankin HJ, Hornicek FJ. Diverse cross-resistance phenotype to ET-743 and PM00104 in multi-drug resistant cell lines. Cancer Chemother Pharmacol 2009; 63:1121-9.

Duara R, Loewenstein DA, Greig MT et al. Pre-MCI and MCI: neuropsychological, clinical, and imaging features and progression rates. Am J Geriatr Psychiatry 2011; 19:951-60.

Duarte N, Ramalhete C, Varga A, Molnár J, Ferreira MJ. Multidrug resistance modulation and apoptosis induction of cancer cells by terpenic compounds isolated from Euphorbia species. Anticancer Res 2009; 29:4467-72.

Dubelaar EJ, Verwer RW, Hofman MA, van Heerikhuize JJ, Ravid R, Swaab DE. ApoE epsilon4 genotype is accompanied by lower metabolic activity in nucleous basalis of Meynert neurons in Alzheimer patients and controls as indicated by the size of the Golgi apparatus. J Neuropathol Exp Neurol 2004; 63:159-69.

Dubertret C, Hanoun N, Adès J, Hamon M, Gorwood P. Family-based association study of the serotonin-6 receptor gene (C267T polymorphism) in schizophrenia. Am J Med Genet B Neuropsychiatr Genet 2004; 126:10-5.

Dubey RK, Gillespie DG, Zacharia LC, Barchiesi F, Imthurn B, Jackson EK. CYP450- and COMT-derived estradiol metabolites inhibit activity of human coronary artery SMCs. Hypertension 2003; 41:807-13.

Dubey S, Hutson P, Alberti D et al. Phase I study of docetaxel and topotecan in patients with advanced malignancies. J Oncol Pharm Pract 2005; 11:131-8.

Dubin RL, Hall CM, Pileri CL et al. Thermostable (SULT1A1) and thermolabile (SULT1A3) phenol sulfotransferases in human osteosarcoma and osteoblast cells. Bone 2001; 28:617-24.

Dubovsky SL, Warren C. Agomelatine, a melatonin agonist with antidepressant properties. Expert Opin Investig Drugs 2009; 18:1533-40.

Duca RC, Mabondzo A, Bravin F, Delaforge M. In vivo effects of zearalenone on the expression of proteins involved in the detoxification of rat xenobiotics. Environ Toxicol 2010. doi:10. 1002/tox. 20617.

Ducharme MP, Bernstein ML, Granvil CP, Gehrcke B, Wainer IW. Phenytoin-induced alteration in the N-dechloroethylation of ifosfamide stereoisomers. Cancer Chemother Pharmacol 1997; 40:531-3.

Ducharme MP, Provenzano R, Dehoorne-Smith M, Edwards DJ. Trough concentrations of cyclosporine in blood following administration with grapefruit juice. Br J Clin Pharmacol 1993; 36:457-9.

Dudley C, Keavney B, Casadei B, Conway J, Bird R, Ratcliffe P. Prediction of patient responses to antihypertensive drugs using genetic polymorphisms: investigation of renin-angiotensin system genes. J Hypertens 1996; 14:259-62.

Duester G, Hatfield GW, Buhler R, Hempel J, Jornvall H, Smith M. Molecular cloning and characterization of cDNA for the beta subunit of human alcohol dehydrogenase. Proc Nat Acad Sci USA 1984; 81:4055-9.

Duez H, van der Veen JN, Duhem C et al. Regulation of bile acid synthesis by the nuclear receptor Rev-erbalpha. Gastroenterology 2008; 135:689-98.

Duff K, Eckman C, Zehr C et al. Increased amyloid-beta-42(43) in brains of mice expressing mutant presenilin 1. Nature 1996; 383:710-3.

Dufficy L, Naumovski N, Ng X et al. G80A reduced folate carrier SNP influences the absorption and cellular translocation of dietary folate and its association with blood pressure in an elderly population. Life Sci 2006; 79:957-66.

Duffy TA, Picha ME, Won ET, Borski RJ, McElroy AE, Conover DO. Ontogenesis of gonadal aromatase gene expression in atlantic silverside (Menidia menidia) populations with genetic and temperature-dependent sex determination. J Exp Zool A Ecol Genet Physiol 2010; 313:421-31.

Dufort I, Labrie F, Luu-The V. Human types 1 and 3 3-alpha-hydroxysteroid dehydrogenases: differential lability and tissue distribution. J Clin Endocr Metab 2001; 86:841-6.

Dufour C, Capasso M, Svahn J et al. Homozygosis for (12) CA repeats in the first intron of the human IFN-gamma gene is significantly associated with the risk of aplastic anaemia in Caucasian population. Br J Haematol 2004; 126:682-5.

Dufour C, Svahn J, Bacigalupo A et al. Genetic polymorphisms of CYP3A4, GSTT1, GSTM1, GSTP1 and NQO1 and the risk of acquired idiopathic aplastic anemia in Caucasian patients. Haematologica 2005; 90:1027-31.

Duguay Y, Báár C, Skorpen F, Guillemette C. A novel functional polymorphism in the uridine diphosphate-glucuronosyltransferase 2B7 promoter with significant impact on promoter activity. Clin Pharmacol Ther 2004; 75:223-33.

Duisken M, Sandner F, Blömeke B, Hollender J. Metabolism of 1,8-cineole by human cytochrome P450 enzymes: identification of a new hydroxylated metabolite. Biochim Biophys Acta 2005; 1722:304-11.

Dulin B, Abraham WT. Pharmacology of carvedilol. Am J Cardiol 2004; 93:3-6.

Dulos J, Boots AH. DHEA metabolism in arthritis: a role for the p450 enzyme Cyp7b at the immune-endocrine crossroad. Ann N Y Acad Sci 2006; 1069:401-13.

Dumanis SB, Cha HJ, Song JM et al. ApoE receptor 2 regulates synapse and dendritic spine formation. PLoS One 2011. doi:10. 1371/journal. pone. 0017203.

Dumas I, Diorio C. Polymorphisms in genes involved in the estrogen pathway and mammographic density. BMC Cancer 2010; 10:636.

Dumond JB, Vourvahis M, Rezk NL et al. A phenotype-genotype approach to predicting CYP450 and P-glycoprotein drug interactions with the mixed inhibitor/inducer tipranavir/ritonavir. Clin Pharmacol Ther 2010; 87:735-42.

Dumont J, Jossé R, Lambert C et al. Preferential induction of the AhR gene battery in HepaRG cells after a single or repeated exposure to heterocyclic aromatic amines. Toxicol Appl Pharmacol 2010; 249:91-100.

Dumontet C, Landi S, Reiman T et al. Genetic polymorphisms associated with outcome in multiple myeloma patients receiving high-dose melphalan. Bone Marrow Transplant 2010; 45:1316-24.

Dunajska K, Lwow F, Milewicz A et al. beta(3)-adrenergic receptor polymorphism and metabolic syndrome in postmenopausal women. Gynecol Endocrinol 2008; 24:133-8.

Dunbar L, Miles W, Wheeler A, Sheridan J, Pulford J, Butler R. The CYP2D6 metaboliser status of patients prescribed risperidone for the treatment of psychosis. N Z Med J 2009; 122:29-34.

Dunbier AK, Anderson H, Ghazoui Z et al. ESR1 is co-expressed with closely adjacent uncharacterised genes spanning a breast cancer susceptibility locus at 6q25. 1. PLoS Genet 2011. doi:10. 1371/journal. pgen. 1001382.

Duncan AMV, Anderson LL, Funk CD, Abramovitz M, Adam M. Chromosomal localization of the human prostanoid receptor gene family. Genomics 1995; 25:740-2.

Duncan JA, Scholey JW, Miller JA. Angiotensin II type 1 receptor gene polymorphisms in humans: physiology and pathophysiology of the genotypes. Curr Opin Nephrol Hypertens 2001; 10:111-6.

Duncan KA, Saldanha CJ. Neuroinflammation induces glial aromatase expression in the uninjured songbird brain. J Neuroinflammation 2011; 8:81.

Dunér P, To F, Beckmann K et al. Immunization of apoE-/- mice with aldehyde-modified fibronectin inhibits the development of atherosclerosis. Cardiovasc Res 2011; 91:528-36.

Duniec-Dmuchowski Z, Ellis E, Strom SC, Kocarek TA. Regulation of CYP3A4 and CYP2B6 expression by liver X receptor agonists. Biochem Pharmacol 2007; 74:1535-40.

Duniec-Dmuchowski Z, Fang HL, Strom SC, Ellis E, Runge-Morris M, Kocarek TA. Human pregnane X receptor activation and CYP3A4/CYP2B6 induction by 2,3-oxidosqualene:lanosterol cyclase inhibition. Drug Metab Dispos 2009; 37:900-8.

Dunn BK, Greene MH, Kelley JM et al. Novel pathway analysis of genomic polymorphism-cancer risk interaction in the breast cancer prevention trial. Int J Mol Epidemiol Genet 2010; 1:332-49.

Dunn S, Hedges L, Sampson K et al. Pharmacokinetic interaction of the antiparasitic agents ivermectin and spinosad in dogs. Drug Metab Dispos 2011; 39:789-95.

Dunne G, Breen L, Collins DM, Roche S, Clynes M, O'Connor R. Modulation of P-gp expression by lapatinib. Invest New Drugs 2011; 29:1284-93.

Dupuis J, Langenberg C, Prokopenko I et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 2010; 42:105-16.

Dupuy AM, Mas E, Ritchie K et al. The relationship between apolipoprotein E4 and lipid metabolism is impaired in Alzheimer's disease. Gerontology 2001; 47:213-8.

Dupuy J, Alvinerie M, Ménez C, Lespine A. Interaction of anthelmintic drugs with P-glycoprotein in recombinant LLC-PK1-mdr1a cells. Chem Biol Interact 2010; 186:280-6.

Durand JP, Gourmel B, Mir O, Goldwasser F. Antiemetic neurokinin-1 antagonist aprepitant and ifosfamide-induced encephalopathy. Ann Oncol 2007; 18:808-9.

Durany N, Riederer P, Cruz-Sanchez FF. Apoliprotein E genotype in Spanish schizophrenic patients. Psychiatr Genet 2000; 10:73-7.

Dure L, Landwehrmeyer G, Golden J et al. IT15 gene expression in fetal human brain. Brain Res 1994; 659:33-41.

Duret C, Daujat-Chavanieu M, Pascussi JM et al. Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor. Mol Pharmacol 2006; 70:329-39.

Durgan DJ, Smith JK, Hotze MA et al. Distinct transcriptional regulation of long-chain acyl-CoA synthetase isoforms and cytosolic thioesterase 1 in the rodent heart by fatty acids and insulin. Am J Physiol Heart Circ Physiol 2006; 290:2480-97.

Durić G, Svetel M, Nikolaevic SI, Dragadević N, Gavrilović J, Kostić VS. Polymorphisms in the genes of cytochrome oxidase P450 2D6 (CYP2D6), paraoxonase 1 (PON1) and apolipoprotein E (APOE) as risk factors for Parkinson's disease. Vojnosanit Pregl 2007; 64:25-30.

Duroudier NP, Tulah AS, Sayers I. Leukotriene pathway genetics and pharmacogenetics in allergy. Allergy 2009; 64:823-39.

Dürr D, Stieger B, Kullak-Ublick GA et al. St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4. Clin Pharmacol Ther 2000; 68:598-604.

Durrmeyer X, Hovhannisyan S, Médard Y et al. Are cytochrome P450 CYP2C8 and CYP2C9 polymorphisms associated with ibuprofen response in very preterm infants? PLoS One 2010. doi:10. 1371/journal. pone. 0012329.

Dusseaux M, Martin E, Serriari N et al. Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells. Blood 2011; 117:1250-9.

Dutheil F, Beaune P, Tzourio C, Loriot MA, Elbaz A. Interaction between ABCB1 and professional exposure to organochlorine insecticides in Parkinson disease. Arch Neurol 2010; 67:739-45.

Dutheil F, Dauchy S, Diry M et al. Xenobiotic-metabolizing enzymes and transporters in the normal human brain: regional and cellular mapping as a basis for putative roles in cerebral function. Drug Metab Dispos 2009; 37:1528-38.

Dutta S, Das S, Guhathakurta S et al. Glutamate receptor 6 gene (GluR6 or GRIK2) polymorphisms in the Indian population: a genetic association study on autism spectrum disorder. Cell Mol Neurobiol 2007; 27:1035-47.

Duyao M, Ambrose C, Myers R et al. Trinucleotide repeat length instability and age of onset in Huntington's disease. Nat Genet 1993; 4:387-92.

Duyao M, Auerbach A, Ryan A et al. Inactivation of the mouse Hungtington's disease gene homolog Hdh. Sciece 1995; 269:407-10.

Duysen EG, Li B, Lockridge O. The butyrylcholinesterase knockout mouse a research tool in the study of drug sensitivity, bio-distribution, obesity and Alzheimer's disease. Expert Opin Drug Metab Toxicol 2009; 5:523-8.

Dvir E, Friedman JE, Lee JY et al. A novel phospholipid derivative of indomethacin, DP-155 [mixture of 1-steroyl and 1-palmitoyl-2-{6-[1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl acetamido]hexanoyl}-sn-glycero-3-phosophatidyl [corrected] choline], shows superior safety and similar efficacy in reducing brain amyloid beta in an Alzheimer's disease model. J Pharmacol Exp Ther 2006; 318:1248-56.

Dvorák Z, Modriansky M, Pichard-Garcia L et al. Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9, and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation. Mol Pharmacol 2003; 64:160-9.

Dvorák Z, Ulrichová J, Modrianský M, Maurel P. Effect of colchicine and its derivatives on the expression of selected isoforms of cytochrome P450 in primary cultures of human hepatocytes. Acta Univ Palacki Olomuc Fac Med 2000; 143:47-50.

Dvorak Z, Ulrichova J, Pichard-Garcia L, Modriansky M, Maurel P. Comparative effect of colchicine and colchiceine on cytotoxicity and CYP gene expression in primary human hepatocytes. Toxicol In Vitro 2002; 16:219-27.

Dvořák Z, Vrzal R, Starha P, Klanicová A, Trávníček Z. Effects of dinuclear copper(II) complexes with 6-(benzylamino)purine derivatives on AhR and PXR dependent expression of cytochromes P450 CYP1A2 and CYP3A4 genes in primary cultures of human hepatocytes. Toxicol In Vitro 2010; 24:425-9.

Dwyer JH, Allayee H, Dwyer KM et al. Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. New Eng J Med 2004; 350:29-37.

Dyer R, McMurray C. Mutant protein in Huntington disease is resistant to proteolysis in affected brain. Nat Genet 2001; 29:270-8.

Dziedziejko V, Kurzawski M, Safranow K, Chlubek D, Pawlik A. The effect of ESR1 and ESR2 gene polymorphisms on the outcome of rheumatoid arthritis treatment with leflunomide. Pharmacogenomics 2010; 12:41-7.

Eades SK, Boineau FG, Christensen ML. Increased tacrolimus levels in a pediatric renal transplant patient attributed to chronic diarrhea. Pediatr Transplant 2000; 4:63-6.

Eagling VA, Back DJ, Barry MG. Differential inhibition of cytochrome P450 isoforms by the protease inhibitors, ritonavir, saquinavir and indinavir. Br J Clin Pharmacol 1997; 44:190-4.

Eagling VA, Howe JL, Barry MJ, Back DJ. The metabolism of zidovudine by human liver microsomes in vitro: formation of 3'-amino-3'-deoxythymidine. Biochem Pharmacol 1994; 48:267-76.

Eagling VA, Profit L, Back DJ. Inhibition of the CYP3A4-mediated metabolism and P-glycoprotein-mediated transport of the HIV-1 protease inhibitor saquinavir by grapefruit juice components. Br J Clin Pharmacol 1999; 48:543-52.

Eagling VA, Tjia JF, Back DJ. Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes. Br J Clin Pharmacol 1998; 45:107-14.

Eagling VA, Wiltshire H, Whitcombe IW, Back DJ. CYP3A4-mediated hepatic metabolism of the HIV-1 protease inhibitor saquinavir in vitro. Xenobiotica 2002; 32:1-17.

Eap CB, Bender S, Gastpar M et al. Steady state plasma levels of the enantiomers of trimipramine and of its metabolites in CYP2D6-, CYP2C19- and CYP3A4/5-phenotyped patients. Ther Drug Monit 2000; 22:209-14.

Eap CB, Bertel-Laubscher R, Zullino D, Amey M, Baumann P. Marked increase of venlafaxine enantiomer concentrations as a consequence of metabolic interactions: a case report. Pharmacopsychiatry 2000; 33:112-5.

Eap CB, Bertschy G, Powell K, Baumann P. Fluvoxamine and fluoxetine do not interact in the same way with the metabolism of the enantiomers of methadone. J Clin Psychopharmacol 1997; 17:113-7.

Eap CB, Bochud M, Elston RC et al. CYP3A5 and ABCB1 genes influence blood pressure and response to treatment, and their effect is modified by salt. Hypertension 2007; 49:1007-14.

Eap CB, Bondolfi G, Zullino D et al. Concentrations of the enantiomers of fluoxetine and norfluoxetine after multiple doses of fluoxetine in cytochrome P4502D6 poor and extensive metabolizers. J Clin Psychopharmacol 2001; 21:330-4.

Eap CB, Bondolfi G, Zullino D et al. Pharmacokinetic drug interaction potential of risperidone with cytochrome p450 isozymes as assessed by the dextromethorphan, the caffeine, and the mephenytoin test. Ther Drug Monit 2001; 23:228-31.

Eap CB, Buclin T, Baumann P. Interindividual variability of the clinical pharmacokinetics of methadone: implications for the treatment of opioid dependence. Clin Pharmacokinet 2002; 41:1153-93.

Eap CB, Buclin T, Hustert E et al. Pharmacokinetics of midazolam in CYP3A4- and CYP3A5-genotyped subjects. Eur J Clin Pharmacol 2004; 60:231-6.

Eap CB, Fellay J, Buclin T et al. CYP3A activity measured by the midazolam test is not related to 3435 C >T polymorphism in the multiple drug resistance transporter gene. Pharmacogenetics 2004; 14:255-60.

Eap CB, Guentert TW, Schãublin-Loidl M et al. Plasma levels of the enantiomers of thioridazine, thioridazine 2-sulfoxide, thioridazine 2-sulfone, and thioridazine 5-sulfoxide in poor and extensive metabolizers of dextromethorphan and mephenytoin. Clin Pharmacol Ther 1996; 59:322-31.

Eap CB, Lima CA, Macciardi F, Woggon B, Powell K, Baumann P. Steady state concentrations of the enantiomers of mianserin and desmethylmianserin in poor and in homozygous and heterozygous extensive metabolizers of debrisoquine. Ther Drug Monit 1998; 20:7-13.

Eap CB, Yasui N, Kaneko S et al. Effects of carbamazepine coadministration on plasma concentrations of the enantiomers of mianserin and of its metabolites. Ther Drug Monit 1999; 21:166-70.

Eason DD, Shepherd AT, Blanck G. Interferon regulatory factor 1 tryptophan 11 to arginine point mutation abolishes DNA binding. Biochim Biophys Acta 1999; 1446:140-4.

Easterbrook J, Fackett D, Li AP. A comparison of aroclor 1254-induced and uninduced rat liver microsomes to human liver microsomes in phenytoin O-deethylation, coumarin 7-hydroxylation, tolbutamide 4-hydroxylation, S-mephenytoin 4'-hydroxylation, chloroxazone 6-hydroxylation and testosterone 6beta-hydroxylation. Chem Biol Interact 2001; 134:243-9.

Easterbrook J, Lu C, Sakai Y, Li AP. Effects of organic solvents on the activities of cytochrome P450 isoforms, UDP-dependent glucuronyl transferase, and phenol sulfotransferase in human hepatocytes. Drug Metab Dispos 2001; 29:141-4.

Easton DF, Bishop DT, Ford D, Crockford GP. Breast Cancer Linkage Consortium: Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. Am J Hum Genet 1993; 52:678-701.

Easton DF, Deffenbaugh AM, Pruss D et al. A systematic genetic assessment of 1,433 sequence variants of unknown clinical significance in the BRCA1 and BRCA2 breast cancer-predisposition genes. Am J Hum Genet 2007; 81:873-83.

Easton N, Fry J, O'Shea E, Watkins A, Kingston S, Marsden CA. Synthesis, in vitro formation, and behavioural effects of glutathione regioisomers of alpha-methyldopamine with relevance to MDA and MDMA (ecstasy). Brain Res 2003; 987:144-54.

Eaton DL. Biotransformation enzyme polymorphism and pesticide susceptibility. Neurotoxicology 2000; 21:101-11.

Ebbin AJ, Huntley C, Tranquada RE. Symptomatic leucine sensitivity in a mother and daughter. Metabolism 1967; 16:926-32.

Ebdrup S, Refsgaard HH, Fledelius C, Jacobsen P. Synthesis and structure-activity relationship for a novel class of potent and selective carbamate-based inhibitors of hormone selective lipase with acute in vivo antilipolytic effects. J Med Chem 2007; 50:5449-56.

Ebert B, Kisiela M, Malátková P, El-Hawari Y, Maser E. Regulation of human carbonyl reductase 3 (CBR3; SDR21C2) expression by Nrf2 in cultured cancer cells. Biochemistry 2010; 49:8499-511.

Ebert B, Kisiela M, Wsól V, Maser E. Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29. Chem Biol Interact 2011; 191:239-49.

Eberwein P, Hiss S, Auw-Haedrich C et al. Epithelial marker expression in Salzmann nodular degeneration shows characteristics of limbal transient amplifying cells and alludes to an involvement of the epithelium in its pathogenesis. Acta Ophthalmol 2010; 88:184-9.

Ebina M, Shibazaki M, Kudo K, Kasai S, Kikuchi H. Correlation of dysfunction of nonmuscle myosin IIA with increased induction of Cyp1a1 in Hepa-1 cells. Biochim Biophys Acta 2011; 1809:176-83.

Ebisawa A, Hiratsuka M, Sakuyama K, Konno Y, Sasaki T, Mizugaki M. Two novel single nucleotide polymorphisms (SNPs) of the CYP2D6 gene in Japanese individuals. Drug Metab Pharmacokinet 2005; 20:294-9.

Ebisawa T, Kajimura N, Uchiyama M et al. Alleic variants of human melatonin 1a receptor: function and prevalence in subjects with circadian rhythm sleep disorders. Biochem Biophys Res Commun 1999; 262:832-7.

Ebmeier CC, Anderson RJ. Human thyroid phenol sulfotransferase enzymes 1A1 and 1A3: activities in normal and diseased thyroid glands, and inhibition by thyroid hormones and phytoestrogens. J Clin Endocrinol Metab 2004; 89:5597-605.

Ebrahim S, Lawlor DA, Shlomo YB et al. Alcohol dehydrogenase type 1C (ADH1C) variants, alcohol consumption traits, HDL-cholesterol and risk of coronary heart disease in women and men: British Women's Heart and Health Study and Caerphilly cohorts. Atherosclerosis 2008; 196:871-8.

Ebrahimi A, Houshmand M, Tonekaboni SH, Fallah Mahboob Passand MS, Zainali S, Moghadasi M. Two novel mutations in SCN1A gene in Iranian patients with epilepsy. Arch Med Res 2010; 41:207-14.

Ebrahimi M, Mohammadi P, Daryadel A, Baharvand H. Assessment of heat shock protein (HSP60, HSP72, HSP90, and HSC70) expression in cultured limbal stem cells following air lifting. Mol Vis 2010; 16:1680-8.

Ebstein RP, Novick O, Umansky R et al. Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking. Nat Genet1996; 12:78-80.

Eck P, Erichsen HC, Taylor JG et al. Comparison of the genomic structure and variation in the two human sodium-dependent vitamin C transporters, SLC23A1 and SLC23A2. Hum Genet 2004; 4:285-94.

Ecker J, Liebisch G, Patsch W, Schmitz G. The conjugated linoleic acid isomer trans-9,trans-11 is a dietary occurring agonist of liver X receptor alpha. Biochem Biophys Res Commun 2009; 388:660-6.

Eckermann G, Lahu G, Nassr N, Bethke TD. Absence of pharmacokinetic interaction between roflumilast and digoxin in healthy adults. J Clin Pharmacol 2011. doi:10. 1177/0091270010389467.

Eckey R, Agarwal DP, Saha N, Goedde HW. Detection and partial characterization of a variant form of cytosolic aldehyde dehydrogenase isozyme. Hum Genet 1986; 72:95-7.

Eckhardt LL, Farley AL, Rodriguez E et al. KCNJ2 mutations in arrhythmia patients referred for LQT testing: a mutation T305A with novel effect on rectification properties. Heart Rhythm 2007; 4:323-9.

Eckman CB, Metha ND, Crook R et al. A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A-beta-42(43). Hum Mol Genet 1997; 6:2087-9.

Echizen H, Tanizaki M, Tatsuno J et al. Identification of CYP3A4 as the enzyme involved in the mono-N-dealkylation of disopyramide enantiomers in humans. Drug Metab Dispos 2000; 28:937-44.

Eddahibi S, Adnot S. Serotonin and pulmonary arterial hypertension. Rev Mal Respir 2006; 23:45-51.

Edenberg HJ. Regulation of the mammalian alcohol dehydrogenase genes. Prog Nucleic Acids Res Molec Biol 2000; 64:295-341.

Edenberg HJ. The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants. Alcohol Res Health 2007; 30:5-13.

Edenberg HJ, Xuei X, Chen HJ et al. Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis. Hum Mol Genet 2006; 15:1539-49.

Eder C, Frankenberger M, Stanzel F et al. Ultrafine carbon particles down-regulate CYP1B1 expression in human monocytes. Part Fibre Toxicol 2009; 6:27.

Edin ML, Wang Z, Bradbury JA et al. Endothelial expression of human cytochrome P450 epoxygenase CYP2C8 increases susceptibility to ischemia-reperfusion injury in isolated mouse heart. FASEB J 2011; 25:3436-47.

Edison E, Shaji RV, Srivastava A, Chandy M. Hyperbilirubinemia in homozygous HbE disease is associated with the UGT1A1 gene polymorphism. Hemoglobin 2005; 29:189-95.

Edmondson AC, Braund PS, Stylianou IM et al. Dense genotyping of candidate gene loci identifies variants associated with high-density lipoprotein cholesterol. Circ Cardiovasc Genet 2011; 4:145-55.

Edsbäcker S, Andersson T. Pharmacokinetics of budesonide (Entocort EC) capsules for Crohn's disease. Clin Pharmacokinet 2004; 43:803-21.

Edvardsen H, Brunsvig PF, Solvang H et al. SNPs in genes coding for ROS metabolism and signalling in association with docetaxel clearance. Pharmacogenomics J 2010; 10:513-23.

Edwards DJ, Fitzsimmons ME, Schuetz EG et al. 6',7'-Dihydroxybergamottin in grapefruit juice and Seville orange juice: effects on cyclosporine disposition, enterocyte CYP3A4, and P-glycoprotein. Clin Pharmacol Ther 1999; 65:237-44.

Edwards FL, Tchounwou PB. Environmental toxicology and health effects associated with methyl parathion exposure-a scientific review. Int J Environ Res Public Health 2005; 2:430-41.

Edwards RJ, Adams DA, Watts PS, Davies DS, Boobis AR. Development of a comprehensive panel of antibodies against the major xenobiotic metabolising forms of cytochrome P450 in humans. Biochem Pharmacol 1998; 56:377-87.

Edwards RJ, Price RJ, Watts PS et al. Induction of cytochrome P450 enzymes in cultured precision-cut human liver slices. Drug Metab Dispos 2003; 31:282-8.

Edwards RJ, Singleton AM, Murray BP, Davies DS, Boobis AR. Short synthetic peptides exploited for reliable and specific targeting of antibodies to the C-termini of cytochrome P450 enzymes. Biochem Pharmacol 1995; 49:39-47.

Edwards TL, Gilbert JR, Haines JL, Martin ER, Pericak-Vance M, Ritchie MD. An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3. Am J Med Genet B Neuropsychiatr Genet 2009; 150:721-35.

Edwards TL, Pericak-Vance M, Gilbert JR, Haines JL, Martin ER, Ritchie MD. An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3. Am J Med Genet B Neuropsychiatr Genet 2009; 150:721-35.

Eechoute K, Sparreboom A, Burger H et al. Drug transporters and imatinib treatment: implications for clinical practice. Clin Cancer Res 2011; 17:406-15.

Efendiev R, Krmar RT, Ogimoto G et al. Hypertension-linked mutation in the adducin alpha-subunit leads to higher AP2-mu-2 phosphorylation and impaired Na+, K+-ATPase trafficking in response to GPCR signals and intracellular sodium. Circ Res 2004; 95:1100-8.

Effendi K, Mori T, Komuta M, Masugi Y, Du W, Sakamoto M. Bmi-1 gene is upregulated in early-stage hepatocellular carcinoma and correlates with ATP-binding cassette transporter B1 expression. Cancer Sci 2010; 101:666-72.

Efrati E, Elkin H, Sprecher E, Krivoy N. Distribution of CYP2C9 and VKORC1 risk alleles for warfarin sensitivity and resistance in the Israeli population. Curr Drug Saf 2010; 5:190-3.

Egan MF, Straub RE, Goldberg TE et al. Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia. Proc Natl Acad Sci USA 2004; 101:12604-9.

Egashira K, Ohtani H, Itoh S et al. Inhibitory effects of pomelo on the metabolism of tacrolimus and the activities of CYP3A4 and P-glycoprotein. Drug Metab Dispos 2004; 32:828-33.

Egecioglu E, Bjursell M, Ljungberg A et al. Growth hormone receptor deficiency results in blunted ghrelin feeding response, obesity, and hypolipidemia in mice. Am J Physiol Endocrinol Metab 2006; 290:317-25.

Egensperger R, Bancher C, Kosel S et al. The apolipoprotein E epsilon-4 allele in Parkinson's disease with Alzheimer's lesions. Biochem Biophys Res Commun 1996; 224:484-6.

Egnell AC, Houston B, Boyer S. In vivo CYP3A4 heteroactivation is a possible mechanism for the drug interaction between felbamate and carbamazepine. J Pharmacol Exp Ther 2003; 305:1251-62.

Egnell AC, Houston JB, Boyer CS. Predictive models of CYP3A4 Heteroactivation: in vitro-in vivo scaling and pharmacophore modeling. J Pharmacol Exp Ther 2005; 312:926-37.

Egorin MJ, Rosen DM, Wolff JH, Callery PS, Musser SM, Eiseman JL. Metabolism of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) by murine and human hepatic preparations. Cancer Res 1998; 58:2385-96.

Ehata S, Johansson E, Katayama R et al. Transforming growth factor-β decreases the cancer-initiating cell population within diffuse-type gastric carcinoma cells. Oncogene 2011; 30:1693-705.

Ehlers CL. Variations in ADH and ALDH in Southwest California Indians. Alcohol Res Health 2007; 30:14-7.

Ehmer U, Vogel A, Schütte JK, Krone B, Manns MP, Strassburg CP. Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4. Hepatology 2004; 39:970-7.

Ehnert S, Nussler AK, Lehmann A, Dooley S. Blood monocyte-derived neohepatocytes as in vitro test system for drug metabolism. Drug Metab Dispos 2008; 36:1922-9.

Ehnert S, Seeliger C, Vester H et al. Autologous serum improves yield and metabolic capacity of monocyte-derived hepatocyte-like cells: possible implication for cell transplantation. Cell Transplant 2011. doi:10. 3727/096368910X550224.

Ehret GB, Desmeules JA, Broers B. Methadone-associated long QT syndrome: improving pharmacotherapy for dependence on illegal opioids and lessons learned for pharmacology. Expert Opin Drug Saf 2007; 6:289-303.

Ehringer MA, Clegg HV, Collins AC et al. Association of the neuronal nicotinic receptor beta2 subunit gene (CHRNB2) with subjective responses to alcohol and nicotine. Am J Med Genet B Neuropsychiatr Genet 2007; 144:596-604.

Eichelbaum M, Baur MP, Dengler HJ et al. Chromosomal assignment of human cytochrome P-450 (debrisoquine/sparteine type) to chromosome 22. Br J Clin Pharmacol 1987; 23:455-8.

Eichelbaum M, Ingelman-Sundberg M, Evans WE. Pharmacogenomics and individualized drug therapy. Annu Rev Med 2006; 57:119-37.

Eichelbaum M, Spannbrucker N, Steincke B, Dengler HJ. Defective N-oxidation of sparteine in man: a new pharmacogenetic defect. Eur J Clin Pharmacol 1979; 16:183-7.

Eicher C, Dewerth A, Kirchner B, Warmann SW, Fuchs J, Armeanu-Ebinger S. Development of a drug resistance model for hepatoblastoma. Int J Oncol 2011; 38:447-54.

Eidelman O, Zhang J, Srivastava M, Pollard HB. Cystic fibrosis and the use of pharmacogenomics to determine surrogate endpoints for drug discovery. Am J Pharmacogenomics 2001; 1:223-38.

Eiden C, Cociglio M, Hillaire-Buys D et al. Pharmacokinetic variability of voriconazole and N-oxide voriconazole measured as therapeutic drug monitoring. Xenobiotica 2010; 40:701-6.

Eiden C, Palenzuela G, Hillaire-Buys D et al. Posaconazole-increased vincristine neurotoxicity in a child: a case report. J Pediatr Hematol Oncol 2009; 31:292-5.

Eiermann B, Engel G, Johansson I, Zanger UM, Bertilsson L. The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine. Br J Clin Pharmacol 1997; 44:439-46.

Eijgelsheim M, Visser LE, Uitterlinden AG, Stricker BH. Protective effect of a GRK5 polymorphism on heart failure and its interaction with beta-adrenergic receptor antagonists. Pharmacogenomics 2008; 9:1551-5.

Eilertsen KE, Mæhre HK, Cludts K, Olsen JO, Hoylaerts MF. Dietary enrichment of apolipoprotein E-deficient mice with extra virgin olive oil in combination with seal oil inhibits atherogenesis. Lipids Health Dis 2011; 10:41.

Einarsdóttir K, Darabi H, Li Y et al. ESR1 and EGF genetic variation in relation to breast cancer risk and survival. Breast Cancer Res 2008; 10:15.

Einbond LS, Soffritti M, Esposti DD et al. Actein activates stress- and statin-associated responses and is bioavailable in Sprague-Dawley rats. Fundam Clin Pharmacol 2009; 23:311-21.

Einem Lindeman T, Poirier MC, Divi RL. The resveratrol analogue, 2,3',4,5'-tetramethoxystilbene, does not inhibit CYP gene expression, enzyme activity and benzo[a]pyrene-DNA adduct formation in MCF-7 cells exposed to benzo[a]pyrene. Mutagenesis 2011; 26:629-35.

Einstein MH, Leanza S, Chiu LG et al. Genetic variants in TAP are associated with high-grade cervical neoplasia. Clin Cancer Res 2009; 15:1019-23.

Eis PS, Garcia-Blanco MA. Quantification of microRNAs, splicing isoforms, and homologous mRNAs with the invader assay. Methods Mol Biol 2008; 488:279-318.

Eisele S, Garbe E, Zeitz M, Schneider T, Somasundaram R. Ciprofloxacin-related acute severe myalgia necessitating emergency care treatment: a case report and review of the literature. Int J Clin Pharmacol Ther 2009; 47:165-8.

Eiselt R, Domanski TL, Zibat A et al. Identification and functional characterization of eight CYP3A4 protein variants. Pharmacogenetics 2001; 11:447-58.

Eisenach JH, McGuire AM, Schwingler RM, Turner ST, Joyner MJ. The Arg16/Gly beta2-adrenergic receptor polymorphism is associated with altered cardiovascular responses to isometric exercise. Physiol Genomics 2004; 16:323-8.

Eisenhardt A, Sperling H, Hauck E et al. ACE gene I/D and NOS3 G894T polymorphisms and response to sildenafil in men with erectile dysfunction. Urology 2003; 62:152-7.

Eisenmann KM, Dykema KJ, Matheson SF et al. 5q- myelodysplastic syndromes: chromosome 5q genes direct a tumor-suppression network sensing actin dynamics. Oncogene 2009; 28:3429-41.

Ejsing TB, Pedersen AD, Linnet K. P-glycoprotein interaction with risperidone and 9-OH-risperidone studied in vitro, in knock-out mice and in drug-drug interaction experiments. Hum Psychopharmacol 2005; 20:493-500.

Ek CJ, Wong A, Liddelow SA, Johansson PA, Dziegielewska KM, Saunders NR. Efflux mechanisms at the developing brain barriers: ABC-transporters in the fetal and postnatal rat. Toxicol Lett 2010; 197:51-9.

Ek M, Söderdahl T, Küppers-Munther B et al. Expression of drug metabolizing enzymes in hepatocyte-like cells derived from human embryonic stem cells. Biochem Pharmacol 2007; 74:496-503.

Ekhart C, Doodeman VD, Rodenhuis S, Smits PH, Beijnen JH, Huitema AD. Influence of polymorphisms of drug metabolizing enzymes (CYP2B6, CYP2C9, CYP2C19, CYP3A4, CYP3A5, GSTA1, GSTP1, ALDH1A1 and ALDH3A1) on the pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide. Pharmacogenet Genomics 2008; 18:515-23.

Ekhart C, Doodeman VD, Rodenhuis S, Smits PH, Beijnen JH, Huitema AD. Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa. Br J Clin Pharmacol 2009; 67:50-60.

Ekhart C, Rodenhuis S, Smits PH, Beijnen JH, Huitema AD. Relations between polymorphisms in drug-metabolising enzymes and toxicity of chemotherapy with cyclophosphamide, thiotepa and carboplatin. Pharmacogenet Genomics 2008; 18:1009-15.

Ekhart C, Rodenhuis S, Smits PH, Beijnen JH, Huitema AD. An overview of the relations between polymorphisms in drug metabolising enzymes and drug transporters and survival after cancer drug treatment. Cancer Treat Rev 2009; 35:18-31.

Ekins S, Berbaum J, Harrison RK. Generation and validation of rapid computational filters for cyp2d6 and cyp3a4. Drug Metab Dispos 2003; 31:1077-80.

Ekins S, Bravi G, Binkley S et al. Three- and four-dimensional quantitative structure activity relationship analyses of cytochrome P-450 3A4 inhibitors. J Pharmacol Exp Ther 1999; 290:429-38.

Ekins S, Bravi G, Wikel JH, Wrighton SA. Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates. J Pharmacol Exp Ther 1999; 291:424-33.

Ekins S, Bugrim A, Brovold L et al. Algorithms for network analysis in systems-ADME/Tox using the MetaCore and MetaDrug platforms. Xenobiotica 2006; 36:877-901.

Ekins S, Stresser DM, Williams JA. In vitro and pharmacophore insights into CYP3A enzymes. Trends Pharmacol Sci 2003; 24:161-6.

Ekroos M, Sjögren T. Structural basis for ligand promiscuity in cytochrome P450 3A4. Proc Natl Acad Sci USA 2006; 103:13682-7.

Ekström G, Gunnarsson UB. Ropivacaine, a new amide-type local anesthetic agent, is metabolized by cytochromes P450 1A and 3A in human liver microsomes. Drug Metab Dispos 1996; 24:955-61.

El BK, Hashimoto Y, Muzandu K et al. Protective effect of Pleurotus cornucopiae mushroom extract on carbon tetrachloride-induced hepatotoxicity. Jpn J Vet Res 2009; 57:109-18.

El Desoky ES, Mohamed HO, Farghaly WM, Hamed SA, Hedaya MA, Siest JP. Study of urinary 6 beta-hydroxycortisol/cortisol ratio in spot urine sample as a biomarker of 3A4 enzyme activity in healthy and epileptic subjects of Egyptian population. Pharmacol Res 2005; 51:575-80.

El Ela AA, Härtter S, Schmitt U, Hiemke C, Spahn-Langguth H, Langguth P. Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds-implications for pharmacokinetics of selected substrates. J Pharm Pharmacol 2004; 56:967-75.

El Gendy MA, El-Kadi AO. Peganum harmala L. differentially modulates cytochrome P450 gene expression in human hepatoma HepG2 cells. Drug Metab Lett 2009; 3:212-6.

El Hallani S, Ducray F, Idbaih A et al. TP53 codon 72 polymorphism is associated with age at onset of glioblastoma. Neurology 2009; 72:332-6.

El Moghrabi S, Houillier P, Picard N et al. Tissue kallikrein permits early renal adaptation to potassium load. Proc Natl Acad Sci USA 2010; 107:13526-31.

El Mouelhi M, Worley DJ, Kuzmak B, Destefano AJ, Thompson GA. Influence of azimilide on CYP2C19-mediated metabolism. J Clin Pharmacol 2004; 44:373-8.

El Mouelhi M, Worley DJ, Kuzmak B, Destefano AJ, Thompson GA. Influence of ketoconazole on azimilide pharmacokinetics in healthy subjects. Br J Clin Pharmacol 2004; 58:641-7.

Elahi A, Bendaly J, Zheng Z et al. Detection of UGT1A10 polymorphisms and their association with orolaryngeal carcinoma risk. Cancer 2003; 98:872-80.

Elahian F, Kalalinia F, Behravan J. Dexamethasone downregulates BCRP mRNA and protein expression in breast cancer cell lines. Oncol Res 2009; 18:9-15.

Elahian F, Kalalinia F, Behravan J. Evaluation of indomethacin and dexamethasone effects on BCRP-mediated drug resistance in MCF-7 parental and resistant cell lines. Drug Chem Toxicol 2010; 33:113-9.

ElAli A, Hermann DM. Apolipoprotein E controls ATP-binding cassette transporters in the ischemic brain. Sci Signal 2010; 3:ra72.

el-Ashmawy IM, el-Nahas AF, Bayad AE. Teratogenic and cytogenetic effects of ivermectin and its interaction with P-glycoprotein inhibitor. Res Vet Sci 2011; 90:116-23.

Elazar M, Liu M, McKenna SA et al. The anti-hepatitis C agent nitazoxanide induces phosphorylation of eukaryotic initiation factor 2alpha via protein kinase activated by double-stranded RNA activation. Gastroenterology 2009; 137:1827-35.

Elbarbry F, Ragheb A, Attia A, Chibbar R, Marfleet T, Shoker A. Cyclosporine-induced changes in drug metabolizing enzymes in hyperlipemic rabbit kidneys could explain its toxicity. Xenobiotica 2010; 40:772-81.

El-Batch M, Hassan AM, Mahmoud HA. Taurine is more effective than melatonin on cytochrome P450 2E1 and some oxidative stress markers in streptozotocin-induced diabetic rats. J Agric Food Chem 2011; 59:4995-5000.

Elbaz A, Levecque C, Clavel J et al. CYP2D6 polymorphism, pesticide exposure, and Parkinson's disease. Ann Neurol 2004; 55:430-4.

Elder JT. PSORS1: linking genetics and immunology. J Invest Dermatol 2006; 126:1205-6.

Eldesoky ES, Kamel SI, Farghaly AM, Bakheet MY, Hedaya MA, Siest JP. Study of the Urinary Ratio of 6 beta-Hydroxycortisol/Cortisol as a Biomarker of CYP3A4 Activity in Egyptian Patients with Chronic Liver Diseases. Biomark Insights 2007; 1:157-64.

Elefteriou F, Ahn JD, Takeda S et al. Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature 2005; 434:514-20.

Eleftheriou G, Bacis G, Fiocchi R, Sebastiano R. Colchicine-induced toxicity in a heart transplant patient with chronic renal failure. Clin Toxicol 2008; 46:827-30.

Elens L, Vandercam B, Yombi JC, Lison D, Wallemacq P, Haufroid V. Influence of host genetic factors on efavirenz plasma and intracellular pharmacokinetics in HIV-1-infected patients. Pharmacogenomics 2010; 11:1223-34.

Elens L, Yombi JC, Lison D, Wallemacq P, Vandercam B, Haufroid V. Association between ABCC2 polymorphism and lopinavir accumulation in peripheral blood mononuclear cells of HIV-infected patients. Pharmacogenomics 2009; 10:1589-97.

Elewski B, Tavakkol A. Safety and tolerability of oral antifungal agents in the treatment of fungal nail disease: a proven reality. Ther Clin Risk Manag 2005; 1:299-306.

El-Gayar S, Ganesh A, Chavarria-Soley G et al. Molecular analysis of CYP1B1 in Omani patients with primary congenital glaucoma: a pilot study. Mol Vis 2009; 15:1325-31.

Elia J, Capasso M, Zaheer Z et al. Candidate gene analysis in an on-going genome-wide association study of attention-deficit hyperactivity disorder: suggestive association signals in ADRA1A. Psychiatr Genet 2009; 19:134-41.

Elias-Sonnenschein LS, Viechtbauer W, Ramakers IH, Verhey FR, Visser PJ. Predictive value of APOE-{varepsilon}4 allele for progression from MCI to AD-type dementia: a meta-analysis. J Neurol Neurosurg Psychiatry 2011; 82:1149-56.

Elipe MV, Huskey SE, Zhu B. Application of LC-NMR for the study of the volatile metabolite of MK-0869, a substance P receptor antagonist. J Pharm Biomed Anal 2003; 30:1431-40.

Elisei R, Romei C, Cosci B et al. RET genetic screening in patients with medullary thyroid cancer and their relatives: experience with 807 individuals at one center. J Clin Endocr Metab 2007; 92:4725-9.

Elizondo G, Medina-Díaz IM. Induction of CYP3A4 by 1alpha,25-dyhydroxyvitamin D3 in HepG2 cells. Life Sci 2003; 73:141-9.

Elkader A, Sproule B. Buprenorphine: clinical pharmacokinetics in the treatment of opioid dependence. Clin Pharmacokinet 2005; 44:661-80.

Elkahwaji J, Robin MA, Berson A et al. Decrease in hepatic cytochrome P450 after interleukin-2 immunotherapy. Biochem Pharmacol 1999; 57:951-4.

Elkalioubie A, Allorge D, Robriquet L et al. Near-fatal tramadol cardiotoxicity in a CYP2D6 ultrarapid metabolizer. Eur J Clin Pharmacol 2011; 67:855-8.

Elkayam T, Amitay-Shaprut S, Dvir-Ginzberg M, Harel T, Cohen S. Enhancing the drug metabolism activities of C3A-a human hepatocyte cell line-by tissue engineering within alginate scaffolds. Tissue Eng 2006; 12:1357-68.

El-Khamisy SF, Katyal S, Patel P, Ju L, McKinnon PJ, Caldecott KW. Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin. DNA Repair 2009; 8:760-6.

Elkins JS, Douglas VC, Johnston SC. Alzheimer disease risk and genetic variation in ACE: a meta-analysis. Neurology 2004; 62:363-8.

El-Lakkany NM, Seif el-Din SH, Badawy AA, Ebeid FA. Effect of artemether alone and in combination with grapefruit juice on hepatic drug-metabolising enzymes and biochemical aspects in experimental Schistosoma mansoni. Int J Parasitol 2004; 34:1405-12.

Elmeliegy MA, Carcaboso AM, Tagen M, Bai F, Stewart CF. Role of ATP-binding cassette and solute carrier transporters in erlotinib CNS penetration and intracellular accumulation. Clin Cancer Res 2011; 17:89-99.

El-Omar EM, Carrington M, Chow WH et al. Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature 2000; 404:398-402.

El-Rayes BF, Gadgeel S, Parchment R, Lorusso P, Philip PA. A phase I study of flavopiridol and docetaxel. Invest New Drugs 2006; 24:305-10.

El-Rayes BF, Gadgeel S, Shields AF, Manza S, Lorusso P, Philip PA. Phase I study of bryostatin 1 and gemcitabine. Clin Cancer Res 2006; 12:7059-62.

El-Remessy AB, Rajesh M, Mukhopadhyay P et al. Cannabinoid 1 receptor activation contributes to vascular inflammation and cell death in a mouse model of diabetic retinopathy and a human retinal cell line. Diabetologia 2011; 54:1567-78.

El-Sankary W, Bombail V, Gibson GG, Plant N. Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element. Drug Metab Dispos 2002; 30:1029-34.

El-Sankary W, Gibson GG, Ayrton A, Plant N. Use of a reporter gene assay to predict and rank the potency and efficacy of CYP3A4 inducers. Drug Metab Dispos 2001; 29:1499-504.

El-Sankary W, Plant NJ, Gibson GG, Moore DJ. Regulation of the CYP3A4 gene by hydrocortisone and xenobiotics: role of the glucocorticoid and pregnane X receptors. Drug Metab Dispos 2000; 28:493-6.

El-Sayed WM. Effect of pregnane X receptor (PXR) prototype agonists on chemoprotective and drug metabolizing enzymes in mice. Eur J Pharmacol 2011; 660:291-7.

Elsby R, Gillen M, Butters C et al. The utility of in vitro data in making accurate predictions of human P-glycoprotein-mediated drug-drug interactions: a case study for AZD5672. Drug Metab Dispos 2011; 39:275-82.

El-Sheikh AA, van den Heuvel JJ, Koenderink JB, Russel FG. Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP) 2/ABCC2- and MRP4/ABCC4-mediated methotrexate transport. J Pharmacol Exp Ther 2007; 320:229-35.

El-Sheikh AA, van den Heuvel JJ, Koenderink JB, Russel FG. Effect of hypouricaemic and hyperuricaemic drugs on the renal urate efflux transporter, multidrug resistance protein 4. Br J Pharmacol 2008; 155:1066-75.

El-Sheikh AA, van den Heuvel JJ, Krieger E, Russel FG, Koenderink JB. Functional role of arginine 375 in transmembrane helix 6 of multidrug resistance protein 4 (MRP4/ABCC4). Mol Pharmacol 2008; 74:964-71.

El-Shennawy GA, Elbialy AA, Isamil AE, El Behery MM. Is genetic polymorphism of ER-α, CYP1A1, and CYP1B1 a risk factor for uterine leiomyoma? Arch Gynecol Obstet 2011; 283:1313-8.

Elsherbiny ME, El-Kadi AO, Brocks DR. The effect of beta-naphthoflavone on the metabolism of amiodarone by hepatic and extra-hepatic microsomes. Toxicol Lett 2010; 195:147-54.

Elvang AB, Volbracht C, Pedersen LØ et al. Differential effects of gamma-secretase and BACE1 inhibition on brain Abeta levels in vitro and in vivo. J Neurochem 2009; 110:1377-87.

Ellard S, Bellanné-Chantelot C, Hattersley AT; European Molecular Genetics Quality Network (EMQN) MODY group. Best practice guidelines for the molecular genetic diagnosis of maturity-onset diabetes of the young. Diabetologia 2008; 51:546-53.

Ellard S, Colclough K. Mutations in the genes encoding the transcription factors hepatocyte nuclear factor 1 alpha (HNF1A) and 4 alpha (HNF4A) in maturity-onset diabetes of the young. Hum Mutat 2006; 27:854-69.

Elleuch N, Depienne C, Benomar A et al. Mutation analysis of the paraplegin gene (SPG7) in patients with hereditary spastic paraplegia. Neurology 2006; 66:654-9.

Ellfolk M, Norlin M, Gyllensten K, Wikvall K. Regulation of human vitamin D(3) 25-hydroxylases in dermal fibroblasts and prostate cancer LNCaP cells. Mol Pharmacol 2009; 75:1392-9.

Ellingrod VL, Bishop JR, Moline J, Lin YC, Miller del D. Leptin and leptin receptor gene polymorphisms and increases in body mass index (BMI) from olanzapine treatment in persons with schizophrenia. Psychopharmacol Bull 2007; 40:57-62.

Ellingrod VL, Miller D, Schultz SK, Wehring H, Arndt S. CYP2D6 polymorphisms and atypical antipsychotic weight gain. Psychiatr Genet 2002; 12:55-8.

Ellingrod VL, Perry PJ. Nefazodone: a new antidepressant. Am J Health Syst Pharm 1995; 52:2799-812.

Ellingrod VL, Schultz SK, Arndt S. Association between cytochrome P4502D6 (CYP2D6) genotype, antipsychotic exposure, and abnormal involuntary movement scale (AIMS) score. Psychiatr Genet 2000; 10:9-11.

Ellinor PT, Nam EG, Shea MA, Milan DJ, Ruskin JN, MacRae CA. Cardiac sodium channel mutation in atrial fibrillation. Heart Rhythm 2008; 1:99-105.

Elliot DJ, Suharjono, Lewis BC et al. Identification of the human cytochromes P450 catalysing the rate-limiting pathways of gliclazide elimination. Br J Clin Pharmacol 2007; 64:450-7.

Elliott DA, Weickert CS, Garner B. Apolipoproteins in the brain: implications for neurological and psychiatric disorders. Clin Lipidol 2010; 51:555-73.

Elliott SL, Crawford C, Mulligan E et al. Mitoxantrone in combination with an inhibitor of DNA-dependent protein kinase: a potential therapy for high risk B-cell chronic lymphocytic leukaemia. Br J Haematol 2011; 152:61-71.

Ellis CE, Frielle T. Characterization of two human beta-1-adrenergic receptor transcripts: cloning and alterations in the failing heart. Biochem Biophys Res Commun 1999; 258:552-8.

Ellis JA, Stebbing M, Harrap SB. Polymorphism of the androgen receptor gene is associated with male pattern baldness. J Invest Dermatol 2001; 116:452-5.

Ellsworth DL, Coady SA, Chen W et al. Influence of the beta2-adrenergic receptor Arg16Gly polymorphism on longitudinal changes in obesity from childhood through young adulthood in a biracial cohort: the Bogalusa Heart Study. Int J Obes Relat Metab Disord 2002; 26:928-37.

Ellsworth DL, Coady SA, Chen W, Srinivasan SR, Boerwinkle E, Berenson GS. Interactive effects between polymorphisms in the beta-adrenergic receptors and longitudinal changes in obesity. Obes Res 2005; 13:519-26.

Ema M, Matsushita N, Sogawa K et al. Human arylhydrocarbon receptor: functional expression and chromosomal assignment to 7p21. J Biochem 1994; 116:845-51.

Emi M, Keicho N, Tokunaga K et al. Association of diffuse panbronchiolitis with microsatellite polymorphism of the human interleukin 8 (IL-8) gene. J Hum Genet 1999; 44:169-72.

Emi Y, Nomura S, Yokota H, Sakaguchi M. ATP-binding cassette transporter isoform C2 localizes to the apical plasma membrane via interactions with scaffolding protein. J Biochem 2011; 149:177-89.

Emile JF, Lamhamedi S, Le Deist F et al. Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency. Science 1998; 80:1432-5.

Emile JF, Théou N, Tabone S et al. Clinicopathologic, phenotypic, and genotypic characteristics of gastrointestinal mesenchymal tumors. Clin Gastroenterol Hepatol 2004; 2:597-605.

Emmelkamp JM, Rockstroh JK. CCR5 antagonists: comparison of efficacy, side effects, pharmacokinetics and interactions-review of the literature. Eur J Med Res 2007; 12:409-17.

Emmenegger U, Shaked Y, Man S et al. Pharmacodynamic and pharmacokinetic study of chronic low-dose metronomic cyclophosphamide therapy in mice. Mol Cancer Ther 2007; 6:2280-9.

Emmerich J, Rosendaal FR, Cattaneo M. Combined effect of factor V Leiden and prothrombin 20210A on the risk of venous thromboembolism-pooled analysis of 8 case-control studies including 2310 cases and 3204 controls. Study Group for Pooled-Analysis in Venous Thromboembolism. Thromb Haemost 2001; 86:809-16.

Emmink BL, van Houdt WJ, Vries RG et al. Differentiated human colorectal cancer cells protect tumor-initiating cells from irinotecan. Gastroenterology 2011; 141:269-78.

Emoto C, Iwasaki K. Enzymatic characteristics of CYP3A5 and CYP3A4: a comparison of in vitro kinetic and drug-drug interaction patterns. Xenobiotica 2006; 36:219-33.

Emoto C, Iwasaki K. Relative roles of CYP2C19 and CYP3A4/5 in midazolam 1'-hydroxylation. Xenobiotica 2007; 37:592-603.

Emoto C, Iwasaki K. Approach to predict the contribution of cytochrome P450 enzymes to drug metabolism in the early drug-discovery stage: the effect of the expression of cytochrome b(5) with recombinant P450 enzymes. Xenobiotica 2007; 37:986-99.

Emoto C, Murase S, Sawada Y, Iwasaki K. In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations in human liver microsomes: a comparison with SKF-525A. Drug Metab Pharmacokinet 2005; 20:351-7.

Emoto C, Murase S, Sawada Y, Jones BC, Iwasaki K. In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations catalyzed by human cytochrome P450 enzymes: a comparison with SKF-525A and ketoconazole. Drug Metab Pharmacokinet 2003; 18:287-95.

Emoto C, Murayama N, Yamazaki H. Effects of enzyme sources on midazolam 1'-hydroxylation activity catalyzed by recombinant cytochrome P450 3A4 in combination with NADPH-cytochrome P450 reductase. Drug Metab Lett 2008; 2:190-2.

Emoto C, Nishida H, Hirai H, Iwasaki K. CYP3A4 and CYP3A5 catalyse the conversion of the N-methyl-D-aspartate (NMDA) antagonist CJ-036878 to two novel dimers. Xenobiotica 2007; 37:1408-20.

Emoto C, Yamato Y, Sato Y et al. Non-invasive method to detect induction of CYP3A4 in chimeric mice with a humanized liver. Xenobiotica 2008; 38:239-48.

Endo T, Ban M, Hirata K, Yamamoto A, Hara Y, Momose Y. Involvement of CYP2A6 in the formation of a novel metabolite, 3-hydroxypilocarpine, from pilocarpine in human liver microsomes. Drug Metab Dispos 2007; 35:476-83.

Endres K, Fahrenholz F. Upregulation of the alpha-secretase ADAM10-risk or reason for hope? FEBS J 2010; 277:1585-96.

Endringer DC, Guimarães KG, Kondratyuk TP, Pezzuto JM, Braga FC. Selective inhibition of aromatase by a dihydroisocoumarin from Xyris pterygoblephara. J Nat Prod 2008; 71:1082-4.

Endrizzi K, Fischer J, Klein K et al. Discriminative quantification of cytochrome P4502D6 and 2D7/8 pseudogene expression by TaqMan real-time reverse transcriptase polymerase chain reaction. Anal Biochem 2002; 300:121-31.

Eng C, Crossey PA, Mulligan LM et al. Mutations in the RET proto-oncogene and the von Hippel-Lindau disease tumour suppressor gene in sporadic and syndromic phaeochromocytomas. J Med Genet 1995; 32:934-7.

Eng KT, Berdis AJ. A novel non-natural nucleoside that influences P-glycoprotein activity and mediates drug resistance. Biochemistry 2010; 49:1640-8.

Engblom D, Saha S, Engstrom L et al. Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis. Nat Neurosci 2003; 6:1137-8.

Engdal S, Nilsen OG. In vitro inhibition of CYP3A4 by herbal remedies frequently used by cancer patients. Phytother Res 2009; 23:906-12.

Engel G, Hofmann U, Heidemann H, Cosme J, Eichelbaum M. Antipyrine as a probe for human oxidative drug metabolism: identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation. Clin Pharmacol Ther 1996; 59:613-23.

Engel T, Kannenberg F, Fobker M et al. Expression of ATP binding cassette-transporter ABCG1 prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol. FEBS Lett 2007; 581:1673-80.

Engelborghs S, Dermaut B, Goeman J et al. Prospective Belgian study of neurodegenerative and vascular dementia: APOE genotype effects. J Neurol Neurosurg Psychiatry 2003; 74:1148-51.

Engelender S, Sharp A, Colomer V et al. Huntingtin-associated protein 1 (HAP1) interacts with the p150(Glued) subunit of dynactin. Hum Molec Genet 1997; 6:2205-12.

Engelman JA, Zejnullahu K, Mitsudomi T et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 2007; 316:1039-43.

Engels FK, Mathot RA, Loos WJ, van Schaik RH, Verweij J. Influence of high-dose ketoconazole on the pharmacokinetics of docetaxel. Cancer Biol Ther 2006; 5:833-9.

Engels FK, Ten Tije AJ, Baker SD et al. Effect of cytochrome P450 3A4 inhibition on the pharmacokinetics of docetaxel. Clin Pharmacol Ther 2004; 75:448-54.

Engler JR, Frede A, Saunders VA, Zannettino AC, Hughes TP, White DL. Chronic myeloid leukemia CD34+ cells have reduced uptake of imatinib due to low OCT-1 activity. Leukemia 2010; 24:765-70.

English BC, Baum CE, Adelberg DE et al. A SNP in CYP2C8 is not associated with the development of bisphosphonate-related osteonecrosis of the jaw in men with castrate-resistant prostate cancer. Ther Clin Risk Manag 2010; 6:579-83.

Engman H, Tannergren C, Artursson P, Lennernäs H. Enantioselective transport and CYP3A4-mediated metabolism of R/S-verapamil in Caco-2 cell monolayers. Eur J Pharm Sci 2003; 19:57-65.

Engman HA, Lennernäs H, Taipalensuu J, Otter C, Leidvik B, Artursson P. CYP3A4, CYP3A5, and MDR1 in human small and large intestinal cell lines suitable for drug transport studies. J Pharm Sci 2001; 90:1736-51.

Engqvist-Goldstein A, Kessels M, Chopra V, Hayden M, Drubin D. An actin-binding protein of the Sla2/Huntingtin interacting protein 1 family is a novel component of clathrin-coated pits and vesicles. J Clin Biol 1999; 147:1503-18.

Engström K, Vahter M, Mlakar SJ et al. Polymorphisms in arsenic(+III oxidation state) methyltransferase (AS3MT) predict gene expression of AS3MT as well as arsenic metabolism. Environ Health Perspect 2011; 119:182-8.

Enna S, Bird E, Bennett J et al. Huntington's chorea: changes in neurotransmitter receptors in the brain. New Eng J Med 1976; 294:1305-9.

Enomoto R, Koshiba C, Suzuki C, Lee E. Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects. Cancer Chemother Pharmacol 2011; 67:1063-72.

Enzinger C, Ropele S, Smith S et al. Accelerated evolution of brain atrophy and 'black holes' in MS patients with APOE-epsilon-4. Ann Neurol 2004; 55:563-9.

Enzinger C, Ropele S, Strasser-Fuchs S et al. Lower levels of N-acetylaspartate in multiple sclerosis patients with the apolipoprotein E epsilon-4 allele. Arch Neurol 2003; 60:65-70.

Eo J, Shin H, Kwon S, Song H, Murphy KM, Lim JH. Complex ovarian defects lead to infertility in Etv5-/- female mice. Mol Hum Reprod 2011; 17:568-76.

Eraly SA. Organic anion transporter 3 inhibitors as potential novel antihypertensives. Pharmacol Res 2008; 58:257-61.

Erdely A, Hulderman T, Salmen-Muniz R et al. Inhalation exposure of gas-metal arc stainless steel welding fume increased atherosclerotic lesions in apolipoprotein E knockout mice. Toxicol Lett 2011; 204:12-6.

Erdely A, Kepka-Lenhart D, Salmen-Muniz R et al. Arginase activities and global arginine bioavailability in wild-type and ApoE-deficient mice: responses to high fat and high cholesterol diets. PLoS One 2010. doi:10. 1371/journal. pone. 0015253.

Erdman AR, Mangravite LM, Urban TJ et al. The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics. Am J Physiol Renal Physiol 2006; 290:905-12.

Erdmann J, Hegemann N, Weidemann A et al. Screening the human bradykinin B2 receptor gene in patients with cardiovascular diseases: identification of a functional mutation in the promoter and a new coding variant (T21M). Am J Med Genet 1998; 80:521-5.

Erdös EG, Tan F, Skidgel RA. Angiotensin I-converting enzyme inhibitors are allosteric enhancers of kinin B1 and B2 receptor function. Hypertension 2010; 55:214-20.

Ereshefsky L, Dugan D. Review of the pharmacokinetics, pharmacogenetics, and drug interaction potential of antidepressants: focus on venlafaxine. Depress Anxiety 2000; 12 Suppl 1:30-44.

Ereshefsky L, Riesenman C, Lam YW. Antidepressant drug interactions and the cytochrome P450 system. The role of cytochrome P450 2D6. Clin Pharmacokinet 1995; 29 Suppl 1:10-8.

Ergen A, Kılıcoglu O, Ozger H, Agachan B, Isbir T. Paraoxonase 1 192 and 55 polymorphisms in osteosarcoma. Mol Biol Rep 2011; 38:4181-4.

Erginel-Unaltuna N, Peoc'h K, Komurcu E, Acuner TT, Issever H, Laplanche JL. Distribution of the M129V polymorphism of the prion protein gene in a Turkish population suggest a high risk for Creutzfeldt-Jakob disease. Europ J Hum Genet 2001; 9:965-8.

Erichsen HC, Engel SA, Eck PK et al. Genetic variation in the sodium-dependent vitamin C transporters, SLC23A1, and SLC23A2 and risk for preterm delivery. Am J Epidemiol 2006; 3:245-54.

Erichsen HC, Peters U, Eck P et al. Genetic variation in sodium-dependent vitamin C transporters SLC23A1 and SLC23A2 and risk of advanced colorectal adenoma. Nutr Cancer 2008; 60:652-9.

Erichsen TJ, Aehlen A, Ehmer U, Kalthoff S, Manns MP, Strassburg CP. Regulation of the human bile acid UDP-glucuronosyltransferase 1A3 by the farnesoid X receptor and bile acids. J Hepatol 2010; 52:570-8.

Erickson DA, Mather G, Trager WF, Levy RH, Keirns JJ. Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitor nevirapine by human hepatic cytochromes P-450. Drug Metab Dispos 1999; 27:1488-95.

Erickson R. Chromosomal imprinting and the parent transmission specific variation in expressivity of Huntington disease. Am J Hum Genet 1985; 37:827-9.

Erickson RP, Cao W, Acuña DK et al. Confirmation of using transgenics and knockouts. Mol Reprod Dev 2008; 75:1071-6.

Erickson-Ridout KK, Zhu J, Lazarus P. Olanzapine metabolism and the significance of UGT1A448V and UGT2B1067Y variants. Pharmacogenet Genomics 2011; 21:539-51.

Eriksen JL, Sagi SA, Smith TE et al. NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo. J Clin Invest 2003; 112:440-9.

Erlich H, Valdes AM, Noble J et al. HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes 2008; 57:1084-92.

Erlotinib: new drug. Non small-cell lung cancer: like gefitinib, no established advantage. Prescrire Int 2006; 15:86-9.

Ernest CS 2nd, Hall SD, Jones DR. Mechanism-based inactivation of CYP3A by HIV protease inhibitors. J Pharmacol Exp Ther 2005; 312:583-91.

Ernst E. St John's wort supplements endanger the success of organ transplantation. Arch Surg 2002; 137:316-9.

Ernst IM, Wagner AE, Lipinski S et al. Cellular uptake, stability, visualization by 'Naturstoff reagent A', and multidrug resistance protein 1 gene-regulatory activity of cyanidin in human keratinocytes. Pharmacol Res 2010; 61:253-8.

Ernst T, Hoffmann J, Erben P et al. ABL single nucleotide polymorphisms may masquerade as BCR-ABL mutations associated with resistance to tyrosine kinase inhibitors in patients with chronic myeloid leukemia. Haematologica 2008; 93:1389-93.

Erps LT, Ritter JK, Hersh JH, Blossom D, Martin NC, Owens IS. Identification of two single base substitutions in the UGT1 gene locus which abolish bilirubin uridine diphosphate glucuronosyltransferase activity in vitro. J Clin Invest 1994; 93:564-70.

Errasti-Murugarren E, Pastor-Anglada M. Drug transporter pharmacogenetics in nucleoside-based therapies. Pharmacogenomics 2010; 11:809-41.

Erratico CA, Moffatt SC, Bandiera SM. Comparative oxidative metabolism of BDE-47 and BDE-99 by rat hepatic microsomes. Toxicol Sci 2011; 123:37-47.

Eruvaram NR, Das M. Phenotype of hepatic xenobiotic metabolizing enzymes and CYP450 isoforms of sanguinarine treated rats: effect of P450 inducers on its toxicity. Toxicol Mech Methods 2009; 19:510-7.

Escayg A, de Waard M, Lee DD et al. Coding and noncoding variation of the human calcium-channel beta4-subunit gene CACNB4 in patients with idiopathic generalized epilepsy and episodic ataxia. Am J Hum Genet 2000; 66:1531-9.

Esch FS, Keim PS, Beattie EC et al. Cleavage of amyloid beta peptide during constitutive processing of its precursor. Science 1990; 248:1122-4.

Escher G, Vögeli I, Escher R et al. Role of CYP27A1 in progesterone metabolism in vitro and in vivo. Am J Physiol Endocrinol Metab 2009; 297:949-55.

Eseverri J. Projection of new antihistamines. Allergol Immunopathol 2000; 28:143-52.

Eshkoli T, Sheiner E, Ben-Zvi Z, Holcberg G. Drug transport across the placenta. Curr Pharm Biotechnol 2011; 12:707-14.

Eskdale J, Gallagher G, Verweij CL, Keijsers V, Westendorp RG, Huizinga TW. Interleukin 10 secretion in relation to human IL-10 locus haplotypes. Proc Natl Acad Sci USA 1998; 95:9465-70.

Esler WP, Wolfe MS. A portrait of Alzheimer secretases - New features and familiar faces. Science 2001; 293:1449-54.

Espelt MV, Croci DO, Bacigalupo ML et al. Novel roles of galectin-1 in hepatocellular carcinoma cell adhesion, polarization and in vivo tumor growth. Hepatology 2011; 53:2097-106.

Estany-Gestal A, Salgado-Barreira A, Sánchez-Diz P, Figueiras A. Influence of CYP2C9 genetic variants on gastrointestinal bleeding associated with nonsteroidal anti-inflammatory drugs: a systematic critical review. Pharmacogenet Genomics 2011; 21:357-64.

Esteban LM, Fong C, Amr D et al. Promoter-, cell-, and ligand-specific transactivation responses of the VDRB1 isoform. Biochem Biophys Res Commun 2005; 334:9-15.

Esterbauer H, Schneitler C, Oberkofler H et al. A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans. Nat Genet 2001; 28:178-83.

Esteva FJ, Guo H, Zhang S et al. PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer. Am J Pathol 2010; 177:1647-56.

Estey T, Cantore M, Weston PA, Carpenter JF, Petrash JM, Vasiliou V. Mechanisms involved in the protection of UV-induced protein inactivation by the corneal crystallin ALDH3A1. J Biol Chem 2007; 282:4382-92.

Esther CR, Marino EM, Howard TE et al. The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice. J Clin Invest 1997; 99:2375-85.

Etheridge AS, Black SR, Patel PR, So J, Mathews JM. An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constituents. Planta Med 2007; 73:731-41.

Etienne-Grimaldi MC, Milano G, Maindrault-Goebel F et al. Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and FOLFOX response in colorectal cancer patients. Br J Clin Pharmacol 2010; 69:58-66.

Evans AE, Poirier O, Kee F et al. Polymorphisms of the angiotensin-converting-enzyme gene in subjects who die from coronary heart disease. Quart J Med 1994; 87:211-4.

Evans AH, Pancholi S, Farmer I et al. EGFR/HER2 inhibitor AEE788 increases ER-mediated transcription in HER2/ER-positive breast cancer cells but functions synergistically with endocrine therapy. Br J Cancer 2010; 102:1235-43.

Evans AM. Influence of dietary components on the gastrointestinal metabolism and transport of drugs. Ther Drug Monit 2000; 22:131-6.

Evans D, Bode A, von der Lippe G, Beil FU, Mann WA. Cerebrovascular atherosclerosis in type III hyperlipidemia is modulated by variation in the apolipoprotein A5 gene. Eur J Med Res 2011; 16:79-84.

Evans DA, Harmer D, Downham DY et al. The genetic control of sparteine and debrisoquine metabolism in man with new methods of analysing bimodal distributions. J Med Genet 1983; 20:321-9.

Evans DC, O'Connor D, Lake BG, Evers R, Allen C, Hargreaves R. Eletriptan metabolism by human hepatic CYP450 enzymes and transport by human P-glycoprotein. Drug Metab Dispos 2003; 31:861-9.

Evans JP, Kandel S, Ortiz de Montellano PR. Isocyanides inhibit human heme oxygenases at the verdoheme stage. Biochemistry 2009; 8:8920-8.

Evans JP, Xu F, Sirisawad M, Miller R, Naumovski L, de Montellano PR. Motexafin gadolinium-induced cell death correlates with heme oxygenase-1 expression and inhibition of P450 reductase-dependent activities. Mol Pharmacol 2007; 71:193-200.

Evans MV, Caldwell JC. Evaluation of two different metabolic hypotheses for dichloromethane toxicity using physiologically based pharmacokinetic modeling for in vivo inhalation gas uptake data exposure in female B6C3F1 mice. Toxicol Appl Pharmacol 2010; 244:280-90.

Evans WE, Relling MV, Rahman A, McLeod HL, Scott EP, Lin JS. Genetic basis for a lower prevalence of deficient CYP2D6 oxidative drug metabolism phenotypes in black Americans. J Clin Invest 1993; 91:2150-4.

Evers DL, Wang X, Huong SM, Andreoni KA, Huang ES. Inhibition of human cytomegalovirus signaling and replication by the immunosuppressant FK778. Antiviral Res 2005; 65:1-12.

Evers R, Kool M, van Deemter L et al. Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA. J Clin Invest 1998; 101:1310-9.

Evert B, Griese EU, Eichelbaum M. Cloning and sequencing of a new non-functional CYP2D6 allele: deletion of T1795 in exon 3 generates a premature stop codon. Pharmacogenetics 1994; 4:271-4.

Ewald AH, Maurer HH. 2,5-Dimethoxyamphetamine-derived designer drugs: studies on the identification of cytochrome P450 (CYP) isoenzymes involved in formation of their main metabolites and on their capability to inhibit CYP2D6. Toxicol Lett 2008; 183:52-7.

Ewesuedo RB, Dolan ME. Pharmacokinetics of oral O6-benzylguanine and evidence of interaction with oral ketoconazole in the rat. Cancer Chemother Pharmacol 2000; 46:150-5.

Ewing MM, de Vries MR, Nordzell M et al. Annexin A5 therapy attenuates vascular inflammation and remodeling and improves endothelial function in mice. Arterioscler Thromb Vasc Biol 2011; 31:95-101.

Exton MS, Artz M, Siffert W, Schedlowski M. G protein beta3 subunit 825T allele is associated with depression in young, healthy subjects. Neuroreport 2003; 14:531-3.

Faber E, Mojzikova R, Plachy R et al. Major molecular response achieved with dasatinib in a CML patient with F317L BCR-ABL kinase domain mutation. Leuk Res 2010; 34:91-3.

Faber P, Barnes G, Srinidhi J et al. Huntingtin interacts with a family of WW domain proteins. Hum Molec Genet 1998; 7:1463-74.

Fabiani E, D'Alò F, Scardocci A et al. Polymorphisms of detoxification and DNA repair enzymes in myelodyplastic syndromes. Leuk Res 2009; 33:1068-71.

Fabre G, Julian B, Saint-Aubert B, Joyeux H, Berger Y. Evidence for CYP3A-mediated N-deethylation of amiodarone in human liver microsomal fractions. Drug Metab Dispos 1993; 21:978-85.

Fabris B, Bortoletto M, Candido R et al. Genetic polymorphisms of the renin-angiotensin-aldosterone system and renal insufficiency in essential hypertension. J Hypertens 2005; 23:309-16.

Fabris C, Vandelli C, Toniutto P et al. Apolipoprotein E genotypes modulate fibrosis progression in patients with chronic hepatitis C and persistently normal transaminases. J Gastroenterol Hepatol 2011; 26:328-33.

Fabris M, Quartuccio L, Lombardi S et al. The CC homozygosis of the -174G>C IL-6 polymorphism predicts a lower efficacy of rituximab therapy in rheumatoid arthritis. Autoimmun Rev 2010. doi:10. 1016/j. autrev. 2010. 06. 012.

Facciolà G, Avenoso A, Scordo MG et al. Small effects of valproic acid on the plasma concentrations of clozapine and its major metabolites in patients with schizophrenic or affective disorders. Ther Drug Monit 1999; 21:341-5.

Facchinetti F, Fasolato C, del Giudice E et al. Nimodipine selectively stimulates beta-amyloid 1-42 secretion by a mechanism independent of calcium influx blockage. Neurobiol Aging 2006; 27:218-27.

Factor SA, Steenland NK, Higgins DS et al. Postural instability/gait disturbance in Parkinson's disease has distinct subtypes: an exploratory analysis. J Neurol Neurosurg Psychiatry 2011; 82:564-8.

Facheris MF, Schneider NK, Lesnick TG et al. Coffee, caffeine-related genes, and Parkinson's disease: a case-control study. Mov Disord 2008; 23:2033-40.

Faerber L, Drechsler S, Ladenburger S, Gschaidmeier H, Fischer W. The neuronal 5-HT3 receptor network after 20 years of research-evolving concepts in management of pain and inflammation. Eur J Pharmacol 2007; 560:1-8.

Faeste CK, Ivanova L, Uhlig S. In vitro metabolism of the mycotoxin enniatin B in different species and CYP P450 reaction phenotyping. Drug Metab Dispos 2011; 39:1768-76.

Fagan AM, Christopher E, Taylor JW et al. ApoAI deficiency results in marked reductions in plasma cholesterol but no alterations in amyloid-beta pathology in a mouse model of Alzheimer's disease-like cerebral amyloidosis. Am J Pathol 2004; 165:1413-22.

Faganel Kotnik B, Grabnar I, Bohanec Grabar P, Dolžan V, Jazbec J. Association of genetic polymorphism in the folate metabolic pathway with methotrexate pharmacokinetics and toxicity in childhood acute lymphoblastic leukaemia and malignant lymphoma. Eur J Clin Pharmacol 2011; 67:993-1006.

Fagerholm R, Hofstetter B, Tommiska J et al. NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer. Nat Genet 2008; 40:844-53.

Fagerholm U. Prediction of human pharmacokinetics-gut-wall metabolism. J Pharm Pharmacol 2007; 59:1335-43.

Fagoonee S, Hobbs RM, de Chiara L et al. Generation of functional hepatocytes from mouse germ line cell-derived pluripotent stem cells in vitro. Stem Cells Dev 2010; 19:1183-94.

Fahmi OA, Boldt S, Kish M, Obach RS, Tremaine LM. Prediction of drug-drug interactions from in vitro induction data: application of the relative induction score approach using cryopreserved human hepatocytes. Drug Metab Dispos 2008; 36:1971-4.

Fahmi OA, Hurst S, Plowchalk D et al. Comparison of different algorithms for predicting clinical drug-drug interactions, based on the use of CYP3A4 in vitro data: predictions of compounds as precipitants of interaction. Drug Metab Dispos 2009; 37:1658-66.

Fahmi OA, Maurer TS, Kish M, Cardenas E, Boldt S, Nettleton D. A combined model for predicting CYP3A4 clinical net drug-drug interaction based on CYP3A4 inhibition, inactivation, and induction determined in vitro. Drug Metab Dispos 2008; 36:1698-708.

Fairbrother KS, Grove J, de Waziers I et al. Detection and characterization of novel polymorphisms in the CYP2E1 gene. Pharmacogenetics 1998; 8:543-52.

Fairfax BP, Davenport EE, Makino S, Hill AV, Vannberg FO, Knight JC. A common haplotype of the TNF receptor 2 gene modulates endotoxin tolerance. J Immunol 2011; 186:3058-65.

Faisel F, Romppanen EL, Hiltunen M et al. Susceptibility to pre-eclampsia in Finnish women is associated with R485K polymorphism in the factor V gene, not with Leiden mutation. Eur J Hum Genet 2004; 12:187-91.

Fajac A, Gligorov J, Rezai K et al. Effect of ABCB1 C3435T polymorphism on docetaxel pharmacokinetics according to menopausal status in breast cancer patients. Br J Cancer 2010; 103:560-6.

Fajans SS, Bell GI, Polonsky KS. Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young. N Engl J Med 2001; 345:971-80.

Fajans SS, Brown MB. Administration of sulfonylureas can increase glucose-induced insulin secretion for decades in patients with maturity-onset diabetes of the young. Diabetes Care 1993; 16:1254-61.

Fajardo G, Zhao M, Powers J, Bernstein D. Differential cardiotoxic/cardioprotective effects of beta-adrenergic receptor subtypes in myocytes and fibroblasts in doxorubicin cardiomyopathy. J Mol Cell Cardiol 2006; 40:375-83.

Fakhoury M, Andreu-Gallien J, Mahr A et al. Should TPMT genotype and activity be used to monitor 6-mercaptopurine treatment in children with acute lymphoblastic leukaemia? J Clin Pharmacy and therapeutics 2007; 6:633-9.

Fakhoury M, Lecordier J, Medard Y, Peuchmaur M, Jacqz-Agrain E. Impact of inflammation on the duodenal mRNA expression of CYP3A and P-glycoprotein in children with Crohn's disease. Inflamm Bowel Dis 2006; 12:745-9.

Fakhoury M, Litalien C, Medard Y et al. Localization and mRNA expression of CYP3A and P-glycoprotein in human duodenum as a function of age. Drug Metab Dispos 2005; 33:1603-7.

Fakkert IE, Jansen L, Meijer K et al. Breast cancer screening in BRCA1 and BRCA2 mutation carriers after risk reducing salpingo-oophorectomy. Breast Cancer Res Treat 2011; 129:157-64.

Falandry C, Canney PA, Freyer G, Dirix LY. Role of combination therapy with aromatase and cyclooxygenase-2 inhibitors in patients with metastatic breast cancer. Ann Oncol 2009; 20:615-20.

Falik-Zaccai TC, Laskar M, Kfir N, Nasser W, Slor H, Khayat M. Cockayne syndrome type II in a Druze isolate in Northern Israel in association with an insertion mutation in ERCC6. Am J Med Genet A 2008; 146:1423-9.

Falus A, Fenyő M, Eder K, Madarasi A. Genome-wide gene expression study indicates the anti-inflammatory effect of polarized light in recurrent childhood respiratory disease. Inflamm Res 2011; 60:965-72.

Falvella FS, Galvan A, Frullanti E et al. Transcription deregulation at the 15q25 locus in association with lung adenocarcinoma risk. Clin Cancer Res 2009; 15:1837-42.

Falzoi M, Mossa A, Congeddu E, Saba L, Pani L. Multiplex genotyping of CYP3A4, CYP3A5, CYP2C9 and CYP2C19 SNPs using MALDI-TOF mass spectrometry. Pharmacogenomics 2010; 11:559-71.

Fallah S, Seifi M, Firoozrai M, Ghohari LH, Samadikuchaksaraei A, Samadirad B. Effect of apolipoprotein E genotypes on incidence and development of coronary stenosis in Iranian patients with coronary artery disease. J Clin Lab Anal 2011; 25:43-6.

Fallo F, Bertello C, Tizzani D et al. Concurrent primary aldosteronism and subclinical cortisol hypersecretion: a prospective study. J Hypertens 2011; 29:1773-7.

Fan AZ, Yesupriya A, Chang MH et al. Gene polymorphisms in association with emerging cardiovascular risk markers in adult women. BMC Med Genet 2010; 11:6.

Fan BJ, Wang DY, Tham CC, Lam DS, Pang CP. Gene expression profiles of human trabecular meshwork cells induced by triamcinolone and dexamethasone. Invest Ophthalmol Vis Sci 2008; 49:1886-97.

Fan HM, Wang Z, Feng FM et al. Association of TNF-alpha-238G/A and 308 G/A gene polymorphisms with pulmonary tuberculosis among patients with coal worker's pneumoconiosis. Biomed Environ Sci 2010; 23:137-45.

Fan J, Liu S, Du Y, Morrison J, Shipman R, Pang KS. Up-regulation of transporters and enzymes by the vitamin D receptor ligands, 1alpha,25-dihydroxyvitamin D3 and vitamin D analogs, in the Caco-2 cell monolayer. J Pharmacol Exp Ther 2009; 330:389-402.

Fan J, Maeng HJ, Du Y, Kwan D, Pang KS. Transport of 5,5-diphenylbarbituric acid and its precursors and their effect on P-gp, MRP2 and CYP3A4 in Caco-2 and LS180 cells. Eur J Pharm Sci 2011; 42:19-29.

Fan J, Stukas S, Wong C et al. An ABCA1-independent pathway for recycling of a poorly lipidated 8. 1 nm apolipoprotein E particle from glia. J Lipid Res 2011; 52:1605-16.

Fan L, Wang G, Wang LS et al. Herbal medicine yin zhi huang induces CYP3A4-mediated sulfoxidation and CYP2C19-dependent hydroxylation of omeprazole. Acta Pharmacol Sin 2007; 28:1685-92.

Fan L, Wang JC, Jiang F et al. Induction of cytochrome P450 2B6 activity by the herbal medicine baicalin as measured by bupropion hydroxylation. Eur J Clin Pharmacol 2009; 65:403-9.

Fan L, Zhang W, Guo D et al. The effect of herbal medicine baicalin on pharmacokinetics of rosuvastatin, substrate of organic anion-transporting polypeptide 1B1. Clin Pharmacol Ther 2008; 83:471-6.

Fan LQ, Hardy DO, Catterall JF, Zhao J, Li SX. Identification and characterization of an androgen-responsive Kap promoter enhancer located in the intron II region of human angiotensinogen gene. J Steroid Biochem Mol Biol 2010; 119:135-40.

Fan M, Liu B, Jiang T, Jiang X, Zhao H, Zhang J. Meta-analysis of the association between the monoamine oxidase-A gene and mood disorders. Psychiatr Genet 2010; 20:1-7.

Fan X, Wang Y, Sun K et al. Polymorphisms of ACE2 gene are associated with essential hypertension and antihypertensive effects of captopril in women. Clin Pharmacol Ther 2007; 82:187-96.

Fan Y, Tao JH, Zhang LP, Li LH, Ye DQ. Association of BLK (rs13277113, rs2248932) polymorphism with systemic lupus erythematosus: a meta-analysis. Mol Biol Rep 2011; 38:4445-53.

Fancello T, Dardis A, Rosano C et al. Molecular analysis of NPC1 and NPC2 gene in 34 Niemann-Pick C Italian patients: identification and structural modeling of novel mutations. Neurogenetics 2009; 10:229-39.

Fanelli M, Filippi E, Sentinelli F et al. The Gly482Ser missense mutation of the peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha) gene associates with reduced insulin sensitivity in normal and glucose-intolerant obese subjects. Dis Markers 2005; 21:175-80.

Fang AF, Damle BD, LaBadie RR, Crownover PH, Hewlett D Jr, Glue PW. Significant decrease in nelfinavir systemic exposure after omeprazole coadministration in healthy subjects. Pharmacotherapy 2008; 28:42-50.

Fang D, Bao Y, Li X et al. Effects of iron deprivation on multidrug resistance of leukemic K562 cells. Chemotherapy 2010; 56:9-16.

Fang HL, Strom SC, Ellis E et al. Positive and negative regulation of human hepatic hydroxysteroid sulfotransferase (SULT2A1) gene transcription by rifampicin: roles of hepatocyte nuclear factor 4alpha and pregnane X receptor. J Pharmacol Exp Ther 2007; 323:586-98.

Fang HM, Xu JM, Mei Q et al. Involvement of cytochrome P450 3A4 and P-glycoprotein in first-pass intestinal extraction of omeprazole in rabbits. Acta Pharmacol Sin 2009; 30:1566-72.

Fang J, Baker GB, Silverstone PH, Coutts RT. Involvement of CYP3A4 and CYP2D6 in the metabolism of haloperidol. Cell Mol Neurobiol 1997; 17:227-33.

Fang J, Bourin M, Baker GB. Metabolism of risperidone to 9-hydroxyrisperidone by human cytochromes P450 2D6 and 3A4. Naunyn Schmiedebergs Arch Pharmacol 1999; 359:147-51.

Fang J, Coutts RT, McKenna KF, Baker GB. Elucidation of individual cytochrome P450 enzymes involved in the metabolism of clozapine. Naunyn Schmiedebergs Arch Pharmacol 1998; 358:592-9.

Fang J, McKay G, Song J, Remillrd A, Li X, Midha K. In vitro characterization of the metabolism of haloperidol using recombinant cytochrome p450 enzymes and human liver microsomes. Drug Metab Dispos 2001; 29:1638-43.

Fang S, Miao J, Xiang L, Ponugoti B, Treuter E, Kemper JK. Coordinated recruitment of histone methyltransferase G9a and other chromatin-modifying enzymes in SHP-mediated regulation of hepatic bile acid metabolism. Mol Cell Biol 2007; 27:1407-24.

Fang W, Geng X, Deng Y et al. Platelet activating factor induces blood brain barrier permeability alteration in vitro. J Neuroimmunol 2011; 230:42-7.

Fang Y, van Meurs JBJ, d'Alesio A et al. Promoter and 3-prime-untranslated-region haplotypes in the vitamin D receptor gene predispose to osteoporotic fracture: the Rotterdam Study. Am J Hum Genet 2005; 77:807-23.

Fang ZZ, Zhang YY, Ge GB et al. Identification of cytochrome P450 (CYP) isoforms involved in the metabolism of corynoline, and assessment of its herb-drug interactions. Phytother Res 2011; 25:256-63.

Fang ZZ, Zhang YY, Ge GB, Huo H, Liang SC, Yang L. Time-dependent inhibition (TDI) of CYP3A4 and CYP2C9 by noscapine potentially explains clinical noscapine-warfarin interaction. Br J Clin Pharmacol 2010; 69:193-9.

Fanous AH, Chen X, Wang X et al. Genetic variation in the serotonin 2A receptor and suicidal ideation in a sample of 270 Irish high-density schizophrenia families. Am J Med Genet B Neuropsychiatr Genet 2009; 150:411-7.

Fanous AH, van den Oord EJ, Riley BP et al. Relationship between a high-risk haplotype in the DTNBP1 (dysbindin) gene and clinical features of schizophrenia. Am J Psychiatry 2005; 162:1824-32.

Fanta S, Jönsson S, Backman JT, Karlsson MO, Hoppu K. Developmental pharmacokinetics of ciclosporin-a population pharmacokinetic study in paediatric renal transplant candidates. Br J Clin Pharmacol 2007; 64:772-84.

Fanta S, Jönsson S, Karlsson MO et al. Long-term changes in cyclosporine pharmacokinetics after renal transplantation in children: evidence for saturable presystemic metabolism and effect of NR1I2 polymorphism. J Clin Pharmacol 2010; 50:581-97.

Fanta S, Niemi M, Jönsson S et al. Pharmacogenetics of cyclosporine in children suggests an age-dependent influence of ABCB1 polymorphisms. Pharmacogenet Genomics 2008; 18:77-90.

Faouzi S, Medzihradszky KF, Hefner C, Maher JJ, Correia MA. Characterization of the physiological turnover of native and inactivated cytochromes P450 3A in cultured rat hepatocytes: a role for the cytosolic AAA ATPase p97? Biochemistry 2007; 46:7793-803.

Farabegoli F, Papi A, Bartolini G, Ostan R, Orlandi M. (-)-Epigallocatechin-3-gallate downregulates Pg-P and BCRP in a tamoxifen resistant MCF-7 cell line. Phytomedicine 2010; 17:356-62.

Farabegoli F, Papi A, Orlandi M. (-)-Epigallocatechin-3-gallate downregulates EGFR, MMP-2, MMP-9 EMMPRIN and inhibits the invasion of MCF-7 tamoxifen resistant cells. Biosci Rep 2010; 31:99-108.

Faraday N, Becker DM, Becker LC. Pharmacogenomics of platelet responsiveness to aspirin. Pharmacogenomics 2007; 8:1413-25.

Faraone SV, Khan SA. Candidate gene studies of attention-deficit/hyperactivity disorder. J Clin Psychiatry 2006; 67:13-20.

Faratian D, Zweemer AJ, Nagumo Y et al. Trastuzumab and pertuzumab produce changes in morphology and estrogen receptor signaling in ovarian cancer xenografts revealing new treatment strategies. Clin Cancer Res 2011; 17:4451-61.

Fargher EA, Tricker K, Newman W et al. Current use of pharmacogenetic testing: a national survey of thiopurine methyltransferase testing prior to azathioprine prescription. J Clin Pharm Ther 2007; 2:187-95.

Farheen S, Sengupta S, Santra A et al. Gilbert's syndrome: High frequency of the (TA)7 TAA allele in India and its interaction with a novel CAT insertion in promoter of the gene for bilirubin UDP-glucuronosyltransferase 1 gene. World J Gastroenterol 2006; 12:2269-75.

Farid NA, Jakubowski JA, Payne CD et al. Effect of rifampin on the pharmacokinetics and pharmacodynamics of prasugrel in healthy male subjects. Curr Med Res Opin 2009; 25:1821-9.

Farid NA, Payne CD, Small DS et al. Cytochrome P450 3A inhibition by ketoconazole affects prasugrel and clopidogrel pharmacokinetics and pharmacodynamics differently. Clin Pharmacol Ther 2007; 81:735-41.

Farinola N, Piller NB. CYP2A6 polymorphisms: is there a role for pharmacogenomics in preventing coumarin-induced hepatotoxicity in lymphedema patients? Pharmacogenomics 2007; 8:151-8.

Farlow M, Lane R, Kudaravalli S, He Y. Differential qualitative responses to rivastigmine in APOE epsilon 4 carriers and noncarriers. Pharmacogenomics J 2004; 4:332-5.

Farlow M, Potkin S, Koumaras B, Veach J, Mirski D. Analysis of outcome in retrieved dropout patients in a rivastigmine vs placebo, 26-week, Alzheimer's disease trial. Arch Neurol 2003; 60:843-8.

Farlow MR. Clinical pharmacokinetics of galantamine. Clin Pharmacokinet 2003; 42:1383-92.

Farlow MR, Lahiri DK, Poirier J, Davignon J, Schneider L, Hui SL. Treatment outcome of tacrine therapy depends on apolipoprotein genotype and gender of the subjects with Alzheimer's disease. Neurology 1998; 50:669-77.

Farmer JA, Torre-Amione G. Comparative tolerability of the HMG-CoA reductase inhibitors. Drug Saf 2000; 23:197-213.

Farnebo L, Jedlinski A, Ansell A et al. Proteins and single nucleotide polymorphisms involved in apoptosis, growth control, and DNA repair predict cisplatin sensitivity in head and neck cancer cell lines. Int J Mol Med 2009; 24:549-56.

Farquhar C, Rowland-Jones S, Mbori-Ngacha D et al. Human leukocyte antigen (HLA) B*18 and protection against mother-to-child HIV type 1 transmission. AIDS Res Hum Retroviruses 2004; 20:692-7.

Farré M, Abanades S, Roset PN et al. Pharmacological interaction between 3,4-methylenedioxymethamphetamine (ecstasy) and paroxetine: pharmacological effects and pharmacokinetics. J Pharmacol Exp Ther 2007; 323:954-62.

Farrer L, Conneally P. A genetic model for age at onset in Huntington disease. Am J Hum Genet 1985; 37:350-7.

Farrer L, Cupples L, Wiater P, Conneally P, Gusella J, Myers R. The normal Huntington disease (HD) allele, or a closely linked gene, influences age at onset of HD. Am J Hum Genet 1993; 53:125-30

Farris SD, Hu JH, Krishnan R et al. Mechanisms of urokinase plasminogen activator (uPA)-mediated atherosclerosis: Role of the uPA receptor and S100A8/A9 proteins. J Biol Chem 2011; 286:22665-77.

Fasching PA, Kollmannsberger B, Strissel PL et al. Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy. J Cancer Res Clin Oncol 2008; 134:1079-86.

Fasullo M, Chen Y, Bortcosh W, Sun M, Egner PA. Aflatoxin B(1)-associated DNA adducts stall S phase and stimulate Rad51 foci in Saccharomyces cerevisiae. J Nucleic Acids 2010. doi:10. 4061/2010/456487.

Fatih N, Camberlein E, Island ML et al. Natural and synthetic STAT3 inhibitors reduce hepcidin expression in differentiated mouse hepatocytes expressing the active phosphorylated STAT3 form. J Mol Med 2010; 88:477-86.

Fatini C, Abbate R, Pepe G et al. Searching for a better assessment of the individual coronary risk profile. The role of angiotensin-converting enzyme, angiotensin II type 1 receptor and angiotensinogen gene polymorphisms. Eur Heart J 2000; 21:633-8.

Fatini C, Sticchi E, Marcucci R et al. S38G single-nucleotide polymorphism at the KCNE1 locus is associated with heart failure. Heart Rhythm 2010; 7:363-7.

Fattinger K, Funk C, Pantze M et al. The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions. Clin Pharmacol Ther 2001; 69:223-31.

Fattinger K, Meier-Abt A. Interactions of phytotherapeutic drugs, foods and drinks with medicines. Ther Umsch 2002; 59:292-300.

Faucette SR, Hawke RL, Shord SS, Lecluyse EL, Lindley CM. Evaluation of the contribution of cytochrome P450 3A4 to human liver microsomal bupropion hydroxylation. Drug Metab Dispos 2001; 29:1123-9.

Faucette SR, Sueyoshi T, Smith CM, Negishi M, Lecluyse EL, Wang H. Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor. J Pharmacol Exp Ther 2006; 317:1200-9.

Faucette SR, Wang H, Hamilton GA et al. Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers. Drug Metab Dispos 2004; 32:348-58.

Faucette SR, Zhang TC, Moore R et al. Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers. J Pharmacol Exp Ther 2007; 320:72-80.

Fava C, Montagnana M, Almgren P et al. Association between adducin-1 G460W variant and blood pressure in Swedes is dependent on interaction with body mass index and gender. Am J Hypertens 2007; 20:981-9.

Fava C, Montagnana M, Almgren P et al. The V433M variant of the CYP4F2 is associated with ischemic stroke in male Swedes beyond its effect on blood pressure. Hypertension 2008; 52:373-80.

Fava C, Montagnana M, Almgren P et al. The common functional polymorphism -50G>T of the CYP2J2 gene is not associated with ischemic coronary and cerebrovascular events in an urban-based sample of Swedes. J Hypertens 2010; 28:294-9.

Favis R, Sun Y, van de Velde H et al. Genetic variation associated with bortezomib-induced peripheral neuropathy. Pharmacogenet Genomics 2011; 21:121-9.

Favre C, Monti JA, Scapini C, Pellegrino J, Carnovale CE, Carrillo MC. Putrescine decreases cytochrome P450 3A4 levels during liver regeneration in the rat. J Hepatol 1998; 28:700-8.

Fayer JL, Zannikos PN, Stevens JC, Luo Y, Sidhu R, Kirkesseli S. Lack of correlation between in vitro inhibition of CYP3A-mediated metabolism by a PPAR-gamma agonist and its effect on the clinical pharmacokinetics of midazolam, an in vivo probe of CYP3A activity. J Clin Pharmacol 2001; 41:305-16.

Fayuk D, Yakel JL. Regulation of nicotinic acetylcholine receptor channel function by acetylcholinesterase inhibitors in rat hippocampal CA1 interneurons. Mol Pharmacol 2004; 66:658-66.

Fayz S, Inaba T. Zidovudine azido-reductase in human liver microsomes: activation by ethacrynic acid, dipyridamole, and indomethacin and inhibition by human immunodeficiency virus protease inhibitors. Antimicrob Agents Chemother 1998; 42:1654-8.

Fazili IS, Jiang W, Wang L et al. Persistent induction of cytochrome P4501A1 in human hepatoma cells by 3-methylcholanthrene: evidence for sustained transcriptional activation of the CYP1A1 promoter. J Pharmacol Exp Ther 2010; 333:99-109.

Féart C, Torrès MJ, Samieri C et al. Adherence to a Mediterranean diet and plasma fatty acids: data from the Bordeaux sample of the Three-City study. Br J Nutr 2011; 106:149-58.

Febbo PG. Genomic approaches to outcome prediction in prostate cancer. Cancer 2009; 115:3046-57.

Fecteau KA, Eiler H, Oliver JW. Effect of combined lignan phytoestrogen and melatonin treatment on secretion of steroid hormones by adrenal carcinoma cells. Am J Vet Res 2011; 72:675-80.

Federico A, Dotti MT, Gallus GN. Cerebrotendinous xanthomatosis. In: Pagon RA, Bird TD, Dolan CR, Stephens K (Eds). GeneReviews. University of Washington, Seattle, 1993-2003. Available from: http://www. ncbi. nlm. nih. gov/books/NBK1409/

Fedier A, Schwarz VA, Walt H, Carpini RD, Haller U, Fink D. Resistance to topoisomerase poisons due to loss of DNA mismatch repair. Int J Cancer 2001; 93:571-6.

Feghhi M, Nikzamir A, Esteghamati A, Farahi F, Nakhjavani M, Rashidi A. The relationship between angiotensin-converting enzyme insertion/deletion polymorphism and proliferative retinopathy in type 2 diabetes. Diabetes Res Clin Pract 2008; 81:1-4.

Fehér A, Juhász A, Rimanóczy A, Kálmán J, Janka Z. Association study of interferon-γ, cytosolic phospholipase A2, and cyclooxygenase-2 gene polymorphisms in Alzheimer disease. Am J Geriatr Psychiatry 2010; 18:983-7.

Feher G, Feher A, Pusch G, Lupkovics G, Szapary L, Papp E. The genetics of antiplatelet drug resistance. Clin Genet 2009; 75:1-18.

Feidt DM, Klein K, Hofmann U et al. Profiling induction of cytochrome p450 enzyme activity by statins using a new liquid chromatography-tandem mass spectrometry cocktail assay in human hepatocytes. Drug Metab Dispos 2010; 38:1589-97.

Feidt DM, Klein K, Nüssler A, Zanger UM. RNA-interference approach to study functions of NADPH: cytochrome P450 oxidoreductase in human hepatocytes. Chem Biodivers 2009; 6:2084-91.

Feierman DE. The effect of paracetamol (acetaminophen) on fentanyl metabolism in vitro. Acta Anaesthesiol Scand 2000; 44:560-3.

Feierman DE, Lasker JM. Metabolism of fentanyl, a synthetic opioid analgesic, by human liver microsomes. Role of CYP3A4. Drug Metab Dispos 1996; 24:932-9.

Feierman DE, Melinkov Z, Nanji AA. Induction of CYP3A by ethanol in multiple in vitro and in vivo models. Alcohol Clin Exp Res 2003; 27:981-8.

Feierman DE, Melnikov Z, Zhang J. The paradoxical effect of acetaminophen on CYP3A4 activity and content in transfected HepG2 cells. Arch Biochem Biophys 2002; 398:109-17.

Feig JE, Pineda-Torra I, Sanson M et al. LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression. J Clin Invest 2010; 120:4415-24.

Feik E, Baierl A, Hieger B et al. Association of IGF1 and IGFBP3 polymorphisms with colorectal polyps and colorectal cancer risk. Cancer Causes Control 2010; 21:91-7.

Feinshtein V, Holcberg G, Amash A et al. Nitrofurantoin transport by placental choriocarcinoma JAr cells: involvement of BCRP, OATP2B1 and other MDR transporters. Arch Gynecol Obstet 2010; 281:1037-44.

Feitosa MF, An P, Ordovas JM et al. Association of gene variants with lipid levels in response to fenofibrate is influenced by metabolic syndrome status. Atherosclerosis 2011; 215:435-9.

Feitsma H, Kuiper RV, Korving J, Nijman IJ, Cuppen E. Zebrafish with mutations in mismatch repair genes develop neurofibromas and other tumors. Cancer Res 2008; 68:5059-66.

Feldman AM. The emerging role of pharmacogenomics in the treatment of patients with heart failure. Ann Thorac Surg 2003; 76:2246-53.

Feldman DS, Carnes CA, Abraham WT, Bristow MR. Mechanisms of disease: beta-adrenergic receptors-alterations in signal transduction and pharmacogenomics in heart failure. Nat Clin Pract Cardiovasc Med 2005; 2:475-83.

Feldweg AM, Leddy JP. Drug Interactions Affecting the Efficacy of Corticosteroid Therapy A Brief Review with An Illustrative Case. J Clin Rheumatol 1999; 5:143-150.

Felix CA, Walker AH, Lange BJ et al. Association of CYP3A4 genotype with treatment-related leukemia. Proc Natl Acad Sci USA 1998; 95:13176-81.

Felix K, Rockwood LD, Pretsch W et al. Moderate G6PD deficiency increases mutation rates in the brain of mice. Free Radic Biol Med 2002; 32:663-73.

Felmlee MA, Lon HK, Gonzalez FJ, Yu AM. Cytochrome P450 expression and regulation in CYP3A4/CYP2D6 double transgenic humanized mice. Drug Metab Dispos 2008; 36:435-41.

Fellay J, Marzolini C, Meaden ER et al. Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study. Lancet 2002; 359:30-6.

Fellay J, Shianna KV, Ge D et al. A whole-genome association study of major determinants for host control of HIV-1. Science 2007; 317:944-7.

Fellerhoff B, Laumbacher B, Mueller N, Gu S, Wank R. Associations between Chlamydophila infections, schizophrenia and risk of HLA-A10. Mol Psychiatry 2007; 12:264-72.

Feng BJ, Sun LD, Soltani-Arabshahi R et al. Multiple Loci within the major histocompatibility complex confer risk of psoriasis. PLoS Genet 2009. doi:10. 1371/journal. pgen. 1000606.

Feng C, Yamashita F, Hashida M. Automated extraction of information from the literature on chemical-CYP3A4 interactions. J Chem Inf Model 2007; 47:2449-55.

Feng DD, Zhang H, Zhang P et al. Down-regulated miR-331-5p and miR-27a are associated with chemotherapy resistance and relapse in leukemia. J Cell Mol Med 2011; 15:2164-75.

Feng J, Sobell JL, Heston LL, Cook EH Jr, Goldman D, Sommer SS. Scanning of the dopamine D1 and D5 receptor genes by REF in neuropsychiatric patients reveals a novel missense change at a highly conserved amino acid. Am J Med Genet 1998; 81:172-8.

Feng J, Sun X, Sun N et al. XPA A23G polymorphism is associated with the elevated response to platinum-based chemotherapy in advanced non-small cell lung cancer. Acta Biochim Biophys Sin 2009; 41:429-35.

Feng J, Zheng J, Gelernter J et al. An in-frame deletion in the alpha(2C) adrenergic receptor is common in African-Americans. Mol Psychiatry 2001; 6:168-72.

Feng Y, Cameron MD, Frackowiak B et al. Structure-activity relationships, and drug metabolism and pharmacokinetic properties for indazole piperazine and indazole piperidine inhibitors of ROCK-II. Bioorg Med Chem Lett 2007; 17:2355-60.

Feng Y, Niu T, Xing H et al. A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men. Am J Hum Genet 2004; 75:112-21.

Fenton RA, Smith CP, Knepper MA. Role of collecting duct urea transporters in the kidney-insights from mouse models. J Membr Biol 2006; 212:119-31.

Fenty-Stewart N, Park JY, Roth SM et al. Independent and combined influence of AGTR1 variants and aerobic exercise on oxidative stress in hypertensives. Blood Press 2009; 18:204-12.

Fenyo IM, Florea IC, Raicu M, Manea A. Tyrphostin AG490 reduces NAPDH oxidase activity and expression in the aorta of hypercholesterolemic apolipoprotein E-deficient mice. Vascul Pharmacol 2011; 54:100-6.

Fer M, Corcos L, Dréano Y et al. Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism. J Lipid Res 2008; 49:2379-89.

Ferder N, Eby CS, Deych E et al. Ability of VKORC1 and CYP2C9 to predict therapeutic warfarin dose during the initial weeks of therapy. J Thromb Haemost 2010; 8:95-100.

Ferdinands JM, Mannino DM, Gwinn ML, Bray MS. ADRB2 Arg16Gly polymorphism, lung function, and mortality: results from the Atherosclerosis Risk in Communities study. PLoS One 2007. doi:10. 1371/journal. pone. 0000289.

Ferdinandusse S, Denis S, Hogenhout EM et al. Clinical, biochemical, and mutational spectrum of peroxisomal acyl-coenzyme A oxidase deficiency. Hum Mutat 2007; 28:904-12.

Ferguson C, Miksys S, Palmour R, Tyndale RF. Independent and combined effects of ethanol self-administration and nicotine treatment on hepatic CYP2E1 in African Green Monkeys. Drug Metab Dispos 2011. doi:10. 1124/dmd. 111. 040378.

Ferguson JF, Phillips CM, McMonagle J et al. NOS3 gene polymorphisms are associated with risk markers of cardiovascular disease, and interact with omega-3 polyunsaturated fatty acids. Atherosclerosis 2010; 211:539-44.

Ferguson JF, Phillips CM, Tierney AC et al. Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance. Am J Clin Nutr 2010; 91:794-801.

Ferguson LR, Han DY, Fraser AG, Huebner C, Lam WJ, Morgan AR. IL23R and IL12B SNPs and Haplotypes Strongly associate with Crohn's disease risk in a New Zealand population. Gastroenterol Res Pract 2010; 2010:539461.

Ferguson LR, Huebner C, Petermann I et al. Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk. World J Gastroenterol 2008; 14:4652-61.

Ferguson LR, Shelling AN, Browning BL, Huebner C, Petermann I. Genes, diet and inflammatory bowel disease. Mutat Res 2007; 622:70-83.

Ferguson RJ, de Morais SM, Benhamou S et al. A new genetic defect in human CYP2C19: mutation of the initiation codon is responsible for poor metabolism of S-mephenytoin. J Pharmacol Exp Ther 1998; 284:356-61.

Ferlin A, Bartoloni L, Rizzo G, Roverato A, Garolla A, Foresta C. Androgen receptor gene CAG and GGC repeat lengths in idiopathic male infertility. Mol Hum Reprod 2004; 10:417-21.

Ferlin A, Ganz F, Pengo M, Selice R, Frigo AC, Foresta C. Association of testicular germ cell tumor with polymorphisms in estrogen receptor and steroid metabolism genes. Endocr Relat Cancer 2010; 17:17-25.

Ferlin A, Garolla A, Bettella A et al. Androgen receptor gene CAG and GGC repeat lengths in cryptorchidism. Eur J Endocrinol 2005; 152:419-25.

Fernandes BJ, Miranda Silva CD, Andrade JM, Matthes AD, Coelho EB, Lanchote VL. Pharmacokinetics of cyclophosphamide enantiomers in patients with breast cancer. Cancer Chemother Pharmacol 2011; 68:897-904.

Fernandes Filho JA, Vedeler CA, Myhr KM, Nyland H, Pandey JP. TNF-alpha and -beta gene polymorphisms in multiple sclerosis: a highly significant role for determinants in the first intron of the TNF-beta gene. Autoimmunity 2002; 35:377-80.

Fernandes Gdos S, Blanke CD, Freitas D, Guedes R, Hoff PM. Perioperative treatment of gastrointestinal stromal tumors. Oncology 2009; 23:54-61.

Fernandes HB, Catches JS, Petralia RS et al. High-affinity kainate receptor subunits are necessary for ionotropic but not metabotropic signaling. Neuron 2009; 63:818-29.

Fernandes LC, Kilicarslan T, Kaplan HL, Tyndale RF, Sellers EM, Romach MK. Treatment of codeine dependence with inhibitors of cytochrome P450 2D6. J Clin Psychopharmacol 2002; 22:326-9.

Fernandez AP, Pozo-Rodrigalvarez A, Serrano J, Martinez-Murillo R. Nitric oxide: target for therapeutic strategies in Alzheimer's disease. Curr Pharm Des 2010; 16:2837-50.

Fernández P, Trzaska S, Wilder T et al. Pharmacological blockade of A2A receptors prevents dermal fibrosis in a model of elevated tissue adenosine. Am J Pathol 2008; 172:1675-82.

Fernández RM, Boru G, Pecina A et al. Ancestral RET haplotype associated with Hirschsprung's disease shows linkage disequilibrium breakpoint at -1249. J Med Genet 2005; 42:322-7.

Fernández-Cruz ML, Valdehita A, Alonso M, Mann E, Herradón B, Navas JM. Biological and chemical studies on aryl hydrocarbon receptor induction by the p53 inhibitor pifithrin-α and its condensation product pifithrin-β. Life Sci 2011; 88:774-83.

Fernández-Hernando C, Suárez Y, Rayner KJ, Moore KJ. MicroRNAs in lipid metabolism. Curr Opin Lipidol 2011; 22:86-92.

Fernández-Novoa L, Lombardi V, Fondevila M, Seoane S, Cacabelos R. Association study of M129V polymorphism at the PRNP gene in Alzheimer disease. Am J Med Genet 2002; 114:829-30.

Fernández-Real JM, Broch M, Vendrell J, Richart C, Ricart W. Interleukin-6 gene polymorphism and lipid abnormalities in healthy subjects. J Clin Endocrinol Metab 2000; 85:1334-9.

Fernández-Real JM, Casamitjana R, Ricart-Engel W. Leptin is involved in gender-related differences in insulin sensitivity. Clin Endocrinol 1998; 49:505-11.

Fernandez-Reyes D, Craig AG, Kyes SA et al. A high frequency African coding polymorphism in the N-terminal domain of ICAM-1 predisposing to cerebral malaria in Kenya. Hum Mol Genet 1997; 6:1357-60.

Fernández-Rubio A, López-Cima MF, González-Arriaga P et al. The TP53 Arg72Pro polymorphism and lung cancer risk in a population of Northern Spain. Lung Cancer 2008; 61:309-16.

Fernandez-Salguero P, Hoffman SM, Cholerton S et al. A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles. Am J Hum Genet 1995; 57:651-60.

Fernando H, Davydov DR, Chin CC, Halpert JR. Role of subunit interactions in P450 oligomers in the loss of homotropic cooperativity in the cytochrome P450 3A4 mutant L211F/D214E/F304W. Arch Biochem Biophys 2007; 460:129-40.

Fernando H, Halpert JR, Davydov DR. Resolution of multiple substrate binding sites in cytochrome P450 3A4: the stoichiometry of the enzyme-substrate complexes probed by FRET and Job's titration. Biochemistry 2006; 45:4199-209.

Fernando H, Halpert JR, Davydov DR. Kinetics of electron transfer in the complex of cytochrome P450 3A4 with the flavin domain of cytochrome P450BM-3 as evidence of functional heterogeneity of the heme protein. Arch Biochem Biophys 2008; 471:20-31.

Fernando MM, Stevens CR, Sabeti PC, et al. Identification of two independent risk factors for lupus within the MHC in United Kingdom families. PLoS Genet 2007. doi:10. 1371/journal. pgen. 0030192.

Ferrándiz-Huertas C, Fernández-Carvajal A, Ferrer-Montiel A. Rab4 interacts with the human P-glycoprotein and modulates its surface expression in multidrug resistant K562 cells. Int J Cancer 2011; 128:192-205.

Ferrari A, Coccia CP, Bertolini A, Sternieri E. Methadone-metabolism, pharmacokinetics and interactions. Pharmacol Res 2004; 50:551-9.

Ferrari MD, Goadsby PJ, Roon KI, Lipton RB. Triptans (serotonin, 5-HT1B/1D agonists) in migraine: detailed results and methods of a meta-analysis of 53 trials. Cephalalgia 2002; 22:633-58.

Ferreira AJ, Raizada MK. Are we poised to target ACE2 for the next generation of antihypertensives? J Mol Med 2008; 86:685-90.

Ferreira PE, Veiga MI, Cavaco I et al. Polymorphism of antimalaria drug metabolizing, nuclear receptor, and drug transport genes among malaria patients in Zanzibar, East Africa. Ther Drug Monit 2008; 30:10-5.

Ferreiro A, Monnier N, Romero NB et al. A recessive form of central core disease, transiently presenting as multi-minicore disease, is associated with a homozygous mutation in the ryanodine receptor type 1 gene. Ann Neurol 2002; 51:750-9.

Ferrell PB Jr, McLeod HL. Carbamazepine, HLA-B*1502 and risk of Stevens-Johnson syndrome and toxic epidermal necrolysis: US FDA recommendations. Pharmacogenomics 2008; 9:1543-6.

Ferrera P, Arias C. Differential effects of COX inhibitors against beta-amyloid-induced neurotoxicity in human neuroblastoma cells. Neurochem Int 2005; 47:589-96.

Ferreri F, Agbokou C, Gauthier S. Cardiovascular effects of cholinesterase inhibitors in Alzheimer's disease. Rev Neurol 2007; 163:968-74.

Ferrero S, Venturini PL, Gillott DJ, Remorgida V. Letrozole and norethisterone acetate versus letrozole and triptorelin in the treatment of endometriosis related pain symptoms: a randomized controlled trial. Reprod Biol Endocrinol 2011; 9:88.

Ferrettini C, Pirulli D, Cosseddu D et al. Molecular analysis of the AGXT gene in Italian patients with primary hyperoxaluria type 1 (PH1). J Nephrol 1998; 11 Suppl 1:18-22.

Ferrini JB, Pichard L, Domergue J, Maurel P. Long-term primary cultures of adult human hepatocytes. Chem Biol Interact 1997; 107:31-45.

Ferris SH. Evaluation of memantine for the treatment of Alzheimer's disease. Expert Opin Pharmacother 2003; 4:2305-13.

Fertleman CR, Baker MD, Parker KA et al. SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes. Neuron 2006; 52:767-74.

Fester L, Prange-Kiel J, Jarry H, Rune GM. Estrogen synthesis in the hippocampus. Cell Tissue Res 2011; 345:285-94.

Fetisova EK, Avetisyan AV, Izyumov DS, Korotetskaya MV, Chernyak BV, Skulachev VP. Mitochondria-targeted antioxidant SkQR1 selectively protects MDR (Pgp 170)-negative cells against oxidative stress. FEBS Lett 2010; 584:562-6.

Fetterman JW Jr, Zdanowicz MM. Therapeutic potential of n-3 polyunsaturated fatty acids in disease. Am J Health Syst Pharm 2009; 66:1169-79.

Feyereisen R. Molecular biology of insecticide resistance. Toxicol Lett 1995; 82-83:83-90.

Fialho RN, Martins L, Pinheiro JP et al. Role of human leukocyte antigen, killer-cell immunoglobulin-like receptors, and cytokine gene polymorphisms in leptospirosis. Hum Immunol 2009; 70:915-20.

Fichtenbaum CJ, Gerber JG. Interactions between antiretroviral drugs and drugs used for the therapy of the metabolic complications encountered during HIV infection. Clin Pharmacokinet 2002; 41:1195-211.

Fichtlscherer S, Dimmeler S, Breuer S, Busse R, Zeiher AM, Fleming I. Inhibition of cytochrome P450 2C9 improves endothelium-dependent, nitric oxide-mediated vasodilatation in patients with coronary artery disease. Circulation 2004; 109:178-83.

Fidlerova J, Kleiblova P, Bilek M et al. Contribution of dihydropyrimidinase gene alterations to the development of serious toxicity in fluoropyrimidine-treated cancer patients. Cancer Chemother Pharmacol 2010; 65:661-9.

Fiegenbaum M, da Silveira FR, van der Sand CR et al. The role of common variants of ABCB1, CYP3A4, and CYP3A5 genes in lipid-lowering efficacy and safety of simvastatin treatment. Clin Pharmacol Ther 2005; 78:551-8.

Fiegenbaum M, da Silveira FR, van der Sand CR et al. Pharmacogenetic study of apolipoprotein E, cholesteryl ester transfer protein and hepatic lipase genes and simvastatin therapy in Brazilian subjects. Clin Chim Acta 2005; 362:182-8.

Field FJ, Watt K, Mathur SN. TNF-alpha decreases ABCA1 expression and attenuates HDL cholesterol efflux in the human intestinal cell line Caco-2. J Lipid Res 2010; 51:1407-15.

Field JJ, Singh AJ, Kanakkanthara A, Halafihi T, Northcote PT, Miller JH. Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis. J Med Chem 2009; 52:7328-32.

Figgitt DP, McClellan KJ. Fluvoxamine. An updated review of its use in the management of adults with anxiety disorders. Drugs 2000; 60:925-54.

Figueroa JD, Malats N, García-Closas M et al. Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes. Carcinogenesis 2008; 29:1955-62.

Filigheddu F, Argiolas G, Degortes S et al. Haplotypes of the adrenergic system predict the blood pressure response to beta-blockers in women with essential hypertension. Pharmacogenomics 2010; 11:319-25.

Filigheddu F, Reid JE, Troffa C et al. Genetic polymorphisms of the beta-adrenergic system: association with essential hypertension and response to beta-blockade. Pharmacogenomics J 2004; 4:154-60.

Filipe B, Baltazar C, Albuquerque C et al. APC or MUTYH mutations account for the majority of clinically well-characterized families with FAP and AFAP phenotype and patients with more than 30 adenomas. Clin Genet 2009; 76:242-55.

Filippi E, Sentinelli F, Romeo S et al. The adiponectin gene SNP+276G>T associates with early-onset coronary artery disease and with lower levels of adiponectin in younger coronary artery disease patients (age <or=50 years). J Mol Med 2005; 83:711-9.

Filippi E, Sentinelli F, Trishitta V et al. Association of the human adiponectin gene and insulin resistance. Eur J Hum Genet 2004; 12:199-205.

Filopanti M, Barbieri AM, Angioni AR et al. Dopamine D2 receptor gene polymorphisms and response to cabergoline therapy in patients with prolactin-secreting pituitary adenomas. Pharmacogenomics J 2008; 8:357-63.

Filopanti M, Ronchi C, Ballarè E et al. Analysis of somatostatin receptors 2 and 5 polymorphisms in patients with acromegaly. J Clin Endocrinol Metab 2005; 90:4824-8.

Filosto M, Mancuso M, Nishigaki Y et al. Clinical and genetic heterogeneity in progressive external ophthalmoplegia due to mutations in polymerase gamma. Arch Neurol 2003; 60:1279-84.

Filppula AM, Laitila J, Neuvonen PJ, Backman JT. Reevaluation of the microsomal metabolism of montelukast: major contribution by CYP2C8 at clinically relevant concentrations. Drug Metab Dispos 2011; 39:904-11.

Finan RR, Mustafa FE, Al-Zaman I, Madan S, Issa AA, Almawi WY. STAT3 polymorphisms linked with idiopathic recurrent miscarriages. Am J Reprod Immunol 2010; 63:22-7.

Finck BN, Kelly DP. Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) regulatory cascade in cardiac physiology and disease. Circulation 2007; 115:2540-8.

Findling RL, Nucci G, Piergies AA et al. Multiple dose pharmacokinetics of paroxetine in children and adolescents with major depressive disorder or obsessive-compulsive disorder. Neuropsychopharmacology 2006; 31:1274-85.

Fingas CD, Katsounas A, Kahraman A et al. Prognostic assessment of three single-nucleotide polymorphisms (GNB3 825C>T, BCL2-938C>A, MCL1-386C>G) in extrahepatic cholangiocarcinoma. Cancer Invest 2010; 28:472-8.

Finkel D, Reynolds CA, Larsson M, Gatz M, Pedersen NL. Both odor identification and ApoE-ε4 contribute to normative cognitive aging. Psychol Aging 2011. doi:10. 1037/a0023371.

Finkelstein Y, Aks SE, Hutson JR et al. Colchicine poisoning: the dark side of an ancient drug. Clin Toxicol 2010; 48:407-14.

Finkelstein Y, Bournissen FG, Hutson JR, Shannon M. Polymorphism of the ADRB2 gene and response to inhaled beta- agonists in children with asthma: a meta-analysis. J Asthma 2009; 46:900-5.

Finken MJ, Meulenbelt I, Dekker FW et al. The 23K variant of the R23K polymorphism in the glucocorticoid receptor gene protects against postnatal growth failure and insulin resistance after preterm birth. J Clin Endocrinol Metab 2007; 92:4777-82.

Finley JC Jr, O'Leary M, Wester D et al. A genetic polymorphism of the alpha2-adrenergic receptor increases autonomic responses to stress. J Appl Physiol 2004; 96:2231-9.

Finn RS, Dering J, Conklin D et al. PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro. Breast Cancer Res 2009; 11:77.

Finney B, Wilkinson WJ, Searchfield L et al. An exon 5-less splice variant of the extracellular calcium-sensing receptor rescues absence of the full-length receptor in the developing mouse lung. Exp Lung Res 2011; 37:269-78.

Finnström N, Ask B, Dahl ML, Gadd M, Rane A. Intra-individual variation and sex differences in gene expression of cytochromes P450 in circulating leukocytes. Pharmacogenomics J 2002; 2:111-6.

Finnström N, Thörn M, Lööf L, Rane A. Independent patterns of cytochrome P450 gene expression in liver and blood in patients with suspected liver disease. Eur J Clin Pharmacol 2001; 57:403-9.

Finsterer J. Management of mitochondrial stroke-like-episodes. Eur J Neurol 2009; 16:1178-84.

Finsterer J. Perspectives of Kennedy's disease. J Neurol Sci 2010; 298:1-10.

Finta C, Zaphiropoulos PG. The human CYP2C locus: a prototype for intergenic and exon repetition splicing events. Genomics 2000; 63:433-8.

Finta C, Zaphiropoulos PG. The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons. Gene 2000; 260:13-23.

Finta C, Zaphiropoulos PG. Intergenic mRNA molecules resulting from trans-splicing. J Biol Chem 2002; 277:5882-90.

Fiorito M, Torrente I, de Cosmo S et al. Interaction of DIO2 T92A and PPARgamma2 P12A polymorphisms in the modulation of metabolic syndrome. Obesity 2007; 15:2889-95.

Firat H, Tourdot S, Ureta-Vidal A et al. Design of a polyepitope construct for the induction of HLA-A0201-restricted HIV 1-specific CTL responses using HLA-A*0201 transgenic, H-2 class I KO mice. Eur J Immunol 2001; 31:3064-74.

Firdous AP, Sindhu ER, Ramnath V, Kuttan R. Anti-mutagenic and anti-carcinogenic potential of the carotenoid meso-zeaxanthin. Asian Pac J Cancer Prev 2010; 11:1795-800.

Firkusny L, Kroemer HK, Eichelbaum M. In vitro characterization of cytochrome P450 catalysed metabolism of the antiemetic tropisetron. Biochem Pharmacol 1995; 49:1777-84.

Fisas A, Codony X, Romero G et al. Chronic 5-HT6 receptor modulation by E-6837 induces hypophagia and sustained weight loss in diet-induced obese rats. Br J Pharmacol 2006; 148:973-83.

Fischel-Ghodsian N. Genetic factors in aminoglycoside toxicity. Ann N Y Acad Sci 1999; 884:99-109.

Fischer A, Pallauf J, Gohil K, Weber SU, Packer L, Rimbach G. Effect of selenium and vitamin E deficiency on differential gene expression in rat liver. Biochem Biophys Res Commun 2001; 285:470-5.

Fischer LM, da Costa KA, Kwock L, Galanko J, Zeisel SH. Dietary choline requirements of women: effects of estrogen and genetic variation. Am J Clin Nutr 2010; 92:1113-9.

Fischer MB, Roeckl C, Parizek P, Schwarz HP, Aguzzi A. Binding of disease-associated prion protein to plasminogen. Nature 2000; 408:479-83.

Fischer PM, Gianella-Borradori A. Recent progress in the discovery and development of cyclin-dependent kinase inhibitors. Expert Opin Investig Drugs 2005; 14:457-77.

Fischer S, Loncar J, Zaja R et al. Constitutive mRNA expression and protein activity levels of nine ABC efflux transporters in seven permanent cell lines derived from different tissues of rainbow trout (Oncorhynchus mykiss). Aquat Toxicol 2011; 101:438-46.

Fischer V, Johanson L, Heitz F et al. The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor fluvastatin: effect on human cytochrome P-450 and implications for metabolic drug interactions. Drug Metab Dispos 1999; 27:410-6.

Fischer V, Vickers AE, Heitz F et al. The polymorphic cytochrome P-4502D6 is involved in the metabolism of both 5-hydroxytryptamine antagonists, tropisetron and ondansetron. Drug Metab Dispos 1994; 22:269-74.

Fishelovitch D, Hazan C, Hirao H, Wolfson HJ, Nussinov R, Shaik S. QM/MM study of the active species of the human cytochrome P450 3A4, and the influence thereof of the multiple substrate binding. J Phys Chem B 2007; 111:13822-32.

Fishelovitch D, Hazan C, Shaik S, Wolfson HJ, Nussinov R. Structural dynamics of the cooperative binding of organic molecules in the human cytochrome P450 3A4. J Am Chem Soc 2007; 129:1602-11.

Fishelovitch D, Shaik S, Wolfson HJ, Nussinov R. Theoretical characterization of substrate access/exit channels in the human cytochrome P450 3A4 enzyme: involvement of phenylalanine residues in the gating mechanism. J Phys Chem B 2009; 113:13018-25.

Fishelovitch D, Shaik S, Wolfson HJ, Nussinov R. How does the reductase help to regulate the catalytic cycle of cytochrome P450 3A4 using the conserved water channel? J Phys Chem B 2010; 114:5964-70.

Fisher CD, Lickteig AJ, Augustine LM et al. Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease. Drug Metab Dispos 2009; 37:2087-94.

Fisher E, Weikert C, Klapper M et al. L-FABP T94A is associated with fasting triglycerides and LDL-cholesterol in women. Mol Genet Metab 2007; 91:278-84.

Fisher JM, Wrighton SA, Watkins PB et al. First-pass midazolam metabolism catalyzed by 1alpha,25-dihydroxy vitamin D3-modified Caco-2 cell monolayers. J Pharmacol Exp Ther 1999; 289:1134-42.

Fishman D, Faulds G, Jeffery R et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 1998; 102:1369-76.

Fisman S, Reniers D, Diaz P. Erythromycin interaction with risperidone or clomipramine in an adolescent. J Child Adolesc Psychopharmacol 1996; 6:133-8.

Fitch WL, Tran T, Young M, Liu L, Chen Y. Revisiting the metabolism of ketoconazole using accurate mass. Drug Metab Lett 2009; 3:191-8.

Fitzgerald ML, Morris AL, Rhee JS, Andersson LP, Mendez AJ, Freeman MW. Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I. J Biol Chem 2002; 277:33178-87.

Fitzgerald ML, Mujawar Z, Tamehiro N. ABC transporters, atherosclerosis and inflammation. Atherosclerosis 2010; 211:361-70.

Fitzgerald PT, Ackerman MJ. Drug-induced torsades de pointes: the evolving role of pharmacogenetics. Heart Rhythm 2005; 2(2 Suppl):30-7.

Fitzsimmons ME, Collins JM. Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small-intestinal cytochrome P4503A4: potential contribution to high first-pass metabolism. Drug Metab Dispos 1997; 25:256-66.

Fitzsimmons WE, First MR. FK778, a synthetic malononitrilamide. Yonsei Med J 2004; 45:1132-5.

Flachs P, Mohamed-Ali V, Horakova O et al. Polyunsaturated fatty acids of marine origin induce adiponectin in mice fed a high-fat diet. Diabetologia 2006; 49:394-7.

Flachsbart F, Ufer M, Kleindorp R, Nikolaus S, Schreiber S, Nebel A. Genetic variation in the CYP2C monooxygenase enzyme subfamily shows no association with longevity in a German population. J Gerontol A Biol Sci Med Sci 2011; 66:1186-91.

Flaherty KT, Lathia C, Frye RF et al. Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study. Cancer Chemother Pharmacol 2011. doi:10. 1007/s00280-011-1585-0.

Flanagan D. Understanding the grapefruit-drug interaction. Gen Dent 2005; 53:282-6.

Flanagan JN, Young MV, Persons KS et al. Vitamin D metabolism in human prostate cells: implications for prostate cancer chemoprevention by vitamin D. Anticancer Res 2006; 26:2567-72.

Flanagan N, Healy E, Ray A et al. Pleiotropic effects of the melanocortin 1 receptor (MC1R) gene on human pigmentation. Hum Mol Genet 2000; 9:2531-7.

Flanagan S, Kapoor R, Banerjee I et al. Dominantly acting ABCC8 mutations in patients with medically unresponsive hyperinsulinaemic hypoglycaemia. Clin Genet 2011; 79:582-7.

Flanagan SE, Clauin S, Bellanné-Chantelot C et al. Update of mutations in the genes encoding the pancreatic beta-cell K(ATP) channel subunits Kir6. 2 (KCNJ11) and sulfonylurea receptor 1 (ABCC8) in diabetes mellitus and hyperinsulinism. Hum Mutat 2009; 30:170-80.

Flanagan SE, Kapoor RR, Mali G et al. Diazoxide-responsive hyperinsulinemic hypoglycemia caused by HNF4A gene mutations. Eur J Endocrinol 2010; 162:987-92.

Flatt PR, Bailey CJ, Green BD. Dipeptidyl peptidase IV (DPP IV) and related molecules in type 2 diabetes. Front Biosci 2008; 13:3648-60.

Flavell DM, Jamshidi Y, Hawe E et al. Peroxisome proliferator-activated receptor alpha gene variants influence progression of coronary atherosclerosis and risk of coronary artery disease. Circulation 2002; 105:1440-5.

Flechtner I, de Lonlay P, Polak M. Diabetes and hypoglycaemia in young children and mutations in the Kir6. 2 subunit of the potassium channel: therapeutic consequences. Diabetes Metab 2006; 32:569-80.

Fleeman N, Dundar Y, Dickson R et al. Cytochrome P450 testing for prescribing antipsychotics in adults with schizophrenia: systematic review and meta-analyses. Pharmacogenomics J 2011; 11:1-14.

Fleishaker JC. Clinical pharmacokinetics of reboxetine, a selective norepinephrine reuptake inhibitor for the treatment of patients with depression. Clin Pharmacokinet 2000; 39:413-27.

Fleishaker JC, Herman BD, Carel BJ, Azie NE. Interaction between ketoconazole and almotriptan in healthy volunteers. J Clin Pharmacol 2003; 43:423-7.

Fleishaker JC, Pearson LK, Pearson PG, Wienkers LC, Hopkins NK, Peters GR. Hormonal effects on tirilazad clearance in women: assessment of the role of CYP3A. J Clin Pharmacol 1999; 39:260-7.

Fleishaker JC, Pearson PG, Wienkers LC, Pearson LK, Moore TA, Peters GR. Biotransformation of tirilazad in human: 4. effect of finasteride on tirilazad clearance and reduced metabolite formation. J Pharmacol Exp Ther 1998; 287:591-7.

Fleishaker JC, Sisson TA, Carel BJ, Azie NE. Pharmacokinetic interaction between verapamil and almotriptan in healthy volunteers. Clin Pharmacol Ther 2000; 67:498-503.

Fleisher AS, Raman R, Siemers ER et al. Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease. Arch Neurol 2008; 65:1031-8.

Flekac M, Skrha J, Hilgertova J, Lacinova Z, Jarolimkova M. Gene polymorphisms of superoxide dismutases and catalase in diabetes mellitus. BMC Med Genet 2008; 9:30.

Fletcher B, Goldstein DB, Bradman AL, Weale ME, Bradman N, Thomas MG. High-throughput analysis of informative CYP2D6 compound haplotypes. Genomics 2003; 81:166-74.

Fleury I, Primeau M, Doreau A et al. Polymorphisms in genes involved in the corticosteroid response and the outcome of childhood acute lymphoblastic leukemia. Am J Pharmacogenomics 2004; 4:331-41.

Flint MS, Hood BL, Sun M, Stewart NA, Jones-Laughner J, Conrads TP. Proteomic analysis of the murine liver in response to a combined exposure to psychological stress and 7,12-dimethylbenz(a)anthracene. J Proteome Res 2010; 9:509-20.

Flockhart DA, Drici MD, Kerbusch T et al. Studies on the mechanism of a fatal clarithromycin-pimozide interaction in a patient with Tourette syndrome. J Clin Psychopharmacol 2000; 20:317-24.

Flockhart DA, O'Kane D, Williams MS et al. Pharmacogenetic testing of CYP2C9 and VKORC1 alleles for warfarin. Genet Med 2008; 10:139-50.

Flomen R, Knight J, Sham P, Kerwin R, Makoff A. Evidence that RNA editing modulates splice site selection in the 5-HT2C receptor gene. Nucleic Acids Res 2004; 32:2113-22.

Flordellis C, Manolis A, Scheinin M, Paris H. Clinical and pharmacological significance of alpha2-adrenoceptor polymorphisms in cardiovascular diseases. Int J Cardiol 2004; 97:367-72.

Floren LC, Bekersky I, Benet LZ et al. Tacrolimus oral bioavailability doubles with coadministration of ketoconazole. Clin Pharmacol Ther 1997; 62:41-9.

Flores-Dorantes T, Arellano-Campos O, Posadas-Sánchez R et al. Association of R230C ABCA1 gene variant with low HDL-C levels and abnormal HDL subclass distribution in Mexican school-aged children. Clin Chim Acta 2010; 411:1214-7.

Flores-Murrieta FJ, Carrasco-Portugal MdelC, Landa C. Comparison of the oral pharmacokinetics of fluconazole and itraconazole in Mexicans. Proc West Pharmacol Soc 2008; 51:63-5.

Florez JC, Burtt N, de Bakker PI et al. Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region. Diabetes 2004; 53:1360-8.

Florez JC, Jablonski KA, Sun MW et al. Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone. J Clin Endocr Metab 2007; 92:1502-9.

Floyd MD, Gervasini G, Masica AL et al. Genotype-phenotype associations for common CYP3A4 and CYP3A5 variants in the basal and induced metabolism of midazolam in European- and African-American men and women. Pharmacogenetics 2003; 13:595-606.

Flück CE, Mallet D, Hofer G et al. Deletion of P399_E401 in NADPH cytochrome P450 oxidoreductase results in partial mixed oxidase deficiency. Biochem Biophys Res Commun 2011; 412:572-7.

Flück CE, Pandey AV. Clinical and biochemical consequences of p450 oxidoreductase deficiency. Endocr Dev 2011; 20:63-79.

Fluhrer R, Friedlein A, Haass C, Walter J. Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis. J Biol Chem 2004; 279:1585-93.

Fogarasi M, Janssen A, Weber BH, Stöhr H. Molecular dissection of TIMP3 mutation S156C associated with Sorsby fundus dystrophy. Matrix Biol 2008; 27:381-92.

Fogelman SM, Schmider J, Venkatakrishnan K et al. O- and N-demethylation of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: effect of metabolic inhibitors and SSRI antidepressants. Neuropsychopharmacology 1999; 20:480-90.

Foisy MM, Yakiwchuk EM, Hughes CA. Induction effects of ritonavir: implications for drug interactions. Ann Pharmacother 2008; 42:1048-59.

Fojo A, Lebo R, Shimizu N et al. Localization of multidrug resistance-associated DNA sequences to human chromosome 7. Somat Cell Molec Genet 1986; 12:415-20.

Fojtíková M, Stolfa J, Novota P, Cejková P, Dostál C, Cerná M. HLA-Cw*06 class I region rather than MICA is associated with psoriatic arthritis in Czech population. Rheumatol Int 2009; 29:1293-9.

Fokina VM, Patrikeeva SL, Zharikova OL, Nanovskaya TN, Hankins GV, Ahmed MS. Transplacental transfer and metabolism of buprenorphine in preterm human placenta. Am J Perinatol 2011; 28:25-32.

Foley KF, DeSanty KP, Kast RE. Bupropion: pharmacology and therapeutic applications. Expert Rev Neurother 2006; 6:1249-65.

Folsom AR, Peacock JM, Boerwinkle E, Cushman M. beta2-adrenergic receptor polymorphism and venous thromboembolism. Thromb Haemost 2008; 99:240.

Foltynie T, Sawcer S, Brayne C, Barker RA. The genetic basis of Parkinson's disease. J Neurol Neurosurg Psychiatry 2002; 73:363-70.

Fong CS, Shyu HY, Shieh JC et al. Association of MTHFR, MTR, and MTRR polymorphisms with Parkinson's disease among ethnic Chinese in Taiwan. Clin Chim Acta 2011; 412:332-8.

Fong CS, Wu RM, Shieh JC et al. Pesticide exposure on southwestern Taiwanese with MnSOD and NQO1 polymorphisms is associated with increased risk of Parkinson's disease. Clin Chim Acta 2007; 378:136-41.

Fonsart J, Menet MC, Debray M et al. Sprague-Dawley rats display sex-linked differences in the pharmacokinetics of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolite 3,4-methylenedioxyamphetamine (MDA). Toxicol Appl Pharmacol 2009; 241:339-47.

Fonseca F, de la Torre R, Díaz L et al. Contribution of cytochrome P450 and ABCB1 genetic variability on methadone pharmacokinetics, dose requirements, and response. PLoS One 2011. doi:10. 1371/journal. pone. 0019527.

Fontaine SM, Hoyer PB, Halpert JR, Sipes IG. Role of induction of specific hepatic cytochrome P450 isoforms in epoxidation of 4-vinylcyclohexene. Drug Metab Dispos 2001; 29:1236-42.

Fontana L, Delort L, Joumard L et al. Genetic polymorphisms in CYP1A1, CYP1B1, COMT, GSTP1 and NAT2 genes and association with bladder cancer risk in a French cohort. Anticancer Res 2009; 29:1631-5.

Fontana P, Dupont A, Gandrille S et al. Adenosine diphosphate-induced platelet aggregation is associated with P2Y(12) gene sequence variations in healthy subjects. Circulation 2003; 108:989-95.

Fontana P, Gandrille S, Remones V et al. Identification of functional polymorphisms of the thromboxane A2 receptor gene in healthy volunteers. Thromb Haemost 2006; 3:356-60.

Fontana P, Gaussem P, Aiach M, Fiessinger JN, Emmerich J, Reny JL. P2Y(12) H2 haplotype is associated with peripheral arterial disease: a case-control study. Circulation 2003; 108:2971-73.

Fontana P, Remones V, Reny JL, Aiach M, Gaussem P. P2Y1 gene polymorphism and ADP-induced platelet response. J Thromb Haemost 2005; 3:2349-50.

Fontana RJ, Lown KS, Paine MF et al. Effects of a chargrilled meat diet on expression of CYP3A, CYP1A, and P-glycoprotein levels in healthy volunteers. Gastroenterology 1999; 117:89-98.

Fontana RJ, Turgeon DK, Woolf TF, Knapp MJ, Foster NL, Watkins PB. The caffeine breath test does not identify patients susceptible to tacrine hepatotoxicity. Hepatology 1996; 23:1429-35.

Fontanière S, Duvillié B, Scharfmann R, Carreira C, Wang ZQ, Zhang CX. Tumour suppressor menin is essential for development of the pancreatic endocrine cells. J Endocrinol 2008; 199:287-98.

Foote KM, Mortlock AA, Heron NM et al. Synthesis and SAR of 1-acetanilide-4-aminopyrazole-substituted quinazolines: selective inhibitors of Aurora B kinase with potent anti-tumor activity. Bioorg Med Chem Lett 2008; 18:1904-9.

Ford GA, Wood SM, Daly AK. CYP2D6 and CYP2C19 genotypes of patients with terodiline cardiotoxicity identified through the yellow card system. Br J Clin Pharmacol 2000; 50:77-80.

Ford NF. Clopidogrel resistance: pharmacokinetic or pharmacogenetic? J Clin Pharmacol 2009; 49:506-12.

Ford SL, Chen YC, Lou Y et al. Pharmacokinetic interaction between fosamprenavir-ritonavir and rifabutin in healthy subjects. Antimicrob Agents Chemother 2008; 52:534-8.

Forero DA, Arboleda GH, Vasquez R, Arboleda H. Candidate genes involved in neural plasticity and the risk for attention-deficit hyperactivity disorder: a meta-analysis of 8 common variants. J Psychiatry Neurosci 2009; 34:361-6.

Foresta C, Strapazzon G, de Toni L et al. Bone mineral density and testicular failure: evidence for a role of vitamin D 25-hydroxylase in human testis. J Clin Endocrinol Metab 2011; 96:646-52.

Forget B, Wertheim C, Mascia P, Pushparaj A, Goldberg SR, Le Foll B. Noradrenergic alpha1 receptors as a novel target for the treatment of nicotine addiction. Neuropsychopharmacology 2010; 35:1751-60.

Forget P, le Polain de Waroux B, Wallemacq P, Gala JL. Life-threatening dextromethorphan intoxication associated with interaction with amitriptyline in a poor CYP2D6 metabolizer: a single case re-exposure study. J Pain Symptom Manage 2008; 36:92-6.

Forkert PG. Mechanisms of lung tumorigenesis by ethyl carbamate and vinyl carbamate. Drug Metab Rev 2010; 42:355-78.

Forleo C, Resta N, Sorrentino S et al. Association of beta-adrenergic receptor polymorphisms and progression to heart failure in patients with idiopathic dilated cardiomyopathy. Am J Med 2004; 117:451-8.

Forleo C, Sorrentino S, Guida P et al. Beta1- and beta2-adrenergic receptor polymorphisms affect susceptibility to idiopathic dilated cardiomyopathy. J Cardiovasc Med 2007; 8:589-95.

Forman MS, Lee VM, Trojanowski JQ. New insights into genetic and molecular mechanisms of brain degeneration in tauopathies. J Chem Neuroanat 2000; 20:225-44.

Formanack ML, Baier LJ. Variation in the FABP2 promoter affects gene expression: implications for prior association studies. Diabetologia 2004; 47:349-51.

Fornage M, Turner ST, Sing CF, Boerwinkle E. Variation at the M235T locus of the angiotensinogen gene and essential hypertension: a population-based case-control study from Rochester, Minnesota. Hum Genet 1995; 96:295-300.

Fornier MN, Rathkopf D, Shah M et al. Phase I dose-finding study of weekly docetaxel followed by flavopiridol for patients with advanced solid tumors. Clin Cancer Res 2007; 13:5841-6.

Forrest GL, Gonzalez B. Carbonyl reductase. Chem Biol Interact 2000; 129:21-40.

Forsberg L, Leeb L, Thoren S, Morgenstern R, Jakobsson PJ. Human glutathione dependent prostaglandin E synthase: gene structure and regulation. FEBS Lett 2000; 471:78-82.

Forti G, Falchetti A, Santoro S, Davis DL, Wilson JD, Russell DW. Steroid 5 alpha-reductase 2 deficiency: virilization in early infancy may be due to partial function of mutant enzyme. Clin Endocrinol 1996; 44:477-82.

Foster A, Mobley E, Wang Z. Complicated pain management in a CYP450 2D6 poor metabolizer. Pain Pract 2007; 7:352-6.

Foster AE, Okur FV, Biagi E et al. Selective elimination of a chemoresistant side population of B-CLL cells by cytotoxic T lymphocytes in subjects receiving an autologous hCD40L/IL-2 tumor vaccine. Leukemia 2010; 24:563-72.

Foster BC, Arnason JT, Saleem A et al. Comparative study of hops-containing products on human cytochrome P450-mediated metabolism. J Agric Food Chem 2011; 59:5159-63.

Foster BC, Kearns N, Arnason JT, Saleem A, Ogrodowczyk C, Desjardins S. Comparative study of hop-containing products on human cytochrome p450-mediated metabolism. J Agric Food Chem 2009; 57:5100-5.

Foster CB, Lehrnbecher T, Samuels S et al. An IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in men infected with human immunodeficiency virus. Blood 2000; 96:2562-7.

Foster DC, Yoshitake S, Davie EW. The nucleotide sequence of the gene for human protein C. Proc Natl Acad Sci USA 1985; 82:4673-7.

Foster DJ, Somogyi AA, Bochner F. Methadone N-demethylation in human liver microsomes: lack of stereoselectivity and involvement of CYP3A4. Br J Clin Pharmacol 1999; 47:403-12.

Foster DJ, Somogyi AA, Dyer KR, White JM, Bochner F. Steady-state pharmacokinetics of (R)- and (S)-methadone in methadone maintenance patients. Br J Clin Pharmacol 2000; 50:427-40.

Foster PP, Rosenblatt KP, Kuljiš RO. Exercise-induced cognitive plasticity, implications for mild cognitive impairment and Alzheimer's disease. Front Neurol 2011; 2:28.

Foti RS, Dickmann LJ, Davis JA et al. Metabolism and related human risk factors for hepatic damage by usnic acid containing nutritional supplements. Xenobiotica 2008; 38:264-80.

Foti RS, Rock DA, Wienkers LC, Wahlstrom JL. Selection of alternative CYP3A4 probe substrates for clinical drug interaction studies Using in vitro data and in vivo simulation. Drug Metab Dispos 2010; 38:981-7.

Fotoohi AK, Assaraf YG, Moshfegh A et al. Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis. Biochem Pharmacol 2009; 77:1410-7.

Fotsch C, Bartberger MD, Bercot EA et al. Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: reducing pregnane X receptor activity and exploring activity in a monkey pharmacodynamic model. J Med Chem 2008; 51:7953-67.

Foucher C, Rattier S, Flavell DM et al. Response to micronized fenofibrate treatment is associated with the peroxisome-proliferator-activated receptors alpha G/C intron7 polymorphism in subjects with type 2 diabetes. Pharmacogenetics 2004; 14:823-9.

Fouladi M, Nicholson HS, Zhou T et al. A phase II study of the farnesyl transferase inhibitor, tipifarnib, in children with recurrent or progressive high-grade glioma, medulloblastoma/primitive neuroectodermal tumor, or brainstem glioma: a Children's Oncology Group study. Cancer 2007; 110:2535-41.

Fournier B, Saudubray JM, Benichou B et al. Large deletion of the peroxisomal acyl-CoA oxidase gene in pseudoneonatal adrenoleukodystrophy. J Clin Invest 1994; 94:526-31.

Fowler EV, Eri R, Hume G et al. TNF-alpha and IL10 SNPs act together to predict disease behaviour in Crohn's disease. J Med Genet 2005; 42:523-8.

Fowler JH, Settle JE, Christakis NA. Correlated genotypes in friendship networks. Proc Natl Acad Sci USA 2011; 108:1993-7.

Fowler JS, Volkow ND, Wang GJ et al. Inhibition of monoamine oxidase B in the brains of smokers. Nature 1996; 379:733-6.

Fowler SJ, Hall IP, Wilson AM, Wheatley AP, Lipworth BJ. 5-Lipoxygenase polymorphism and in-vivo response to leukotriene receptor antagonists. Eur J Clin Pharmacol 2002; 58:187-90.

Fowler SM, Riley RJ, Pritchard MP, Sutcliffe MJ, Friedberg T, Wolf CR. Amino acid 305 determines catalytic center accessibility in CYP3A4. Biochemistry 2000; 39:4406-14.

Fowler SM, Taylor JM, Friedberg T, Wolf CR, Riley RJ. CYP3A4 active site volume modification by mutagenesis of leucine 211. Drug Metab Dispos 2002; 30:452-6.

Fox CS, Yang Q, Cupples LA et al. Sex-specific association between estrogen receptor-alpha gene variation and measures of adiposity: the Framingham Heart Study. J Clin Endocrinol Metab 2005; 90:6257-62.

Foxenberg RJ, Ellison CA, Knaak JB, Ma C, Olson JR. Cytochrome P450-specific human PBPK/PD models for the organophosphorus pesticides: chlorpyrifos and parathion. Toxicology 2011; 285:57-66.

Fradin S, Goulet-Salmon B, Chantepie M et al. Relationship between polymorphisms in the renin-angiotensin system and nephropathy in type 2 diabetic patients. Diabetes Metab 2002; 28:27-32.

Fraering PC, Ye W, Strub JM et al. Purification and characterization of the human gamma-secretase complex. Biochemistry 2004; 43:9774-89.

Fraga AG, da Silva LL, Fraga CA, Barreiro EJ. CYP1A2-mediated biotransformation of cardioactive 2-thienylidene-3,4-methylenedioxybenzoylhydrazine (LASSBio-294) by rat liver microsomes and human recombinant CYP enzymes. Eur J Med Chem 2011; 46:349-55.

Fragoso JM, Delgadillo H, Juárez-Cedillo T et al. The interleukin 6 -572 G>C (rs1800796) polymorphism is associated with the risk of developing acute coronary syndrome. Genet Test Mol Biomarkers 2010; 14:759-63.

Fragoso JM, Rodríguez-Pérez JM, González J et al. Beta1-adrenergic receptor gene polymorphisms in Mexican patients with idiopathic dilated cardiomyopathy. Exp Mol Pathol 2006; 80:279-82.

Frampton GA, Lazcano EA, Li H, Mohamad A, DeMorrow S. Resveratrol enhances the sensitivity of cholangiocarcinoma to chemotherapeutic agents. Lab Invest 2010; 90:1325-38.

Francis R, McGrath G, Zhang G et al. Aph-1 and pen-2 are required for Notch pathway signalling, gamma-secretase cleavage of beta-APP, and presenilin protein accumulation. Dev Cell 2002; 3:85-97.

Franco E, Palumbo L, Crobu F et al. Renin-angiotensin-aldosterone system polymorphisms: a role or a hole in occurrence and long-term prognosis of acute myocardial infarction at young age. BMC Med Genet 2007; 8:27.

Francois AA, Nishida CR, de Montellano PR, Phillips IR, Shephard EA. Human flavin-containing monooxygenase 2. 1 catalyzes oxygenation of the antitubercular drugs thiacetazone and ethionamide. Drug Metab Dispos 2009; 37:178-86.

Francois J. Retinoblastoma and osteogenic sarcoma. Ophthalmologica 1977; 175:185-91.

Franco-Salinas G, de la Rosette JJ, Michel MC. Pharmacokinetics and pharmacodynamics of tamsulosin in its modified-release and oral controlled absorption system formulations. Clin Pharmacokinet 2010; 49:177-88.

Frank D, Jaehde U, Fuhr U. Evaluation of probe drugs and pharmacokinetic metrics for CYP2D6 phenotyping. Eur J Clin Pharmacol 2007; 63:321-33.

Frank D, Kuhn C, van Eickels M et al. Calsarcin-1 protects against angiotensin-II-induced cardiac hypertrophy. Circulation 2007; 116:2587-96.

Frank DJ, Denisov IG, Sligar SG. Mixing apples and oranges: Analysis of heterotropic cooperativity in cytochrome P450 3A4. Arch Biochem Biophys 2009; 488:146-52.

Frank H, Gröger N, Diener M, Becker C, Braun T, Boettger T. Lactaturia and loss of sodium-dependent lactate uptake in the colon of SLC5A8-deficient mice. J Biol Chem 2008; 283:24729-37.

Franke A, Balschun T, Karlsen TH et al. Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat Genet 2008; 40:1319-23

Franke RM, Baker SD, Mathijssen RH, Schuetz EG, Sparreboom A. Influence of solute carriers on the pharmacokinetics of CYP3A4 probes. Clin Pharmacol Ther 2008; 84:704-9.

Franke RM, Lancaster CS, Peer CJ et al. Effect of ABCC2 (MRP2) transport function on erythromycin metabolism. Clin Pharmacol Ther 2011; 89:693-701.

Frankfort SV, Doodeman VD, Bakker R et al. ABCB1 genotypes and haplotypes in patients with dementia and age-matched non-demented control patients. Mol Neurodegener 2006; 1:13.

Franklin MR, Constance JE. Comparative 1-substituted imidazole inhibition of cytochrome p450 isozyme-selective activities in human and mouse hepatic microsomes. Drug Metab Rev 2007; 39:309-22.

Franklin MR, Hathaway LB. 2-Diethylaminoethyl-2,2-diphenylvalerate-HCl (SKF525A) revisited: comparative cytochrome P450 inhibition in human liver microsomes by SKF525A, its metabolites, and SKF-acid and SKF-alcohol. Drug Metab Dispos 2008; 36:2539-46.

Franklin TR, Wang Z, Li Y et al. Dopamine transporter genotype modulation of neural responses to smoking cues: confirmation in a new cohort. Addict Biol 2011; 16:308-22.

Franko A, Dolzan V, Arnerić N, Dodic-Fikfak M. The influence of genetic polymorphisms of GSTP1 on the development of asbestosis. J Occup Environ Med 2008; 50:7-12.

Fransson MN, Gréen H, Litton JE, Friberg LE. Influence of Cremophor EL and genetic polymorphisms on the pharmacokinetics of paclitaxel and its metabolites using a mechanism-based model. Drug Metab Dispos 2011; 39:247-55.

Fransvea E, Angelotti U, Antonaci S, Giannelli G. Blocking transforming growth factor-beta up-regulates E-cadherin and reduces migration and invasion of hepatocellular carcinoma cells. Hepatology 2008; 5:1557-66.

Franzellitti S, Buratti S, Valbonesi P, Capuzzo A, Fabbri E. The β-blocker propranolol affects cAMP-dependent signaling and induces the stress response in Mediterranean mussels, Mytilus galloprovincialis. Aquat Toxicol 2011; 101:299-308.

Frassetto LA, Poon S, Tsourounis C, Valera C, Benet LZ. Effects of uptake and efflux transporter inhibition on erythromycin breath test results. Clin Pharmacol Ther 2007; 81:828-32.

Frayling TM. Commentary: Genetic association studies see light at the end of the tunnel. Int J Epidemiol 2008; 37:133-5.

Frech MS, Torre KM, Robinson GW, Furth PA. Loss of cyclin D1 in concert with deregulated estrogen receptor alpha expression induces DNA damage response activation and interrupts mammary gland morphogenesis. Oncogene 2008; 27:3186-93.

Frederick KS, Maurer TS, Kalgutkar AS et al. Pharmacokinetics, disposition and lipid-modulating activity of 5-{2-[4-(3,4-difluorophenoxy)-phenyl]-ethylsulfamoyl}-2-methyl-benzoic acid, a potent and subtype-selective peroxisome proliferator-activated receptor alpha agonist in preclinical species and human. Xenobiotica 2009; 39:766-81.

Fredericks S, Holt DW, MacPhee IA. The pharmacogenetics of immunosuppression for organ transplantation: a route to individualization of drug administration. Am J Pharmacogenomics 2003; 3:291-301.

Frederiksen L, Brødbaek K, Fenger M et al. Comment: studies of the Pro12Ala polymorphism of the PPAR-gamma gene in the Danish MONICA cohort: homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome. J Clin Endocrinol Metab 2002; 87:3989-92.

Frederiksen L, Brødbaek K, Fenger M et al. No interactions between polymorphisms in the beta3-adrenergic receptor gene and the PPAR-gamma gene on the risk of the insulin resistance syndrome in the Danish MONICA cohort. Diabetologia 2003; 46:729-31.

Fredholm BB, Arslan G, Halldner L, Kull B, Schulte G, Wasserman W. Structure and function of adenosine receptors and their genes. Naunyn Schmiedebergs Arch Pharmacol 2000; 362:364-74.

Freedman RS, Wang E, Voiculescu S et al. Comparative analysis of peritoneum and tumor eicosanoids and pathways in advanced ovarian cancer. Clin Cancer Res 2007; 13:5736-44.

Freeman C, Spelman K. A critical evaluation of drug interactions with Echinacea spp. Mol Nutr Food Res 2008; 52:789-98.

Freeman DJ, Juan T, Reiner M et al. Association of K-ras mutational status and clinical outcomes in patients with metastatic colorectal cancer receiving panitumumab alone. Clin Colorectal Cancer 2008; 7:184-90.

Frei E, Bieler CA, Arlt VM, Wiessler M, Stiborová M. Covalent binding of the anticancer drug ellipticine to DNA in V79 cells transfected with human cytochrome P450 enzymes. Biochem Pharmacol 2002; 64:289-95.

Freigang S, Ampenberger F, Spohn G et al. Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis. Eur J Immunol 2011; 41:2040-51.

Freimuth RR, Xiao M, Marsh S et al. Polymorphism discovery in 51 chemotherapy pathway genes. Hum Mol Genet 2005; 14:3595-603.

Freitas AI, Mendonça I, Brión M et al. RAS gene polymorphisms, classical risk factors and the advent of coronary artery disease in the Portuguese population. BMC Cardiovasc Disord 2008; 8:15.

Freitas RF, Bauab RL, Montanari CA. Novel application of 2D and 3D-similarity searches to identify substrates among cytochrome P450 2C9, 2D6, and 3A4. J Chem Inf Model 2010; 50:97-109.

Freitas RN, Khaw KT, Wu K et al. HMGCR gene polymorphism is associated with stroke risk in the EPIC-Norfolk study. Eur J Cardiovasc Prev Rehabil 2010; 17:89-93.

Frémin C, Ezan F, Guegan JP et al. The complexity of ERK1 and ERK2 MAPKs in multiple hepatocyte fate responses. J Cell Physiol 2011. doi:10. 1002/jcp. 22742.

Fremont JJ, Wang RW, King CD. Coimmunoprecipitation of UDP-glucuronosyltransferase isoforms and cytochrome P450 3A4. Mol Pharmacol 2005; 67:260-2.

French CJ, Zaman AK, Sobel BE. The angiotensin receptor blocker, Azilsartan medoxomil (TAK-491), suppresses vascular wall expression of plasminogen activator inhibitor type-I (PAI-I) protein potentially facilitating the stabilization of atherosclerotic plaques. J Cardiovasc Pharmacol 2011; 58:143-8.

Frere C, Cuisset T, Morange PE et al. Effect of cytochrome p450 polymorphisms on platelet reactivity after treatment with clopidogrel in acute coronary syndrome. Am J Cardiol 2008; 101:1088-93.

Freson K, Jaeken J, van Helvoirt M et al. Functional polymorphisms in the paternally expressed XLalphas and its cofactor ALEX decrease their mutual interaction and enhance receptor-mediated cAMP formation. Hum Mol Genet 2003; 12:1121-30.

Frey UH, Alakus H, Wohlschlaeger J, et al. GNAS1 T393C polymorphism and survival in patients with sporadic colorectal cancer. Clin Cancer Res 2005; 11:5071-7.

Frey UH, Hauner H, Jöckel KH, Manthey I, Brockmeyer N, Siffert W. A novel promoter polymorphism in the human gene GNAS affects binding of transcription factor upstream stimulatory factor 1, Galphas protein expression and body weight regulation. Pharmacogenet Genomics 2008; 18:141-51.

Frey UH, Lümmen G, Jäger T et al. The GNAS1 T393C polymorphism predicts survival in patients with clear cell renal cell carcinoma. Clin Cancer Res 2006; 12:759-63.

Friederich P, Solth A, Schillemeit S, Isbrandt D. Local anaesthetic sensitivities of cloned HERG channels from human heart: comparison with HERG/MiRP1 and HERG/MiRP1 T8A. Br J Anaesth 2004; 92:93-101.

Friedland G, Andrews L, Schreibman T et al. Lack of an effect of atazanavir on steady-state pharmacokinetics of methadone in patients chronically treated for opiate addiction. AIDS 2005; 19:1635-41.

Friedrich C, Ring A, Brand T, Sennewald R, Graefe-Mody EU, Woerle HJ. Evaluation of the pharmacokinetic interaction after multiple oral doses of linagliptin and digoxin in healthy volunteers. Eur J Drug Metab Pharmacokinet 2011; 36:17-24.

Frikke-Schmidt R, Nordestgaard BG, Thudium D, Moes Gronholdt ML, Tybjaerg-Hansen A. APOE genotype predicts AD and other dementia but not ischemic cerebrovascular disease. Neurology 2001; 56:194-200.

Frikke-Schmidt R, Sing CF, Nordestgaard BG, Steffensen R, Tybjaerg-Hansen A. Subsets of SNPs define rare genotype classes that predict ischemic heart disease. Hum Genet 2007; 120:865-77.

Frisoni GB, Geroldi C, Bianchetti A et al. Apolipoprotein E epsilon-4 allele frequency in vascular dementia and Alzheimer's disease. Stroke 1994; 25:1703.

Fritz HG, Holzmayr M, Walter B, Moeritz KU, Lupp A, Bauer R. The effect of mild hypothermia on plasma fentanyl concentration and biotransformation in juvenile pigs. Anesth Analg 2005; 100:996-1002.

Fritze F, Ehrt U, Sønnesyn H et al. Depression in mild dementia: associations with diagnosis, APOE genotype and clinical features. Int J Geriatr Psychiatry 2011; 26:1054-61.

Froehlich TE, McGough JJ, Stein MA. Progress and promise of attention-deficit hyperactivity disorder pharmacogenetics. CNS Drugs 2010; 24:99-117.

Fröhlich E, Kueznik T, Samberger C, Roblegg E, Wrighton C, Pieber TR. Size-dependent effects of nanoparticles on the activity of cytochrome P450 isoenzymes. Toxicol Appl Pharmacol 2010; 242:326-32.

Froicu M, Zhu Y, Cantorna MT. Vitamin D receptor is required to control gastrointestinal immunity in IL-10 knockout mice. Immunology 2006; 117:310-8.

Fromm MF. The influence of MDR1 polymorphisms on P-glycoprotein expression and function in humans. Adv Drug Deliv Rev 2002; 54:1295-310.

Fromm MF. Genetically determined differences in P-glycoprotein function: implications for disease risk. Toxicology 2002; 181-2:299-303.

Fromm MF, Busse D, Kroemer HK, Eichelbaum M. Differential induction of prehepatic and hepatic metabolism of verapamil by rifampin. Hepatology 1996; 24:796-801.

Fromm MF, Eckhardt K, Li S et al. Loss of analgesic effect of morphine due to coadministration of rifampin. Pain 1997; 72:261-7.

Frudakis TN, Thomas MJ, Ginjupalli SN, Handelin B, Gabriel R, Gomez HJ. CYP2D6*4 polymorphism is associated with statin-induced muscle effects. Pharmacogenet Genomics 2007; 17:695-707.

Fruttero R, Crosetti M, Chegaev K et al. Phenylsulfonylfuroxans as modulators of multidrug-resistance-associated protein-1 and P-glycoprotein. J Med Chem 2010; 53:5467-75.

Fry DW, Harvey PJ, Keller PR et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther 2004; 3:1427-38.

Frye RF, Branch RA. Effect of chronic disulfiram administration on the activities of CYP1A2, CYP2C19, CYP2D6, CYP2E1, and N-acetyltransferase in healthy human subjects. Br J Clin Pharmacol 2002; 53:155-62.

Frye RF, Fitzgerald SM, Lagattuta TF, Hruska MW, Egorin MJ. Effect of St John's wort on imatinib mesylate pharmacokinetics. Clin Pharmacol Ther 2004; 76:323-9.

Frye RF, Tammara B, Cowart TD, Bramer SL. Effect of disulfiram-mediated CYP2E1 inhibition on the disposition of vesnarinone. J Clin Pharmacol 1999; 39:1177-83.

Frye RF, Zgheib NK, Matzke GR et al. Liver disease selectively modulates cytochrome P450-mediated metabolism. Clin Pharmacol Ther 2006; 80:235-45.

Fu AL, Zhou CY, Chen X. Thyroid hormone prevents cognitive deficit in a mouse model of Alzheimer's disease. Neuropharmacology 2010; 58:722-9.

Fu L, Zhao Y, Wu X et al. CYP7A1 genotypes and haplotypes associated with hypertension in an obese Han Chinese population. Hypertens Res 2011; 34:722-7.

Fu M, Kazlauskaite R, Baracho MdeF et al. Mutations in Gng31g and AGPAT2 in Berardinelli-Seip congenital lipodystrophy and Brunzell syndrome: phenotype variability suggests important modifier effects. J Clin Endocr Metab 2004; 89:2916-22.

Fu Y, Fan CH, Deng HH et al. Association of CYP2D6 and CYP1A2 gene polymorphism with tardive dyskinesia in Chinese schizophrenic patients. Acta Pharmacol Sin 2006; 27:328-32.

Fu Y, He F, Tang NL et al. NEDD9 gene polymorphism influences the risk of Alzheimer disease and cognitive function in Chinese older persons. Alzheimer Dis Assoc Disord 2011. doi:10. 1097/WAD. 0b013e3182135ef3.

Fu Z, Nakayama T, Sato N et al. A haplotype of the CYP4F2 gene is associated with cerebral infarction in Japanese men. Am J Hypertens 2008; 21:1216-23.

Fu Z, Nakayama T, Sato N et al. Haplotype-based case-control study of the human CYP4F2 gene and essential hypertension in Japanese subjects. Hypertens Res 2008; 31:1719-26.

Fu Z, Nakayama T, Sato N et al. A haplotype of the CYP4F2 gene associated with myocardial infarction in Japanese men. Mol Genet Metab 2009; 96:145-7.

Fu Z, Regan K, Zhang L et al. Deficiencies in Chfr and Mlh1 synergistically enhance tumor susceptibility in mice. J Clin Invest 2009; 119:2714-24.

Fuchs D, Daniel V, Sadeghi M, Opelz G, Naujokat C. Salinomycin overcomes ABC transporter-mediated multidrug and apoptosis resistance in human leukemia stem cell-like KG-1a cells. Biochem Biophys Res Commun 2010; 394:1098-104.

Fuhr U. Drug interactions with grapefruit juice. Extent, probable mechanism and clinical relevance. Drug Saf 1998; 18:251-72.

Fuhr U, Beckmann-Knopp S, Jetter A, Lück H, Mengs U. The effect of silymarin on oral nifedipine pharmacokinetics. Planta Med 2007; 73:1429-35.

Fuhr U, Jetter A. Rabeprazole: pharmacokinetics and pharmacokinetic drug interactions. Pharmazie 2002; 57:595-601.

Fuhr U, Jetter A, Kirchheiner J. Appropriate phenotyping procedures for drug metabolizing enzymes and transporters in humans and their simultaneous use in the "cocktail" approach. Clin Pharmacol Ther 2007; 81:270-83.

Fuhr U, Kober S, Zaigler M, Mutschler E, Spahn-Langguth H. Rate-limiting biotransformation of triamterene is mediated by CYP1A2. Int J Clin Pharmacol Ther 2005; 43:327-34.

Fujihara J, Fujii Y, Agusa T et al. Ethnic differences in five intronic polymorphisms associated with arsenic metabolism within human arsenic (+3 oxidation state) methyltransferase (AS3MT) gene. Toxicol Appl Pharmacol 2009; 234:41-6.

Fujihara J, Kunito T, Agusa T et al. Population differences in the human arsenic (+3 oxidation state) methyltransferase (AS3MT) gene polymorphism detected by using genotyping method. Toxicol Appl Pharmacol 2007; 225:251-4.

Fujihara J, Soejima M, Koda Y, Kunito T, Takeshita H. Asian specific low mutation frequencies of the M287T polymorphism in the human arsenic (+3 oxidation state) methyltransferase (AS3MT) gene. Mutat Res 2008; 654:158-61.

Fujihara J, Soejima M, Yasuda T et al. Global analysis of genetic variation in human arsenic (+3 oxidation state) methyltransferase (AS3MT). Toxicol Appl Pharmacol 2010; 243:292-9.

Fujii Y, Kabumoto H, Nishimura K et al. Purification, characterization, and directed evolution study of a vitamin D3 hydroxylase from Pseudonocardia autotrophica. Biochem Biophys Res Commun 2009; 385:170-5.

Fujii Y, Shibata H, Kikuta R et al. Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia. Psychiatr Genet 2003; 13:71-6.

Fujimaki Y, Arai N, Nakazawa T, Fujimaki M. Nefiracetam metabolism by human liver microsomes: role of cytochrome P450 3A4 and cytochrome P450 1A2 in 5-hydroxynefiracetam formation. J Pharm Pharmacol 2001; 53:795-804.

Fujimaki Y, Hakusui H, Yamazoe Y. Nefiracetam hydroxylation by rat liver microsomes and expressed human cytochrome P450s. Xenobiotica 1996; 26:821-30.

Fujimura H, Murakami N, Miwa S, Aruga C, Toriumi W. The suitability of rat hepatoma cell line H4IIE for evaluating the potentials of compounds to induce CYP3A23 expression. Exp Toxicol Pathol 2010. doi:10. 1016/j. etp. 2010. 11. 010.

Fujimura T, Takahashi S, Urano T et al. Expression of cytochrome P450 3A4 and its clinical significance in human prostate cancer. Urology 2009; 74:391-7.

Fujino H, Saito T, Tsunenari Y, Kojima J. Interaction between several medicines and statins. Arzneimittelforschung 2003; 53:145-53.

Fujino H, Saito T, Tsunenari Y, Kojima J, Sakaeda T. Metabolic properties of the acid and lactone forms of HMG-CoA reductase inhibitors. Xenobiotica 2004; 34:961-71.

Fujino H, Yamada I, Shimada S, Hirano M, Tsunenari Y, Kojima J. Interaction between fibrates and statins-metabolic interactions with gemfibrozil. Drug Metabol Drug Interact 2003; 19:161-76.

Fujino H, Yamada I, Shimada S, Nagao T, Yoneda M. Metabolic fate of pitavastatin (NK-104), a new inhibitor of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase. Effects on drug-metabolizing systems in rats and humans. Arzneimittelforschung 2002; 52:745-53.

Fujino H, Yamada I, Shimada S, Yoneda M, Kojima J. Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase: human UDP-glucuronosyltransferase enzymes involved in lactonization. Xenobiotica 2003; 33:27-41.

Fujita K. Food-drug interactions via human cytochrome P450 3A (CYP3A). Drug Metabol Drug Interact 2004; 20:195-217.

Fujita K, Ando Y, Nagashima F et al. Novel single nucleotide polymorphism of UGT1A7 gene in Japanese. Drug Metab Pharmacokinet 2006; 21:75-8.

Fujita K, Ando Y, Narabayashi M et al. Gefitinib (Iressa) inhibits the CYP3A4-mediated formation of 7-ethyl-10-(4-amino-1-piperidino)carbonyloxycamptothecin but activates that of 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino]carbonyloxycamptothecin from irinotecan. Drug Metab Dispos 2005; 33:1785-90.

Fujita K, Kamataki T. Screening of organosulfur compounds as inhibitors of human CYP2A6. Drug Metab Dispos 2001; 29:983-9.

Fujita K, Kamataki T. Predicting the mutagenicity of tobacco-related N-nitrosamines in humans using 11 strains of Salmonella typhimurium YG7108, each coexpressing a form of human cytochrome P450 along with NADPH-cytochrome P450 reductase. Environ Mol Mutagen 2001; 38:339-46.

Fujita K, Kamataki T. Role of human cytochrome P450 (CYP) in the metabolic activation of N-alkylnitrosamines: application of genetically engineered Salmonella typhimurium YG7108 expressing each form of CYP together with human NADPH-cytochrome P450 reductase. Mutat Res 2001; 483:35-41.

Fujita K, Nagashima F, Yamamoto W et al. Association of ATP-binding cassette, sub-family C, number 2 (ABCC2) genotype with pharmacokinetics of irinotecan in Japanese patients with metastatic colorectal cancer treated with irinotecan plus infusional 5-fluorouracil/leucovorin (FOLFIRI) Biol Pharm Bull 2008; 31:2137-42.

Fujita K, Nakayama K, Yamazaki Y et al. Construction of Salmonella typhimurium YG7108 strains, each coexpressing a form of human cytochrome P450 with NADPH-cytochrome P450 reductase. Environ Mol Mutagen 2001; 38:329-38.

Fujita K, Sugiyama M, Akiyama Y, Ando Y, Sasaki Y. The small-molecule tyrosine kinase inhibitor nilotinib is a potent noncompetitive inhibitor of the SN-38 glucuronidation by human UGT1A1. Cancer Chemother Pharmacol 2011; 67:237-41.

Fujita T, Kawase A, Niwa T et al. Comparative evaluation of 12 immature citrus fruit extracts for the inhibition of cytochrome P450 isoform activities. Biol Pharm Bull 2008; 31:925-30.

Fujitaka K, Oguri T, Isobe T, Fujiwara Y, Kohno N. Induction of cytochrome P450 3A4 by docetaxel in peripheral mononuclear cells and its expression in lung cancer. Cancer Chemother Pharmacol 2001; 48:42-6.

Fujiwara H, Tatsumi K, Miki K et al. Recurrent T354P mutation of the Na+/I- symporter in patients with iodide transport defect. J Clin Endocrinol Metab 1998; 83:2940-3.

Fujiwara Y, Ichihashi M, Kano Y, Goto K, Shimizu K. A new human photosensitive subject with a defect in the recovery of DNA synthesis after ultraviolet-light irradiation. J Invest Dermatol 1981; 77:256-63.

Fukami M, Shozu M, Soneda S et al. Aromatase excess syndrome: identification of cryptic duplications and deletions leading to gain of function of CYP19A1 and assessment of phenotypic determinants. J Clin Endocrinol Metab 2011; 96:1035-43.

Fukami T, Nakajima M, Higashi E et al. Characterization of novel CYP2A6 polymorphic alleles (CYP2A6*18 and CYP2A6*19) that affect enzymatic activity. Drug Metab Dispos 2005; 33:1202-10.

Fukami T, Nakajima M, Higashi E, Yamanaka H, McLeod HL, Yokoi T. A novel CYP2A6*20 allele found in African-American population produces a truncated protein lacking enzymatic activity. Biochem Pharmacol 2005; 70:801-8.

Fukami T, Nakajima M, Matsumoto I, Zen Y, Oda M, Yokoi T. Immunohistochemical analysis of CYP2A13 in various types of human lung cancers. Cancer Sci 2010; 101:1024-8.

Fukami T, Nakajima M, Yamanaka H, Fukushima Y, McLeod HL, Yokoi T. A novel duplication type of CYP2A6 gene in African-American population. Drug Metab Dispos 2007; 35:515-20.

Fukami T, Nakajima M, Yoshida R et al. A novel polymorphism of human CYP2A6 gene CYP2A6*17 has an amino acid substitution (V365M) that decreases enzymatic activity in vitro and in vivo. Clin Pharmacol Ther 2004; 76:519-27.

Fukasawa T, Suzuki A, Otani K. Effects of genetic polymorphism of cytochrome P450 enzymes on the pharmacokinetics of benzodiazepines. J Clin Pharm Ther 2007; 32:333-41.

Fukasawa T, Yasui-Furukori N, Aoshima T, Suzuki A, Tateishi T, Otani K. Single oral dose pharmacokinetics of quazepam is influenced by CYP2C19 activity. Ther Drug Monit 2004; 26:529-33.

Fukasawa T, Yasui-Furukori N, Suzuki A, Inoue Y, Tateishi T, Otani K. Pharmacokinetics and pharmacodynamics of etizolam are influenced by polymorphic CYP2C19 activity. Eur J Clin Pharmacol 2005; 61:791-5.

Fukazawa T, Yajima K, Miyamoto Y. Evaluation of drug-drug interaction potential of beraprost sodium mediated by P450 in vitro. Yakugaku Zasshi 2008; 128:1459-65.

Fukuda D, Enomoto S, Hirata Y, Nagai R, Sata M. The angiotensin receptor blocker, telmisartan, reduces and stabilizes atherosclerosis in ApoE and AT1aR double deficient mice. Biomed Pharmacother 2010; 64:712-7.

Fukuda K, Guo L, Ohashi N, Yoshikawa M, Yamazoe Y. Amounts and variation in grapefruit juice of the main components causing grapefruit-drug interaction. J Chromatogr B Biomed Sci Appl 2000; 741:195-203.

Fukuda K, Ohta T, Oshima Y, Ohashi N, Yoshikawa M, Yamazoe Y. Specific CYP3A4 inhibitors in grapefruit juice: furocoumarin dimers as components of drug interaction. Pharmacogenetics 1997; 7:391-6.

Fukuda T, Nishida Y, Imaoka S et al. The decreased in vivo clearance of CYP2D6 substrates by CYP2D6*10 might be caused not only by the low-expression but also by low affinity of CYP2D6. Arch Biochem Biophys 2000; 380:303-8.

Fukuda T, Nishida Y, Zhou Q, Yamamoto I, Kondo S, Azuma J. The impact of the CYP2D6 and CYP2C19 genotypes on venlafaxine pharmacokinetics in a Japanese population. Eur J Clin Pharmacol 2000; 56:175-80.

Fukuda T, Onishi S, Fukuen S et al. CYP3A5 genotype did not impact on nifedipine disposition in healthy volunteers. Pharmacogenomics J 2004; 4:34-9.

Fukuda Y, Aguilar-Bryan L, Vaxillaire M et al. Conserved intramolecular disulfide bond is critical to trafficking and fate of ATP-binding cassette (ABC) transporters ABCB6 and sulfonylurea receptor 1 (SUR1)/ABCC8. J Biol Chem 2011; 286:8481-92.

Fukudo M, Yano I, Masuda S et al. Population pharmacokinetic and pharmacogenomic analysis of tacrolimus in pediatric living-donor liver transplant recipients. Clin Pharmacol Ther 2006; 80:331-45.

Fukudo M, Yano I, Yoshimura A et al. Impact of MDR1 and CYP3A5 on the oral clearance of tacrolimus and tacrolimus-related renal dysfunction in adult living-donor liver transplant patients. Pharmacogenet Genomics 2008; 18:413-23.

Fukuen S, Fukuda T, Matsuda H et al. Identification of the novel splicing variants for the hPXR in human livers. Biochem Biophys Res Commun 2002; 298:433-8.

Fukui N, Suzuki Y, Sawamura K et al. Dose-dependent effects of the 3435 C>T genotype of ABCB1 gene on the steady-state plasma concentration of fluvoxamine in psychiatric patients. Ther Drug Monit 2007; 29:185-9.

Fukumori S, Murata T, Taguchi M, Hashimoto Y. Rapid and drastic induction of CYP3A4 mRNA expression via vitamin D receptor in human intestinal LS180 cells. Drug Metab Pharmacokinet 2007; 22:377-81.

Fukumoto K, Kobayashi T, Tachibana K et al. Effect of amiodarone on the serum concentration/dose ratio of metoprolol in patients with cardiac arrhythmia. Drug Metab Pharmacokinet 2006; 21:501-5.

Fukunaga AK, Marsh S, Murry DJ, Hurley TD, McLeod HL. Identification and analysis of single-nucleotide polymorphisms in the gemcitabine pharmacologic pathway. Pharmacogenomics J 2004; 4:307-14.

Fukunaga-Kalabis M, Martinez G, Nguyen TK et al. Tenascin-C promotes melanoma progression by maintaining the ABCB5-positive side population. Oncogene 2010; 29:6115-24.

Fukushima M, Han KH, Taneichi Y et al. Amylomyces rouxii strain CBS 438. 76 affects cholesterol metabolism in cholesterol-fed rats. J Nutr Sci Vitaminol 2005; 51:453-9.

Fukushima-Uesaka H, Maekawa K, Ozawa S et al. Fourteen novel single nucleotide polymorphisms in the SLC22A2 gene encoding human organic cation transporter (OCT2). Drug Metab Pharmacokinet 2004; 19:239-44.

Fukushima-Uesaka H, Saito Y, Maekawa K et al. Genetic variations and haplotypes of CYP2C19 in a Japanese population. Drug Metab Pharmacokinet 2005; 20:300-7.

Fukushima-Uesaka H, Saito Y, Maekawa K et al. Genetic polymorphisms of copper- and platinum drug-efflux transporters ATP7A and ATP7B in Japanese cancer patients. Drug Metab Pharmacokinet 2009; 24:565-74.

Fukushima-Uesaka H, Saito Y, Tohkin M et al. Genetic variations and haplotype structures of the ABC transporter gene ABCC1 in a Japanese population. Drug Metab Pharmacokinet 2007; 22:48-60.

Fukushima-Uesaka H, Saito Y, Watanabe H et al. Haplotypes of CYP3A4 and their close linkage with CYP3A5 haplotypes in a Japanese population. Hum Mutat 2004; 23:100.

Fulco PP, Hynicka L, Rackley D. Raltegravir-based HAART regimen in a patient with large B-cell lymphoma. Ann Pharmacother 2010; 44:377-82.

Fulco PP, Zingone MM, Higginson RT. Possible antiretroviral therapy-warfarin drug interaction. Pharmacotherapy 2008; 28:945-9.

Funakoshi N, Duret C, Pascussi JM et al. Comparison of hepatic-like cell production from human embryonic stem cells and adult liver progenitor cells: CAR transduction activates a battery of detoxification genes. Stem Cell Rev 2011; 7:518-31.

Funck-Brentano C, Becquemont L, Kroemer HK et al. Variable disposition kinetics and electrocardiographic effects of flecainide during repeated dosing in humans: contribution of genetic factors, dose-dependent clearance, and interaction with amiodarone. Clin Pharmacol Ther 1994; 55:256-69.

Funck-Brentano C, Becquemont L, Lenevu A, Roux A, Jaillon P, Beaune P. Inhibition by omeprazole of proguanil metabolism: mechanism of the interaction in vitro and prediction of in vivo results from the in vitro experiments. J Pharmacol Exp Ther 1997; 280:730-8.

Funck-Brentano C, Boëlle PY, Verstuyft C, Bornert C, Becquemont L, Poirier JM. Measurement of CYP2D6 and CYP3A4 activity in vivo with dextromethorphan: sources of variability and predictors of adverse effects in 419 healthy subjects. Eur J Clin Pharmacol 2005; 61:821-9.

Fung HB, Kirschenbaum HL, Hameed R. Amprenavir: a new human immunodeficiency virus type 1 protease inhibitor. Clin Ther 2000; 22:549-72.

Fung KL, Gottesman MM. A synonymous polymorphism in a common MDR1 (ABCB1) haplotype shapes protein function. Biochim Biophys Acta 2009; 1794:860-71.

Fung Y-KT, Murphree AL, T'Ang A, Qian J, Hinrichs SH, Benedict WF. Structural evidence for the authenticity of the human retinoblastoma gene. Science 1987; 236:1657-61.

Funk C, Ponelle C, Scheuermann G, Pantze M. Cholestatic potential of troglitazone as a possible factor contributing to troglitazone-induced hepatotoxicity: in vivo and in vitro interaction at the canalicular bile salt export pump (Bsep) in the rat. Mol Pharmacol 2001; 59:627-35.

Funk CD. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 2001; 294:1871-5.

Funke B, Finn CT, Plocik AM et al. Association of the DTNBP1 locus with schizophrenia in a U. S. population. Am J Hum Genet 2004; 75:891-8.

Furman KD, Grimm DR, Mueller T et al. Impact of CYP2D6 intermediate metabolizer alleles on single-dose desipramine pharmacokinetics. Pharmacogenetics 2004; 14:279-84.

Furnes B, Schlenk D. Evaluation of xenobiotic N- and S-oxidation by variant flavin-containing monooxygenase 1 (FMO1) enzymes. Toxicol Sci 2004; 78:196-203.

Fürnrohr BG, Wach S, Kelly JA et al. Polymorphisms in the Hsp70 gene locus are genetically associated with systemic lupus erythematosus. Ann Rheum Dis 2010; 69:1983-9.

Furster C, Wikvall K. Identification of CYP3A4 as the major enzyme responsible for 25-hydroxylation of 5beta-cholestane-3alpha,7alpha,12alpha-triol in human liver microsomes. Biochim Biophys Acta 1999; 1437:46-52.

Furukawa M, Okubo T, Ogino M et al. Adenovirus vector-mediated reporter system for in vivo analyses of human CYP3A4 gene activation. J Biochem 2002; 131:71-8.

Furukawa Y, Kish SJ, Bebin EM et al. Dystonia with motor delay in compound heterozygotes for GTP-cyclohydrolase I gene mutations. Ann Neurol 1998; 44:10-6.

Furukori H. Involvement of cytochromeP4503A4 in the metabolism of haloperidol and bromperidol. Nihon Shinkei Seishin Yakurigaku Zasshi 1998; 18:9-14.

Furukori H, Kondo T, Yasui N et al. Effects of itraconazole on the steady-state plasma concentrations of bromperidol and reduced bromperidol in schizophrenic patients. Psychopharmacology 1999; 145:189-92.

Furukori H, Otani K, Yasui N et al. Effect of carbamazepine on the single oral dose pharmacokinetics of alprazolam. Neuropsychopharmacology 1998; 18:364-9.

Furumatsu K, Nishiumi S, Kawano Y et al. A role of the aryl hydrocarbon receptor in attenuation of colitis. Dig Dis Sci 2011; 56:2532-44.

Furumiya K, Mizutani T. Inhibition of human CYP3A4, UGT1A6, and P-glycoprotein with halogenated xanthene food dyes and prevention by superoxide dismutase. J Toxicol Environ Health A 2008; 71:1307-13.

Furuta J, Nobeyama Y, Umebayashi Y, Otsuka F, Kikuchi K, Ushijima T. Silencing of Peroxiredoxin 2 and aberrant methylation of 33 CpG islands in putative promoter regions in human malignant melanomas. Cancer Res 2006; 66:6080-6.

Furuta K, Adachi K, Ohara S et al. Relationship between the acid-inhibitory effects of two proton pump inhibitors and CYP2C19 genotype in Japanese subjects: a randomized two-way crossover study. J Int Med Res 2010; 38:1473-83.

Furuta S, Akagawa N, Kamada E et al. Involvement of CYP2C9 and UGT2B7 in the metabolism of zaltoprofen, a nonsteroidal anti-inflammatory drug, and its lack of clinically significant CYP inhibition potential. Br J Clin Pharmacol 2002; 54:295-303.

Furuta S, Jiang X, Gu B, Cheng E, Chen PL, Lee WH. Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells. Proc Nat Acad Sci USA 2005; 102:9176-81.

Furuta S, Kamada E, Omata T et al. Drug-drug interactions of Z-338, a novel gastroprokinetic agent, with terfenadine, comparison with cisapride, and involvement of UGT1A9 and 1A8 in the human metabolism of Z-338. Eur J Pharmacol 2004; 497:223-31.

Furuta T, Iwaki T, Umemura K. Influences of different proton pump inhibitors on the anti-platelet function of clopidogrel in relation to CYP2C19 genotypes. Br J Clin Pharmacol 2010; 70:383-92.

Furuta T, Kodaira C, Nishino M et al. [13C]-pantoprazole breath test to predict CYP2C19 phenotype and efficacy of a proton pump inhibitor, lansoprazole. Aliment Pharmacol Ther 2009; 30:294-300.

Furuta T, Ohashi K, Kobayashi K et al. Effects of clarithromycin on the metabolism of omeprazole in relation to CYP2C19 genotype status in humans. Clin Pharmacol Ther 1999; 66:265-74.

Furuta T, Shirai N, Kodaira M et al. Pharmacogenomics-based tailored versus standard therapeutic regimen for eradication of H. pylori. Clin Pharmacol Ther 2007; 81:521-8.

Furuta T, Shirai N, Watanabe F et al. Effect of cytochrome P4502C19 genotypic differences on cure rates for gastroesophageal reflux disease by lansoprazole. Clin Pharmacol Ther 2002; 72:453-60.

Furuta T, Sugimoto M, Kodaira C et al. CYP2C19 genotype is associated with symptomatic recurrence of GERD during maintenance therapy with low-dose lansoprazole. Eur J Clin Pharmacol 2009; 65:693-8.

Furuyama S, Uehara Y, Zhang B et al. Genotypic effect of ABCG1 gene promoter -257T>G polymorphism on coronary artery disease severity in Japanese men. J Atheroscler Thromb 2009; 16:194-200.

Fuse I, Mito M, Hattori A et al. Defective signal transduction induced by thromboxane A2 in a patient with a mild bleeding disorder: impaired phospholipase C activation despite normal phospholipase A2 activation. Blood 1993; 81:994-1000.

Fuse N, Miyazawa A, Takahashi K, Noro M, Nakazawa T, Nishida K. Mutation spectrum of the CYP1B1 gene for congenital glaucoma in the Japanese population. Jpn J Ophthalmol 2010; 54:1-6.

Fuselli S, Dupanloup I, Frigato E et al. Molecular diversity at the CYP2D6 locus in the Mediterranean region. Eur J Hum Genet 2004; 12:916-24.

Fuso A, Seminara L, Cavallaro RA, D'Anselmi F, Scarpa S. S-adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production. Mol Cell Neurosci 2005; 28:195-204.

Fustier P, Le Corre L, Chalabi N et al. Resveratrol increases BRCA1 and BRCA2 mRNA expression in breast tumour cell lines. Br J Cancer 2003; 89:168-72.

Fux R, Mörike K, Pröhmer AM et al. Impact of CYP2D6 genotype on adverse effects during treatment with metoprolol: a prospective clinical study. Clin Pharmacol Ther 2005; 78:378-87.

Fyrberg A, Peterson C, Kågedal B, Lotfi K. Induction of fetal hemoglobin and ABCB1 gene expression in 9-β-D-arabinofuranosylguanine-resistant MOLT-4 cells. Cancer Chemother Pharmacol 2011; 68:583-91.

Gabriely I, Yang XM, Cases JA, Ma XH, Rossetti L, Barzilai N. Hyperglycemia modulates angiotensinogen gene expression. Am J Physiol Regul Integr Comp Physiol 2001; 281:795-802.

Gade-Andavolu R, Comings DE, MacMurray J et al. Association of CCR5 delta32 deletion with early death in multiple sclerosis. Genet Med 2004; 6:126-31.

Gadeyne C, van der Heyden S, Gasthuys F, Croubels S, Schauvliege S, Polis I. The influence of modulation of P-glycoprotein and/or Cytochrome P450 3A on the pharmacokinetics and pharmacodynamics of orally administered in dogs. J Vet Pharmacol Ther 2011; 34:417-23.

Gadhe CG, Madhavan T, Kothandan G, Cho SJ. In silico quantitative structure-activity relationship studies on P-gp modulators of tetrahydroisoquinoline-ethyl-phenylamine series. BMC Struct Biol 2011; 11:5.

Gaedigk A, Baker DW, Totah RA et al. Variability of CYP2J2 expression in human fetal tissues. J Pharmacol Exp Ther 2006; 319:523-32.

Gaedigk A, Bhathena A, Ndjountché L et al. Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans. Pharmacogenomics J 2005; 5:173-82.

Gaedigk A, Blum M, Gaedigk R, Eichelbaum M, Meyer UA. Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism. Am J Hum Genet 1991; 48:943-50.

Gaedigk A, Bradford LD, Alander SW, Leeder JS. CYP2D6*36 gene arrangements within the cyp2d6 locus: association of CYP2D6*36 with poor metabolizer status. Drug Metab Dispos 2006; 34:563-9.

Gaedigk A, Bradford LD, Marcucci KA, Leeder JS. Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans. Clin Pharmacol Ther 2002; 72:76-89.

Gaedigk A, Coetsee C. The CYP2D6 gene locus in South African Coloureds: unique allele distributions, novel alleles and gene arrangements. Eur J Clin Pharmacol 2008; 64:465-75.

Gaedigk A, Eklund JD, Pearce RE et al. Identification and characterization of CYP2D6*56B, an allele associated with the poor metabolizer phenotype. Clin Pharmacol Ther 2007; 81:817-20.

Gaedigk A, Frank D, Fuhr U. Identification of a novel non-functional CYP2D6 allele, CYP2D6*69, in a Caucasian poor metabolizer individual. Eur J Clin Pharmacol 2009; 65:97-100.

Gaedigk A, Gotschall RR, Forbes NS, Simon SD, Kearns GL, Leeder JS. Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data. Pharmacogenetics 1999; 9:669-82.

Gaedigk A, Isidoro-García M, Pearce RE et al. Discovery of the nonfunctional CYP2D6 31 allele in Spanish, Puerto Rican, and US Hispanic populations. Eur J Clin Pharmacol 2010; 66:859-64.

Gaedigk A, Ndjountché L, Gaedigk R, Leeder JS, Bradford LD. Discovery of a novel nonfunctional cytochrome P450 2D6 allele, CYP2D642, in African American subjects. Clin Pharmacol Ther 2003; 73:575-6.

Gaedigk A, Ndjountché L, Leeder JS, Bradford LD. Limited association of the 2988g > a single nucleotide polymorphism with CYP2D641 in black subjects. Clin Pharmacol Ther 2005; 77:228-30.

Gaedigk A, Ryder DL, Bradford LD, Leeder JS. CYP2D6 poor metabolizer status can be ruled out by a single genotyping assay for the -1584G promoter polymorphism. Clin Chem 2003; 49:1008-11.

Gage BF, Eby C, Johnson JA et al. Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin. Clin Pharmacol Ther 2008; 84:326-31.

Gagné JF, Montminy V, Belanger P, Journault K, Gaucher G, Guillemette C. Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38). Mol Pharmacol 2002; 62:608-17.

Gagnon J, Mauriège P, Roy S et al. The Trp64Arg mutation of the beta3 adrenergic receptor gene has no effect on obesity phenotypes in the Québec Family Study and Swedish Obese Subjects cohorts. J Clin Invest 1996; 98:2086-93.

Gagnon JF, Bernard O, Villeneuve L, Têtu B, Guillemette C. Irinotecan inactivation is modulated by epigenetic silencing of UGT1A1 in colon cancer. Clin Cancer Res 2006; 12:1850-8.

Gahan LJ, Pauchet Y, Vogel H, Heckel DG. An ABC transporter mutation is correlated with insect resistance to Bacillus thuringiensis Cry1Ac toxin. PLoS Genet 2010. doi:10. 1371/journal. pgen. 1001248.

Gaillard I, Clauser E, Corvol P. Structure of human angiotensinogen gene. DNA 1989; 8:87-99.

Gait JE. Hemolytic reactions to nitrofurantoin in patients with glucose-6-phosphate dehydrogenase deficiency: theory and practice. DICP 1990; 24:1210-3.

Gajiwala KS, Wu JC, Christensen J et al. KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients. Proc Natl Acad Sci USA 2009; 106:1542-7.

Galani A, Kitsiou-Tzeli S, Sofokleous C, Kanavakis E, Kalpini-Mavrou A. Androgen insensitivity syndrome: clinical features and molecular defects. Hormones 2008; 7:217-29.

Galata Z, Moschonis G, Makridakis M et al. Plasma proteomic analysis in obese and overweight prepubertal children. Eur J Clin Invest 2011. doi:10. 1111/j. 1365-2362. 2011. 02536. x.

Galbally M, Lewis AJ, Lum J, Buist A. Serotonin discontinuation syndrome following in utero exposure to antidepressant medication: prospective controlled study. Aust N Z J Psychiatry 2009; 43:846-54.

Galbiatti AL, Ruiz MT, Chicote-Biselli PM et al. 5-Methyltetrahydrofolate-homocysteine methyltransferase gene polymorphism (MTR) and risk of head and neck cancer. Braz J Med Biol Res 2010; 43:445-50.

Gale RE, Green C, Allen C et al. The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia. Blood 2008; 111:2776-84.

Gale SE, Frolov A, Han X et al. A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation. J Biol Chem 2006; 281:11082-9.

Gałecki P, Florkowski A, Bieńkiewicz M, Szemraj J. Functional polymorphism of cyclooxygenase-2 gene (G-765C) in depressive patients. Neuropsychobiology 2010; 62:116-20.

Galetin A, Brown C, Hallifax D, Ito K, Houston JB. Utility of recombinant enzyme kinetics in prediction of human clearance: impact of variability, CYP3A5, and CYP2C19 on CYP3A4 probe substrates. Drug Metab Dispos 2004; 32:1411-20.

Galetin A, Burt H, Gibbons L, Houston JB. Prediction of time-dependent CYP3A4 drug-drug interactions: impact of enzyme degradation, parallel elimination pathways, and intestinal inhibition. Drug Metab Dispos 2006; 34:166-75.

Galetin A, Clarke SE, Houston JB. Quinidine and haloperidol as modifiers of CYP3A4 activity: multisite kinetic model approach. Drug Metab Dispos 2002; 30:1512-22.

Galetin A, Clarke SE, Houston JB. Multisite kinetic analysis of interactions between prototypical CYP3A4 subgroup substrates: midazolam, testosterone, and nifedipine. Drug Metab Dispos 2003; 31:1108-16.

Galetin A, Gertz M, Houston JB. Potential role of intestinal first-pass metabolism in the prediction of drug-drug interactions. Expert Opin Drug Metab Toxicol 2008; 4:909-22.

Galetin A, Hinton LK, Burt H, Obach RS, Houston JB. Maximal inhibition of intestinal first-pass metabolism as a pragmatic indicator of intestinal contribution to the drug-drug interactions for CYP3A4 cleared drugs. Curr Drug Metab 2007; 8:685-93.

Galetin A, Houston JB. Intestinal and hepatic metabolic activity of five cytochrome P450 enzymes: impact on prediction of first-pass metabolism. J Pharmacol Exp Ther 2006; 318:1220-9.

Galetin A, Ito K, Hallifax D, Houston JB. CYP3A4 substrate selection and substitution in the prediction of potential drug-drug interactions. J Pharmacol Exp Ther 2005; 314:180-90.

Gälman C, Bonde Y, Matasconi M, Angelin B, Rudling M. Dramatically increased intestinal absorption of cholesterol following hypophysectomy is normalized by thyroid hormone. Gastroenterology 2008; 134:1127-36.

Galteau MM, Shamsa F. Urinary 6beta-hydroxycortisol: a validated test for evaluating drug induction or drug inhibition mediated through CYP3A in humans and in animals. Eur J Clin Pharmacol 2003; 59:713-33.

Galvani AP, Novembre J. The evolutionary history of the CCR5-Delta32 HIV-resistance mutation. Microbes Infect 2005; 7:302-9.

Gallagher CJ, Keene KL, Mychaleckyj JC et al. Investigation of the estrogen receptor-alpha gene with type 2 diabetes and/or nephropathy in African-American and European-American populations. Diabetes 2007; 56:675-84.

Gallagher EP, Kunze KL, Stapleton PL, Eaton DL. The kinetics of aflatoxin B1 oxidation by human cDNA-expressed and human liver microsomal cytochromes P450 1A2 and 3A4. Toxicol Appl Pharmacol 1996; 141:595-606.

Gallagher EP, Wienkers LC, Stapleton PL, Kunze KL, Eaton DL. Role of human microsomal and human complementary DNA-expressed cytochromes P4501A2 and P4503A4 in the bioactivation of aflatoxin B1. Cancer Res 1994; 54:101-8.

Gallemann D, Wimmer E, Hoefer CC et al. In vitro characterization of sarizotan metabolism: hepatic clearance, identification and characterization of metabolites, drug metabolizing enzymes identification and evaluation of cytochrome P450 inhibition. Drug Metab Dispos 2010; 38:905-16.

Galletti F, Iacone R, Ragone E et al. Lack of association between polymorphism in the beta2-adrenergic receptor gene, hypertension, and obesity in the Olivetti heart study. Am J Hypertens 2004; 17:718-20.

Gallus GN, Dotti MT, Mignarri A et al. Four novel CYP27A1 mutations in seven Italian patients with CTX. Eur J Neurol 2010; 17:1259-62.

Galluzzi JR, Cupples LA, Otvos JD, Wilson PW, Schaefer EJ, Ordovas JM. Association of the A/T54 polymorphism in the intestinal fatty acid binding protein with variations in plasma lipids in the Framingham Offspring Study. Atherosclerosis 2001; 159:417-24.

Gambetti P, Parchi P. Insomnia in prion diseases: sporadic and familial. N Engl J Med 1999; 340:1675-7.

Gambetti P, Petersen R, Monari L, Tabaton M, Autilio-Gambetti L. Fatal familial insomnia and the widening spectrum of prion diseases. Brit Med Bull 1993; 49:980-94.

Gambetti P, Petersen RB, Parchi P et al. Inherited prion diseases. In: Prusiner SB (Ed). Prion biology and diseases. Cold Spring Harbor Laboratory Press, New York, 1999:509-83.

Gambier N, Batt AM, Marie B, Pfister M, Siest G, Visvikis-Siest S. Association of CYP2A6*1B genetic variant with the amount of smoking in French adults from the Stanislas cohort. Pharmacogenomics J 2005; 5:271-5.

Gambier N, Marteau JB, Batt AM et al. Interaction between CYP1A1 T3801C and AHR G1661A polymorphisms according to smoking status on blood pressure in the Stanislas cohort. J Hypertens 2006; 24:2199-205.

Gambillara E, Laffitte E, Widmer N et al. Severe pustular eruption associated with imatinib and voriconazole in a patient with chronic myeloid leukemia. Dermatology 2005; 211:363-5.

Gamble JT, Nakatsu K, Marks GS. Comparison of the formation of N-alkylprotoporphyrin IX after interaction of porphyrinogenic xenobiotics with single cDNA-expressed human P450 enzymes in microsomes prepared from baculovirus-infected insect cells and human lymphoblastoid cell lines. Drug Metab Dispos 2003; 31:202-5.

Gamblin TC, Chen F, Zambrano A et al. Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease. Proc Natl Acad Sci USA 2003; 100:10032-7.

Gamelin L, Capitain O, Morel A et al. Predictive factors of oxaliplatin neurotoxicity: the involvement of the oxalate outcome pathway. Clin Cancer Res 2007; 13:6359-68.

Gamerdinger M, Clement AB, Behl C. Cholesterol-like effects of selective cyclooxygenase inhibitors and fibrates on cellular membranes and amyloid-beta production. Mol Pharmacol 2007; 72:141-51.

Gamliel A, Teicher C, Hartmann T, Beyreuther K, Stein R. Overexpression of wild-type presenilin 2 or its familial Alzheimer's disease-associated mutant does not induce or increase susceptibility to apoptosis in different cell lines. Neuroscience 2003; 117:19-28.

Gamliel-Lazarovich A, Gantman A, Coleman R, Jeng AY, Kaplan M, Keidar S. FAD286, an aldosterone synthase inhibitor, reduced atherosclerosis and inflammation in apolipoprotein E-deficient mice. J Hypertens 2010; 28:1900-7.

Gan GG, Phipps ME, Lee MM et al. Contribution of VKORC1 and CYP2C9 polymorphisms in the interethnic variability of warfarin dose in Malaysian populations. Ann Hematol 2011; 90:635-41.

Gan HK, Kaye AH, Luwor RB. The EGFRvIII variant in glioblastoma multiforme. J Clin Neurosci 2009; 16:748-54.

Gan HT, Tham M, Hariharan S, Ramasamy S, Yu YH, Ahmed S. Identification of ApoE as an autocrine/paracrine factor that stimulates neural stem cell survival via MAPK/ERK signaling pathway. J Neurochem 2011; 117:565-78.

Gan J, Liu-Kreyche P, Humphreys WG. In vitro assessment of cytochrome P450 inhibition and induction potential of tanespimycin and its major metabolite, 17-amino-17-demethoxygeldanamycin. Cancer Chemother Pharmacol 2011. doi:10. 1007/s00280-011-1672-2.

Gan J, Qu Q, He B, Shyu WC, Rodrigues AD, He K. Troglitazone thiol adduct formation in human liver microsomes: enzyme kinetics and reaction phenotyping. Drug Metab Lett 2008; 2:184-9.

Gan L, Ye S, Chu A et al. Identification of cathepsin B as a mediator of neuronal death induced by Aβ-activated microglial cells using a functional genomics approach. J Biol Chem 2004; 279:5565-72.

Gan LS, Moseley MA, Khosla B et al. CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells. Drug Metab Dispos 1996; 24:344-9.

Gan SH, Ismail R, Wan Adnan WA, Zulmi W, Kumaraswamy N, Larmie ET. Relationship between Type A and B personality and debrisoquine hydroxylation capacity. Br J Clin Pharmacol 2004; 57:785-9.

Gan SH, Ismail R, Wan Adnan WA, Zulmi W. Impact of CYP2D6 genetic polymorphism on tramadol pharmacokinetics and pharmacodynamics. Mol Diagn Ther 2007; 11:171-81.

Gandara DR, Kawaguchi T, Crowley J et al. Japanese-US common-arm analysis of paclitaxel plus carboplatin in advanced non-small-cell lung cancer: a model for assessing population-related pharmacogenomics. J Clin Oncol 2009; 27:3540-6.

Gandrille S, Jude B, Alhenc-Gelas M, Millaire A, Aiach M. Compound heterozygosity in a family with protein C deficiency illustrating the complexity of the underlying molecular mechanism. Thromb Haemost 1993; 70:747-52.

Ganesan S, Sahu R, Walker LA, Tekwani BL. Cytochrome P450-dependent toxicity of dapsone in human erythrocytes. J Appl Toxicol 2010; 30:271-5.

Ganesan S, Tekwani BL, Sahu R, Tripathi LM, Walker LA. Cytochrome P(450)-dependent toxic effects of primaquine on human erythrocytes. Toxicol Appl Pharmacol 2009; 241:14-22.

Ganfornina MD, Do Carmo S, Lora JM et al. Apolipoprotein D is involved in the mechanisms regulating protection from oxidative stress. Aging Cell 2008; 7:506-15.

Ganguly A, Basu S, Banerjee K et al. Redox active copper chelate overcomes multidrug resistance in T-lymphoblastic leukemia cell by triggering apoptosis. Mol Biosyst 2011; 7:1701-12.

Ganguly A, Basu S, Chakraborty P et al. Targeting mitochondrial cell death pathway to overcome drug resistance with a newly developed iron chelate. PLoS One 2010. doi:10. 1371/journal. pone. 0011253.

Ganor Y, Goldberg-Stern H, Amrom D et al. Autoimmune epilepsy: some epilepsy patients harbor autoantibodies to glutamate receptors and dsDNA on both sides of the blood-brain barrier, which may kill neurons and decrease in brain fluids after hemispherotomy. Clin Dev Immunol 2004; 11:241-52.

Ganta S, Devalapally H, Amiji M. Curcumin enhances oral bioavailability and anti-tumor therapeutic efficacy of paclitaxel upon administration in nanoemulsion formulation. J Pharm Sci 2010; 99:4630-41.

Gantenbein M, Attolini L, Bruguerolle B et al. Oxidative metabolism of bupivacaine into pipecolylxylidine in humans is mainly catalyzed by CYP3A. Drug Metab Dispos 2000; 28:383-5.

Gantla S, Bakker CT, Deocharan B et al. Splice-site mutations: a novel genetic mechanism of Crigler-Najjar syndrome type 1. Am J Hum Genet 1998; 62:585-92.

Gantois I, Fang K, Jiang L et al. Ablation of D1 dopamine receptor-expressing cells generates mice with seizures, dystonia, hyperactivity, and impaired oral behavior. Proc Natl Acad Sci USA 2007; 104:4182-7.

Ganzer S, Artl S, Schoder V et al. CSF-tau, CSF-Abeta1-42, APOE-genotype and clinical parameters in the diagnosis of Alzheimer's disease: combination of CSF-tau and MMSE yields highest sensitivity and specificity. J Neural Transm 2003; 110:1149-60.

Ganzera M, Schneider P, Stuppner H. Inhibitory effects of the essential oil of chamomile (Matricaria recutita L. ) and its major constituents on human cytochrome P450 enzymes. Life Sci 2006; 78:856-61.

Gao A, Liang H, Wang X et al. Reversal effects of two new milbemycin compounds on multidrug resistance in MCF-7/adr cells in vitro. Eur J Pharmacol 2011; 659:108-13.

Gao A, Wang X, Xiang W, Liang H, Gao J, Yan Y. Reversal of P-glycoprotein-mediated multidrug resistance in vitro by doramectin and nemadectin. J Pharm Pharmacol 2010; 62:393-9.

Gao F, Fang Q, Zhang R et al. Polymorphism of DsbA-L gene associates with insulin secretion and body fat distribution in Chinese population. Endocr J 2009; 56:487-94.

Gao F, Johnson DL, Ekins S et al. Optimizing higher throughput methods to assess drug-drug interactions for CYP1A2, CYP2C9, CYP2C19, CYP2D6, rCYP2D6, and CYP3A4 in vitro using a single point IC(50). J Biomol Screen 2002; 7:373-82.

Gao LB, Zhou B, Zhang L et al. R497K polymorphism in epidermal growth factor receptor gene is associated with the risk of acute coronary syndrome. BMC Med Genet 2008; 9:74.

Gao N, Nester RA, Sarkar MA. 4-Hydroxy estradiol but not 2-hydroxy estradiol induces expression of hypoxia-inducible factor 1alpha and vascular endothelial growth factor A through phosphatidylinositol 3-kinase/Akt/FRAP pathway in OVCAR-3 and A2780-CP70 human ovarian carcinoma cells. Toxicol Appl Pharmacol 2004; 196:124-35.

Gao N, Qiao HL, Jia LJ, Tian X, Zhang YW. Relationships between specific serum IgE, IgG, IFN-gamma level and IFN-gamma, IFNR1 polymorphisms in patients with penicillin allergy. Eur J Clin Pharmacol 2008; 64:971-7.

Gao N, Qu X, Yan J, Huang Q, Yuan HY, Ouyang DS. L-FABP T94A decreased fatty acid uptake and altered hepatic triglyceride and cholesterol accumulation in Chang liver cells stably transfected with L-FABP. Mol Cell Biochem 2010; 345:207-14.

Gao P, Wei JM, Li PY et al. Screening of deoxyribozyme with high reversal efficiency against multidrug resistance in breast carcinoma cells. J Cell Mol Med 2011; 15:2130-8.

Gao Q, Niti M, Feng L, Yap KB, Ng TP. Omega-3 polyunsaturated fatty acid supplements and cognitive decline: Singapore Longitudinal Aging Studies. J Nutr Health Aging 2011; 15:32-5.

Gao S, Kinzig KP, Aja S et al. Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake. Proc Nat Acad Sci USA 2007; 104:17358-63.

Gao SP, Mark KG, Leslie K et al. Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas. J Clin Invest 2007; 117:3846-56.

Gao W. Androgen receptor as a therapeutic target. Adv Drug Deliv Rev 2010; 62:1277-84.

Gao W, Wu Z, Bohl CE, Yang J, Miller DD, Dalton JT. Characterization of the in vitro metabolism of selective androgen receptor modulator using human, rat, and dog liver enzyme preparations. Drug Metab Dispos 2006; 34:243-53.

Gao X, Bashirova A, Iversen AK et al. AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis. Nat Med 2005; 11:1290-2.

Gao X, Nelson GW, Karacki P et al. Effect of a single amino acid change in MHC class I molecules on the rate of progression to AIDS. N Engl J Med 2001; 344:1668-75.

Gao X, O'Brien TR, Welzel TM et al. HLA-B alleles associate consistently with HIV heterosexual transmission, viral load, and progression to AIDS, but not susceptibility to infection. AIDS 2010; 24:1835-40.

Gao Y, Liu D, Wang H, Zhu J, Chen C. Functional characterization of five CYP2C8 variants and prediction of CYP2C8 genotype-dependent effects on in vitro and in vivo drug-drug interactions. Xenobiotica 2010; 40:467-75.

Gao Y, Zhang LR, Fu Q. CYP3A4*1G polymorphism is associated with lipid-lowering efficacy of atorvastatin but not of simvastatin. Eur J Clin Pharmacol 2008; 64:877-82.

Gao YD, Olson SH, Balkovec JM et al. Attenuating pregnane X receptor (PXR) activation: a molecular modelling approach. Xenobiotica 2007; 37:124-38.

Gapska P, Scott RJ, Serrano-Fernandez P et al. Vitamin D receptor variants and the malignant melanoma risk: a population-based study. Cancer Epidemiol 2009; 33:103-7.

Garai K, Baban B, Frieden C. Dissociation of apolipoprotein E oligomers to monomer is required for high-affinity binding to phospholipid vesicles. Biochemistry 2011; 50:2550-8.

Garattini E, Fratelli M, Terao M. Mammalian aldehyde oxidases: genetics, evolution and biochemistry. Cell Mol Life Sci 2008; 65:1019-48.

Garbett K, Gal-Chis R, Gaszner G, Lewis DA, Mirnics K. Transcriptome alterations in the prefrontal cortex of subjects with schizophrenia who committed suicide. Neuropsychopharmacol Hung 2008; 10:9-14.

Garcés C, Benavente M, Ortega H et al. Influence of birth weight on the apo E genetic determinants of plasma lipid levels in children. Pediat Res 2002; 52:873-8.

Garcia EA, Newhouse S, Caulfield MJ, Munroe PB. Genes and hypertension. Curr Pharm Des 2003; 9:1679-89.

Garcia M, Rager J, Wang Q et al. Cryopreserved human hepatocytes as alternative in vitro model for cytochrome p450 induction studies. In Vitro Cell Dev Biol Anim 2003; 39:283-7.

Garcia SM, Curioni OA, de Carvalho MB, Gattás GJ. Polymorphisms in alcohol metabolizing genes and the risk of head and neck cancer in a Brazilian population. Alcohol Alcohol 2010; 45:6-12.

Garcia-Barceló M, Chow LY, Lam KL, Chiu HF, Wing YK, Waye MM. Occurrence of CYP2D6 gene duplication in Hong Kong Chinese. Clin Chem 2000; 46:1411-3.

García-Casado Z, Guerrero-Zotano A, Llombart-Cussac A et al. A polymorphism at the 3'-UTR region of the aromatase gene defines a subgroup of postmenopausal breast cancer patients with poor response to neoadjuvant letrozole. BMC Cancer 2010; 10:36.

Garcia-Garcia AB, Blesa S, Martinez-Hervas S et al. Semiquantitative multiplex PCR: a useful tool for large rearrangement screening and characterization. Hum Mutat 2006; 27:822-8.

García-Martín E, Ayuso P, Martínez C, Blanca M, Agúndez JA. Histamine pharmacogenomics. Pharmacogenomics 2009; 10:867-83.

García-Martín E, Martínez C, Alonso-Navarro H et al. Dopamine receptor D3 (DRD3) genotype and allelic variants and risk for essential tremor. Mov Disord 2009; 24:1910-5.

García-Martín E, Martínez C, Pizarro RM et al. CYP3A4 variant alleles in white individuals with low CYP3A4 enzyme activity. Clin Pharmacol Ther 2002; 71:196-204.

García-Martín E, Martínez C, Tabarés B, Frías J, Agúndez JA. Interindividual variability in ibuprofen pharmacokinetics is related to interaction of cytochrome P450 2C8 and 2C9 amino acid polymorphisms. Clin Pharmacol Ther 2004; 76:119-27.

García-Martín E, Pizarro RM, Martínez C et al. Acquired resistance to the anticancer drug paclitaxel is associated with induction of cytochrome P450 2C8. Pharmacogenomics 2006; 7:575-85.

García-Suástegui WA, Huerta-Chagoya A, Carrasco-Colín KL et al. Seasonal variations in the levels of PAH-DNA adducts in young adults living in Mexico City. Mutagenesis 2011; 26:385-91.

Gardemann A, Fink M, Stricker J et al. ACE I/D gene polymorphism: presence of the ACE D allele increases the risk of coronary artery disease in younger individuals. Atherosclerosis 1998; 139:153-9.

Gardemann A, Stricker J, Humme J et al. Angiotensinogen T174M and M235T gene polymorphisms are associated with the extent of coronary atherosclerosis. Atherosclerosis 1999; 145:309-14.

Gardiner K, Du Y. A-to-I editing of the 5HT2C receptor and behaviour. Brief Funct Genomic Proteomic 2006; 5:37-42.

Gardiner SJ, Begg EJ. Pharmacogenetics, drug-metabolizing enzymes, and clinical practice. Pharmacol Rev 2006; 58:521-90.

Gardner ER, Burger H, van Schaik RH et al. Association of enzyme and transporter genotypes with the pharmacokinetics of imatinib. Clin Pharmacol Ther 2006; 80:192-201.

Gardner ER, Kelly M, Springman E et al. Antiangiogenic and antitumor activity of LP-261, a novel oral tubulin binding agent, alone and in combination with bevacizumab. Invest New Drugs 2010. doi:10. 1007/s10637-010-9520-5.

Gardner-Stephen DA, Mackenzie PI. Liver-enriched transcription factors and their role in regulating UDP glucuronosyltransferase gene expression. Curr Drug Metab 2008; 9:439-52.

Garenc C, Aubert S, Laroche J et al. Gene polymorphisms in the Quebec population: a risk to develop hypertriglyceridemia. Biochem Biophys Res Commun 2006; 344:588-96.

Garenc C, Pérusse L, Chagnon YC et al. Effects of beta2-adrenergic receptor gene variants on adiposity: the HERITAGE Family Study. Obes Res 2003; 11:612-8.

Gareri P, de Fazio P, Gallelli L et al. Venlafaxine-propafenone interaction resulting in hallucinations and psicomotor agitation. Ann Pharmacother 2008; 42:434-8.

Garey KW, Peloquin CA, Godo PG, Nafziger AN, Amsden GW. Lack of effect of zafirlukast on the pharmacokinetics of azithromycin, clarithromycin, and 14-hydroxyclarithromycin in healthy volunteers. Antimicrob Agents Chemother 1999; 43:1152-5.

Garfield AS, Heisler LK. Pharmacological targeting of the serotonergic system for the treatment of obesity. J Physiol 2009; 587:49-60.

Garg A, Agarwal AK. Lipodystrophies: disorders of adipose tissue biology. Biochim Biophys Acta 2009; 1791:507-13.

Garg SK, Kumar N, Bhargava VK, Prabhakar SK. Effect of grapefruit juice on carbamazepine bioavailability in patients with epilepsy. Clin Pharmacol Ther 1998; 64:286-8.

Garlepp MJ, Tabarias H, van Bockxmeer FM, Zilko PJ, Laing B, Mastaglia FL. Apolipoprotein E epsilon 4 in inclusion body myositis. Ann Neurol 1995; 38:957-9.

Garmy-Susini B, Jin H, Zhu Y, Sung RJ, Hwang R, Varner J. Integrin alpha-4-beta-1-VCAM-1-mediated adhesion between endothelial and mural cells is required for blood vessel maturation. J Clin Invest 2005; 115:1542-51.

Garnero P, Munoz F, Borel O, Sornay-Rendu E, Delmas PD. Vitamin D receptor gene polymorphisms are associated with the risk of fractures in postmenopausal women, independently of bone mineral density. J Clin Endocr Metab 2005; 90:4829-35.

Garnett WR. Clinical implications of drug interactions with coxibs. Pharmacotherapy 2001; 21:1223-32.

Garnier A, Bendall JK, Fuchs S et al. Cardiac specific increase in aldosterone production induces coronary dysfunction in aldosterone synthase-transgenic mice. Circulation 2004; 110:1819-25.

Garnock-Jones KP, Keating GM. Atomoxetine: a review of its use in attention-deficit hyperactivity disorder in children and adolescents. Paediatr Drugs 2009; 11:203-26.

Garriock HA, Tanowitz M, Kraft JB et al. Association of mu-opioid receptor variants and response to citalopram treatment in major depressive disorder. Am J Psychiatry 2010; 167:565-73.

Garrison JL, Kunkel EJ, Hedge RS, Taunton J. A substrate-specific inhibitor of protein translocation into the endoplasmic reticulum. Nature 2005; 436:285-9.

Garrity-Park MM, Loftus EV Jr, Bryant SC, Sandborn WJ, Smyrk TC. Tumor necrosis factor-alpha polymorphisms in ulcerative colitis-associated colorectal cancer. Am J Gastroenterol 2008; 103:407-15.

Garry PJ, Baumgartner RN, Brodie SG et al. Estrogen replacement therapy, serum lipids, and polymorphism of the apolipoprotein E gene. Clin Chem 1999; 45:1214-23.

Garsa AA, McLeod HL, Marsh S. CYP3A4 and CYP3A5 genotyping by Pyrosequencing. BMC Med Genet 2005; 6:19.

Gasche Y, Daali Y, Fathi M et al. Codeine intoxication associated with ultrarapid CYP2D6 metabolism. N Engl J Med 2004; 351:2827-31.

Gashaw I, Kirchheiner J, Goldammer M et al. Cytochrome p450 3A4 messenger ribonucleic acid induction by rifampin in human peripheral blood mononuclear cells: correlation with alprazolam pharmacokinetics. Clin Pharmacol Ther 2003; 74:448-57.

Gasnier C, Benachour N, Clair E et al. Dig1 protects against cell death provoked by glyphosate-based herbicides in human liver cell lines. J Occup Med Toxicol 2010; 5:29.

Gasnier C, Laurant C, Decroix-Laporte C et al. Defined plant extracts can protect human cells against combined xenobiotic effects. J Occup Med Toxicol 2011; 6:3.

Gaspari T, Hongbin Liu, Welungoda I et al. A GLP-1 receptor agonist liraglutide inhibits endothelial cell dysfunction and vascular adhesion molecule expression in an ApoE-/- mouse model. Diab Vasc Dis Res 2011; 8:117-24.

Gasparini L, Ongini E, Wenk G. Non-steroidal anti-inflammatory drugs (NSAIDs) in Alzheimer's disease: old and new mechanisms of action. J Neurochem 2004; 91:521-36.

Gasperino J. Gender is a risk factor for lung cancer. Med Hypotheses 2011; 76:328-31.

Gass RJ, Gal J, Fogle PW, Detmar-Hanna D, Gerber JG. Neither dapsone hydroxylation nor cortisol 6beta-hydroxylation detects the inhibition of CYP3A4 by HIV-1 protease inhibitors. Eur J Clin Pharmacol 1998; 54:741-7.

Gassler N, Herr I, Schneider A et al. Impaired expression of acyl-CoA synthetase 5 in sporadic colorectal adenocarcinomas. J Pathol 2005; 207:295-300.

Gassó P, Mas S, Alvarez S et al. Xenobiotic metabolizing and transporter genes: gene-gene interactions in schizophrenia and related disorders. Pharmacogenomics 2010; 11:1725-31.

Gassó P, Mas S, Bernardo M, Álvarez S, Parellada E, Lafuente A. A common variant in DRD3 gene is associated with risperidone-induced extrapyramidal symptoms. Pharmacogenomics J 2009; 9:404-10.

Gatanaga H, Hayashida T, Tsuchiya K et al. Successful efavirenz dose reduction in HIV type 1-infected individuals with cytochrome P450 2B6 *6 and *26. Clin Infect Dis 2007; 45:1230-7.

Gatanaga H, Oka S. Successful genotype-tailored treatment with small-dose efavirenz. AIDS 2009; 23:433-4.

Gatanaga H, Yazaki H, Tanuma J et al. HLA-Cw8 primarily associated with hypersensitivity to nevirapine. AIDS 2007; 21:264-5.

Gates MA, Tworoger SS, Terry KL et al. Talc use, variants of the GSTM1, GSTT1, and NAT2 genes, and risk of epithelial ovarian cancer. Cancer Epidemiol Biomarkers Prev 2008; 17:2436-44.

Gätke MR, Bundgaard JR, Viby-Mogensen J. Two novel mutations in the BCHE gene in patients with prolonged duration of action of mivacurium or succinylcholine during anaesthesia. Pharmacogenet Genomics 2007; 17:995-9.

Gattermann N, Retzlaff S, Wang YL et al. Heteroplasmic point mutations of mitochondrial DNA affecting subunit I of cytochrome c oxidase in two patients with acquired idiopathic sideroblastic anemia. Blood 1997; 90:4961-72.

Gattermann N, Wulfert M, Junge B, Germing U, Haas R, Hofhaus G. Ineffective hematopoiesis linked with a mitochondrial tRNA mutation (G3242A) in a patient with myelodysplastic syndrome. Blood 2004; 103:1499-502.

Gaudet MM, Chanock S, Dunning A et al. HSD17B1 genetic variants and hormone receptor-defined breast cancer. Cancer Epidemiol Biomarkers Prev 2008; 17:2766-72.

Gaudet MM, Chanock S, Lissowska J et al. Genetic variation of Cytochrome P450 1B1 (CYP1B1) and risk of breast cancer among Polish women. Pharmacogenet Genomics 2006; 16:547-53.

Gaudineau C, Auclair K. Inhibition of human P450 enzymes by nicotinic acid and nicotinamide. Biochem Biophys Res Commun 2004; 317:950-6.

Gaudineau C, Beckerman R, Welbourn S, Auclair K. Inhibition of human P450 enzymes by multiple constituents of the Ginkgo biloba extract. Biochem Biophys Res Commun 2004; 318:1072-8.

Gaussin V, Tomlinson JE, Depre C et al. Common genomic response in different mouse models of beta-adrenergic-induced cardiomyopathy Circulation 2003; 108:2926-33.

Gaustadnes M, Wilcken B, Oliveriusova J et al. The molecular basis of cystathionine beta-synthase deficiency in Australian patients: genotype-phenotype correlations and response to treatment. Hum Mutat 2002; 20:117-26.

Gauthier L, Charrin B, Borrell-Pages M et al. Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell 2004; 118:127-38.

Gavalas NG, Akhtar S, Gawkrodger DJ, Watson PF, Weetman AP, Kemp EH. Analysis of allelic variants in the catalase gene in patients with the skin depigmenting disorder vitiligo. Biochem Biophys Res Commun 2006; 345:1586-91.

Gavras I, Gavras H. Role of alpha2-adrenergic receptors in hypertension. Am J Hypertens 2001; 14:171-7.

Gavrilova SI, Kolykhalov IV, Fedorova YB et al. Potential of preventive treatment of Alzheimer's disease: results of a three-year prospective open comparative trial of the efficacy and safety of courses of treatment with cerebrolysin and cavinton in elderly patients with mild cognitive impairment syndrome. Neurosci Behav Physiol 2011; 41:391-8.

Gawrońska-Szklarz B, Siuda A, Kurzawski M, Bielicki D, Marlicz W, Droździk M. Effects of CYP2C19, MDR1, and interleukin 1-B gene variants on the eradication rate of Helicobacter pylori infection by triple therapy with pantoprazole, amoxicillin, and metronidazole. Eur J Clin Pharmacol 2010; 66:681-7.

Gawrońska-Szklarz B, Wrześniewska J, Starzyńska T et al. Effect of CYP2C19 and MDR1 polymorphisms on cure rate in patients with acid-related disorders with Helicobacter pylori infection. Eur J Clin Pharmacol 2005; 61:375-9.

Gawronska-Szklarz B, Zarzycki M, Musial HD, Pudlo A, Loniewski I, Drozdzik M. Lidocaine pharmacokinetics in postmenopausal women on hormone therapy. Menopause 2006; 13:793-8.

Gay SC, Shah MB, Talakad JC et al. Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2. 0-A resolution. Mol Pharmacol 2010; 77:529-38.

Gayathri SB, Radha V, Vimaleswaran KS, Mohan V. Association of the PPARGC1A gene polymorphism with diabetic nephropathy in an Asian Indian population (CURES-41). Metab Syndr Relat Disord 2010; 8:119-26.

Gaysina D, Cohen-Woods S, Chow PC et al. Association of the dystrobrevin binding protein 1 gene (DTNBP1) in a bipolar case-control study (BACCS). Am J Med Genet B Neuropsychiatr Genet 2009; 150:836-44.

Gaysina D, Pierce M, Richards M, Hotopf M, Kuh D, Hardy R. Association between adolescent emotional problems and metabolic syndrome: The modifying effect of C-reactive protein gene (CRP) polymorphisms. Brain Behav Immun 2011; 25:750-8.

Gayther SA, Song H, Ramus SJ et al. Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer. Cancer Res 2007; 67:3027-35.

Gazdar AF. Activating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors. Oncogene 2009; 28 Suppl 1:24-31.

Gazi IF, Apostolou FA, Liberopoulos EN et al. Leptospirosis is associated with markedly increased triglycerides and small dense low-density lipoprotein and decreased high-density lipoprotein. Lipids 2011; 46:953-60.

Gazouli M, Mantzaris G, Kotsinas A et al. Association between polymorphisms in the Toll-like receptor 4, CD14, and CARD15/NOD2 and inflammatory bowel disease in the Greek population. World J Gastroenterol 2005; 11:681-5.

Gazzin S, Berengeno AL, Strazielle N et al. Modulation of Mrp1 (ABCc1) and Pgp (ABCb1) by bilirubin at the blood-CSF and blood-brain barriers in the Gunn rat. PLoS One 2011. doi:10. 1371/journal. pone. 0016165.

Ge D, Gooljar SB, Kyriakou T et al. Association of common JAK2 variants with body fat, insulin sensitivity and lipid profile. Obesity 2008; 16:492-6.

Ge D, Huang J, He J et al. beta2-Adrenergic receptor gene variations associated with stage-2 hypertension in northern Han Chinese. Ann Hum Genet 2005; 69:36-44.

Gebeyehu E, Engidawork E, Bijnsdorp A, Aminy A, Diczfalusy U, Aklillu E. Sex and CYP3A5 genotype influence total CYP3A activity: high CYP3A activity and a unique distribution of CYP3A5 variant alleles in Ethiopians. Pharmacogenomics J 2011; 11:130-7.

Gebril OH, Kirby J, Savva G, Brayne C, Ince PG. HFE H63D, C282Y and AGTR1 A1166C polymorphisms and brain white matter lesions in the aging brain. J Neurogenet 2011; 25:7-14.

Geese WJ, Achanzar W, Rubin C et al. Genetic and gene expression studies implicate renin and endothelin-1 in edema caused by peroxisome proliferator-activated receptor gamma agonists. Pharmacogenet Genomics 2008; 18:903-10.

Gefitinib: new preparation. Non small-cell lung cancer: stricter assessment needed. Prescrire Int 2004; 13:168-70.

Geick A, Eichelbaum M, Burk O. Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J Biol Chem 2001; 276:14581-7.

Geiger EV, Doehring A, Kirchhof A, Lötsch J. Functional variants of the human 5-lipoxygenase gene and their genetic diagnosis. Prostaglandins Leukot Essent Fatty Acids 2009; 80:255-62.

Geisel J, Kivistö KT, Griese EU, Eichelbaum M. The efficacy of simvastatin is not influenced by CYP2D6 polymorphism. Clin Pharmacol Ther 2002; 72:595-6.

Geisen C, Luxembourg B, Watzka M et al. Prediction of phenprocoumon maintenance dose and phenprocoumon plasma concentration by genetic and non-genetic parameters. Eur J Clin Pharmacol 2011; 67:371-81.

Geisler T, Zürn C, Paterok M et al. Statins do not adversely affect post-interventional residual platelet aggregation and outcomes in patients undergoing coronary stenting treated by dual antiplatelet therapy. Eur Heart J 2008; 29:1635-43.

Geldenhuys WJ, van der Schyf CJ. Serotonin 5-HT6 receptor antagonists for the treatment of Alzheimer's disease. Curr Top Med Chem 2008; 8:1035-48.

Geldenhuys WJ, van der Schyf CJ. The serotonin 5-HT6 receptor: a viable drug target for treating cognitive deficits in Alzheimer's disease. Expert Rev Neurother 2009; 9:1073-85.

Gelder CM, Lambkin R, Hart KW et al. Associations between human leukocyte antigens and nonresponsiveness to influenza vaccine. J Infect Dis 2002; 185:114-7.

Gelineau-van Waes J, Maddox JR, Smith LM et al. Microarray analysis of E9. 5 reduced folate carrier (RFC1; Slc19a1) knockout embryos reveals altered expression of genes in the cubilin-megalin multiligand endocytic receptor complex. BMC Genomics 2008; 9:156.

Gélisse P, Hillaire-Buys D, Halaili E et al. Carbamazepine and clarithromycin: a clinically relevant drug interaction. Rev Neurol 2007; 163:1096-9.

Gellera C, Meoni C, Castellotti B et al. Errors in Huntington disease diagnostic test caused by trinucleotide deletion in the IT15 gene. Am J Hum Genet 1996; 59:475-7.

Gellner K, Eiselt R, Hustert E et al. Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene. Pharmacogenetics 2001; 11:111-21.

Gemmati D, Ongaro A, Tognazzo S et al. Methylenetetrahydrofolate reductase C677T and A1298C gene variants in adult non-Hodgkin's lymphoma patients: association with toxicity and survival. Haematologica 2007; 92:478-85.

Generaux GT, Bonomo FM, Johnson M, Mahar Doan KM. Impact of SLCO1B1 (OATP1B1) and ABCG2 (BCRP) genetic polymorphisms and inhibition on LDL-C lowering and myopathy of statins. Xenobiotica 2011; 41:639-51.

Geneviève D, Proulle V, Isidor B et al. Thromboxane synthase mutations in an increased bone density disorder (Ghosal syndrome). Nat Genet 2008; 40:284-6.

Genin E, Hannequin D, Wallon D et al. APOE and Alzheimer disease: a major gene with semi-dominant inheritance. Mol Psychiatry 2011; 16:903-7.

Gennari L, Merlotti D, Nuti R. Aromatase activity and bone loss. Adv Clin Chem 2011; 54:129-64.

Gennuso F, Fernetti C, Tirolo C et al. Bilirubin protects astrocytes from its own toxicity by inducing up-regulation and translocation of multidrug resistance-associated protein 1 (Mrp1). Proc Nat Acad Sci USA 2004; 101:2470-5.

Genoud N, Behrens A, Miele G et al. Disruption of Doppel prevents neurodegeneration in mice with extentive Prnp deletions. Proc Nat Acad Sci USA 2004; 101:4198-203.

Genovese S, Epifano F, Curini M, Menger D, Zembruski NC, Weiss J. In vitro effects of natural prenyloxycinnamic acids on human cytochrome P450 isozyme activity and expression. Phytomedicine 2011; 18:586-91.

Genschel J, Haas R, Propsting MJ, Schmidt HHJ. Apolipoprotein A-I induced amyloidosis. FEBS Lett 1998; 430:145-9.

Genser D. Food and drug interaction: consequences for the nutrition/health status. Ann Nutr Metab 2008; 52 Suppl 1:29-32.

Gentile DM, Tomlinson ES, Maggs JL, Park BK, Back DJ. Dexamethasone metabolism by human liver in vitro. Metabolite identification and inhibition of 6-hydroxylation. J Pharmacol Exp Ther 1996; 277:105-12.

Gentile DM, Verhoeven CH, Shimada T, Back DJ. The role of CYP2C in the in vitro bioactivation of the contraceptive steroid desogestrel. J Pharmacol Exp Ther 1998; 287:975-82.

Gentile G, Borro M, Lala N, Missori S, Simmaco M, Martelletti P. Genetic polymorphisms related to efficacy and overuse of triptans in chronic migraine. J Headache Pain 2010; 11:431-5.

Gentile G, Missori S, Borro M, Sebastianelli A, Simmaco M, Martelletti P. Frequencies of genetic polymorphisms related to triptans metabolism in chronic migraine. J Headache Pain 2010; 11:151-6.

Gentile S, Martin N, Scappini E, Williams J, Erxleben C, Armstrong DL. The human ERG1 channel polymorphism, K897T, creates a phosphorylation site that inhibits channel activity. Proc Natl Acad Sci USA 2008; 105:14704-8.

Gentilini D, Somigliana E, Vigano P, Vignali M, Busacca M, Di Blasio AM. The vascular endothelial growth factor +405G>C polymorphism in endometriosis. Hum Reprod 2008; 1:211-5.

Genualdo V, Spalenza V, Perucatti A et al. Fluorescence in situ hybridization mapping of six loci containing genes involved in the dioxin metabolism of domestic bovids. J Appl Genet 2011; 52:229-32.

Genvigir FD, Hirata MH, Hirata RD. ABCA1 expression and statins: inhibitory effect in peripheral blood mononuclear cells. Pharmacogenomics 2009; 10:997-1005.

Genvigir FD, Rodrigues AC, Cerda A et al. Effects of lipid-lowering drugs on reverse cholesterol transport gene expressions in peripheral blood mononuclear and HepG2 cells. Pharmacogenomics 2010; 11:1235-46.

Genvigir FD, Rodrigues AC, Cerda A, Hirata MH, Curi R, Hirata RD. ABCA1 and ABCG1 expressions are regulated by statins and ezetimibe in Caco-2 cells. Drug Metabol Drug Interact 2011; 26:33-6.

Genvigir FD, Soares SA, Hirata MH et al. Effects of ABCA1 SNPs, including the C-105T novel variant, on serum lipids of Brazilian individuals. Clin Chim Acta 2008; 389:79-86.

George J, Dharanipragada K, Krishnamachari S, Chandrasekaran A, Sam SS, Sunder E. A single-nucleotide polymorphism in the MDR1 gene as a predictor of response to neoadjuvant chemotherapy in breast cancer. Clin Breast Cancer 2009; 9:161-5.

George J, Goodwin B, Liddle C, Tapner M, Farrell GC. Time-dependent expression of cytochrome P450 genes in primary cultures of well-differentiated human hepatocytes. J Lab Clin Med 1997; 129:638-48.

George J, Liddle C, Murray M, Byth K, Farrell GC. Pre-translational regulation of cytochrome P450 genes is responsible for disease-specific changes of individual P450 enzymes among patients with cirrhosis. Biochem Pharmacol 1995; 49:873-81.

George S, Kasimis BS, Cogswell J et al. Phase I study of flavopiridol in combination with Paclitaxel and Carboplatin in patients with non-small-cell lung cancer. Clin Lung Cancer 2008; 9:160-5.

Geraudie P, Hinfray N, Gerbron M, Porcher JM, Brion F, Minier C. Brain cytochrome P450 aromatase activity in roach (Rutilus rutilus): Seasonal variations and impact of environmental contaminants. Aquat Toxicol 2011; 105:378-384.

Gerbal-Chaloin S, Pascussi JM, Pichard-Garcia L et al. Induction of CYP2C genes in human hepatocytes in primary culture. Drug Metab Dispos 2001; 29:242-51.

Gerbal-Chaloin S, Pichard-Garcia L, Fabre JM et al. Role of CYP3A4 in the regulation of the aryl hydrocarbon receptor by omeprazole sulphide. Cell Signal 2006; 18:740-50.

Gerber JG, Rhodes RJ, Gal J. Stereoselective metabolism of methadone N-demethylation by cytochrome P4502B6 and 2C19. Chirality 2004; 16:36-44.

Gerber JG, Rosenkranz SL, Fichtenbaum CJ et al. Effect of efavirenz on the pharmacokinetics of simvastatin, atorvastatin, and pravastatin: results of AIDS Clinical Trials Group 5108 Study. J Acquir Immune Defic Syndr 2005; 39:307-12.

Gerdes LU, Gerdes C, Kervinen K et al. The apolipoprotein epsilon4 allele determines prognosis and the effect onprognosis of simvastatin in survivors of myocardial infarction: a substudy of the Scandinavian simvastatin survival study. Circulation 2000; 101:1366-71.

Gerger A, Hofmann G, Langsenlehner U et al. Integrin alpha-2 and beta-3 gene polymorphisms and colorectal cancer risk. Int J Colorectal Dis 2009; 24:159-63.

Gerhard T, Gong Y, Beitelshees AL et al. Alpha-adducin polymorphism associated with increased risk of adverse cardiovascular outcomes: results from GENEtic Substudy of the International VErapamil SR-trandolapril STudy (INVEST-GENES). Am Heart J 2008; 156:397-404.

Gerhardsson L, Lundh T, Minthon L, Londos E. Metal concentrations in plasma and cerebrospinal fluid in patients with Alzheimer's disease. Dement Geriatr Cogn Disord 2008; 25:508-15.

Gerk PM, Li W, Megaraj V, Vore M. Human multidrug resistance protein 2 transports the therapeutic bile salt tauroursodeoxycholate. J Pharmacol Exp Ther 2007; 320:893-9.

German P, Parikh S, Lawrence J et al. Lopinavir/ritonavir affects pharmacokinetic exposure of artemether/lumefantrine in HIV-uninfected healthy volunteers. J Acquir Immune Defic Syndr 2009; 51:424-9.

Gerónimo-Pardo M, Cuartero-del-Pozo AB, Jiménez-Vizuete JM, Cortiñas-Sáez M, Peyró-García R. Clarithromycin-nifedipine interaction as possible cause of vasodilatory shock. Ann Pharmacother 2005; 39:538-42.

Gerr F, Frumkin H, Hodgins P. Hemolytic anemia following succimer administration in a glucose-6-phosphate dehydrogenase deficient patient. J Toxicol Clin Toxicol 1994; 32:569-75.

Gerretsen P, Pollock BG. Pharmacogenetics and the serotonin transporter in late-life depression. Expert Opin Drug Metab Toxicol 2008; 4:1465-78.

Gerritsen G, Rensen PC, Kypreos KE, Zannis VI, Havekes LM, Willems van Dijk K. ApoC-III deficiency prevents hyperlipidemia induced by apoE overexpression. J Lipid Res 2005; 46:1466-73.

Gerstenberg G, Aoshima T, Fukasawa T et al. Effects of the CYP 2D6 genotype and cigarette smoking on the steady-state plasma concentrations of fluvoxamine and its major metabolite fluvoxamino acid in Japanese depressed patients. Ther Drug Monit 2003; 25:463-8.

Gerstenblith MR, Goldstein AM, Fargnoli MC, Peris K, Landi MT. Comprehensive evaluation of allele frequency differences of MC1R variants across populations. Hum Mutat 2007; 28:495-505.

Gerstmann J, Straussler E, Scheinker I. Ueber eine eigenartige hereditaer-familiaere Erkrankung des Zentralnervensystems. Z Ges Neurol Psychiat 1936; 154:736-62.

Gervais F, Singajara R, Xanthoudakis S et al. Recruitment and activation of caspase-8 by the huntingtin-interacting protein Hip-1 and a novel partner Hippi. Nat Cell Biol 2002; 4:95-105.

Gervais FG, Xu D, Robertson GS et al. Involvement of caspases in proteolytic claevage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A-beta peptide formation. Cell 1999; 97:395-406.

Gervasini G, García-Martín E, Ladero JM et al. Genetic variability in CYP3A4 and CYP3A5 in primary liver, gastric and colorectal cancer patients. BMC Cancer 2007; 7:118.

Gervasini G, Martínez C, Benítez J, Agúndez JA. Effect of neurotransmitters on NADPH-cytochrome P450 reductase in vitro activity. Drug Metab Lett 2007; 1:172-5.

Gervasini G, Vizcaino S, Carrillo JA, Caballero MJ, Benitez J. The effect of CYP2J2, CYP3A4, CYP3A5 and the MDR1 polymorphisms and gender on the urinary excretion of the metabolites of the H-receptor antihistamine ebastine: a pilot study. Br J Clin Pharmacol 2006; 62:177-86.

Gervasini G, Vizcaino S, Gasiba C, Carrillo JA, Benítez J. Differences in CYP3A5*3 genotype distribution and combinations with other polymorphisms between Spaniards and Other Caucasian populations. Ther Drug Monit 2005; 27:819-21.

Gerzenshtein L, Patel SM, Scarsi KK, Postelnick MJ, Flaherty JP. Breakthrough Candida infections in patients receiving voriconazole. Ann Pharmacother 2005; 39:1342-5.

Getachew Y, James L, Lee WM, Thiele DL, Miller BC. Susceptibility to acetaminophen (APAP) toxicity unexpectedly is decreased during acute viral hepatitis in mice. Biochem Pharmacol 2010; 79:1363-71.

Getz GS, Wool GD, Reardon CA. HDL apolipoprotein-related peptides in the treatment of atherosclerosis and other inflammatory disorders. Curr Pharm Des 2010; 16:3173-84.

Gewiese-Rabsch J, Drucker C, Malchow S, Scheller J, Rose-John S. Role of IL-6 trans-signaling in CCl4 induced liver damage. Biochim Biophys Acta 2010; 1802:1054-61.

Gex-Fabry M, Eap CB, Oneda B et al. CYP2D6 and ABCB1 genetic variability: influence on paroxetine plasma level and therapeutic response. Ther Drug Monit 2008; 30:474-82.

Ghaemmaghami S, Ahn M, Lessard P et al. Continuous quinacrine treatment results in the formation of drug-resistant prions. PLoS Pathog 2009. doi:10. 1371/journal. ppat. 1000673.

Ghahramani P, Ellis SW, Lennard MS, Ramsay LE, Tucker GT. Cytochromes P450 mediating the N-demethylation of amitriptyline. Br J Clin Pharmacol 1997; 43:137-44.

Ghai S, Monga R, Mohanty TK, Chauhan MS, Singh D. Tissue-specific promoter methylation coincides with Cyp19 gene expression in buffalo (Bubalus bubalis) placenta of different stages of gestation. Gen Comp Endocrinol 2010; 169:182-9.

Ghali JK, Koren MJ, Taylor JR et al. Efficacy and safety of oral conivaptan: a V1A/V2 vasopressin receptor antagonist, assessed in a randomized, placebo-controlled trial in patients with euvolemic or hypervolemic hyponatremia. J Clin Endocrinol Metab 2006; 91:2145-52.

Ghanem CI, Arias A, Novak A et al. Acetaminophen-induced stimulation of MDR1 expression and activity in rat intestine and in LS 174T human intestinal cell line. Biochem Pharmacol 2011; 81:244-50.

Ghanem CI, Ruiz ML, Villanueva SS et al. Effect of repeated administration with subtoxic doses of acetaminophen to rats on enterohepatic recirculation of a subsequent toxic dose. Biochem Pharmacol 2009; 77:1621-8.

Ghassabian S, Chetty M, Tattam BN et al. A high-throughput assay using liquid chromatography-tandem mass spectrometry for simultaneous in vivo phenotyping of 5 major cytochrome p450 enzymes in patients. Ther Drug Monit 2009; 31:239-46.

Ghebranious N, Mukesh B, Giampietro PF et al. A pilot study of gene/gene and gene/environment interactions in Alzheimer disease. Clin Med Res 2011; 9:17-25.

Ghebremedhin E, Schultz C, Thal DR et al. Gendet and age modify the association between APOE and AD-related neuropathology. Neurology 2001; 56:1696-701.

Ghelani AM, Samanta A, Jones AC, Mastana SS. Association analysis of TNFR2, VDR, A2M, GSTT1, GSTM1, and ACE genes with rheumatoid arthritis in South Asians and Caucasians of East Midlands in the United Kingdom. Rheumatol Int 2011; 31:1355-61.

Ghilardi G, Biondi ML, Battaglioli L, Zambon A, Guagnellini E, Scorza R. Genetic risk factor characterizes abdominal aortic aneurysm from arterial occlusive disease in human beings: CCR5 Delta 32 deletion. J Vasc Surg 2004; 40:995-1000.

Ghirmai S, Azar MR, Cashman JR. Synthesis and pharmacological evaluation of 6-naltrexamine analogs for alcohol cessation. Bioorg Med Chem 2009; 17:6671-81.

Ghobadi C, Gregory A, Crewe HK, Rostami-Hodjegan A, Lennard MS. CYP2D6 is primarily responsible for the metabolism of clomiphene. Drug Metab Pharmacokinet 2008; 23:101-5.

Ghodke Y, Joshi K, Patwardhan B. Traditional medicine to modern pharmacogenomics: Ayurveda Prakriti type and CYP2C19 gene polymorphism associated with the metabolic variability. Evid Based Complement Alternat Med 2009. doi:10. 1093/ecam/nep206.

Ghorbanihaghjo A, Veisi P, Argani H et al. Prevention of DNA damage in renal transplantation by losartan and enalapril: the role of renin-angiotensin system polymorphisms. Clin Exp Nephrol 2008; 12:65-73.

Ghosal A, Chowdhury SK, Gupta S et al. Identification of human liver cytochrome P450 enzymes involved in the metabolism of SCH 351125, a CCR5 antagonist. Xenobiotica 2005; 35:405-17.

Ghosal A, Chowdhury SK, Tong W et al. Identification of human liver cytochrome P450 enzymes responsible for the metabolism of lonafarnib (Sarasar). Drug Metab Dispos 2006; 34:628-35.

Ghosal A, Gupta S, Ramanathan R et al. Metabolism of loratadine and further characterization of its in vitro metabolites. Drug Metab Lett 2009; 3:162-70.

Ghosal A, Hapangama N, Yuan Y et al. Rapid determination of enzyme activities of recombinant human cytochromes P450, human liver microsomes and hepatocytes. Biopharm Drug Dispos 2003; 24:375-84.

Ghosal A, Lu X, Penner N et al. Identification of human liver cytochrome P450 enzymes involved in the metabolism of SCH 530348 (Vorapaxar), a potent oral thrombin protease-activated receptor 1 antagonist. Drug Metab Dispos 2011; 39:30-8.

Ghosal A, Ramanathan R, Yuan Y et al. Identification of human liver cytochrome P450 enzymes involved in biotransformation of vicriviroc, a CCR5 receptor antagonist. Drug Metab Dispos 2007; 35:2186-95.

Ghosal A, Satoh H, Thomas PE, Bush E, Moore D. Inhibition and kinetics of cytochrome P4503A activity in microsomes from rat, human, and cdna-expressed human cytochrome P450. Drug Metab Dispos 1996; 24:940-7.

Ghosal A, Yuan Y, Hapangama N et al. Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of 3-hydroxydesloratadine. Biopharm Drug Dispos 2004; 25:243-52.

Ghose R, Omoluabi O, Gandhi A et al. Role of high-fat diet in regulation of gene expression of drug metabolizing enzymes and transporters. Life Sci 2011; 89:57-64.

Ghosh A, Hellewell JS. A review of the efficacy and tolerability of agomelatine in the treatment of major depression. Expert Opin Investig Drugs 2007; 16:1999-2004.

Ghosh AK, Bilcer G, Hong L, Koelsch G, Tang J. Memapsin 2 (beta-secretase) inhibitor drug, between fantasy and reality. Curr Alzheimer Res 2007; 4:418-22.

Ghosh AK, Gemma S, Tang J. beta-Secretase as a therapeutic target for Alzheimer's disease. Neurotherapeutics 2008; 5:399-408.

Ghosh C, Gonzalez-Martinez J, Hossain M et al. Pattern of P450 expression at the human blood-brain barrier: Roles of epileptic condition and laminar flow. Epilepsia 2010; 51:1408-17.

Ghosh D, Jiang W, Lo J, Egbuta C. Higher order organization of human placental aromatase. Steroids 2011; 76:753-8.

Ghosh J, Joshi G, Pradhan S, Mittal B. Investigation of TNFA 308G > A and TNFB 252G > A polymorphisms in genetic susceptibility to migraine. J Neurol 2010; 257:898-904.

Ghosh K, Shankarkumar U, Shetty S, Mohanty D. Chronic synovitis and HLA B27 in patients with severe haemophilia. Lancet 2003; 361:933-4.

Ghosh M, Wang H, Ai Y et al. COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARdelta activation. J Exp Med 2007; 204:2053-61.

Ghotbi R, Gomez A, Milani L et al. Allele-specific expression and gene methylation in the control of CYP1A2 mRNA level in human livers. Pharmacogenomics J 2009; 9:208-17.

Ghotbi R, Mannheimer B, Aklillu E et al. Carriers of the UGT1A4 142T>G gene variant are predisposed to reduced olanzapine exposure-an impact similar to male gender or smoking in schizophrenic patients. Eur J Clin Pharmacol 2010; 66:465-74.

Giacobini E. Cholinesterases and cholinesterase inhibitors. Martin Dunitz, London, 2000.

Giacobini E. Cholinesterases in human brain: the effect of cholinesterase inhibitors on Alzheimer's disease and related disorders. In Giacobini E, Pepeu G (Eds). The Brain Cholinergic System in Health and Disease. Oxon: Healthcare 2006; 235-64.

Giantin M, Carletti M, Capolongo F et al. Effect of breed upon cytochromes P450 and phase II enzyme expression in cattle liver. Drug Metab Dispos 2008; 36:885-93.

Giantin M, Lopparelli RM, Zancanella V et al. Effects of illicit dexamethasone upon hepatic drug metabolizing enzymes and related transcription factors mRNAs and their potential use as biomarkers in cattle. J Agric Food Chem 2010; 58:1342-9.

Giao PT, de Vries PJ. Pharmacokinetic interactions of antimalarial agents. Clin Pharmacokinet 2001; 40:343-73.

Giasson BI, Forman MS, Higuchi M et al. Initiation and synergistic fibrillization of tau and alpha-synuclein. Science 2003; 300:636-40.

Gibbons AS, Udawela M, Jeon WJ, Seo MS, Brooks L, Dean B. The neurobiology of APOE in schizophrenia and mood disorders. Front Biosci 2011; 16:962-79.

Gibbs MA, Baillie MT, Shen DD, Kunze KL, Thummel KE. Persistent inhibition of CYP3A4 by ketoconazole in modified Caco-2 cells. Pharm Res 2000; 17:299-305.

Gibbs MA, Thummel KE, Shen DD, Kunze KL. Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: comparison of Ki values and impact of CYP3A5 expression. Drug Metab Dispos 1999; 27:180-7.

Gibson AW, Edberg JC, Wu J, Westendorp RG, Huizinga TW, Kimberly RP. Novel single nucleotide polymorphisms in the distal IL-10 promoter affect IL-10 production and enhance the risk of systemic lupus erythematosus. J Immunol 2001; 166:3915-22.

Gibson GG, el-Sankary W, Plant NJ. Receptor-dependent regulation of the CYP3A4 gene. Toxicology 2002; 181-182:199-202.

Gibson GG, Plant NJ, Swales KE, Ayrton A, El-Sankary W. Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man. Xenobiotica 2002; 32:165-206.

Giegling I, Moreno-de-Luca D, Calati R et al. Tyrosine hydroxylase and DOPA decarboxylase gene variants in personality traits. Neuropsychobiology 2009; 59:23-7.

Giera S, Bansal R, Ortiz-Toro TM, Taub DG, Zoeller RT. Individual polychlorinated biphenyl (PCB) congenersp produce tissue- and gene-specific effects on thyroid hormone signaling during development. Endocrinology 2011; 152:2909-19.

Giessmann T, May K, Modess C et al. Carbamazepine regulates intestinal P-glycoprotein and multidrug resistance protein MRP2 and influences disposition of talinolol in humans. Clin Pharmacol Ther 2004; 76:192-200.

Giessmann T, Modess C, Hecker U et al. CYP2D6 genotype and induction of intestinal drug transporters by rifampin predict presystemic clearance of carvedilol in healthy subjects. Clin Pharmacol Ther 2004; 75:213-22.

Gietl A, Giegling I, Hartmann AM et al. ABCG1 gene variants in suicidal behavior and aggression-related traits. Eur Neuropsychopharmacol 2007; 17:410-6.

Gigante PR, Kotchetkov IS, Kellner CP et al. Polymorphisms in complement component 3 (C3F) and complement factor H (Y402H) increase the risk of postoperative neurocognitive dysfunction following carotid endarterectomy. J Neurol Neurosurg Psychiatry 2011; 82:247-53.

Gil Berglund E, Johannsson G, Beck O, Bengtsson BA, Rane A. Growth hormone replacement therapy induces codeine clearance. Eur J Clin Invest 2002; 32:507-12.

Gil JP. Amodiaquine pharmacogenetics. Pharmacogenomics 2008; 9:1385-90.

Gilardi F, Mitro N, Godio C et al. The pharmacological exploitation of cholesterol 7alpha-hydroxylase, the key enzyme in bile acid synthesis: from binding resins to chromatin remodelling to reduce plasma cholesterol. Pharmacol Ther 2007; 116:449-72.

Gilardi F, Viviani B, Galmozzi A et al. Expression of sterol 27-hydroxylase in glial cells and its regulation by liver X receptor signaling. Neuroscience 2009; 164:530-40.

Gilbert AM, Bursavich MG, Lombardi S et al. N-((8-hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2). Bioorg Med Chem Lett 2008; 18:6454-7.

Gilbert JA, Salavaggione OE, Ji Y et al. Gemcitabine pharmacogenomics: cytidine deaminase and deoxycytidylate deaminase gene resequencing and functional genomics. Clin Cancer Res 2006; 12:1794-803.

Gilbert SM, Benson MC, McKiernan JM. Linkage disequilibrium between the androgen receptor gene CAG and GGC repeats in the African-American population. Curr Urol Rep 2002; 3:189-93.

Gildea JJ, Wang X, Jose PA, Felder RA. Differential D1 and D5 receptor regulation and degradation of the angiotensin type 1 receptor. Hypertension 2008; 51:360-6.

Gilep AA, Guryev OL, Usanov SA, Estabrook RW. An enzymatically active chimeric protein containing the hydrophilic form of NADPH-cytochrome P450 reductase fused to the membrane-binding domain of cytochrome b5. Biochem Biophys Res Commun 2001; 284:937-41.

Gilep AA, Guryev OL, Usanov SA, Estabrook RW. Apo-cytochrome b5 as an indicator of changes in heme accessability: preliminary studies with cytochrome P450 3A4. J Inorg Biochem 2001; 87:237-44.

Gilep AA, Guryev OL, Usanov SA, Estabrook RW. Reconstitution of the enzymatic activities of cytochrome P450s using recombinant flavocytochromes containing rat cytochrome b(5) fused to NADPH-cytochrome P450 reductase with various membrane-binding segments. Arch Biochem Biophys 2001; 390:215-21.

Gilmer TM, Cable L, Alligood K et al. Impact of common epidermal growth factor receptor and HER2 variants on receptor activity and inhibition by lapatinib. Cancer Res 2008; 68:571-9.

Gilot D, Le Meur N, Giudicelli F et al. RNAi-based screening identifies kinases interfering with dioxin-mediated up-regulation of CYP1A1 activity. PLoS One 2011. doi:10. 1371/journal. pone. 0018261.

Gill HJ, Tingle MD, Park BK. N-Hydroxylation of dapsone by multiple enzymes of cytochrome P450: implications for inhibition of haemotoxicity. Br J Clin Pharmacol 1995; 40:531-8.

Gill RM, Lee TH, Utter GH et al. The TNF (-308A) polymorphism is associated with microchimerism in transfused trauma patients. Blood 2008; 111:3880-3.

Gillespie JR, Ulici V, Dupuis H et al. Deletion of glycogen synthase kinase-3β in cartilage results in up-regulation of glycogen synthase kinase-3α protein expression. Endocrinology 2011; 152:1755-66.

Gillies GE, McArthur S. Estrogen actions in the brain and the basis for differential action in men and women: a case for sex-specific medicines. Pharmacol Rev 2010; 62:155-98.

Gillman PK. Tricyclic antidepressant pharmacology and therapeutic drug interactions updated. Br J Pharmacol 2007; 151:737-48.

Gillum JG, Israel DS, Polk RE. Pharmacokinetic drug interactions with antimicrobial agents. Clin Pharmacokinet 1993; 25:450-82.

Ginguené C, Champier J, Maallem S et al. P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) localize in the microvessels forming the blood-tumor barrier in ependymomas. Brain Pathol 2010; 20:926-35.

Ginosar Y, Davidson EM, Meroz Y, Blotnick S, Shacham M, Caraco Y. Mu-opioid receptor (A118G) single-nucleotide polymorphism affects alfentanil requirements for extracorporeal shock wave lithotripsy: a pharmacokinetic-pharmacodynamic study. Br J Anaesth 2009; 103:420-7.

Giordano C, Pichiorri F, Blakely EL et al. Isolated distal myopathy of the upper limbs associated with mitochondrial DNA depletion and polymerase gamma mutations. Arch Neurol 2010; 67:1144-6.

Giordano C, Powell H, Leopizzi M et al. Fatal congenital myopathy and gastrointestinal pseudo-obstruction due to POLG1 mutations. Neurology 2009; 72:1103-5.

Giovannetti E, Erdem L, Olcay E, Leon LG, Peters GJ. Influence of polymorphisms on EGFR targeted therapy in non-small-cell lung cancer. Front Biosci 2011; 16:116-30.

Giovannetti E, Mey V, Nannizzi S, Pasqualetti G, del Tacca M, Danesi R. Pharmacogenetics of anticancer drug sensitivity in pancreatic cancer. Mol Cancer Ther 2006; 5:1387-95.

Giovannucci E, Stampfer MJ, Krithivas K et al. The CAG repeat within the androgen receptor gene and its relationship to prostate cancer. Proc Natl Acad Sci U S A 1997; 94:3320-3.

Girard H, Court MH, Bernard O et al. Identification of common polymorphisms in the promoter of the UGT1A9 gene: evidence that UGT1A9 protein and activity levels are strongly genetically controlled in the liver. Pharmacogenetics 2004; 14:501-15.

Girard H, Levesque E, Bellemare J, Journault K, Caillier B, Guillemette C. Genetic diversity at the UGT1 locus is amplified by a novel 3-prime alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity. Pharmacogenet Genomics 2007; 17:1077-89.

Girard H, Villeneuve L, Court MH et al. The novel UGT1A9 intronic I399 polymorphism appears as a predictor of 7-ethyl-10-hydroxycamptothecin glucuronidation levels in the liver. Drug Metab Dispos 2006; 34:1220-8.

Girardin F, Pechère-Bertschi A. Antihypertensive therapy and drug-drug interactions. Rev Med Suisse 2005; 1:2099-100, 2102-4.

Giraud C, Manceau S, Treluyer JM. ABC transporters in human lymphocytes: expression, activity and role, modulating factors and consequences for antiretroviral therapies. Expert Opin Drug Metab Toxicol 2010; 6:571-89.

Giraud C, Tran A, Rey E, Vincent J, Tréluyer JM, Pons G. In vitro characterization of clobazam metabolism by recombinant cytochrome P450 enzymes: importance of CYP2C19. Drug Metab Dispos 2004; 32:1279-86.

Giraud C, Treluyer JM, Rey E et al. In vitro and in vivo inhibitory effect of stiripentol on clobazam metabolism. Drug Metab Dispos 2006; 34:608-11.

Giraud M, Vandiedonck C, Garchon HJ. Genetic factors in autoimmune myasthenia gravis. Ann N Y Acad Sci 2008; 1132:180-92.

Girelli D, Russo C, Ferraresi P et al. Polymorphisms in the factor VII gene and the risk of myocardial infarction in patients with coronary artery disease. N Engl J Med 2000; 343:774-80.

Girennavar B, Jayaprakasha GK, Jadegoud Y, Nagana Gowda GA, Patil BS. Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit. Bioorg Med Chem 2007; 15:3684-91.

Girennavar B, Jayaprakasha GK, Patil BS. Potent inhibition of human cytochrome P450 3A4, 2D6, and 2C9 isoenzymes by grapefruit juice and its furocoumarins. J Food Sci 2007; 72:417-21.

Girennavar B, Poulose SM, Jayaprakasha GK, Bhat NG, Patil BS. Furocoumarins from grapefruit juice and their effect on human CYP 3A4 and CYP 1B1 isoenzymes. Bioorg Med Chem 2006; 14:2606-12.

Girish C, Manikandan S. Aprepitant: a substance P antagonist for chemotherapy induced nausea and vomiting. Indian J Cancer 2007; 44:25-30.

Girolami F, Spalenza V, Carletti M et al. Gene expression and inducibility of the aryl hydrocarbon receptor-dependent pathway in cultured bovine blood lymphocytes. Toxicol Lett 2011; 206:204-9.

Gisbert JP, Gomollón F, Cara C et al. Thiopurine methyltransferase activity in Spain: a study of 14,545 patients. Dig Dis Sci 2007; 5:1262-9.

Giubergia V, Gravina LP, Castaños C, Chertkoff L, Grenoville M. Influence of beta2-adrenoceptor polymorphisms on the response to chronic use of albuterol in asthmatic children. Pediatr Pulmonol 2008; 43:421-5.

Giuffre' I. Molecular analysis of Italian patients with congenital glaucoma. Ophthalmic Genet 2011. doi:10. 3109/13816810. 2011. 596891.

Giusti B, Gori AM, Marcucci R et al. Cytochrome P450 2C19 loss-of-function polymorphism, but not CYP3A4 IVS10 + 12G/A and P2Y12 T744C polymorphisms, is associated with response variability to dual antiplatelet treatment in high-risk vascular patients. Pharmacogenet Genomics 2007; 17:1057-64.

Giusti B, Gori AM, Marcucci R, Abbate R. Relation of CYP2C19 loss-of-function polymorphism to the occurrence of stent thrombosis. Expert Opin Drug Metab Toxicol 2010; 6:393-407.

Giusti B, Saracini C, Bolli P et al. Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm. J Med Genet 2008; 45:721-30.

Givan S, Sprague G. The ankyrin-repeat containing protein Akr1p is required for the endocytosis of yeast pheromone receptors. Molec Biol Cell 1997; 8:1317-27.

Giwercman A, Rylander L, Rignell-Hydbom A et al. Androgen receptor gene CAG repeat length as a modifier of the association between persistent organohalogen pollutant exposure markers and semen characteristics. Pharmacogenet Genomics 2007; 17:391-401.

Gizatullin R, Zaboli G, Jönsson EG, Asberg M, Leopardi R. Haplotype analysis reveals tryptophan hydroxylase (TPH) 1 gene variants associated with major depression. Biol Psychiatry 2006; 59:295-300.

Gizer IR, Ficks C, Waldman ID. Candidate gene studies of ADHD: a meta-analytic review. Hum Genet 2009; 126:51-90.

Gjerde J, Hauglid M, Breilid H et al. Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy number on tamoxifen metabolism. Ann Oncol 2008; 19:56-61.

Gjesing AP, Andersen G, Albrechtsen A et al. Studies of associations between the Arg389Gly polymorphism of the beta1-adrenergic receptor gene (ADRB1) and hypertension and obesity in 7677 Danish white subjects. Diabet Med 2007; 24:392-7.

Gjesing AP, Andersen G, Borch-Johnsen K, Jørgensen T, Hansen T, Pedersen O. Association of the beta3-adrenergic receptor Trp64Arg polymorphism with common metabolic traits: studies of 7605 middle-aged white people. Mol Genet Metab 2008; 94:90-7.

Gjesing AP, Sparsø T, Borch-Johnsen K et al. No consistent effect of ADRB2 haplotypes on obesity, hypertension and quantitative traits of body fatness and blood pressure among 6,514 adult Danes. PLoS One 2009. doi:10. 1371/journal. pone. 0007206.

Gladding P, Webster M, Zeng I et al. The pharmacogenetics and pharmacodynamics of clopidogrel response: an analysis from the PRINC (Plavix Response in Coronary Intervention) trial. JACC Cardiovasc Interv 2008; 1:620-7.

Glaeser H, Bailey DG, Dresser GK et al. Intestinal drug transporter expression and the impact of grapefruit juice in humans. Clin Pharmacol Ther 2007; 81:362-70.

Glaeser H, Drescher S, Eichelbaum M, Fromm MF. Influence of rifampicin on the expression and function of human intestinal cytochrome P450 enzymes. Br J Clin Pharmacol 2005; 59:199-206.

Glaeser H, Drescher S, Hofmann U et al. Impact of concentration and rate of intraluminal drug delivery on absorption and gut wall metabolism of verapamil in humans. Clin Pharmacol Ther 2004; 76:230-8.

Glaeser H, Drescher S, van der Kuip H et al. Shed human enterocytes as a tool for the study of expression and function of intestinal drug-metabolizing enzymes and transporters. Clin Pharmacol Ther 2002; 71:131-40.

Glaser B. Familial Hyperinsulinism (FHI). In: Pagon RA, Bird TC, Dolan CR, Stephens K (Eds). GeneReviews. University of Washington, Seattle, 1993-2003. Available from: http://www. ncbi. nlm. nih. gov/books/NBK1375/

Glasgow SC, Yu J, Carvalho LP, Shannon WD, Fleshman JW, McLeod HL. Unfavourable expression of pharmacologic markers in mucinous colorectal cancer. Br J Cancer 2005; 92:259-64.

Glatt H. Sulfotransferases in the bioactivation of xenobiotics. Chem Biol Interact 2000; 129:141-70.

Glatt SJ, Bousman C, Wang RS et al. Evaluation of OPRM1 variants in heroin dependence by family-based association testing and meta-analysis. Drug Alcohol Depend 2007; 90:159-65.

Gleeson MP, Davis AM, Chohan KK et al. Generation of in-silico cytochrome P450 1A2, 2C9, 2C19, 2D6, and 3A4 inhibition QSAR models. J Comput Aided Mol Des 2007; 21:559-73.

Gleiter CH, Mörike KE. Clinical pharmacokinetics of candesartan. Clin Pharmacokinet 2002; 41:7-17.

Glenner GG, Wong CW. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 1984; 120:885-90.

Glessner JT, Wang K, Cai G et al. Autism genome-wide copy number variation reveals ubiquitin and neuronal genes. Nature 2009; 459:569-73.

Glimelius B, Garmo H, Berglund A et al. Prediction of irinotecan and 5-fluorouracil toxicity and response in patients with advanced colorectal cancer. Pharmacogenomics J 2011; 11:61-71.

Glöckner F, Meske V, Lütjohann D, Ohm TG. Dietary cholesterol and its effect on tau protein: a study in apolipoprotein E-deficient and P301L human tau mice. J Neuropathol Exp Neurol 2011; 70:292-301.

Glockner F, Ohn TG. Hippocampal apolipoprotein D level depends on Braak stage and APOE genotype. Neuroscience 2003; 122:103-10.

Gloria-Bottini F, Magrini A, Cozzoli E, Bergamaschi A, Bottini E. ADA genetic polymorphism and the effect of smoking on neonatal bilirubinemia and developmental parameters. Early Hum Dev 2008; 84:739-43.

Gloria-Bottini F, Ronchetti F, Ammendola L, Bottini N. Adenosine deaminase polymorphism and the relationship of total immunoglobulin E with skin prick test: a study on school children. Allergy Asthma Proc 2006; 27:115-8.

Glossop JR, Dawes PT, Nixon NB, Mattey DL. Polymorphism in the tumour necrosis factor receptor II gene is associated with circulating levels of soluble tumour necrosis factor receptors in rheumatoid arthritis. Arthritis Res Ther 2005; 7:1227-34.

Glover DD, McRobie DJ, Tracy TS. Effects of gestational and overt diabetes on placental cytochromes P450 and glutathione S-transferase. Prim Care Update Ob Gyns 1998; 5:189.

Glowacka D, Loesch C, Johnson KT et al. The T393C polymorphism of the Galphas gene (GNAS1) is associated with the course of Graves' disease. Horm Metab Res 2009; 41:430-5.

Główka F, Karaźniewicz-Łada M, Grześkowiak E, Rogozinska D, Romanowski W. Clinical pharmacokinetics of ketoprofen enantiomers in wild type of Cyp 2c8 and Cyp 2c9 patients with rheumatoid arthritis. Eur J Drug Metab Pharmacokinet 2011; 36:167-73.

Gloyn AL, Diatloff-Zito C, Edghill EL et al. KCNJ11 activating mutations are associated with developmental delay, epilepsy and neonatal diabetes syndrome and other neurological features. Eur J Hum Genet 2006; 14:824-30.

Gloyn AL, Hashim Y, Ashcroft SJ et al. Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6. 2 with Type 2 diabetes mellitus (UKPDS 53). Diabet Med 2001; 18:206-12.

Gloyn AL, Weedon MN, Owen KR et al. Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6. 2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. Diabetes 2003; 52:568-72.

Gluba A, Banach M, Mikhailidis DP, Rysz J. Genetic determinants of cardiovascular disease: the renin-angiotensin-aldosterone system, paraoxonases, endothelin-1, nitric oxide synthase and adrenergic receptors. In Vivo 2009; 23:797-812.

Glück S, Gorouhi F. Clinical and economic benefits of aromatase inhibitor therapy in early-stage breast cancer. Am J Health Syst Pharm 2011; 68:1699-706.

Glue P, Banfield CR, Perhach JL, Mather GG, Racha JK, Levy RH. Pharmacokinetic interactions with felbamate. In vitro-in vivo correlation. Clin Pharmacokinet 1997; 33:214-24.

Glukhov AV, Flagg TP, Fedorov VV, Efimov IR, Nichols CG. Differential K(ATP) channel pharmacology in intact mouse heart. J Mol Cell Cardiol 2010; 48:152-60.

Glynn SA, Boersma BJ, Howe TM et al. A mitochondrial target sequence polymorphism in manganese superoxide dismutase predicts inferior survival in breast cancer patients treated with cyclophosphamide. Clin Cancer Res 2009; 15:4165-73.

Gnerre C, Blättler S, Kaufmann MR, Looser R, Meyer UA. Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene. Pharmacogenetics 2004; 14:635-45.

Gnewuch C, Liebisch G, Langmann T et al. Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inflammatory bowel disease. World J Gastroenterol 2009; 15:3134-41.

Gnoth MJ, Buetehorn U, Muenster U, Schwarz T, Sandmann S. In vitro and in vivo P-glycoprotein transport characteristics of rivaroxaban. J Pharmacol Exp Ther 2011; 338:372-80.

Gnoth MJ, Sandmann S, Engel K, Radtke M. In vitro to in vivo comparison of the substrate characteristics of sorafenib tosylate toward P-glycoprotein. Drug Metab Dispos 2010; 38:1341-6.

Goard CA, Mather RG, Vinepal B et al. Differential interactions between statins and P-glycoprotein: implications for exploiting statins as anticancer agents. Int J Cancer 2010; 127:2936-48.

Goate A, Chartier-Harlin M-C, Mullan M et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 1991; 349:704-6.

Gobbi S, Zimmer C, Belluti F et al. Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation. J Med Chem 2010; 53:5347-51.

Goda K, Bacsó Z, Szabó G. Multidrug resistance through the spectacle of P-glycoprotein. Curr Cancer Drug Targets 2009; 9:281-97.

Goda R, Nagai D, Akiyama Y et al. Detection of a new N-oxidized metabolite of flutamide, N-[4-nitro-3-(trifluoromethyl)phenyl]hydroxylamine, in human liver microsomes and urine of prostate cancer patients. Drug Metab Dispos 2006; 34:828-35.

Godard-Codding CA, Clark R, Fossi MC et al. Pacific Ocean-wide profile of CYP1A1 expression, stable carbon and nitrogen isotope ratios, and organic contaminant burden in sperm whale skin biopsies. Environ Health Perspect 2011; 119:337-43.

Godawska-Matysik A, Kieć-Kononowicz K. Biotransformation of praziquantel by human cytochrome p450 3A4 (CYP 3A4). Acta Pol Pharm 2006; 63:381-5.

Godbillon J, Richard J, Gerardin A, Meinertz T, Kasper W, Jähnchen E. Pharmacokinetics of the enantiomers of acenocoumarol in man. Br J Clin Pharmacol 1981; 12:621-9.

Godin C, Auclair A, Ferland M, Hebert SS, Carreau M, Levesque G. Presenilin-1 is indirectly implicated in Notch1 cleavage. Neuroreport 2003; 14:1613-6.

Godin N, Liu F, Lau GJ et al. Catalase overexpression prevents hypertension and tubular apoptosis in angiotensinogen transgenic mice. Kidney Int 2010; 77:1086-97.

Godlewska BR, Olajossy-Hilkesberger L, Ciwoniuk M et al. Olanzapine-induced weight gain is associated with the -759C/T and -697G/C polymorphisms of the HTR2C gene. Pharmacogenomics J 2009; 9:234-41.

Godoy W, Albano RM, Moraes EG et al. CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism. Carcinogenesis 2002; 23:611-6.

Gödtel-Armbrust U, Metzger A, Kroll U, Kelber O, Wojnowski L. Variability in PXR-mediated induction of CYP3A4 by commercial preparations and dry extracts of St. John's wort. Naunyn Schmiedebergs Arch Pharmacol 2007; 375:377-82.

Goecke TW, Ekici AB, Niesler B et al. Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy. Acta Obstet Gynecol Scand 2010; 89:7-14.

Goedde HW, Agarwal DP, Fritze G et al. Distribution of ADH-2 and ALDH2 genotypes in different populations. Hum Genet 1992; 88:344-6.

Goedert M, Crowther RA, Spillantini MG. Tau mutations cause frontotemporal dementias. Neuron 1998; 21:955-8.

Goedert M, Spillantini MG, Crowther RA et al. Tau gene mutation in familial progressive subcortical gliosis. Nat Medicine 1999; 5:454-7.

Goedert M, Spillantini MG, Potier MC, Ulrich J, Crowther RA. Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain. EMBO J 1989; 8:393-9.

Goedert M, Wischik CM, Crowther RA, Walker JE, Klug A. Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer's disease: identification as the microtubule-associated protein tau. Proc Nat Acad Sci USA 1988; 85:4051-5.

Goekkurt E, Hoehn S, Wolschke C et al. Polymorphisms of glutathione S-transferases (GST) and thymidylate synthase (TS)-novel predictors for response and survival in gastric cancer patients. Br J Cancer 2006; 94:281-6.

Goekkurt E, Stoehlmacher J, Stueber C et al. Pharmacogenetic analysis of liver toxicity after busulfan/cyclophosphamide-based allogeneic hematopoietic stem cell transplantation. Anticancer Res 2007; 27:4377-80.

Goel S, Cohen M, Cömezoglu SN et al. The effect of ketoconazole on the pharmacokinetics and pharmacodynamics of ixabepilone: a first in class epothilone B analogue in late-phase clinical development. Clin Cancer Res 2008; 14:2701-9.

Goel VK, Ibrahim N, Jiang G et al. Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice. Oncogene 2009; 28:2289-98.

Goetz AK, Dix DJ. Toxicogenomic effects common to triazole antifungals and conserved between rats and humans. Toxicol Appl Pharmacol 2009; 238:80-9.

Goetz MP, Rae JM, Suman VJ et al. Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes. J Clin Oncol 2005; 23:9312-8.

Goetz MP, Schaid DJ, Wickerham DL et al. Evaluation of CYP2D6 and efficacy of tamoxifen and raloxifene in women treated for breast cancer chemoprevention: Results from the NSABP P-1 and P-2 clinical trials. Clin Cancer Res 2011. doi:10. 1158/1078-0432. CCR-11-0860.

Goetz MP, Suman VJ, Couch FJ et al. Cytochrome P450 2D6 and homeobox 13/interleukin-17B receptor: combining inherited and tumor gene markers for prediction of tamoxifen resistance. Clin Cancer Res 2008; 14:5864-8.

Goetz MP, Suman VJ, Ingle JN et al. A two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifen. Clin Cancer Res 2006; 12:2080-7.

Goh BC, Lee SC, Wang LZ et al. Explaining interindividual variability of docetaxel pharmacokinetics and pharmacodynamics in Asians through phenotyping and genotyping strategies. J Clin Oncol 2002; 20:3683-90.

Goh BC, Reddy NJ, Dandamudi UB et al. An evaluation of the drug interaction potential of pazopanib, an oral vascular endothelial growth factor receptor tyrosine kinase inhibitor, using a modified Cooperstown 5+1 cocktail in patients with advanced solid tumors. Clin Pharmacol Ther 2010; 88:652-9.

Gohin M, Bodinier P, Fostier A, Bobe J, Chesnel F. Aromatase expression in Xenopus oocytes: a three cell-type model for the ovarian estradiol synthesis. J Mol Endocrinol 2011; 47:241-50.

Gökalp O, Gunes A, Cam H et al. Mild hypoglycaemic attacks induced by sulphonylureas related to CYP2C9, CYP2C19 and CYP2C8 polymorphisms in routine clinical setting. Eur J Clin Pharmacol 2011. doi:10. 1007/s00228-011-1078-4.

Gökbuget N, Hoelzer D. Treatment of adult acute lymphoblastic leukemia. Semin Hematol 2009; 46:64-75.

Gołab-Janowska M, Honczarenko K, Gawrońska-Szklarz B, Potemkowski A. CYP2D6 gene polymorphism as a probable risk factor for Alzheimer's disease and Parkinson's disease with dementia. Neurol Neurochir Pol 2007; 41:113-21.

Gold LS, de Roos AJ, Brown EE et al. Associations of common variants in genes involved in metabolism and response to exogenous chemicals with risk of multiple myeloma. Cancer Epidemiol 2009; 33:276-80.

Goldberg RJ. Antidepressant use in the elderly. Current status of nefazodone, venlafaxine and moclobemide. Drugs Aging 1997; 11:119-31.

Goldberg RM, Niedzwiecki D, Bertagnolli M, Blackstock AW, Tepper JE, Mayer RJ. Cancer and leukemia group B gastrointestinal cancer committee. Clin Cancer Res 2006; 12:3589-95.

Goldberg Y, Nicholson D, Rasper D et al. Cleavage of huntingtin by apopain, a propoptotic cysteine protease, is modulated by the polyglutamine tract. Nat Genet 1996; 13:442-9.

Goldenberg MM. Safety and efficacy of sildenafil citrate in the treatment of male erectile dysfunction. Clin Ther 1998; 20:1033-48.

Goldenstein BL, Nelson BW, Xu K et al. Regulator of G protein signaling protein suppression of Galphao protein-mediated alpha2A adrenergic receptor inhibition of mouse hippocampal CA3 epileptiform activity. Mol Pharmacol 2009; 75:1222-30.

Goldfarb LG, Brown P, Haltia M et al. Creutzfeldt-Jakob disease cosegregates with the codon 178-asn PRNP mutation in families of European origin. Ann Neurol 1992; 31:274-81.

Goldfarb LG, Brown P, McCombie WR et al. Transmissible familial Creatzfeldt-Jakob disease associated with five, seven, and eight extra octapeptide coding repeats in the PRNP gene. Proc Nat Acad Sci USA 1991; 88:10926-30.

Goldgaber D, Goldfarb LG, Brown P et al. Mutations in familial Creutzfeldt-Jakob disease and Gerstmann-Straussler-Scheinker's syndrome. Exp Neurol 1989; 106:204-6.

Goldman FD, Ballas ZK, Schutte BC et al. Defective expression of p56lck in an infant with severe combined immunodeficiency. J Clin Invest 1998; 102:421-9.

Goldschmidt N, Azaz-Livshits T, Gotsman, Nir-Paz R, Ben-Yehuda A, Muszkat M. Compound cardiac toxicity of oral erythromycin and verapamil. Ann Pharmacother 2001; 35:1396-9.

Goldstein AM. Familial melanoma, pancreatic cancer and germline CDKN2A mutations. Hum Mutat 2004; 23:630.

Goldstein AM, Chidambaram A, Halpern A et al. Rarity of CDK4 germline mutations in familial melanoma. Melanoma Res 2002; 12:51-5.

Goldstein FC, Ashley AV, Gearing M et al. Apolipoprotein E and age onset of Alzheimer's disease in African American patients. Neurology 2001; 57:1923-5.

Goldstein JA, Blaisdell JA, Limdi NA. A potentially deleterious new CYP2C9 polymorphism identified in an African American patient with major hemorrhage on warfarin therapy. Blood Cells Mol Dis 2009; 42:155-8.

Goldstone JV, McArthur AG, Kubota A et al. Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish. BMC Genomics 2010; 11:643.

Goldwasser J, Cohen PY, Yang E, Balaguer P, Yarmush ML, Nahmias Y. Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: role of PPARalpha, PPARgamma and LXRalpha. PLoS One 2010. doi:10. 1371/journal. pone. 0012399.

Goldwater DR, Dougherty C, Schumacher M, Villano SA. Effect of ketoconazole on the pharmacokinetics of maribavir in healthy adults. Antimicrob Agents Chemother 2008; 52:1794-8.

Goler-Baron V, Assaraf YG. Structure and function of ABCG2-rich extracellular vesicles mediating multidrug resistance. PLoS One 2011. doi:10. 1371/journal. pone. 0016007.

Golovleva I, Biasotto M, Verpy E et al. Novel variants of human IFN-alpha detected in tumor cell lines and biopsy specimens. J Interferon Cytokine Res 1997; 17:637-45.

Golledge J, Biros E, Warrington N et al. A population-based study of polymorphisms in genes related to sex hormones and abdominal aortic aneurysm. Eur J Hum Genet 2011; 19:363-6.

Gomaa MS, Simons C, Brancale A. Homology model of 1alpha,25-dihydroxyvitamin D3 24-hydroxylase cytochrome P450 24A1 (CYP24A1): active site architecture and ligand binding. J Steroid Biochem Mol Biol 2007; 104:53-60.

Gomaa MS, Yee SW, Milbourne CE, Barbera MC, Simons C, Brancale A. Homology model of human retinoic acid metabolising enzyme cytochrome P450 26A1 (CYP26A1): active site architecture and ligand binding. J Enzyme Inhib Med Chem 2006; 21:361-9.

Gomes KB, Fernandes AP, Ferreira ACS et al. Mutations in the seipin and AGPAT2 genes clustering in consanguineous families with Berardinelli-Seip congenital lipodystrophy from two separate geographical regions of Brazil. J Clin Endocr Metab 2004; 89:357-61.

Gomes KB, Pardini VC, Ferreira AC, Fernandes AP. Phenotypic heterogeneity in biochemical parameters correlates with mutations in AGPAT2 or Seipin genes among Berardinelli-Seip congenital lipodystrophy patients. J Inherit Metab Dis 2005; 28:1123-31.

Gomes LG, Huang N, Agrawal V, Mendonça BB, Bachega TA, Miller WL. Extraadrenal 21-hydroxylation by CYP2C19 and CYP3A4: effect on 21-hydroxylase deficiency. J Clin Endocrinol Metab 2009; 94:89-95.

Gomez CF, Constantine L, Moen M, Vaz A, Wang W, Huggett DB. Ibuprofen metabolism in the liver and gill of rainbow trout, Oncorhynchus mykiss. Bull Environ Contam Toxicol 2011; 86:247-51.

Gómez de Barreda E, Pérez M, Gómez Ramos P et al. Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits. Neurobiol Dis 2010; 37:622-9.

Gómez-Lechón MJ, Donato T, Jover R et al. Expression and induction of a large set of drug-metabolizing enzymes by the highly differentiated human hepatoma cell line BC2. Eur J Biochem 2001; 268:1448-59.

Gómez-Reino JJ, Pablos JL, Carreira PE et al. Association of rheumatoid arthritis with a functional chemokine receptor, CCR5. Arthritis Rheum 1999; 42:989-92.

Gomez-Rubio P, Meza-Montenegro MM, Cantu-Soto E, Klimecki WT. Genetic association between intronic variants in AS3MT and arsenic methylation efficiency is focused on a large linkage disequilibrium cluster in chromosome 10. J Appl Toxicol 2010; 30:260-70.

Gomez-Sanchez JC, Delgado-Esteban M, Rodriguez-Hernandez I et al. The human Tp53 Arg72Pro polymorphism explains different functional prognosis in stroke. J Exp Med 2011; 208:429-37.

Gomis R. Repaglinide as monotherapy in type 2 diabetes. Exp Clin Endocrinol Diabetes 1999; 107 Suppl 4:133-5.

Gong H, Guo P, Zhai Y et al. Estrogen deprivation and inhibition of breast cancer growth in vivo through activation of the orphan nuclear receptor liver X receptor. Mol Endocrinol 2007; 21:1781-90.

Gong H, Jarzynka MJ, Cole TJ et al. Glucocorticoids antagonize estrogens by glucocorticoid receptor-mediated activation of estrogen sulfotransferase. Cancer Res 2008; 68:7386-93.

Gong IY, Tirona RG, Schwarz UI et al. Prospective evaluation of a pharmacogenetics-guided warfarin loading and maintenance dose regimen for initiation of therapy. Blood 2011; 118:3163-71.

Gong P, Cederbaum AI, Nieto N. Increased expression of cytochrome P450 2E1 induces heme oxygenase-1 through ERK MAPK pathway. J Biol Chem 2003; 278:29693-700.

Gong QH, Cho JW, Huang T et al. Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus. Pharmacogenetics 2001; 11:357-68.

Gong R, Liu Z, Li L. Epistatic effect of plasminogen activator inhibitor 1 and beta-fibrinogen genes on risk of glomerular microthrombosis in lupus nephritis: interaction with environmental/clinical factors. Arthritis Rheum 2007; 56:1608-17.

Gong X, Schwartz PH, Linskey ME, Bota DA. Neural stem/progenitors and glioma stem-like cells have differential sensitivity to chemotherapy. Neurology 2011; 76:1126-34.

Gongadze N, Kezeli T, Antelava N. Prolong QT interval and "torsades de pointes" associated with different group of drugs. Georgian Med News 2007; 12:45-9.

Gonias SL, Lysiak JJ, Umans L, van Leuven F, Webb DJ, Wen J. Murine alpha-macroglobulins demonstrate divergent activities as neutralizers of transforming growth factor-beta and as inducers of nitric oxide synthesis: a possible mechanism for the endotoxin insensitivity of the alpha-2-macroglobulin gene knock-out mouse. J Biol Chem 1996; 271:24982-88.

Gonsorcikova L, Vaxillaire M, Pruhova S et al. Familial mild hyperglycemia associated with a novel ABCC8-V84I mutation within three generations. Pediatr Diabetes 2011; 12:266-9.

Gontero P, Sargent JM, Hopster DJ et al. Ex vivo chemosensitivity to mitomycin C in bladder cancer and its relationship with P-glycoprotein and apoptotic factors. Anticancer Res 2002; 22:4073-80.

González A, Alvarez-García V, Martínez-Campa C, Alonso-González C, Cos S. Melatonin promotes differentiation of 3T3-L1 fibroblasts. J Pineal Res 2011. doi:10. 1111/j. 1600-079X. 2011. 00911. x.

González Della Valle A, Khakharia S, Glueck CJ et al. VKORC1 variant genotypes influence warfarin response in patients undergoing total joint arthroplasty: a pilot study. Clin Orthop Relat Res 2009; 467:1773-80.

Gonzalez FJ. Role of gene knockout and transgenic mice in the study of xenobiotic metabolism. Drug Metab Rev 2003; 35:319-35.

Gonzalez FJ. Cytochrome P450 humanised mice. Hum Genomics 2004; 1:300-6.

Gonzalez FJ. CYP3A4 and pregnane X receptor humanized mice. J Biochem Mol Toxicol 2007; 21:158-62.

González HM, Romero EM, Chavez Tde J, Peregrina AA, Quezada V, Hoyo-Vadillo C. Phenotype of CYP2C19 and CYP3A4 by determination of omeprazole and its two main metabolites in plasma using liquid chromatography with liquid-liquid extraction. J Chromatogr B Analyt Technol Biomed Life Sci 2002; 780:459-65.

González HM, Romero EM, Peregrina AA et al. CYP2C19- and CYP3A4-dependent omeprazole metabolism in West Mexicans. J Clin Pharmacol 2003; 43:1211-5.

González I, Peñas-Lledó EM, Pérez B, Dorado P, Álvarez M, Llerena A. Relation between CYP2D6 phenotype and genotype and personality in healthy volunteers. Pharmacogenomics 2008; 9:833-40.

Gonzalez MC, Marteau C, Franchi J, Migliore-Samour D. Cytochrome P450 4A11 expression in human keratinocytes: effects of ultraviolet irradiation. Br J Dermatol 2001; 145:749-57.

González P, Alvarez R, Batalla A et al. Genetic variation at the chemokine receptors CCR5/CCR2 in myocardial infarction. Genes Immun 2001; 2:191-5.

González R, Collado JA, Nell S et al. Cytoprotective properties of alpha-tocopherol are related to gene regulation in cultured D-galactosamine-treated human hepatocytes. Free Radic Biol Med 2007; 43:1439-52.

González R, Cruz A, Ferrín G et al. Cytoprotective properties of rifampicin are rel